Abstract:
OBJECTIVES:To characterize testosterone profile changes over time in a cohort of prostate cancer (PCa) patients managed with active surveillance (AS) and to assess its correlation with the initial disease characteristics and further progression. METHODS:We conducted retrospective chart review of PCa patients managed with AS. Patients were followed with PSA, total, free and bioavailable testosterone measurements, physical examination, and by repeat biopsies or periodic magnetic resonance imaging. Disease progression was identified by follow-up biopsy changes or by imaging. A Cox proportional hazard regression models were used to assess the association between testosterone profile at baseline and the risk of progression. RESULTS:For the 122 patients included in analyses, the mean age at diagnosis was 65.8 years; the mean follow-up time was 7.8 years. At baseline, 108 (88.5%) patients had a Gleason score of ≤ 6. In all, 45 (36.8%) patients had disease progression, with a mean time to progression of 4.6 years. During follow-up, PSA levels showed a rising trend, while testosterone profile levels showed a trend of decrease over time. There was no significant correlation between PSA and testosterone profile (total, free, and bioavailable) level changes over time (ρ = - 0.14, - 0.11 and - 0.16, P = 0.16, 0.34, and 0.20, respectively). In addition, multivariable analysis showed that serum-free testosterone was an independent predictor of disease progression (HR 0.93, 95% CI 0.88-0.99, P = 0.029). CONCLUSION:Our study results showed that testosterone profile measurements tended to decrease over time in PCa patients managed with AS. Free testosterone was a significant independent variable of disease progression.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Zakaria AS,Dragomir A,Kassouf W,Tanguay S,Aprikian Adoi
10.1007/s00345-018-2270-2subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1209-1217issue
8eissn
0724-4983issn
1433-8726pii
10.1007/s00345-018-2270-2journal_volume
36pub_type
杂志文章abstract:PURPOSES:To describe the differential tissue expression of tumor-associated trypsin inhibitor (TATI) in normal bladder urothelium, primary urothelial carcinoma of the bladder (UCB) and metastatic UCB and to assess the association of TATI expression with molecular markers commonly altered in UCB and clinical outcomes af...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0727-7
更新日期:2012-12-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1723-0
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journal_title:World journal of urology
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更新日期:2019-05-01 00:00:00
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1241-5
更新日期:2014-12-01 00:00:00
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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journal_title:World journal of urology
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journal_title:World journal of urology
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journal_title:World journal of urology
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
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更新日期:2011-08-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
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更新日期:2005-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF00184246
更新日期:1994-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-004-0410-3
更新日期:2004-11-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-006-0113-z
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To evaluate the clinical significance of invasive urothelial carcinoma that is ambiguous for muscularis propria invasion on initial transurethral resection of bladder tumor (TURBT). METHODS:All consecutive in-house TURBTs with invasive urothelial carcinoma from 1999 to 2017 that underwent radical cystectomy (R...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02782-y
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:Assess knowledge and awareness concerning human papillomavirus (HPV) infection, HPV-associated diseases, and the existence of a specific vaccine among non-HPV-screened Caucasian-European adults after the market introduction of HPV vaccines. METHODS:A cohort of 934 consecutive patients seeking their first medic...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1379-1
更新日期:2015-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1272-y
更新日期:2015-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03333-6
更新日期:2020-07-04 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1122-3
更新日期:2014-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-007-0167-6
更新日期:2007-06-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2106-5
更新日期:2018-01-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03367-w
更新日期:2020-07-21 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-017-2023-7
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Data assessing the effectiveness of single-use flexible ureteropyeloscopy (FURS) are limited. This study evaluates and compares single-use FURS with conventional reusable FURS. METHODS:A systematic search using electronic databases (Pubmed and Embase) was performed for studies evaluating single-use FURS in the...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-017-2131-4
更新日期:2018-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1435-x
更新日期:2015-09-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0235-6
更新日期:2008-04-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-018-2290-y
更新日期:2018-09-01 00:00:00
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journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-008-0288-6
更新日期:2009-04-01 00:00:00