Abstract：
:The treatment of clinically locally advanced prostate cancer (cT3-4) is subject to controversies. Patients with lymph node metastases as well as patients with overstaged localized and thus curable disease fall into this category. Radical prostatectomy, external beam radiotherapy and early or deferred hormonal therapy are possible treatment options. Multimodal treatment (i.e., a combination of these options) is frequently used. After radical prostatectomy, Gleason score-adjusted disease-specific survival does not differ meaningfully between the tumor stages pT2 and pT3-4. In the case of lymph node metastases after radical prostatectomy, but not in node-negative disease, adjuvant hormonal treatment seems to improve survival. Adjuvant radiotherapy may improve biochemical and local control in locally advanced prostate cancer, a survival benefit has, however, not yet been proven. External beam radiotherapy alone provides unfavourable survival rates in locally advanced prostate cancer. Adjuvant hormonal treatment may improve outcome in this setting. When no curative treatment is chosen, early hormonal treatment seems to provide modest benefit compared with deferred therapy.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Wirth MP,Hakenberg OW,Froehner Mdoi
10.1007/s00345-007-0158-7subject
Has Abstractpub_date
2007-04-01 00:00:00pages
169-76issue
2eissn
0724-4983issn
1433-8726journal_volume
25pub_type
杂志文章,评审abstract：INTRODUCTION:Following its introduction in 1980, shock wave lithotripsy (SWL) rapidly emerged as the first-line treatment for the majority of patients with urolithiasis. Millions of SWL therapies have since been performed worldwide, and nowadays, SWL still remains to be the least invasive therapy modality for urinary s...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-014-1369-3
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVES:To characterize testosterone profile changes over time in a cohort of prostate cancer (PCa) patients managed with active surveillance (AS) and to assess its correlation with the initial disease characteristics and further progression. METHODS:We conducted retrospective chart review of PCa patients managed w...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2270-2
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To assess the performance of EAU risk classification in PCa patients according to the biopsy pathway (standard versus MRI guided) and to develop a new, more accurate, targeted biopsy (TB)-based classification. MATERIALS AND METHODS:We included 1345 patients consecutively operated by radical prostatectomy (RP) ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03053-6
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Robotic-assisted laparoscopic (RAL) surgery has gained momentum in pediatric urology. Technological adaptations such as the development of 5 mm instruments have led to robotic procedures being performed on younger children and those having smaller body habitus, with improved cosmesis. However, concerns have bee...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02765-z
更新日期：2020-08-01 00:00:00
abstract：:Urinary bladder cancer (UBC) is a common disease worldwide. At any point in time 2.7 million people have a history of UBC. The incidence of UBC varies over the world with highest rates in developed communities. But the burden of UBC will increase in less developed areas of the world. These changes can be attributed to...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0383-3
更新日期：2009-06-01 00:00:00
abstract：:Many human tumors such as bladder carcinoma that are initially responsive to chemotherapy eventually fail to respond to treatment. For most drugs, dose escalation that may be required for a cure cannot be achieved because sensitive tissues such as bone marrow limit cytotoxic therapy. Approaches to prevent or circumven...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00184246
更新日期：1994-01-01 00:00:00
abstract：:The effects of pelvic floor muscle contraction on rectal and vesical function were studied in 19 healthy volunteers with the aim of shedding light on some of the hitherto vague aspects of the mechanisms involved in micturition and defecation and their disorders. Rectal and vesical pressures were recorded during pubore...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450100218
更新日期：2001-08-01 00:00:00
abstract：:Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect coverage depends more on the remaining genital skin than on the etio...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050115
更新日期：1999-04-01 00:00:00
abstract：INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-012-0899-9
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.2...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-015-1646-9
更新日期：2016-04-01 00:00:00
abstract：:In multivariate analysis, GS of the regular prostatectomy specimen was the only statistically significant parameter for pT2R1 prostate cancer. ...
journal_title：World journal of urology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00345-020-03136-9
更新日期：2020-06-01 00:00:00
abstract：:Although anejaculation is a relatively uncommon occurrence in the general population, over 12,000 new cases are reported annually. Anejaculation may result from spinal cord injury (SCI), retroperitoneal lymph node dissection (RPLND), diabetes mellitis, transverse myelitis, multiple sclerosis, or psychogenic disorders....
