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Bladder-sparing approaches to invasive disease.

Abstract：

:Although immediate radical cystectomy remains the standard of care for invasive bladder cancer, a large body of international experience from single institutions and cooperative groups has accumulated, suggesting favorable results with bladder-sparing approaches in appropriately selected patients. Modern selective bladder preservation with trimodality therapy, consisting of transurethral resection of the bladder tumor, radiation, and chemotherapy, can achieve complete response rates of 60-80%, 5-year survival rates of 50-60%, and survival rates with an intact bladder of 40-45%. Although no randomized comparisons between cystectomy and trimodality therapy exist, long-term data confirm that the 10-year overall and disease-specific survival rates for patients in bladder-sparing protocols are comparable to outcomes reported in contemporary cystectomy series. In addition, quality of life studies have demonstrated that the retained native bladder functions well. Thus, trimodality therapy with careful cystoscopic surveillance and with prompt cystectomy for invasive recurrences has emerged as a legitimate alternative to extirpative surgery. Future work will continue to optimize the bladder-sparing regimen while limiting toxicity.

journal_name

World J Urol

journal_title

World journal of urology

authors

Efstathiou JA,Zietman AL,Kaufman DS,Heney NM,Coen JJ,Shipley WU

doi

10.1007/s00345-006-0114-y

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

517-29

issue

5

eissn

0724-4983

issn

1433-8726

journal_volume

24

pub_type

杂志文章,评审

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