Abstract:
:Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF alpha) are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to be the predominant EGF-related growth factor in the normal prostate and in benign prostatic hyperplasia (BPH). Evidence indicates that EGF and TGF alpha are important for maintainence of the structural and functional integrity of the benign prostatic epithelium. The EGF-related peptides are primarily localized to the secretory epithelium of the benign prostate, and their production and secretion is augmented by the presence of circulating androgens. EGFR are located in the basal/neuroendocrine (NE) compartment of the benign prostate and exhibit relatively androgen-independent expression. The EGF-related peptides and EGFR are also present in neoplastic prostatic tissues. There is currently no direct evidence to implicate EGFR activation in the pathogenesis of BPH. However, the EGF-related peptides appear to play a functional role in the growth of prostatic carcinoma cells, with TGF alpha being the predominant growth factor. Numerous investigators have demonstrated the functional significance of a TGF alpha/EGFR-mediated autocrine growth pathway in cultured prostatic carcinoma cells. Studies of cultured prostate cancer cells, but not normal epithelial cells, demonstrate constitutive activation of EGFR. Androgen-independent cancer cells exhibit more EGFR expression and phosphorylation than do androgen-responsive prostate cancer cells. Most studies indicate that EGFR do not play a functional role in androgen-stimulated growth of prostate cancer cells. Several studies have correlated EGFR expression with increased nuclear size and tumor dedifferentiation. Future studies should focus on determining both the prognostic significance of EGFR expression and whether manipulation of EGFR-mediated growth can be exploited for therapeutic benefit in human prostate cancer.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Sherwood ER,Lee Cdoi
10.1007/BF00185972subject
Has Abstractpub_date
1995-01-01 00:00:00pages
290-6issue
5eissn
0724-4983issn
1433-8726journal_volume
13pub_type
杂志文章,评审abstract::Urinary bladder cancer (UBC) is a common disease worldwide. At any point in time 2.7 million people have a history of UBC. The incidence of UBC varies over the world with highest rates in developed communities. But the burden of UBC will increase in less developed areas of the world. These changes can be attributed to...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-009-0383-3
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To assess the long-term patient-reported outcomes following TO-TVT as a secondary continence procedure in women with recurrent stress urinary incontinence (R-SUI). METHODS:A secondary analysis of the 9-year follow-up of the E-TOT study was performed: 341 women with predominant SUI symptoms were randomised to u...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-016-1969-1
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:The challenges in providing urologic care across borders and in resource-constrained settings are poorly understood. We sought to better characterize the impediments to the delivery of urological care in low- and middle-income countries (LMICs) compared to high-income countries (HICs). METHODS:A 70 question on...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03101-6
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Reactive oxygen species (ROS) are produced during the interaction between oxalate/calcium oxalate monohydrate (COM) crystals and renal epithelial cells and are responsible for the various cellular responses through the activation of NADPH oxidase (Nox). Ox and COM also activate the renin-ang...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1563-y
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To investigate the spontaneous clearance rates of remnant particles following miniaturized percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS). METHODS:Among 624 patients who underwent mini-PCNL or RIRS at our institution from 2011 to 2015, we collected data of 247 patients with 2...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-016-1807-5
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:To investigate pathological and oncological outcomes of obese patients who underwent robot-assisted radical prostatectomy (RARP) compared with laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (RRP) since limited comparative data exist with regard to oncological and survival o...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1326-1
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To evaluate the still controversially discussed prognostic role of preoperative platelet level (PPL) and thrombocytosis (TC) in patients who undergo surgery for renal cell carcinoma (RCC) based on the largest patient series reported to date. METHODS:A total of 3,139 patients, who underwent radical or nephron-s...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-012-0931-0
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:To report our experience with pelvic reconstructive surgery with transobturator mesh implants in elderly women. MATERIALS AND METHODS:A total of 32 women aged >75 years with pelvic organ prolapse receiving anterior and/or posterior repair using transobturator mesh implants were included. Concomitant mid-urethr...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0863-8
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To examine the prevalence of lower urinary tract symptoms (LUTS) and the bother they impose in a population-based sample of adults in Brazil. METHODS:A cross-sectional population-based survey was conducted between September 2006 and January 2007 in the city of Salvador, Brazil. Cluster samples of representativ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-013-1057-8
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:Given that the tumor-promoting inflammation has been previously established in squamous cell carcinoma of the bladder but its contribution to development of urothelial carcinoma (UC) still remains elusive, our aim was to study changes in expression and activity of inflammation-mediating NF-κB and STAT3 transcri...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1237-1
更新日期:2014-12-01 00:00:00
abstract::The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450000146
更新日期:2000-10-01 00:00:00
abstract::Successful management of transitional-cell carcinoma of the urinary bladder is greatly dependent upon regular surveillance and early detection of persistent or recurrent carcinoma. The development of a highly sensitive urinary test for the detection of transitional-cell carcinoma of the bladder could have a dramatic i...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/BF02201981
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:The "trifecta" is a summary measure of outcome after partial nephrectomy (PN) that encompasses three parameters: negative surgical margin, ≤ 10% decrease in post-operative estimated glomerular filtration rate (eGFR) and absence of urological complications. We assessed trifecta rates in patients undergoing ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03349-y
更新日期:2020-07-12 00:00:00
abstract:PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03497-1
更新日期:2020-10-26 00:00:00
abstract:OBJECTIVES:To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS:We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 cor...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-008-0264-1
更新日期:2008-08-01 00:00:00
abstract::The treatment of lower urinary symptoms secondary to benign prostatic hyperplasia (BPH) after failure of medical therapies remains controversial for most urologic surgeons. The complications of traditional surgery are the driving force behind the development of several minimally invasive treatments of symptomatic BPH....
