Abstract：
PURPOSE:To test the association between family history of prostate cancer (FH) and prostate cancer (PCa) risk in a large screening program in Brazil, as no conclusive study has yet investigated this. METHODS:Between 2004 and 2007, 17,569 men were screened in 231 small municipalities using mobile screening units. Positive FH was defined as any relative having PCa among screened men. Men were biopsied if they had digital rectal examination suggestive of PCa or PSA >4.0 ng/mL or PSA of 2.5-4 ng/mL with percent free PSA ≤ 15 %. We analyzed the association between FH and PCa using multivariable logistic regression in the first screening round of the program. RESULTS:Positive FH was present in 735 men (4.2 % of total), and they were younger, better educated and more likely to have had previous PCa screening (41.5 vs. 28.5 %; P < 0.001) compared to men with negative FH. FH status did not affect compliance rates in men recommended to undergo biopsy (P = 0.94). In first round, PCa was detected in 3.1 % of screened men (n = 552). In multivariable analysis, positive FH was associated with increased PCa risk (OR = 1.79; 95 % CI, 1.21-2.65; P = 0.003). However, Gleason scores (P = 0.78) or percent of positive cores (P = 0.32) among men with positive biopsies were similar, regardless of FH status. CONCLUSIONS:In Brazil, men with positive FH were at increased PCa risk, which could not be explained by differential biopsy rates. This finding suggests that FH is also a true PCa risk factor in Brazil, a country with highly diverse population in terms of race, ethnicity, culture and socioeconomic status.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Muller RL,Faria EF,Carvalhal GF,Reis RB,Mauad EC,Carvalho AL,Freedland SJdoi
10.1007/s00345-012-0904-3subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1273-8issue
5eissn
0724-4983issn
1433-8726journal_volume
31pub_type
杂志文章,多中心研究abstract：OBJECTIVES:To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS:We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 cor...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-008-0264-1
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To provide appropriate evidence for treatment planning of patients with an impacted proximal ureteral stones ≥1.5 cm in size, by analyzing the therapeutic outcomes for those undergoing minimally invasive percutaneous antegrade ureterolithotripsy and retrograde ureterolithotripsy. PATIENTS AND METHODS:From Se...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-013-1026-2
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:Robotic-assisted laparoscopic (RAL) surgery has gained momentum in pediatric urology. Technological adaptations such as the development of 5 mm instruments have led to robotic procedures being performed on younger children and those having smaller body habitus, with improved cosmesis. However, concerns have bee...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02765-z
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate c...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0797-6
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To assess treatments and survival of patients with muscle invasive bladder cancer (MIBC) in the Comprehensive Cancer Center Northern Netherlands (CCCN) region. STUDY DESIGN AND SETTING:Retrospective cohort analysis. Data of 548 patients with MIBC diagnosed between 1997 and 2002 were collected from the CCCN c...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0546-2
更新日期：2010-08-01 00:00:00
abstract：INTRODUCTION:With low life expectancy rates in hemodialysis patients, the preservation of renal parenchyma must be weighed against the oncological outcomes in considering partial nephrectomy (PN) in solitary kidneys. The main objective of this study was to assess the oncologic and functional outcomes after PN in patien...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0576-9
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:To assess the long-term patient-reported outcomes following TO-TVT as a secondary continence procedure in women with recurrent stress urinary incontinence (R-SUI). METHODS:A secondary analysis of the 9-year follow-up of the E-TOT study was performed: 341 women with predominant SUI symptoms were randomised to u...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-016-1969-1
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) provides reasonable performance in detecting significant cancers. Still, it is unclear about whether all PI-RADS 4 lesions show the same cancer detection rate (CDR) regardless of tumor size. The aim was to compare the CDRs of small (< 10 mm) and l...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02924-2
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:To evaluate the perioperative morbidity of PC-RPLND in two intermediate volume centers and to identify predictors of high morbidity. METHODS:Retrospective analysis of 124 patients treated with open PC-RPLND at two tertiary referral centers between 2001 and 2018. Perioperative morbidity was determined by analyz...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03229-5
更新日期：2020-05-05 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:The possibility of performing remote-surgery has been the goal to achieve, since the early development of the first surgical robotic platforms. This systematic review aims to analyse the state of the art in the field and to provide an overview of the possible growth of this technology. METH...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02996-0
更新日期：2020-10-01 00:00:00
abstract：:The aim of this article is to describe the current ultrasound (US) contrast agents employed in the characterization of renal tumors and to report our experience in the use of a contrast-specific ultrasound technique pulse inversion harmonic imaging (PIHI).A total of 23 renal masses were prospectively evaluated by conv...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-004-0410-3
更新日期：2004-11-01 00:00:00
abstract：:This review paper highlights the important health issue of orchialgia and the chronic pelvic pain syndrome. There are a number of specific and non-specific etiologies and different treatment options based on the sub-categorization of orchialgia. The focus of this article is on the specific etiologies of chronic orchia...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-013-1092-5
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Oxidative stress is believed to be one of the important etiologies in carcinogenesis that has not been systemically investigated in urothelial carcinoma (UC). Through data mining from a published transcriptomic database of UC of urinary bladders (UBUCs) (GSE31684), glutathione peroxidase 2 (GPX2) was identified...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1522-7
