Abstract:
:This article reviews the definition, incidence, pathological characteristics and natural history of low risk localised prostate cancer. Low risk disease is typically defined as clinical stage T1/T2a, biopsy Gleason score =6, PSA < 10. This risk classification has provided a useful system for reporting of outcomes and for the production of clinical guidelines. However, the low-risk disease is a broad category with a range of pathological characteristics and clinical behaviour. Many, but not all, low-risk prostate cancers are clinically insignificant, destined never to cause any harm. The challenge of managing low risk localized prostate cancer is to distinguish patients with clinically relevant cancers, who may benefit from radical treatment, from the remainder who do not need any intervention. The natural history of untreated low-risk localised prostate cancer has not been well studied, partly because it is a relatively recent entity, and partly because it has been standard practice for men with low risk disease to receive treatment. Data from watchful waiting in the pre-PSA era, modelling studies to take account of the lead time and overdiagnosis associated with PSA testing, and the early results of active surveillance can all provide insights into the likely natural history of low risk disease. There remains a major unmet need for markers of individual prostate cancer behaviour within the low-risk category. Such markers could be used to distinguish those men with truly indolent disease, suitable for observation, from those with significant prostate cancer that stand to benefit from treatment.
journal_name
World J Uroljournal_title
World journal of urologyauthors
O'Donnell H,Parker Cdoi
10.1007/s00345-008-0277-9subject
Has Abstractpub_date
2008-10-01 00:00:00pages
415-22issue
5eissn
0724-4983issn
1433-8726journal_volume
26pub_type
杂志文章,评审abstract::In this prospective study a comparison of 4-versus 7-MHz transrectal ultrasonography for the detection of prostatic carcinoma is reported. A total of 150 prostates were biopsied due to suspicion of malignancy arising at either digital rectal examination, 4- and/or 7-MHz transrectal ultrasonography, or elevated serum p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182174
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) are the next steps in the evolution of laparoscopic surgery, promising reduced morbidity and improved cosmetic result. The inconsistent terminology initially used led to confusion. Understanding the tech...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-012-0899-9
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Several studies have reported brain activations and functional connectivity (FC) during micturition using functional magnetic resonance imaging (fMRI) and concurrent urodynamics (UDS) testing. However, due to the invasive nature of UDS procedure, non-invasive resting-state fMRI is being explored as a potenti...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-021-03599-4
更新日期:2021-01-29 00:00:00
abstract::Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect coverage depends more on the remaining genital skin than on the etio...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450050115
更新日期:1999-04-01 00:00:00
abstract::The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s003450000146
更新日期:2000-10-01 00:00:00
abstract:INTRODUCTION:Muscle-invasive bladder cancer (MIBC) is an aggressive disease for which treatment strategies are continuously evolving. We characterized trends in treatment modalities for MIBC from 2004 to 2013 (the "pre-immunotherapy era") and identified predictors of receiving the current standard of care treatment: ne...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-018-2371-y
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:The factors affecting spermatogenesis in adulthood in patients with hypospadias (HS) are not clearly understood. In the present study, risk factors affecting post-pubertal high serum follicle-stimulating hormone (FSH) were evaluated in patients with HS. MATERIALS AND METHODS:Among those with a history of HS su...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-019-02687-w
更新日期:2019-12-01 00:00:00
abstract::The widespread use of measurement of prostate-specific antigen for prostate cancer screening has led to a dramatic increase in the number of transrectal biopsies. Although transrectal ultrasound-guided prostate biopsy is the gold standard in the diagnosis of prostate cancer, the strategies for initial and repeat biops...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-007-0151-1
更新日期:2007-03-01 00:00:00
abstract::Many women develop stress urinary incontinence (SUI) after childbirth, but the exact neuronal changes are largely unknown. This study is designed to identify the neuronal changes associated with pregnancy, delivery and ovariectomy. A total of 10 virgin and 48 pregnant rats were used. Cystometry and stress/sneeze tests...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-004-0444-6
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVES:Androgen receptor (AR) action in benign and malignant tissue is potentiated by a number of co-regulatory proteins that may interact with one or more receptor domains. With improvement of research methodologies, it became possible to detect a number of co-activators whose expression is increased in prostate c...
journal_title:World journal of urology
pub_type: 杂志文章,评审
doi:10.1007/s00345-011-0797-6
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Numerous recent studies have shown that concomitant carcinoma in situ (CIS) can be closely associated with the prognosis of patients with bladder cancer (BCa). However, the prognostic value of CIS in BCa is still not conclusive. Hence, we performed a systematic review and meta-analysis to explore the associa...
journal_title:World journal of urology
pub_type: 杂志文章,meta分析
doi:10.1007/s00345-019-02738-2
更新日期:2020-01-01 00:00:00
abstract::The purpose of the present study was to examine the outcome profiles of a large number of patients with locally advanced adenocarcinoma of the prostate following radical perineal prostatectomy (RPP) for clinically organ-confined disease. Of 1662 men who underwent RPP performed by a single surgeon between January 1972 ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003459900100
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:Robotic radical prostatectomy claims optimal oncologic results, minimal morbidity and best outcomes of urinary continence and erection function. Potential benefits concerning side effects and complications compared to open radical prostatectomy are analysed. METHODS:Out of 450 robotic radical prostatectomie...