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-006-0063-5
更新日期:2006-09-01 00:00:00
abstract::The author presents the life and achievements of Johann von Mikulicz-Radecki and his contribution to European and world surgery. Mikulicz was born in Czernowitz, then a part of the Austro-Hungarian Empire. He was educated in numerous Austrian schools and graduated at Vienna University in 1875. In 1880 he became surgeo...
journal_title:World journal of urology
pub_type: 传,历史文章
doi:10.1007/s00345-007-0227-y
更新日期:2008-02-01 00:00:00
abstract::The development of human benign prostatic hyperplasia (BPH) clearly requires a combination of testicular androgens and the ageing process. Although the role of androgens as the causative factor for human benign prostatic hyperplasia is debated, they undoubtedly play, at least, a permissive role. The principal prostati...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-002-0248-5
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:MicroRNAs (miRNAs) play an important role as regulators of gene expression in tumourigenesis by controlling many biological processes in growth, development, differentiation and apoptosis. Previous studies have shown an altered expression of specific miRNAs in clear cell renal cell carcinoma (ccRCC). But the fu...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0633-4
更新日期:2011-06-01 00:00:00
abstract::The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (...
journal_title:World journal of urology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00192265
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To review the United States National Cancer Database (NCDB) from 2004 to 2015 and analyze survival outcomes of invasive non-urachal adenocarcinoma based on treatment modality. METHODS:The NCDB 2004-2015 bladder dataset was queried for adenocarcinoma histology, excluding urachal variant, and limited to patients...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2411-7
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To place chemoprevention of prostate cancer in current clinical context. METHODS:Review of recently published updates of large, randomized, controlled trials of primary chemoprevention of prostate cancer. RESULTS:With extended post-intervention follow-up, SELECT demonstrated a 17% increased risk of prostat...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0822-9
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To examine phosphodiesterase type 5 (PDE5) expression in the anterior fibromuscular stroma (AFMS) of the prostate. Although PDE5 expression was identified in the human prostate, differences in PDE5 expression in intra-prostatic regions are unknown. The AFMS in the prostate has peculiar innervations that could c...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03095-1
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To describe the clinical characteristics of struvite stones and determine the preoperative predictors of sepsis in struvite patients undergoing percutaneous nephrolithotomy (PCNL). METHODS:A retrospective study of patients who underwent PCNL between April 2011 and March 2018 was performed. The data of the stru...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02748-0
更新日期:2020-01-01 00:00:00
abstract::The surgical complications encountered in 478 patients who underwent primary retroperitoneal lymph-node dissection for clinical stage A and B nonseminomatous testicular cancer during the period ranging from 1982 to 1992 were reviewed. There were 54 complications in 51 patients (10.6%), and there was no surgery-related...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00192272
更新日期:1994-01-01 00:00:00
abstract::Contemporary literature regarding the management of neobladder-vaginal fistula and stress urinary incontinence following radical cystectomy and neobladder reconstruction in women is reviewed in this article. Neobladder-vaginal fistula is uncommon but mandates meticulous repair. Compared to the native bladder, the wall...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-005-0013-7
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Nocturia is prevalent and bothersome in men with lower urinary tract symptoms suggestive of BPH (LUTS/BPH). α-Adrenoceptor antagonists without subtype selectivity have inconsistently shown significant effects on nocturia in these patients. We explored the effects of the α1A-adrenoceptor subtype-selective ant...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-013-1228-7
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:Neurogenic bladder due to spinal cord injury has significant consequences for patients' health and quality of life. Regular surveillance is required to assess the status of the upper and lower urinary lower urinary tracts and prevent their deterioration. In this review, we examine surveillance techniques in neu...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-018-2345-0
更新日期:2018-10-01 00:00:00
abstract::Urinary bladder cancer (UBC) ranks ninth in worldwide cancer incidence. It is more frequent in men than in women. We review the main established/proposed factors, both environmental and genetic, associated with bladder cancer etiology and prognosis. Data were extracted from previous reviews and original articles ident...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0168-5
更新日期:2007-06-01 00:00:00
abstract::We report on a 17-year-old white woman with multiple bilateral renal angiomyolipomas (AMLs) in the absence of tuberous sclerosis. Multiple hyperdense lesions were detected in both kidneys by sonography. A computed tomography (CT) scan confirmed mainly fatty tissue. Sparing as much functional tissue as possible, eight ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-001-0242-3
更新日期:2002-09-01 00:00:00