Abstract：
PURPOSE:Cabazitaxel, a semi-synthetic taxane of the third generation, inhibits prostate cancer (PC) cell growth by affecting the microtubule architecture. Since cabazitaxel has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presence of cabazitaxel were characterized. METHODS:AR and HSP expressions were assessed via Western blotting utilizing a PC-cell-line in vitro system incubated with cabazitaxel. RESULTS:Incubation experiments with 0.3 nM cabazitaxel exhibited significantly reduced levels of AR and the AR-associated factors HSP90α, HSP40, and HSP70/HSP90 organising protein. Furthermore, expression of the anti-apoptotic factor HSP60 was suppressed. In contrast to other anticancer compounds, cabazitaxel did not alter the cytoprotective chemoresistance factor HSP27. CONCLUSIONS:Despite the deregulation of microtubule organisation, cabazitaxel has been shown to suppress the expression of HSP. Very notably, and may be as a result of down-regulated HSP, cabazitaxel additionally inhibits the expression of the AR in AR-positive PC cells. Thus, cabazitaxel bears an additional anti-proliferative activity which is at least in part specific for PC cells.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Rottach AM,Ahrend H,Martin B,Walther R,Zimmermann U,Burchardt M,Stope MBdoi
10.1007/s00345-018-2615-xsubject
Has Abstractpub_date
2019-10-01 00:00:00pages
2137-2145issue
10eissn
0724-4983issn
1433-8726pii
10.1007/s00345-018-2615-xjournal_volume
37pub_type
杂志文章abstract：PURPOSE:To compare prognostic performance of MSKCC and IMDC risk models in patients with synchronous mRCC. METHODS:Retrospective analysis of pre-therapeutic MSKCC and IMDC prognostic factors and outcomes in patients with synchronous mRCC treated at a single institute in the targeted therapy era was performed. Cytoredu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1769-7
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:The significance of a positive UroVysion FISH assay is uncertain in patients with normal cystoscopy. This multicenter study evaluates the clinical significance of a positive FISH assay in patients with no visible tumor and excluding those with a positive cytology. METHODS:A multi-institutional, retrospectiv...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1452-9
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:Urinary tract infection (UTI) is the most common bacterial infection among infectious complications in kidney transplant recipients (KTR). After transplantation, infections can result from surgical complications, donor-derived infections, pre-existing recipient infections, and nosocomial infections. Post-transp...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03173-4
更新日期：2020-11-01 00:00:00
abstract：:The funding number was incorrect in the original published article. The correct funding number should read as follows. ...
journal_title：World journal of urology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00345-018-2289-4
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To assess the common practice to transiently place an indwelling transurethral catheter in case of hospitalization of women with febrile urinary tract infections. So far, this intervention has not been scientifically investigated. METHODS:Inclusion criteria were female gender, a leucocyte esterase-positive uri...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-018-2474-5
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:We hypothesized that a relevant number of patients with clinically high-risk prostate cancer (PCA) indeed harbor overall favorable tumor characteristics (OFTC) (i.e., pT2a-c and Gleason score ≤3 + 4 = 7 and pN0/X) and that in these patients radical prostatectomy (RP) alone is most likely curative. METHODS:Betw...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1274-9
更新日期：2015-01-01 00:00:00
abstract：:The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00192265
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:During rejection, leukocytes are recruited from the peripheral circulation into the graft leading to the damage of endothelial cells, capillary perfusion failure and graft loss. Chemokines play a pivotal role in the recruitment of leukocytes to the endothelium. Viral macrophage inflammatory protein-II (vMIP-II)...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0556-0
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To evaluate contemporary international trends in the implementation of minimally invasive adrenalectomy and to assess contemporary outcomes of different minimally invasive techniques performed at urologic centers worldwide. METHODS:A retrospective multinational multicenter study of patients who underwent min...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-016-1791-9
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:To analyse the surgical margins status of prostatic glands, resected by laparoscopic radical prostatectomy (LRP) for prostate cancer, and to correlate it with biochemical free survival rate (BFSR). METHODS:Data were collected prospectively from 405 patients undergoing LRP from 2000 to 2009 at a single institut...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0711-2
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:There are sparse data describing outcomes of bone-only oligometastatic prostate cancer in comparison with lymph node disease treated with stereotactic body radiotherapy (SBRT). The primary aim of this study was to report progression-free survival (PFS) data for patients with bone-only disease. Influence of horm...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02873-w
更新日期：2019-12-01 00:00:00
abstract：:The diagnosis of prostate cancer is based on histology. Prostate biopsies are obtained based on the triad of prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound. Because prostate biopsies still have a large percentage of negative outcomes, patient selection and biopsy direction...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0189-0
