Genomics and clinical correlates of renal cell carcinoma.

Abstract:

PURPOSE:Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have now been well characterised thanks to large collaborative projects such as The Cancer Genome Atlas (TCGA). Not only has knowledge of the genomic landscape helped inform the development of new drugs, it also promises to fine tune prognostication. METHODS:A literature review was performed summarising the current knowledge on the genetic basis of RCC. RESULTS:The Von Hippel-Lindau (VHL) tumour suppressor gene undergoes bi-allelic knockout in the vast majority of clear cell RCCs. The next most prevalent aberrations include a cohort of chromatin-modifying genes with diverse roles including PBRM1, SETD2, BAP1, and KMD5C. The most common non-clear cell renal cancers have also undergone genomic profiling and are characterised by distinct genomic landscapes. Many recurrent mutations have prognostic value and show promise in aiding decisions regarding treatment stratification. Intra-tumour heterogeneity appears to hamper the clinical applicability of sparsely sampled tumours. Ways to abrogate heterogeneity will be required to optimise the genomic classification of tumours. CONCLUSION:The somatic mutational landscape of the more common renal cancers is well known. Correlation with outcome needs to be more comprehensively furnished, particularly for small renal masses, rarer non-clear cell renal cancers, and for all tumours undergoing targeted therapy.

journal_name

World J Urol

journal_title

World journal of urology

authors

Mitchell TJ,Rossi SH,Klatte T,Stewart GD

doi

10.1007/s00345-018-2429-x

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1899-1911

issue

12

eissn

0724-4983

issn

1433-8726

pii

10.1007/s00345-018-2429-x

journal_volume

36

pub_type

杂志文章,评审
  • Predictors of admission in patients presenting to the emergency department with urinary tract infection.

    abstract:PURPOSE:Previous studies examining the management of urinary tract infections (UTI) showed marked variability in the economical burden of care, with a tenfold increase in costs when patients require admission to the hospital. We sought to examine the patient and emergency department (ED) characteristics associated with...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00345-013-1167-3

    authors: Sammon JD,Sharma P,Rahbar H,Roghmann F,Ghani KR,Sukumar S,Karakiewicz PI,Peabody JO,Elder JS,Menon M,Sun M,Trinh QD

    更新日期:2014-06-01 00:00:00

  • A population-based survey of lower urinary tract symptoms (LUTS) and symptom-specific bother: results from the Brazilian LUTS epidemiology study (BLUES).

    abstract:PURPOSE:To examine the prevalence of lower urinary tract symptoms (LUTS) and the bother they impose in a population-based sample of adults in Brazil. METHODS:A cross-sectional population-based survey was conducted between September 2006 and January 2007 in the city of Salvador, Brazil. Cluster samples of representativ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-013-1057-8

    authors: Moreira ED Jr,Neves RC,Neto AF,Duarte FG,Moreira TL,Lobo CF,Glasser DB

    更新日期:2013-12-01 00:00:00

  • Prospective evaluation of a urinary biomarker panel to detect and predict recurrence of non-muscle-invasive bladder cancer.

    abstract:PURPOSE:To perform a feasibility phase study of a panel of putative protein biomarkers and determine whether it can identify and predict tumor recurrence in patients with non-muscle-invasive bladder cancer (NMIBC) on follow-up. METHODS:We prospectively analyzed the urine of 152 patients previously treated for NMIBC. Q...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03188-x

    authors: Srougi V,Reis ST,Viana N,Gallucci FP,Leite KR,Srougi M,Nahas WC

    更新日期:2020-04-06 00:00:00

  • Establishing and monitoring of urethral sphincter deficiency in a large animal model.

    abstract:BACKGROUND:Different methods for induction and monitoring of urethral sphincter deficiency were explored in a large animal model. METHODS:Sphincter deficiency was established in female pigs by dilatation and cauterization, and amount and frequencies of voiding were monitored and explored by pad test. Sphincteric closu...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-017-2088-3

    authors: Kelp A,Albrecht A,Amend B,Klünder M,Rapp P,Sawodny O,Stenzl A,Aicher WK

    更新日期:2017-12-01 00:00:00

  • Initial experiences with the Hemopatch® as a hemostatic agent in zero-ischemia partial nephrectomy.

