Abstract:
PURPOSE:We investigated hemodynamics in patients receiving delta-Aminolevulinic acid (delta-ALA) to visualize tumor margins prior to radical retro pubic prostatectomy. PATIENTS:Twenty patients undergoing elective open radical retro pubic prostatectomy (RRP). METHODS:Cohort observational study. Ten patients receiving 20 mg/kg of delta-ALA orally prior to surgery (delta-ALA) and 10 patients undergoing RRP without the application of delta-ALA served as a retrospectively matched cohort (CONTROL). MEASUREMENTS:Changes in heart rate (HR), mean arterial blood pressure (MAP), and functional hemodynamic parameters were assessed by electrocardiogram, non-invasive and invasive blood pressure monitoring plus transcardiopulmonary thermodilution. RESULTS:Patients of both groups did not differ in means of age, body mass index, or ASA classification. During surgery, HR and MAP did not differ significantly between both groups. Also, the amount of IV crystalloids and colloids did not differ significantly. In contrast, the amount of vasopressor necessary to maintain MAP within the target range of 70-90 mmHg was significantly higher in delta-ALA when compared to CONTROL (0.08 ± 0.04 μg/kg/min (delta-ALA) vs. 0.03 ± 0.02 μg/kg/min (CONTROL); P < 0.01). Immediately after surgery, patients of delta-ALA showed a significantly higher heart rate (82 ± 18 min(-1) vs. 67 ± 9 min(-1); P < 0.05) compared to patients of CONTROL. Cardiac index, global end-diastolic volume index, and extravascular lung water index were significantly higher after surgery, when compared to baseline values (P < 0.05). CONCLUSIONS:Orally administered delta-ALA prior to open radical prostatectomy induces hemodynamic instability in the perioperative period requiring vasopressor support. Further, an increase of extravascular lung water points toward an increased vascular permeability induced by delta-ALA.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Eichhorn V,Maerz A,Salomon G,Blanc IF,Reuter DA,Goetz AEdoi
10.1007/s00345-011-0788-7subject
Has Abstractpub_date
2013-04-01 00:00:00pages
371-6issue
2eissn
0724-4983issn
1433-8726journal_volume
31pub_type
临床试验,杂志文章abstract:INTRODUCTION:Adherent perirenal fat (APF) can be defined as inflammatory fat sticking to renal parenchyma, whose dissection is difficult and makes it troublesome to expose the tumour. Our objective was to evaluate the impact of APF on the technical difficulty of robot-assisted partial nephrectomy (RPN). PATIENTS AND M...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1500-0
更新日期:2015-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章,收录出版
doi:10.1007/s00345-007-0202-7
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abstract::The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00192265
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abstract:PURPOSE:Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neu...
journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0316-6
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abstract::To evaluate the diagnostic efficacy of transrectal ultrasound (TRUS)-guided biopsy of the prostatic fossa in men with biochemical relapse following radical retropubic prostatectomy (RP). Thirty patients, with detectable prostate specific antigen (PSA) and negative imaging for metastases after RP, were evaluated for lo...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-007-0167-6
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1237-1
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
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journal_title:World journal of urology
pub_type: 临床试验,杂志文章
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journal_title:World journal of urology
pub_type: 临床试验,杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2020-07-21 00:00:00
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journal_title:World journal of urology
pub_type: 临床试验,杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章,meta分析
doi:10.1007/s00345-015-1505-8
更新日期:2015-07-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-014-1431-1
更新日期:2015-09-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1413-3
更新日期:2014-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-007-0222-3
更新日期:2008-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03095-1
更新日期:2020-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0158-7
更新日期:2007-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050082
更新日期:1998-01-01 00:00:00