Abstract:
:Urinary bladder cancer (UBC) ranks ninth in worldwide cancer incidence. It is more frequent in men than in women. We review the main established/proposed factors, both environmental and genetic, associated with bladder cancer etiology and prognosis. Data were extracted from previous reviews and original articles identified from PubMed searches, reference lists, and book chapters dealing with the reviewed topics. Evaluation and consensus of both the contribution of each factor in bladder cancer burden and the appropriateness of the available evidences was done during an ad hoc meeting held during the 18th Congress of the European Society for Urological Research. Cigarette smoking and specific occupational exposures are the main known causes of UBC. Phenacetin, chlornaphazine and cyclophosphamide also increase the risk of bladder cancer. Chronic infection by Schistosoma haematobium is a cause of squamous cell carcinoma of the bladder. NAT2 slow acetylator and GSTM1 null genotypes are associated with an increased risk of this cancer. Vegetables and fresh fruits protect against this tumor. Regarding prognosis, there is little knowledge on the predictive role of environmental exposures and genetic polymorphisms on tumor recurrence and progression and patient's death. Although active tobacco smoking is the most commonly studied factor, no definitive conclusion can be drawn from the literature. More research is needed regarding the effect of complex etiological factors in bladder carcinogenesis. Subgroup analysis according to stage, grade, and molecular features may help in identifying specific etiological and prognostic factors involved in different bladder cancer progression pathways.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Murta-Nascimento C,Schmitz-Dräger BJ,Zeegers MP,Steineck G,Kogevinas M,Real FX,Malats Ndoi
10.1007/s00345-007-0168-5subject
Has Abstractpub_date
2007-06-01 00:00:00pages
285-95issue
3eissn
0724-4983issn
1433-8726journal_volume
25pub_type
杂志文章,评审abstract::The present discussion on the natural history, growth rate pathophysiology, morbidity, and possible treatment of benign prostatic hyperplasia (BPH) reinforces the need to objectify mechanical BPH-induced obstruction with pressure-flow study. Different methods for the quantification of BPH-induced obstruction exist and...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182667
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Reactive oxygen species (ROS) are produced during the interaction between oxalate/calcium oxalate monohydrate (COM) crystals and renal epithelial cells and are responsible for the various cellular responses through the activation of NADPH oxidase (Nox). Ox and COM also activate the renin-ang...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1563-y
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:We hypothesized that a relevant number of patients with clinically high-risk prostate cancer (PCA) indeed harbor overall favorable tumor characteristics (OFTC) (i.e., pT2a-c and Gleason score ≤3 + 4 = 7 and pN0/X) and that in these patients radical prostatectomy (RP) alone is most likely curative. METHODS:Betw...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1274-9
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-018-2538-6
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1960-x
更新日期:2017-06-01 00:00:00
abstract::This review paper highlights the important health issue of orchialgia and the chronic pelvic pain syndrome. There are a number of specific and non-specific etiologies and different treatment options based on the sub-categorization of orchialgia. The focus of this article is on the specific etiologies of chronic orchia...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-013-1092-5
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To compare the efficacy, safety, Patient Global Impression of Improvement (PGI-I), and complications rates after 180-W GreenLight laser (180-W GL laser) standard and anatomical photoselective vaporization (sPVP and aPVP). METHODS:Within a multi-institutional database, we identified patients who underwent sPVP ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2106-5
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Salvage radiotherapy (SRT) for biochemical recurrence (BCR) following radical prostatectomy (RP) should if possible be added at a prostate-specific antigen (PSA) level of <1-2 ng/mL. The value of positron emission tomography combined with computed tomography (PET/CT) at such low PSA values is not defined. The p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1547-y
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:Management of prostate cancer following radiation therapy remains challenging, especially for younger men or those with life expectancy greater than 10 years. We outline the efficacy, safety and adequacy of radical prostatectomy for the treatment of radiorecurrent localized prostate cancer. METHODS:A systemati...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-013-1029-z
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:Radiation for tumors arising in the pelvis has been utilized for over a 100 years. Adverse effects (AEs) of radiotherapy (RT) continue to accumulate with time and are reported to show decades after treatment. The benefit of RT for pelvic tumors is well described as is their acute AEs. Late AEs are less well d...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-010-0603-x
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of age, stone size, location, radiolucency, extraction of stone fragments, size of ureteroscope and presence and degree of hydronephrosis on the efficacy and safety of holmium:YAG (Ho:YAG) laser lithotripsy in the ureteroscopic treatment of ureteral stones in children. METHODS:Between...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1152-x
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To reach standardized terminology in focal therapy (FT) for prostate cancer (PCa). METHODS:A four-stage modified Delphi consensus project was undertaken among a panel of international experts in the field of FT for PCa. Data on terminology in FT was collected from the panel by three rounds of online questionna...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-016-1782-x
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:The factors affecting spermatogenesis in adulthood in patients with hypospadias (HS) are not clearly understood. In the present study, risk factors affecting post-pubertal high serum follicle-stimulating hormone (FSH) were evaluated in patients with HS. MATERIALS AND METHODS:Among those with a history of HS su...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02687-w
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:Although randomized controlled trials (RCTs) remain the gold standard for determining evidence-based clinical practices, large disease registries that enroll large numbers of patients have become paramount as a relatively cost-effective additional tool. METHODS:We highlight the advantages of disease regis...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0658-3
更新日期:2011-06-01 00:00:00
abstract:: ...