    abstract:PURPOSE:Nephron-sparing surgery (NSS) is the gold standard treatment for resectable renal tumors. In the last decade, laparoscopic partial nephrectomy (LPN) has evolved in technical, surgical and oncological aspects and is an accepted treatment option for local-stage renal tumors. Improvements in not only surgical tech...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-014-1404-4

    authors: Imkamp F,Tolkach Y,Wolters M,Jutzi S,Kramer M,Herrmann T

    更新日期:2015-10-01 00:00:00

  • Achieving the "trifecta" with open versus minimally invasive partial nephrectomy.

    abstract:INTRODUCTION:The "trifecta" is a summary measure of outcome after partial nephrectomy (PN) that encompasses three parameters: negative surgical margin, ≤ 10% decrease in post-operative estimated glomerular filtration rate (eGFR) and absence of urological complications. We assessed trifecta rates in patients undergoing ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03349-y

    authors: Ghavimi S,Saarela O,Pouliot F,Rendon RA,Finelli A,Kapoor A,Moore RB,Breau RH,Lavallee L,Lacombe L,Fairey A,Jewett M,Liu Z,Tanguay S,Black PC

    更新日期:2020-07-12 00:00:00

  • Gender effect on renal outcome in patients with urothelial carcinoma.

    abstract:PURPOSE:Taiwan is a highly endemic area for urothelial carcinoma (UC) and chronic kidney disease (CKD). We evaluate the gender effect on the relationship between renal outcome and clinical characteristics of CKD patients with UC. METHODS:The clinical and pathologic records of 404 patients were retrospectively analyzed...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-011-0682-3

    authors: Hung PH,Shen CH,Tsai HB,Hsiao CY,Chiang PC,Guo HR,Hung KY

    更新日期:2011-08-01 00:00:00

  • Significance of baseline bone markers on disease progression and survival in hormone-sensitive prostate cancer with bone metastasis.

    abstract:PURPOSE:This study evaluated the baseline patient characteristics associated with the time to biochemical progression and overall survival in patients who participated in a phase II trial on zoledronic acid combined with the initial androgen-deprivation therapy for treatment-naïve bone-metastatic prostate cancer. METH...

    journal_title:World journal of urology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00345-014-1431-1

    authors: Nozawa M,Hara I,Matsuyama H,Iki M,Nagao K,Nishioka T,Komura T,Esa A,Uejima S,Imanishi M,Uekado Y,Ogawa T,Kajikawa H,Uemura H

    更新日期:2015-09-01 00:00:00

  • Clearance rates of residual stone fragments and dusts after endoscopic lithotripsy procedures using a holmium laser: 2-year follow-up results.

    abstract:PURPOSE:To investigate the spontaneous clearance rates of remnant particles following miniaturized percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS). METHODS:Among 624 patients who underwent mini-PCNL or RIRS at our institution from 2011 to 2015, we collected data of 247 patients with 2...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-016-1807-5

    authors: Kang M,Son H,Jeong H,Cho MC,Cho SY

    更新日期:2016-11-01 00:00:00

  • Quality of leadership in multidisciplinary cancer tumor boards: development and evaluation of a leadership assessment instrument (ATLAS).

    abstract:BACKGROUND:High-quality leadership and chairing skills are vital for good performance in multidisciplinary tumor boards (MTBs), but no instruments currently exist for assessing and improving these skills. OBJECTIVE:To construct and validate a robust instrument for assessment of MTB leading and chairing skills. DESIGN...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2255-1

    authors: Jalil R,Soukup T,Akhter W,Sevdalis N,Green JSA

    更新日期:2018-07-01 00:00:00

  • The surgeon and his intention: Gustav Simon (1824-1876), his first planned nephrectomy and further contributions to urology.

    abstract::One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...

    journal_title:World journal of urology

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/s003450050125

    authors: Moll F,Rathert P

    更新日期:1999-06-01 00:00:00

  • Robotic surgery in infants and children: an argument for smaller and fewer incisions.

    abstract:PURPOSE:Robotic-assisted laparoscopic (RAL) surgery has gained momentum in pediatric urology. Technological adaptations such as the development of 5 mm instruments have led to robotic procedures being performed on younger children and those having smaller body habitus, with improved cosmesis. However, concerns have bee...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-019-02765-z

    authors: Kawal T,Sahadev R,Srinivasan A,Chu D,Weiss D,Long C,Van Batavia J,Bodar Y,Shah J,Shukla AR

