Abstract：
PURPOSE:To investigate a potential correlation between the achievement of a cut-off of nadir PSA (nPSA) after brachytherapy (BRT) with biochemical Disease-Free Survival (bDFS) and to define the rate of post-BRT PSA bounces. METHODS:Retrospective analysis was carried out in 105 consecutive patients affected with early-stage prostate adenocarcinoma who underwent (125)I BRT. Only patients with a minimum follow-up ≥24 months were included. Biochemical DFS was chosen as primary endpoint. RESULTS:At a median follow-up of 51.2 months, 3- and 5-year bDFS were 96.8 and 91.2%, respectively. Median time to biochemical failure (BF) was 54 months. By Kaplan-Meier analysis, patients achieving nPSA ≤ 0.35 ng/mL had significantly higher bDFS (3- and 5-year bDFS: 100 and 98.5 % vs. 83.3 and 66.7 %, respectively; p = 0.001). Bounce PSA occurred in 28.6% of patients, at a median time of 21.5 months. No BFs were observed in the bounce group. Achieving a nPSA ≤ 0.35 ng/mL was the only factor independently associated with long-term bDFS on both univariate (p = 0.000) and multivariate analysis (HR 3.82; p = 0.003). CONCLUSIONS:Patients attaining a nPSA ≤ 0.35 ng/mL are significantly more likely to experience long-term freedom-from-biochemical failure. Bounce PSA occurs in approximately 30% of patients. Time to onset of PSA increase seems the most reliable feature to distinguish bounce from failure. Tailored follow-up strategies are needed for patients at higher risk of recurrence, and caution is advised in interpreting an early increase in PSA levels in the first 24-30 months after BRT.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Guarneri A,Botticella A,Ragona R,Filippi AR,Munoz F,Casetta G,Gontero P,Tizzani A,Ricardi Udoi
10.1007/s00345-012-0932-zsubject
Has Abstractpub_date
2013-04-01 00:00:00pages
411-5issue
2eissn
0724-4983issn
1433-8726journal_volume
31pub_type
杂志文章abstract：OBJECTIVE:It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS:It is a cross-sectional study on pat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2432-2
更新日期：2019-04-01 00:00:00
abstract：:Surgery following chemotherapy for treatment of metastatic testis cancer is reserved for partial remissions with localized tumors considered resectable. After primary chemotherapy, about 90% will have teratoma or necrosis and only 10% will have cancer. The concept of two cycles of post operative chemotherapy in this s...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00185671
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population. METHODS:Between June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1571-y
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2593-z
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS:We identified 261 patients who received TT for synchronous mRCC with or without prior CN. To a...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2154-x
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:We aim to analyze the efficacy of different focus sizes and the influence of pulse pressure (intensity) during shock wave lithotripsy (SWL) in terms of stone fragmentation. METHODS:Combination of three focal sizes (F1 = 2 mm, F2 = 4 mm, F3 = 8 mm) and 11 output pressure settings (intensity 10-20) of a piezoele...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03069-y
更新日期：2020-10-01 00:00:00
abstract：:A review of the current literature is conducted to explore the developmental aspects, animal and human experiences and the effects of pharmacological manipulation to explain the role androgens play in sexual function with special emphasis on erectile function and the erectile tissue. This review reveals that androgens...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF01275152
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:We aim to evaluate prostate-specific antigen (PSA) trends in post-primary focal cryotherapy (PFC) patients. MATERIALS AND METHODS:This was an institutional review board-approved retrospective study of PFC patients from 2010 to 2015. Patients with at least one post-PFC PSA were included in the study. Biochemica...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2130-5
更新日期：2018-02-01 00:00:00
abstract：:Transcutaneous application of low-frequency electric current in the treatment of partially or temporarily denervated striated muscles is widely used to prevent or treat muscular atrophy. Due to the high regenerative capacity of smooth-muscle cells, this approach should be beneficial in the treatment of diseases with s...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00182971
更新日期：1995-01-01 00:00:00
abstract：:Local recurrent prostate cancer after radical treatment is found in the majority of men with a rising PSA. Salvage treatment procedures for recurrent disease, such as radiation therapy and ablative procedures, can provide long-term responses in well-selected cases. Prostate magnetic resonance imaging (MRI) allows diag...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02677-y
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:We compared perioperative and long-term renal functional outcomes of robot-assisted partial nephrectomy (RAPN) with laparoscopic partial nephrectomy (LPN) for small renal masses. MATERIALS AND METHODS:A total of 1,032 patients were included for evaluation; propensity score matching was performed to adjust for ...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-015-1488-5
更新日期：2015-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-015-1640-2
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:To characterize the clinical and pathologic staging of patients with urothelial carcinoma (UC) in bladder diverticula (BD) after undergoing radical cystectomy (RC) and determine the impact of UCBD on recurrence and survival. METHODS:We reviewed our institutional database of patients who underwent RC for UC (19...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1472-5
