Abstract:
:Can urolithiasis start as an intratubular event? Under severe hyperoxaluric conditions in animal models at least crystal formation can. Recently models have been presented that assess the chances of crystal formation under more normal conditions. These models describe changes in fluid composition as this passes through the nephron, these conditions being simulated in in vitro experiments. It appears that under naturally occurring intratubular conditions calcium-salt crystallization takes place within the time tubular fluid normally spends in the nephron. Precipitation starts with a calcium-phosphate phase under conditions found in the thin lambs. This crystalline phase then (partly) dissolves when collecting duct conditions are used, thereby inducing formation of calcium oxalates. Under these conditions the latter increase in size by way of crystal growth and agglomeration. Large particle formation and cell adhesion can eventually result in particle retention and subsequent stone formation. Viewing urolithiasis as originally an intratubular event has consequences for in vitro experiments and treatments, which are discussed in this paper.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Kok DJdoi
10.1007/BF01367659subject
Has Abstractpub_date
1997-01-01 00:00:00pages
219-28issue
4eissn
0724-4983issn
1433-8726journal_volume
15pub_type
杂志文章,评审abstract:PURPOSE:The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC....
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03076-4
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:Kidney transplantation (KT) is the preferred treatment for patients with end-stage renal disease (ESRD). To reduce the morbidity of the open surgery, a robotic-assisted approach has been recently introduced. Our aim is to evaluate surgical and functional results on 17 cases of robotic-assisted kidney trans...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2006-8
更新日期:2017-10-01 00:00:00
abstract::Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predom...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00185972
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Patients and their families utilize online resources when dealing with a diagnosis of bladder cancer. Many patients have questions regarding clinical management options. Online research forums may help researchers and providers identify research areas of interest. Our objective was to review online forums and i...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2479-0
更新日期:2019-06-01 00:00:00
abstract::In this prospective study a comparison of 4-versus 7-MHz transrectal ultrasonography for the detection of prostatic carcinoma is reported. A total of 150 prostates were biopsied due to suspicion of malignancy arising at either digital rectal examination, 4- and/or 7-MHz transrectal ultrasonography, or elevated serum p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182174
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2243-5
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To evaluate contemporary international trends in the implementation of minimally invasive adrenalectomy and to assess contemporary outcomes of different minimally invasive techniques performed at urologic centers worldwide. METHODS:A retrospective multinational multicenter study of patients who underwent min...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-016-1791-9
更新日期:2016-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0864-7
更新日期:2013-10-01 00:00:00
abstract::A Persian Gulf War veteran presented to the University Neuro-Urology service for management of severe chronic perineal pain. The overall physical and neurological exam was unremarkable. However, the rectal exam and the urodynamic study revealed a severe pelvic floor dysfunction. A neuro-behavioral approach is recommen...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/pl00007098
更新日期:2001-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1522-7
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:To evaluate the clinical significance of invasive urothelial carcinoma that is ambiguous for muscularis propria invasion on initial transurethral resection of bladder tumor (TURBT). METHODS:All consecutive in-house TURBTs with invasive urothelial carcinoma from 1999 to 2017 that underwent radical cystectomy (R...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02782-y
更新日期:2020-02-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-006-0114-y
更新日期:2006-11-01 00:00:00
abstract::Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect coverage depends more on the remaining genital skin than on the etio...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050115
更新日期:1999-04-01 00:00:00
abstract:PURPOSE:We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients. MATERIALS AND METHODS:This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemica...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2130-5
更新日期:2018-02-01 00:00:00
abstract::Candiduria is commonly seen in hospitalized patients and most of the patients are asymptomatic, but it may be due to cystitis, pyelonephritis, prostatitis, epididymo-orchitis or disseminated candidiasis. Major risk factors are diabetes mellitus, indwelling urinary catheters, use of broad-spectrum antibiotics, urinary ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02991-5
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:The conservative management of upper tract urothelial carcinoma (UTUC) has historically been offered to patients with imperative indications. The recent International Consultation on Urologic Diseases (ICUD) publication on UTUC stratified treatment allocations based on high- and low-risk groups. This repor...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1859-6
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Robotic radical prostatectomy claims optimal oncologic results, minimal morbidity and best outcomes of urinary continence and erection function. Potential benefits concerning side effects and complications compared to open radical prostatectomy are analysed. METHODS:Out of 450 robotic radical prostatectomie...
journal_title:World journal of urology
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1007/s00345-008-0287-7
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:To assess the common practice to transiently place an indwelling transurethral catheter in case of hospitalization of women with febrile urinary tract infections. So far, this intervention has not been scientifically investigated. METHODS:Inclusion criteria were female gender, a leucocyte esterase-positive uri...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-018-2474-5
更新日期:2019-05-01 00:00:00
abstract:INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-012-0899-9
更新日期:2012-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2605-z
更新日期:2019-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00345-013-1053-z
更新日期:2013-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-013-1092-5
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:Bladder perforation is the second most common complication during transurethral resection of bladder tumours. It is unknown whether perforation affects the natural history of the tumour through cell seeding. The aim of this study was to study the impact of perforation on the oncologic outcomes of bladder car...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1197-x
更新日期:2014-10-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2052-2
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To determine the clinical performance of a blood-based test for clinically significant (CS) prostate cancer (PCa) (grade group ≥ 2) intended for use in men with prostate serum antigen levels in the 'grey zone' (PSA < 10 ng/ml). The test quantifies a previously described 3.4 kb mitochondrial DNA (mtDNA) deletion...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2152-z
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1960-x
更新日期:2017-06-01 00:00:00
abstract:PURPOSE/OBJECTIVE(S):Recent in vitro and in vivo evidence has suggested that statin medications may have anticancer activity. We sought to determine whether statin use was associated with improved clinical outcome in men treated with brachytherapy for prostate cancer. MATERIALS/METHODS:A database of men with prostate ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1281-x
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The aim of the study is to evaluate the impact of having a nadir and persistently detectable ultrasensitive prostate-specific antigen (uPSA) between 0.01 and 0.1 ng/ml post-robot-assisted radical prostatectomy (RARP), on future biochemical recurrence (BCR). METHODS:We conducted a retrospective analysis of a pr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03367-w
更新日期:2020-07-21 00:00:00
abstract:PURPOSE:We aimed to explore the knowledge, attitudes, and practices towards prostate cancer (PCa) risk factors and prevention amongst men living in the southern Italian peninsula. METHODS:We retrospectively reviewed data collected during free preventive visits carried out by the Prevention and Research in Oncology (PR...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2074-9
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:We sought the association of preoperative serum total testosterone (tT), hypogonadism, 17β estradiol (E2), and sex hormone-binding globulin (SHBG) with early biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS:Sex steroids were assessed the day before surgery (7-11 a.m.) in a cohort of 605 p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0856-7
更新日期:2013-04-01 00:00:00