Analysis of long-term survival in patients with localized renal cell carcinoma: laparoscopic versus open radical nephrectomy.

Abstract:

OBJECTIVES:To assess the impact of surgical approaches and clinico-pathological parameters on the prognosis of localized renal cell carcinoma (RCC) after laparoscopic radical nephrectomy (LRN) or open radical nephrectomy (ORN). METHODS:Between 2002 and 2008, 336 patients with localized RCC were treated at our two institutions. Of these, 261 were classified as clinical stage pT1 and 75 as pT2, the mean age was 52.3 years. One hundred forty-two patients underwent LRN, and 194 underwent ORN. The medical records of all patients were retrospectively reviewed. RESULTS:The mean follow-up was 44 months (12-84 months). The 3-, 5-, and 7-year cancer-specific survival (CSS) rates of LRN group (96.3, 94.6, and 92.5%, respectively) were equivalent to ORN (97.4, 94.2, and 91.4%, respectively). The mean CSS rates were not significantly different between LRN and ORN groups for either pT1 (82.3 vs. 81.6 months, P = 0.713) or pT2 (69.0 vs. 72.1 months, P = 0.729). Univariate analysis demonstrated significant impact of tumor stage (pT1 vs. pT2, P = 0.002) and tumor grade (G1/2 vs. G3/4, P = 0.045) on CSS. Surgical approach (laparoscopic or open) was not a statistically significant factor on CSS. Multivariate analysis identified that tumor stage was an independent prognostic factor for CSS of localized RCC (P = 0.007). CONCLUSIONS:Based on the long-term follow-up, our evaluation suggests that LRN is oncologically equivalent to ORN for patients with pT1 or pT2 tumors. Among the clinical variables, tumor stage appears to be an independent prognostic factor of CSS of localized RCC patients.

journal_name

World J Urol

journal_title

World journal of urology

authors

Luo JH,Zhou FJ,Xie D,Zhang ZL,Liao B,Zhao HW,Dai YP,Chen LW,Chen W

doi

10.1007/s00345-009-0487-9

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

289-93

issue

3

eissn

0724-4983

issn

1433-8726

journal_volume

28

pub_type

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