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:Radical cystectomy (RC) can be associated with significant blood loss. Allogenic blood transfusion (ABT) may alter disease outcome because of a theoretical immunomodulatory effect. We evaluated the effects of ABT on overall survival (OS) and progression-free survival (PFS) of patients undergoing RC for urotheli...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1257-x
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Urinary cytology (C) and cystoscopy remain the gold standard for the detection and screening of bladder cancer (BC). In this prospective study, we analyzed whether baseline C, ImmunoCyt (I), BTA Stat (B), hemoglobin dipstick (H), and NMP22 BladderChek (N) can predict recurrence and progression. METHODS:Urinary...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-016-1795-5
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Robotic partial nephrectomy (RPN) is a minimally-invasive technique used to treat renal tumors. A clinical pathway and prospective research protocol (AMBU-REIN) were specifically set up to establish and assess the routine use of day-case RPN. METHODS:The AMBU-REIN study was conducted in the framework of the Fr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03283-z
更新日期：2020-06-08 00:00:00
abstract：:Oxybutynin is a tertiary amine, which undergoes an extensive first-pass metabolism. It has an active metabolite, N-desethyl oxybutynin, and the effect of oral oxybutynin is to a large extent exerted by this metabolite. Oxybutynin has both an antimuscarinic and a direct muscle relaxant effect, and, in addition, local a...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/pl00007103
更新日期：2001-11-01 00:00:00
abstract：PURPOSE:Partial nephrectomy (PN) outcomes may be better at academic institutions than at non-academic centers. Peer-review, sub-specialized practice profile, higher individual surgeon and institutional caseload may explain this observation. To the best of our knowledge, the role of institutional academic affiliation ha...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-011-0759-z
更新日期：2012-08-01 00:00:00
abstract：:Renal cystic disease, ranging from simple cysts to autosomal dominant polycystic kidney disease (ADPKD), can lead to significant complications such as pain, hypertension, infection, upper urinary tract obstruction, and even renal failure. For patients with preserved renal function, laparoscopic ablation of renal cysts...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/pl00007076
更新日期：2000-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03101-6
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVES:To understand how prioritization of treatment attributes and treatment choice varies by patient characteristics, we sought to specifically determine how demographic variables affect patient treatment preference. PATIENTS AND METHODS:Male patients with urethral stricture disease participated in a choice-base...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2066-9
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Different methods for induction and monitoring of urethral sphincter deficiency were explored in a large animal model. METHODS:Sphincter deficiency was established in female pigs by dilatation and cauterization, and amount and frequencies of voiding were monitored and explored by pad test. Sphincteric closu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2088-3
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVES:To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS:We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 cor...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-008-0264-1
更新日期：2008-08-01 00:00:00
abstract：:The surgical complications encountered in 478 patients who underwent primary retroperitoneal lymph-node dissection for clinical stage A and B nonseminomatous testicular cancer during the period ranging from 1982 to 1992 were reviewed. There were 54 complications in 51 patients (10.6%), and there was no surgery-related...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00192272
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVES:The objective of our study was to study trainees' feedback and rating of models for training transurethral resection of bladder lesions (TURBT) and prostate (TURP) during simulation. METHODS:The study was performed during the ''Transurethral resection (TUR) module" at the boot camp held in 2019. Prior to th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03559-4
更新日期：2021-01-04 00:00:00
abstract：PURPOSE:The lack of precedent in transitioning from pediatric to adult care poses a challenge to providers for patients with spina bifida (SB). The purpose of this study was to summarize perceptions about best practices for the care of adult spina bifida patients. MATERIALS AND METHODS:A national survey was electronic...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02635-8
更新日期：2019-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2255-1
更新日期：2018-07-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1541-4
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-018-2538-6
更新日期：2019-09-01 00:00:00
abstract：:To evaluate the diagnostic efficacy of transrectal ultrasound (TRUS)-guided biopsy of the prostatic fossa in men with biochemical relapse following radical retropubic prostatectomy (RP). Thirty patients, with detectable prostate specific antigen (PSA) and negative imaging for metastases after RP, were evaluated for lo...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0167-6
更新日期：2007-06-01 00:00:00
