Abstract：
PURPOSE:The introduction of collagenase Clostridium histolyticum (CCH) has revolutionized the treatment of Peyronie's disease. The efficacy of this therapy has been well demonstrated and the safety profile is favorable. However, post-injection complications are poorly characterized and management of these complications lacks standardization. METHODS:This review includes literature published in English and indexed in the PubMed®, Embase® or Google Scholar™ databases. What follows is a synopsis of relevant articles, including original research studies, in an attempt to better define CCH complications and their respective management strategies. RESULTS:Adverse effects of therapy are common but generally self-limiting. Penile pain and edema are expected events, and most patients experience hematologic sequelae (bleeding, hematoma, ecchymosis, etc.). The intervention rate for penile hematoma is low. Penile fracture is a morbid complication of therapy that is rare and may be challenging to diagnose given the frequency with which pronounced bruising and swelling are encountered. Imaging is a useful adjunct in situations of diagnostic uncertainty. Alternative injection protocols have been evaluated to limit the cost and morbidity of CCH therapy. Clinical efficacy of these protocols is promising, but prospective evaluation is lacking. CONCLUSIONS:No standardized protocols exist for management of post-injection complications of CCH therapy. The majority of these complications are managed conservatively, but suspected penile fracture should be carefully evaluated and imaging employed when needed. Future prospective studies of alternative injection protocols are warranted to decrease morbidity while maintaining efficacy.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Greear GM,Koprowski CJ,Hsieh TCdoi
10.1007/s00345-019-02817-4subject
Has Abstractpub_date
2020-02-01 00:00:00pages
287-292issue
2eissn
0724-4983issn
1433-8726pii
10.1007/s00345-019-02817-4journal_volume
38pub_type
杂志文章,评审abstract：PURPOSE:A paucity of data exists on the insignificant disease potentially suitable for active surveillance (AS) among men with intermediate-risk prostate cancer (PCa). We tried to identify pathologically insignificant disease and its preoperative predictors in men who underwent radical prostatectomy (RP) for intermedia...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1413-3
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:The anti-androgen withdrawal syndrome (AAWS) can be seen in one-third of patients after discontinuation of first-generation non-steroidal anti-androgen therapy. With the introduction of new agents for anti-androgen therapy as well as alternate mechanisms of action, new therapeutic options before and after do...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1288-3
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To compare long-term functional outcomes after robotic vs. retropubic RP for patients with localized prostate cancer in routine care. METHODS:"HAROW" was a large German noninterventional health services research study that prospectively evaluated the treatment of patients with localized prostate cancer (≤ T2c)...
journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2020-07-01 00:00:00
abstract：:We are fortunate that our ability to diagnose the specific adrenal entities that mandate a surgical approach is extremely accurate. The combination of analytical methodology to measure the appropriate adrenocortical and medullary hormone production and the radiology techniques for localization are superb. The manageme...
journal_title：World journal of urology
pub_type： 杂志文章,评审
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journal_title：World journal of urology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02656-3
更新日期：2019-06-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
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更新日期：2019-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03349-y
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03367-w
更新日期：2020-07-21 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0204-5
更新日期：2007-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1481-z
更新日期：2015-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-017-2008-6
更新日期：2017-09-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-013-1122-3
更新日期：2014-04-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0935-9
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journal_title：World journal of urology
pub_type： 杂志文章
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journal_title：World journal of urology
pub_type： 杂志文章
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：2017-03-01 00:00:00
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journal_title：World journal of urology
pub_type： 临床试验,杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2020-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-008-0320-x
更新日期：2009-02-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：2013-08-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：World journal of urology
pub_type： 杂志文章,评审
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更新日期：1997-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-03-23 00:00:00
abstract：:The original article can be found online. ...
journal_title：World journal of urology
pub_type： 已发布勘误
doi：10.1007/s00345-020-03495-3
更新日期：2020-10-24 00:00:00