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:To investigate pathological and oncological outcomes of obese patients who underwent robot-assisted radical prostatectomy (RARP) compared with laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (RRP) since limited comparative data exist with regard to oncological and survival o...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1326-1
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:To evaluate whether stone dust can be obtained from all prevailing stone composition types using the thulium fiber laser (TFL) for lithotripsy. Where applicable, stone dust was further characterized by morpho-constitutional analysis. METHODS:Human urinary stones were submitted to in vitro lithotripsy using a F...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03217-9
更新日期：2020-05-03 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:Previous studies reported improved outcomes for bladder cancer patients who had radical cystectomy (RC) performed by surgeons and hospitals with high annual RC volumes. The objective of this study was to determine the effect of high hospital and surgeon volume on overall survival after RC fo...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1457-4
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:To evaluate the opinion of urologists and their audience regarding patient safety and educational value of live surgical demonstrations (LSD) and semi-live surgical demonstrations (semi-LSD). METHODS:Following the '2017 Challenges in Endourology' meeting, a survey addressing patient safety and the educational ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2291-x
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:We sought the association of preoperative serum total testosterone (tT), hypogonadism, 17β estradiol (E2), and sex hormone-binding globulin (SHBG) with early biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS:Sex steroids were assessed the day before surgery (7-11 a.m.) in a cohort of 605 p...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0856-7
更新日期：2013-04-01 00:00:00
abstract：:Gastrin releasing peptide (GRP) is a neuropeptide that has been suggested to play a role in the development of some malignancies. Our aim was: (1) to identify the expression of GRP in cancerous prostate glands, and (2) to correlate its expression to various pathological parameters and to the patient's clinical outcome...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0339-y
更新日期：2003-08-01 00:00:00
abstract：PURPOSE:To compare oncological, functional, and toxicity outcomes of patients with radiation-recurrent prostate cancer (PCa) after external beam radiation therapy (EBRT) or brachytherapy (BT) treated with salvage high-intensity focused ultrasound (S-HIFU) or salvage radical prostatectomy (S-RP). METHODS:This retrospec...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02640-x
更新日期：2019-08-01 00:00:00
abstract：:One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...
journal_title：World journal of urology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s003450050125
更新日期：1999-06-01 00:00:00
abstract：PURPOSE:We compared perioperative and long-term renal functional outcomes of robot-assisted partial nephrectomy (RAPN) with laparoscopic partial nephrectomy (LPN) for small renal masses. MATERIALS AND METHODS:A total of 1,032 patients were included for evaluation; propensity score matching was performed to adjust for ...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-015-1488-5
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:To evaluate the thermal effect of Ho:YAG laser lithotripsy in a standardized in vitro model via real-time temperature measurement. METHODS:Our model comprised a 20 ml test tube simulating the renal pelvis that was immersed in a 37 °C water bath. Two different laser fibers [FlexiFib (15-45 W), RigiFib 1000 (45-...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2303-x
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Previous studies of the cell cycle progression (CCP) score in surgical specimens of prostate cancer (PCa) in patients treated by radical prostatectomy (RP) demonstrated significant association with time to biochemical recurrence (BCR). In this study, we compared the ability of the CCP score and the expression o...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-018-2290-y
更新日期：2018-09-01 00:00:00
abstract：:Familial risks for cancer are important for clinical counseling and understanding cancer etiology. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0 to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Urological cancer cases were retrieved fro...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0375-7
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS:Between 2000 and 2011, 4038 patients who underwent R...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-016-1979-z
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:We sought whether serum total testosterone (tT), estradiol (E2), tT/E2 ratio, and sex hormone-binding globulin (SHBG) significantly fluctuate throughout time in men with prostate cancer (PCa). METHODS:Circulating hormones were measured in a cohort of 631 candidates for radical prostatectomy. Hormone levels wer...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-1009-8
更新日期：2013-04-01 00:00:00
abstract：:The diagnosis of prostate cancer (PCa) can be challenging due to the limited performance of current diagnostic tests, including PSA, digital rectal examination and transrectal conventional US. Multiparametric MRI has improved PCa diagnosis and is recommended prior to biopsy; however, mp-MRI does miss a substantial num...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03193-0
更新日期：2020-04-18 00:00:00
abstract：PURPOSE:The mechanisms responsible for the pathogenesis of long-term renal damage induced by extracorporeal shock wave lithotripsy (ESWL) are not clear. The present study was designed to investigate the role of nuclear factor κB (NFκB) signal pathway in the pathogenesis of chronic shock wave-induced renal damage in rat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0515-9
更新日期：2010-10-01 00:00:00
abstract：PURPOSE:Current systemic treatment of targeted therapies, namely the vascular endothelial growth factor-antibody (VEGF-AB), VEGF receptor tyrosine kinase inhibitor (TKI) and mammalian target of rapamycin (mTOR) inhibitors, have improved progression-free survival and replaced non-specific immunotherapy with cytokines in...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-016-1868-5
更新日期：2017-02-01 00:00:00