journal_title:World journal of urology
pub_type: 社论
doi:10.1007/s00345-019-02659-0
更新日期:2019-02-01 00:00:00
abstract::The landscape has dramatically changed for patients seeking treatment for rapid ejaculation. Previously, psychotherapy or behavioral treatment was considered to be the treatment of choice for this troubling sexual dysfunction. Since the early 1990s, an efficacious alternative treatment has emerged-the off-label admini...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-004-0489-6
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:Despite the increasing number of studies confirming the importance of neoadjuvant chemotherapy (NC) in patients before radical cystectomy (RC) for bladder cancer (BCa), NC remains underused. The aim of our study was to develop a nomogram predicting the cancer-specific mortality (CSM) of patients who underwent R...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-015-1640-2
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:The da Vinci Single-Port (SP) platform (Intuitive Surgical Inc, Sunnyvale CA) is a recently approved robotic surgical platform which features several novel modifications from previously available single trocar models including a flexible camera, articulating instruments, and navigator guidance for real-tim...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-019-02898-1
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:Peyronie's disease (PD) is a localized connective tissue disorder of the penile tunica albuginea (TA) with a still obscure etiopathology. Recent studies from our laboratory have demonstrated differences in Smad3 and Smad4 gene expression of PD-fibroblasts and non-PD-fibroblasts after stimulation with recom...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0320-x
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:To introduce the detailed procedures of two innovative surgical options for pediatric buried penis and prospectively compare their efficacy and safety. METHODS:A single-center, non-randomized, prospective study was conducted at the Zhongnan Hospital of Wuhan University, where patients were operated on using...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2243-5
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of adjuvant systemic chemotherapy for locally advanced (pT3-4pN0/xM0) upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS:We retrospectively reviewed the medical records of 109 patients with pT3-4pN0/xM0 UTUC who had undergone radical nephroureterectomy between 1996 and 2013...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2032-6
更新日期:2017-10-01 00:00:00
abstract::Small-intestinal submucosa (SIS) is a unique biomaterial that has been shown to induce tissue-specific regeneration in numerous organ systems. In the urinary tract, animal studies have demonstrated that SIS promotes functional bladder regeneration. Other preliminary studies have suggested that SIS may also be extremel...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/PL00007071
更新日期:2000-02-01 00:00:00
abstract::A basic understanding of the mediators and related mechanisms involved in the genital physiology of the female sexual response, and, in particular, the physiology of arousal, is paramount for the clinical practitioner whose medical knowledge and practice pertain to female sexual dysfunction. Familiarity with establish...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-002-0271-6
更新日期:2002-06-01 00:00:00
abstract:PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-03014-z
更新日期:2020-09-01 00:00:00
abstract::In multivariate analysis, GS of the regular prostatectomy specimen was the only statistically significant parameter for pT2R1 prostate cancer. ...
journal_title:World journal of urology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00345-020-03136-9
更新日期:2020-06-01 00:00:00
abstract::Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00183119
更新日期:1996-01-01 00:00:00
abstract::The nuclear factor of kappa beta (NF-kappaB) transcription factor regulates the transcription of numerous genes including that of interleukin 6 (IL-6). The IL-6 acts as an autocrine and paracrine growth factor of androgen-independent prostate cancer. An aberrant expression of the IL-6 gene and an increase in IL-6 expr...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0175-6
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:Vesico-ureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. Surgery is an important part of its management. Laparoscopic ureteric reimplantation using the Lich-Gregoir technique is an option for VUR. The aim of this study is to assess short- and medium-...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2064-y
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:This study aimed to identify non-neoplastic pathologic changes in partial nephrectomy specimens of patients without a known history of medical comorbidities. Routine analysis of this tissue may allow the clinician to identify subclinical renal disease. METHODS:We retrospectively reviewed our database of patien...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0720-1
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2396-2
更新日期:2019-03-01 00:00:00