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182035
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To evaluate the opinion of urologists and their audience regarding patient safety and educational value of live surgical demonstrations (LSD) and semi-live surgical demonstrations (semi-LSD). METHODS:Following the '2017 Challenges in Endourology' meeting, a survey addressing patient safety and the educational ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2291-x
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:To evaluate the 6-month effects of the recommended drug and light dosage in focal vascular-targeted photodynamic therapy (VTP) using TOOKAD(®) Soluble in patients with localized prostate cancer (LPCa). METHODS:We performed a pooled analysis of 117 men with LPCa, PSA <10 ng/mL, and Gleason score ≤ 7 (3 + 4), fr...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-015-1505-8
更新日期：2015-07-01 00:00:00
abstract：:Transcutaneous application of low-frequency electric current in the treatment of partially or temporarily denervated striated muscles is widely used to prevent or treat muscular atrophy. Due to the high regenerative capacity of smooth-muscle cells, this approach should be beneficial in the treatment of diseases with s...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182971
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To provide most recent and high quality evidence concerning the comparison between monopolar and bipolar transurethral resection of non-muscle invasive bladder tumors. MATERIALS AND METHODS:Two researchers performed a systematic review of the current literature independently, to identify studies published in...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03313-w
更新日期：2020-06-26 00:00:00
abstract：:Mycophenolate mofetil (MM) is the ester derivative of mycophenolic acid (MPA), which exerts immunosuppressive activity by inhibiting de novo purine biosynthesis. Following animal models and pilot studies in human renal allograft recipients that confirmed MM's ability to prevent and half rejection episodes, 3 large mul...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00182076
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prost...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1960-x
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVES:Psychosocial factors reported by patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) promote greater pain, disability, and ultimately poorer quality of life (QOL). We targeted those parameters in the development of a cognitive-behavioral (CB) program designed specifically for CP/CPPS. M...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0235-6
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the impact of experience on the outcome of image fusion-guided prostate biopsies performed by urologists working at a high-volume medical center. METHODS:The first 210 consecutive fusion biopsies were analyzed following installation of the software-based biopsy platform Arte...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2605-z
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS:The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2098-1
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:Lymph node dissection (LND) is not routinely performed during radical nephroureterectomy (RNU) in upper tract urothelial carcinomas (UTUC), and its clinical relevance is unclear. The purpose of the present study was to evaluate the impact of LND on clinical outcomes in a large multicenter series of RNU for UTUC...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-011-0705-0
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:The purpose this study is to evaluate the efficacy of multiparametric ultrasound-targeted biopsies in patients undergoing initial biopsy of the prostate for the suspicion of prostate cancer. MATERIALS AND METHODS:A total of 167 patients who are biopsy naïve underwent multiparametric ultrasound-targeted biopsy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2187-9
更新日期：2018-05-01 00:00:00
abstract：:All organisms contain 1,000s of proteins and peptides in their body fluids, which undergo disease-specific changes. Advances in the understanding of the functional relevance of these polypeptides under different (patho)physiological conditions and the identification of indicative changes with disease would greatly enh...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0206-3
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION:The "trifecta" is a summary measure of outcome after partial nephrectomy (PN) that encompasses three parameters: negative surgical margin, ≤ 10% decrease in post-operative estimated glomerular filtration rate (eGFR) and absence of urological complications. We assessed trifecta rates in patients undergoing ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03349-y
更新日期：2020-07-12 00:00:00
abstract：PURPOSE:It was our aim in this study to develop a technique that is rather simple, overcomes the problems of Devine and Horton glanuloplasty in patients with small glans, and is flexible to be tailored to any hypospadias surgery. METHODS:A total of 11 patients were included in this preliminary report. A triangular ski...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-009-0386-0
更新日期：2009-10-01 00:00:00
abstract：:Clinical epidemiology is sometimes called the basic science of clinical medicine. In terms of the pathogenesis of testicular germ cell tumors (GCTs), clinical epidemiology analyzes suspected risk factors. The present review highlights the risk factors established so far and briefly summarizes those factors currently u...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0398-8
更新日期：2004-04-01 00:00:00
abstract：:With the advantages of constant availability, minimal loss of bowel, relative simplicity (no mesentery interfering with implantation, high mobility of the tube), minimized risk of stone formation (no use of staples), reliable continence (no leak point) and easy catheterization (longitudinal folds), this straightforwar...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s003450050059
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:This study aims to determine whether intra-network and inter-network brain connectivities are altered using an independent component analysis (ICA). METHODS:Resting-state functional MRI (rs-fMRI) data were acquired from 26 patients with OAB and 28 healthy controls (HC). Eleven resting-state networks (RSNs) wer...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02838-z
更新日期：2020-04-01 00:00:00
abstract：:Despite several new urine markers urinary cytology remains the gold standard for the non-invasive detection of bladder carcinoma. The use of monoclonal antibodies against tumor associated antigens offers a promising approach to improve urinary cytology. The aim of this study was to compare fluorescence immunocytology ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0390-8
更新日期：2004-06-01 00:00:00