    更新日期:2020-08-01 00:00:00

  • Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of low-risk upper tract urothelial carcinoma.

    abstract:INTRODUCTION:The conservative management of upper tract urothelial carcinoma (UTUC) has historically been offered to patients with imperative indications. The recent International Consultation on Urologic Diseases (ICUD) publication on UTUC stratified treatment allocations based on high- and low-risk groups. This repor...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-016-1859-6

    authors: Mandalapu RS,Remzi M,de Reijke TM,Margulis V,Palou J,Kapoor A,Yossepowitch O,Coleman J,Traxer O,Anderson JK,Catto J,de la Rosette J,O'Brien T,Zlotta A,Matin SF

    更新日期:2017-03-01 00:00:00

  • The association between plant-based content in diet and testosterone levels in US adults.

    abstract:PURPOSE:To evaluate the association between the plant-based content of diet and serum testosterone levels in men from the national health and nutrition examination survey (NHANES) database. MATERIALS AND METHODS:Data on demographics, diet, and testosterone levels was acquired from the NHANES database. Using the food f...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03276-y

    authors: Kuchakulla M,Nackeeran S,Blachman-Braun R,Ramasamy R

    更新日期:2020-05-28 00:00:00

  • Evaluation of sexual function in women at two stages of multiple sclerosis.

    abstract:PURPOSE:In the present study, we aimed to evaluate the sexual function in patients with multiple sclerosis (MS) who were examined in two subgroups and compare the results to the control group with a validated questionnaire. METHODS:A total of 23 consecutive female MS patients divided into groups with relapsing-remitti...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-012-0891-4

    authors: Firdolas F,Ozan T,Onur R,Bulut S,Orhan I

    更新日期:2013-08-01 00:00:00

  • Clinical results of sacral neuromodulation for chronic voiding dysfunction using unilateral sacral foramen electrodes.

    abstract::The aim of this study was to determine the long-term clinical efficacy and complications of neuromodulation with a unilateral sacral foramen electrode in 36 patients with chronic voiding dysfunction. Following a positive effect of a percutaneous nerve evaluation test, patients underwent open surgery. A permanent elect...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s003450050074

    authors: Weil EH,Ruiz-Cerdá JL,Eerdmans PH,Janknegt RA,Van Kerrebroeck PE

    更新日期:1998-01-01 00:00:00

  • Parental awareness of testicular torsion amongst Irish parents.

    abstract:PURPOSE:Testicular torsion is the most concerning underlying cause of acute scrotal pain that can lead to loss of the affected testicle. Whether a torted testicle can be salvaged surgically is directly affected by prompt presentation and diagnosis. This study aims to evaluate the awareness of testicular torsion amongst...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2269-8

    authors: Yap LC,Keenan R,Khan J,Cozman C,Dowling C,Cullen I,Darcy F

    更新日期:2018-09-01 00:00:00

  • Standard vs. anatomical 180-W GreenLight laser photoselective vaporization of the prostate: a propensity score analysis.

    abstract:PURPOSE:To compare the efficacy, safety, Patient Global Impression of Improvement (PGI-I), and complications rates after 180-W GreenLight laser (180-W GL laser) standard and anatomical photoselective vaporization (sPVP and aPVP). METHODS:Within a multi-institutional database, we identified patients who underwent sPVP ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-017-2106-5

    authors: Cindolo L,De Nunzio C,Greco F,Destefanis P,Bergamaschi F,Ferrari G,Fasolis G,Palmieri F,Divan C,Oriti R,Ruggera L,Tubaro A,Dadone C,De Rienzo G,Frattini A,Mirone V,Schips L,Members of Green Laser Italian Group.

