Abstract：
PURPOSE:Treatment options for antimuscarinic refractory neurogenic detrusor overactivity (NDO) are botulinum toxin type A injections (BTX-A) and augmentation cystoplasty (AC). We estimated initial and cumulative 5-year costs of these treatments. MATERIALS AND METHODS:Base case is an individual with antimuscarinic refractory NDO and decreased bladder compliance. Primary analysis is from the health care payor perspective. Model probabilities and ranges were derived from literature and chart review. Reimbursements were derived from the average of insurance carriers. Complication cost calculations were based on standard practice. Decision-analysis model was made with TreeAge Pro Healthcare 2009 Software, Inc. and rolled back for cost calculation. One-way sensitivity analysis was performed on all variables, and two-way sensitivity analyses were based on these results. RESULTS:Average reimbursement for one BTX-A injection and AC was $2,946.83 and $25,041.53, respectively. BTX-A treatment was less expensive over 5 years, costing $28,065. The model was only sensitive within a reasonable clinical range for Botox durability. BTX-A was more cost-effective over 5 years if the effect lasted for >5.1 months. The model was based on an AC complication rate of 40%. If the PAC complication rate<14%, AC was cheaper over 5 years. The model was sensitive to surgeons costs of BTX-A ($3,027) and facility costs of BTX-A ($1,004) and AC ($17,100). CONCLUSIONS:This is the first cost analysis of BTX-A and AC. BTX-A is cheaper at durations>5.1 months and AC was cheaper when the cost of BTX-A increases or the AC complication rate dropped below 14%.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Padmanabhan P,Scarpero HM,Milam DF,Dmochowski RR,Penson DFdoi
10.1007/s00345-010-0618-3subject
Has Abstractpub_date
2011-02-01 00:00:00pages
51-7issue
1eissn
0724-4983issn
1433-8726journal_volume
29pub_type
杂志文章abstract：PURPOSE:We hypothesized that a relevant number of patients with clinically high-risk prostate cancer (PCA) indeed harbor overall favorable tumor characteristics (OFTC) (i.e., pT2a-c and Gleason score ≤3 + 4 = 7 and pN0/X) and that in these patients radical prostatectomy (RP) alone is most likely curative. METHODS:Betw...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1274-9
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:We aimed to investigate the association between nocturia and serum metabolites identified using metabolomics analysis. METHODS:This study enrolled 66 men aged 65-80 years, recruited from the outpatient department of a university hospital. The participants were stratified as follows: Nocturia group [45 men with...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02647-4
更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION:Urinary incontinence in men after radical prostatectomy affects strongly quality of life. If conservative treatment fails, surgical treatment consists of implantable devices. If the requirement of manual dexterity in the artificial sphincter is to be avoided, the ProACT system offers a readjustable system,...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2483-4
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To evaluate temporary double J ureteric stenting (TDJS) as a test to diagnose ureteropelvic junction obstruction (UPJO) in equivocal cases. MATERIALS AND METHODS:One hundred and nine consecutive adult patients with loin pain and ipsilateral equivocal UPJO (EqUPJO) on radioisotope diuretic renogram (RDR) were e...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0464-3
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To review the etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:A literature review for the years 1985-2012 was performed using the MEDLINE database of the United States National Library of Medicine. RESULTS:The evidence for ongoing infection in men with CP/CPPS ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1061-z
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated. MATERIALS AND METHODS:One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. RESULTS:The ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02767-x
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:MicroRNAs (miRNAs) play an important role as regulators of gene expression in tumourigenesis by controlling many biological processes in growth, development, differentiation and apoptosis. Previous studies have shown an altered expression of specific miRNAs in clear cell renal cell carcinoma (ccRCC). But the fu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0633-4
更新日期：2011-06-01 00:00:00
abstract：:Local recurrent prostate cancer after radical treatment is found in the majority of men with a rising PSA. Salvage treatment procedures for recurrent disease, such as radiation therapy and ablative procedures, can provide long-term responses in well-selected cases. Prostate magnetic resonance imaging (MRI) allows diag...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02677-y
更新日期：2019-08-01 00:00:00
abstract：:Our objectives were to assess the value of extracorporeal shock wave lithotripsy (ESWL) in treating pediatric urolithiasis, and to determine the factors that may affect treatment success. Between January 1993 and August 2002, 129 children with upper urinary tract calculi (134 renoureteral units) were treated using a D...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-003-0385-5
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:Previous studies examining the management of urinary tract infections (UTI) showed marked variability in the economical burden of care, with a tenfold increase in costs when patients require admission to the hospital. We sought to examine the patient and emergency department (ED) characteristics associated with...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-013-1167-3
更新日期：2014-06-01 00:00:00
abstract：:A once-daily (o.d.) formulation of alfuzosin has recently been developed in order to improve the convenience of dosing and to provide optimal pharmacokinetic coverage over a 24-h period. The results of two double-blind, placebo-controlled phase III studies of similar design that included 983 patients with LUTS that su...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-002-0244-9
更新日期：2002-04-01 00:00:00
abstract：PURPOSE:To describe results of a simplified technique to configure the vesicourethral anastomosis and to restore posterior musculofascial plate during laparoscopic radical prostatectomy with a "single knot-single running" suture. METHODS:Between December 2006 and 2009, a conventional Van Velthoven anastomosis (group A...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-012-0840-2
