Abstract：
PURPOSE:To identify factors predicting the risk of inguinal metastasis in squamous cell carcinoma of the penis. The therapeutic advantages of early lymphadenectomy in squamous cell carcinoma of the penis must be counterbalanced against its post-operative morbidity. Loss to follow up is a major problem in developing countries. Generating a nomogram based on clinical lymph node status and histopathological findings in the primary tumor could facilitate clinical decision making in the management of penile cancer. METHODS:We prospectively studied 106 patients with penile squamous cell cancer treated from September 2001 to August 2007 at our institution. All patients were offered lymphadenectomy (LAD). A multivariate logistic regression model was used to develop a nomogram. We highlight the problems of loss to follow up in these patients. RESULTS:Of 53 who opted for LAD, 22 had nodal metastasis. The presence of high grade (P = 0.004), lymphovascular invasion (LVI) (P = 0.01) and palpable inguinal lymph nodes (P = 0.05) were the strongest predictors of metastasis. Of 51 who refused LAD, 22 were lost to follow up. Out of these, 16 were at high risk and 9 of them came back with inoperable fungating nodes. A nomogram predicting the risk of lymph node metastasis showed a bias corrected good concordance index (0.74) and good calibration. CONCLUSIONS:High grade and LVI in the tumor along with clinical stage of the inguinal nodes were the strongest predictors of metastasis. These features helped us to develop a nomogram to predict and to identify patients at risk of nodal metastasis.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Bhagat SK,Gopalakrishnan G,Kekre NS,Chacko NK,Kumar S,Manipadam MT,Samuel Pdoi
10.1007/s00345-009-0421-1subject
Has Abstractpub_date
2010-02-01 00:00:00pages
93-8issue
1eissn
0724-4983issn
1433-8726journal_volume
28pub_type
杂志文章abstract：:Upon feeling the urge to urinate, the urinary bladder contracts, the urethral sphincters relax and urine flows through the urethra. These actions are mediated by the micturition reflex. We investigated the hypothesis that vesical contraction is maintained by positive feedback through continuous flow of urine through t...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0340-5
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:High-quality leadership and chairing skills are vital for good performance in multidisciplinary tumor boards (MTBs), but no instruments currently exist for assessing and improving these skills. OBJECTIVE:To construct and validate a robust instrument for assessment of MTB leading and chairing skills. DESIGN...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2255-1
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Previous study compared limited number of parameters post the treatment of cold knife and laser urethrotomy for urethral stricture and controversy about the superiority of those two techniques still remains. This study aims to update the evidence and provide better clinical guidance. METHOD:We systematicall...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-019-02729-3
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated. MATERIALS AND METHODS:One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. RESULTS:The ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02767-x
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the factors affecting the lower urinary tract symptoms (LUTS) related quality of life (QoL) score. METHODS:This retrospective study analyzed 29,123 men who underwent health check-ups from January 2007 to July 2011 at a single institution. Those patients who completed th...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2052-2
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:To explore the role of prostate biopsy core length on prediction of index tumor clinical significance and localization on radical prostatectomy (RP) and time to recurrence, hypothesizing 10-, 10-12-, or > 12-mm minimum core as potential biopsy quality control. METHODS:Assessed 2424 prostate biopsy cores and co...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2242-6
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:To investigate, if and how omitting gadolinium-based contrast agents (GBCA) and dynamic contrast-enhanced imaging (DCE) influences diagnostic accuracy and tumor detection rates of prostate MRI. METHODS:In this retrospective study, 236 patients were included. The results of biparametric (bpMRI) and multiparamet...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2428-y
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Living donor nephrectomy is a high-stake procedure involving healthy individuals, therefore every effort should be made to define each patient's individualized risk and improve potential donors' information. The aim of this study was to evaluate the interest of the Mayo adhesive probability (MAP) score, an imag...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03513-4
更新日期：2020-11-11 00:00:00
abstract：OBJECTIVE:Robotic-assisted radical cystectomy (RARC) is a less invasive means of performing the radical cystectomy operation, which holds promise for improved patient morbidity. We review the history, technique and current literature pertaining to RARC and place the current results in context with the open procedure. ...