journal_title:World journal of urology
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1007/s00345-008-0287-7
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To provide appropriate evidence for treatment planning of patients with an impacted proximal ureteral stones ≥1.5 cm in size, by analyzing the therapeutic outcomes for those undergoing minimally invasive percutaneous antegrade ureterolithotripsy and retrograde ureterolithotripsy. PATIENTS AND METHODS:From Se...
journal_title:World journal of urology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00345-013-1026-2
更新日期:2013-12-01 00:00:00
abstract::The use of intestinal segments in genitourinary reconstruction could influence vitamin metabolism and affect the skeletal bone and its mineral content in the long term. In 137 patients, serum levels of the vitamins A, B1, B2, B6, B12, D, and E and of folic acid, bile acid, and ammonia as well as levels of intracorpusc...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s003450050069
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:The purpose of the study is to introduce our experience of a modified single-port minilaparoscopic technique for the treatment of pediatric hydrocele. METHODS:Between June 2008 and May 2012, 279 boys (115 communicating hydrocele and 164 "non-communicating" hydrocele, diagnosis based on preoperative physical ex...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1259-8
更新日期:2014-12-01 00:00:00
abstract::The thin mucus or glycosaminoglycan layer of the bladder may be implicated in the pathogenesis of many bladder disease states. We have developed a specific antimucus, antisera stabilization technique to study the ultrastructural morphological appearance of the layer in both normal and abnormal bladders that should pro...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF00182045
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Herein, current developments in open and minimally invasive renal surgery are presented. MATERIALS AND METHODS:This also includes considerations on the appropriate indication for the two surgical procedures in small renal tumours, locally advanced disease (>pT2), complicated renal tumours as well as cytor...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0238-3
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:The mechanisms responsible for the pathogenesis of long-term renal damage induced by extracorporeal shock wave lithotripsy (ESWL) are not clear. The present study was designed to investigate the role of nuclear factor κB (NFκB) signal pathway in the pathogenesis of chronic shock wave-induced renal damage in rat...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-010-0515-9
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:Vesico-ureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. Surgery is an important part of its management. Laparoscopic ureteric reimplantation using the Lich-Gregoir technique is an option for VUR. The aim of this study is to assess short- and medium-...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-017-2064-y
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To investigate the impact of gender differences on treatment success, intraoperative and postoperative complications in patients undergoing ureteroscopy (URS). MATERIALS AND METHODS:A prospectively maintained database of 927 consecutively performed ureteroscopies on solitary ureteral stones in four different c...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-014-1435-x
更新日期:2015-09-01 00:00:00
abstract::Orthotopic urinary diversion via the Kock ileal neobladder is the preferred form of bladder reconstruction in men and, now, in women undergoing cystectomy at the University of Southern California. Through June of 1993, 266 men were diverted in this fashion. There were 3 perioperative mortalities (1.1%); early complica...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/BF01836343
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Nephron-sparing surgery (NSS) is the gold standard treatment for resectable renal tumors. In the last decade, laparoscopic partial nephrectomy (LPN) has evolved in technical, surgical and oncological aspects and is an accepted treatment option for local-stage renal tumors. Improvements in not only surgical tech...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-014-1404-4
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Complete urethral replacement using unseeded matrices has been proposed as a possible therapy in cases of congenital or acquired anomalies producing significant defects. Tissue regeneration involves fibrin deposition, re-epithelialization, and remodeling that are limited by the size of the defect. Scar formatio...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-008-0316-6
更新日期:2008-08-01 00:00:00
abstract:INTRODUCTION:Percutaneous stone removal increasingly plays an important role among the different approaches of interventional stone therapy, particularly since the development of miniaturized instruments is resulting in lower morbidity for the patients. One major drawback of smaller instruments is the increased difficu...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-015-1541-4
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:Because there is a lack of evidence, it is not generally recommended to use adjuvant radiotherapy plus chemotherapy to treat lymph node disease in penile cancer. The aim of this study was to determine the benefit of using adjuvant radiotherapy after inguinal surgery for penile cancer. METHODS:Multi-institution...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-020-03179-y
更新日期:2020-04-17 00:00:00
abstract:PURPOSE:We sought the association of preoperative serum total testosterone (tT), hypogonadism, 17β estradiol (E2), and sex hormone-binding globulin (SHBG) with early biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS:Sex steroids were assessed the day before surgery (7-11 a.m.) in a cohort of 605 p...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-012-0856-7
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:Previous studies examining the management of urinary tract infections (UTI) showed marked variability in the economical burden of care, with a tenfold increase in costs when patients require admission to the hospital. We sought to examine the patient and emergency department (ED) characteristics associated with...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00345-013-1167-3
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To explore efficacy and safety of Botulinum Neurotoxin Type A (BoNT-A) prostatic injection in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperperplasia. MATERIALS AND METHODS:A phase 3 multicenter open-labeled study randomised patients to receive BoNT-A prostatic injection or o...
journal_title:World journal of urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00345-018-2193-y
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Chronic inflammation has been considered a potential risk factor for prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross talk between innate immunity and adaptive immunity. In this study, sequence variants in the TLR4 gene were investigated to determ...
journal_title:World journal of urology
pub_type: 杂志文章
doi:10.1007/s00345-011-0690-3
更新日期:2012-04-01 00:00:00