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:The significance of a positive UroVysion FISH assay is uncertain in patients with normal cystoscopy. This multicenter study evaluates the clinical significance of a positive FISH assay in patients with no visible tumor and excluding those with a positive cytology. METHODS:A multi-institutional, retrospectiv...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1452-9
更新日期：2015-09-01 00:00:00
abstract：:This paper provides an overview of the scientific and practical aspects of assessing health-related quality of life (HRQL). The paper provides a brief overview of developments in the field and then discusses the definition of HRQL. The different types of HRQL measure available to researchers are described, with specif...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050132
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS:Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels wer...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-1009-8
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:To assess the long-term patient-reported outcomes following TO-TVT as a secondary continence procedure in women with recurrent stress urinary incontinence (R-SUI). METHODS:A secondary analysis of the 9-year follow-up of the E-TOT study was performed: 341 women with predominant SUI symptoms were randomised to u...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-016-1969-1
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVES:To evaluate retrospectively the objective and subjective parameters in 42 male patients who underwent bone anchored sub-urethral sling positioning (BAUS) for SUI (stress urinary incontinence) due to ISD (intrinsic sphincter deficiency). METHODS:Patients with SUI due to radical retropubic prostatectomy (36 p...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0222-3
更新日期：2008-04-01 00:00:00
abstract：:It is well established that transmitters of the nonadrenergic-noncholinergic (NANC) system are involved in the control of sexual arousal and penile erection in healthy males. The proerectile activity of dopamine D1/D2 receptor agonist apomorphine-HCl (IXENSE, UPRIMA) involves oxytocinergic pathways descending from the...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-002-0300-5
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:To assess the efficacy of an accelerated proficiency-based training protocol in robotic simulation practice in delivering durable proficiency compared to conventional training methods. METHODS:Novice medical students (n = 16) were randomized into either the accelerated skills acquisition protocol (ASAP) or con...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02858-9
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:We reviewed our patients with pathologic T3b renal cell carcinoma (RCC) to determine which factors influenced survival in this high risk patient group. METHODS:From April 1988 to August 2006, 722 patients underwent nephrectomy for RCC at Vanderbilt University. 128 patients (17%) had T3b disease by 2002 AJCC...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0358-9
更新日期：2009-02-01 00:00:00
abstract：:The diagnosis of prostate cancer is based on histology. Prostate biopsies are obtained based on the triad of prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound. Because prostate biopsies still have a large percentage of negative outcomes, patient selection and biopsy direction...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0189-0
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2243-5
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Orchialgia after laproscopic renal surgery has been rarely reported in literature, and gonadal vein ligation is considered the main etiology. Our objective was to study the incidence, intensity and to find out any specific factors that could lead to orchialgia. MATERIALS AND METHODS:All patients planned for la...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0864-7
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:To assess long-term clinical and oncological outcome in women undergoing radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. METHODS:From 1995 to 2010, a total of 121 women with clinically organ-confined urothelial carcinoma underwent radical cystectomy with an orthotopic ileal ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0837-x
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC....
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03076-4
更新日期：2020-11-01 00:00:00
abstract：:Serotonin (5-hydroxytryptamine; 5-HT), a vasoactive bioamine with potent contractile activity, is thought to act indirectly in the urinary bladder by the stimulation of its presynaptic receptors. This results in the release of acetylcholine (ACh), which then acts on muscarinic receptors to produce bladder contractilit...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050142
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:To compare oncological, functional, and toxicity outcomes of patients with radiation-recurrent prostate cancer (PCa) after external beam radiation therapy (EBRT) or brachytherapy (BT) treated with salvage high-intensity focused ultrasound (S-HIFU) or salvage radical prostatectomy (S-RP). METHODS:This retrospec...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02640-x
更新日期：2019-08-01 00:00:00
abstract：:The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00192265
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To analyse the surgical margins status of prostatic glands, resected by laparoscopic radical prostatectomy (LRP) for prostate cancer, and to correlate it with biochemical free survival rate (BFSR). METHODS:Data were collected prospectively from 405 patients undergoing LRP from 2000 to 2009 at a single institut...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0711-2
更新日期：2012-04-01 00:00:00
abstract：:Noncontrast helical computed tomography (CT) has recently been found to be superior to excretory urography (IVU) in the evaluation of patients with suspected ureterolithiasis. Noncontrast helical CT does not require the use of intravenous contrast material with its associated cost and risk of adverse reactions and can...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050020
更新日期：1998-01-01 00:00:00