更新日期：2007-08-01 00:00:00
abstract：PURPOSE:The aim of this study is to review the current literature that reports outcomes of Peyronie's disease (PD) reconstructive surgery using the collagen fleece TachoSil® (Baxter, CA, USA), a novel graft that has self-adhesive properties and gained popularity in recent years. METHODS:A literature review was perform...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02792-w
更新日期：2020-02-01 00:00:00
abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) represents a significant and rising burden of disease, with rapidly evolving treatment modalities. The role of cytoreductive nephrectomy (CN) is controversial in this setting. As such, London Cancer has pursued a multidisciplinary team (MDT) approach when assessing suitabi...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03107-0
更新日期：2020-12-01 00:00:00
abstract：:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeu...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-001-0236-1
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVE:It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS:It is a cross-sectional study on pat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2432-2
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:We report on a 62-year-old gentleman presenting at our urological department with an advanced renal cell cancer of the right kidney (10 cm in diameter), with an extensive caval vein thrombus (level IV) and bilateral pulmonary metastases. Another suspicious lesion at the left hemithorax was radiologically des...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0955-5
更新日期：2014-02-01 00:00:00
abstract：PURPOSE:Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have now been well characterised thanks to large collaborative projects such as The Cancer Genome Atlas (TCGA). Not only has knowledge of the genomic landscape helped inform the development of new drugs, it also promises to fine tune progn...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2429-x
更新日期：2018-12-01 00:00:00
abstract：:The diagnosis of prostate cancer (PCa) can be challenging due to the limited performance of current diagnostic tests, including PSA, digital rectal examination and transrectal conventional US. Multiparametric MRI has improved PCa diagnosis and is recommended prior to biopsy; however, mp-MRI does miss a substantial num...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03193-0
更新日期：2020-04-18 00:00:00
abstract：INTRODUCTION:Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options. MATERIALS AND METHODS:In this study, the changes in bone structure under standardized testosterone- (T), raloxifen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0373-5
更新日期：2009-08-01 00:00:00
abstract：:Vesicoureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. The current indications for the surgical correction of VUR depend on the presence or absence of renal scars. If no scars are present, primary ureteral reimplantation is only indicated in high-grade bil...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0408-x
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2593-z
更新日期：2019-09-01 00:00:00
abstract：:A basic understanding of the mediators and related mechanisms involved in the genital physiology of the female sexual response, and, in particular, the physiology of arousal, is paramount for the clinical practitioner whose medical knowledge and practice pertain to female sexual dysfunction. Familiarity with establish...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-002-0271-6
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:To compare oncological, functional, and toxicity outcomes of patients with radiation-recurrent prostate cancer (PCa) after external beam radiation therapy (EBRT) or brachytherapy (BT) treated with salvage high-intensity focused ultrasound (S-HIFU) or salvage radical prostatectomy (S-RP). METHODS:This retrospec...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02640-x
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:Investigate the short-term effect of sildenafil on microcirculation, especially the velocity, the pattern of the flow and the recruitment of the leukocyte in postcapillaries. METHODS:In male Sprague-Dawley rats, the microcirculatory consequences of 60 min experimental testicular torsion, followed by 240 min of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2340-5
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Asymptomatic bacteriuria is common in diabetic women. Treatment of asymptomatic bacteriuria is not beneficial, but the natural history of the microbiology of asymptomatic bacteriuria has not been well described. OBJECTIVE:To describe the microbiological outcomes of bacteriuria in diabetic women with untreat...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-005-0042-2
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03014-z
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:It has been reported that apoptosis of penile erectile tissue occurs after penile denervation, castration, and diabetes mellitus in animal studies. Aim of this study was to investigate apoptosis in corpora cavernosa of patients with organic erectile dysfunction (ED). METHODS:Cavernous biopsies were obtained...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0332-6
更新日期：2009-04-01 00:00:00
abstract：INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-012-0899-9
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of stone components in postoperative fever following RIRS, and to investigate the role of quick stone component analysis during RIRS procedure. PATIENTS AND METHODS:1493 patients with RIRS were retrospectively reviewed. Propensity score matching (PSM) analysis was performed as infection ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03268-y
更新日期：2020-05-24 00:00:00