journal_title：World journal of urology
pub_type： 历史文章,杂志文章,评审
doi：10.1007/s00345-013-1053-z
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:The bromodomain and extra-terminal (BET) family of proteins provides a scaffolding platform for the recruitment and tethering of transcription factors to acetylated chromatin, thereby modulating gene expression. In this study, we evaluated the efficacy of the BET-inhibitor PFI-1 to diminish AR/AR-V7 signaling...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2382-8
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Chronic intraprostatic inflammation is suspected to play a major role in the pathogenesis of prostate cancer (PCa). Polymorphisms in interleukin-10 (IL-10), a key anti-inflammatory cytokine gene can influence immune response and immune evasion of tumor cells. Its role as an anti-metastatic molecule is also w...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0361-1
更新日期：2009-06-01 00:00:00
abstract：:The aim of this project was to evaluate the ice-water test as a predictor of the response to intradetrusor botulinum toxin injection in patients with neurogenic detrusor overactivity. We retrospectively evaluated the urodynamic parameters in 22 patients with neurogenic bladder dysfunction and positive ice-water test. ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0208-1
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:To compare oncological, functional, and toxicity outcomes of patients with radiation-recurrent prostate cancer (PCa) after external beam radiation therapy (EBRT) or brachytherapy (BT) treated with salvage high-intensity focused ultrasound (S-HIFU) or salvage radical prostatectomy (S-RP). METHODS:This retrospec...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02640-x
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS:We identified 261 patients who received TT for synchronous mRCC with or without prior CN. To a...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2154-x
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:This study aims to determine whether intra-network and inter-network brain connectivities are altered using an independent component analysis (ICA). METHODS:Resting-state functional MRI (rs-fMRI) data were acquired from 26 patients with OAB and 28 healthy controls (HC). Eleven resting-state networks (RSNs) wer...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02838-z
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Rectal culture screening for fluoroquinolone (FQ)-resistant Enterobacteriaceae before transrectal ultrasound guided prostate (TRUSPB) biopsy and targeted antibiotic prophylaxis (TAP) may decrease post-TRUSPB infection rates compared to empiric (EAP) regimens. The objective of this study was to evaluate the effe...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2217-7
更新日期：2018-07-01 00:00:00
abstract：:Sacral nerve modulation (SNM) is an effective way to treat non-neurogenic dysfunctions of pelvic organs. For over 20 years, this technique has been used for the treatment of overactive bladder, urinary retention, pelvic pain and even more recently, fecal incontinence and constipation. The objective of the study is to ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0204-5
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:To investigate transient receptor potential vanilloid 4 (TRPV4) expression and the effects of ruthenium red (RR)-TRPV antagonist-on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO). METHODS:Rats were randomly assigned to 3 groups. The control group (n = 10) included sham-operated rat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1099-y
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:The effect of living donor kidney allograft size on recipient outcomes is not well understood. In this study, we sought to investigate the relationship between preoperatively measured donor kidney volume and recipient estimated glomerular filtration rate (eGFR) in living donor kidney transplantation (LDKT). ME...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2595-x
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03497-1
更新日期：2020-10-26 00:00:00
abstract：PURPOSE:To assess the impact of prolonged catheterization time on 1-week (short-term), 3-month (intermediate-term) and 1-year (long-term) UC. METHODS:Between 2008 and 2015, 6918 men underwent RP by four high-volume surgeons. Exclusion criteria were baseline urinary incontinence (UI) and radiotherapy prior or within 12...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2274-y
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To review the recent advances in terms of surgical technique and new robotic platforms applied to radical perineal prostatectomy (RPP). METHODS:A literature review was performed focusing on original articles on perineal prostatectomy searching via Medline/Pubmed and Embase. The entire spectrum was covered such...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-03004-1
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVE:To explore efficacy and safety of Botulinum Neurotoxin Type A (BoNT-A) prostatic injection in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperperplasia. MATERIALS AND METHODS:A phase 3 multicenter open-labeled study randomised patients to receive BoNT-A prostatic injection or o...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00345-018-2193-y
更新日期：2018-06-01 00:00:00
abstract：INTRODUCTION:With low life expectancy rates in hemodialysis patients, the preservation of renal parenchyma must be weighed against the oncological outcomes in considering partial nephrectomy (PN) in solitary kidneys. The main objective of this study was to assess the oncologic and functional outcomes after PN in patien...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-010-0576-9
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:To report our experience with pelvic reconstructive surgery with transobturator mesh implants in elderly women. MATERIALS AND METHODS:A total of 32 women aged >75 years with pelvic organ prolapse receiving anterior and/or posterior repair using transobturator mesh implants were included. Concomitant mid-urethr...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0863-8
更新日期：2013-06-01 00:00:00
abstract：PURPOSE:To evaluate whether stone dust can be obtained from all prevailing stone composition types using the thulium fiber laser (TFL) for lithotripsy. Where applicable, stone dust was further characterized by morpho-constitutional analysis. METHODS:Human urinary stones were submitted to in vitro lithotripsy using a F...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03217-9
更新日期：2020-05-03 00:00:00
abstract：:A once-daily (o.d.) formulation of alfuzosin has recently been developed in order to improve the convenience of dosing and to provide optimal pharmacokinetic coverage over a 24-h period. The results of two double-blind, placebo-controlled phase III studies of similar design that included 983 patients with LUTS that su...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-002-0244-9
更新日期：2002-04-01 00:00:00
abstract：PURPOSE:To evaluate the clinical significance of invasive urothelial carcinoma that is ambiguous for muscularis propria invasion on initial transurethral resection of bladder tumor (TURBT). METHODS:All consecutive in-house TURBTs with invasive urothelial carcinoma from 1999 to 2017 that underwent radical cystectomy (R...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02782-y
更新日期：2020-02-01 00:00:00
abstract：PURPOSE:To investigate the association between overactive bladder (OAB) and coronary artery disease (CAD) as demonstrated on coronary angiography in patients > 65 years. METHODS:The patients who were > 65 years completed an OAB-V8 form before undergoing coronary angiography at a tertiary care hospital. The presence of...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2098-1
更新日期：2018-01-01 00:00:00
abstract：:The original article can be found online. ...
journal_title：World journal of urology
pub_type： 已发布勘误
doi：10.1007/s00345-020-03495-3
更新日期：2020-10-24 00:00:00