    更新日期:2018-01-01 00:00:00

  • An alternative procedure for the creation of an ileal conduit in patients undergoing pelvic exenteration: dextrotransmesenteric location.

    abstract::Ileal conduits have long been accepted as a standard method for urinary diversion, but conventional ileal conduits are not always suitable for patients whose ureters are for the greater part compromised by neoplasm or preoperative irradiation, resulting in a shortening of the ureters. Bowel migration into the large ca...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s003450050092

    authors: Hatano T,Hayakawa M,Koyama Y,Sugaya K,Miyazato T,Ogawa Y

    更新日期:1998-01-01 00:00:00

  • A comparison of prostate cancer detection rates by 12 or 6 core biopsy at different prostate-specific antigen densities in Korean men.

    abstract:OBJECTIVES:To evaluate the diagnostic value of 12 core biopsy versus sextant biopsy at different prostatic-specific antigen densities (PSAD). METHODS:We retrospectively analyzed the records of 1,463 patients who underwent transrectal ultrasound-guided prostate biopsies at our institution. 995 patients underwent 12 cor...

    journal_title:World journal of urology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00345-008-0264-1

    authors: Jeong H,Jeong BC,Kwak C,Lee E,Lee SE,Kim TB

    更新日期:2008-08-01 00:00:00

  • Differences in histopathological evaluation of standard lymph node dissections result in differences in nodal count but not in survival.

    abstract:OBJECTIVE:To analyse whether the reported differences in nodal yield at pelvic lymph node dissection (PLND) for bladder cancer, between two hospitals, are reflected in the survival rates. PATIENTS AND METHODS:We assessed follow-up data of all 174 patients (mean age: 62.7, median follow-up: 3 years) who underwent PLND ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-012-0916-z

    authors: Mertens LS,Meijer RP,van Werkhoven E,Bex A,van der Poel HG,van Rhijn BW,Meinhardt W,Horenblas S

    更新日期:2013-10-01 00:00:00

  • (18)F-choline PET/CT for early detection of metastases in biochemical recurrence following radical prostatectomy.

    abstract:PURPOSE:Salvage radiotherapy (SRT) for biochemical recurrence (BCR) following radical prostatectomy (RP) should if possible be added at a prostate-specific antigen (PSA) level of <1-2 ng/mL. The value of positron emission tomography combined with computed tomography (PET/CT) at such low PSA values is not defined. The p...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-015-1547-y

    authors: Kjölhede H,Ahlgren G,Almquist H,Liedberg F,Lyttkens K,Ohlsson T,Bratt O

    更新日期:2015-11-01 00:00:00

  • Epidemiology of urinary bladder cancer: from tumor development to patient's death.

    abstract::Urinary bladder cancer (UBC) ranks ninth in worldwide cancer incidence. It is more frequent in men than in women. We review the main established/proposed factors, both environmental and genetic, associated with bladder cancer etiology and prognosis. Data were extracted from previous reviews and original articles ident...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-007-0168-5

    authors: Murta-Nascimento C,Schmitz-Dräger BJ,Zeegers MP,Steineck G,Kogevinas M,Real FX,Malats N

    更新日期:2007-06-01 00:00:00

  • The prognostic role of preoperative circulating neutrophil-lymphocyte ratio in primary bladder cancer patients undergoing radical cystectomy: a meta-analysis.

    abstract:BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...

    journal_title:World journal of urology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00345-018-2593-z

    authors: Hu G,Xu F,Zhong K,Wang S,Xu Q,Huang L,Cheng P

    更新日期:2019-09-01 00:00:00

  • Orthotopic urinary diversion: the Kock ileal neobladder.

    abstract::Orthotopic urinary diversion via the Kock ileal neobladder is the preferred form of bladder reconstruction in men and, now, in women undergoing cystectomy at the University of Southern California. Through June of 1993, 266 men were diverted in this fashion. There were 3 perioperative mortalities (1.1%); early complica...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/BF01836343

    authors: Elmajian DA,Stein JP,Skinner DG

    更新日期:1996-01-01 00:00:00

  • Statin use is associated with decreased prostate cancer recurrence in men treated with brachytherapy.

    abstract:PURPOSE/OBJECTIVE(S):Recent in vitro and in vivo evidence has suggested that statin medications may have anticancer activity. We sought to determine whether statin use was associated with improved clinical outcome in men treated with brachytherapy for prostate cancer. MATERIALS/METHODS:A database of men with prostate ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-014-1281-x

    authors: Oh DS,Koontz B,Freedland SJ,Gerber L,Patel P,Lewis S,Yoo DS,Oleson J,Salama JK

    更新日期:2015-01-01 00:00:00

  • Higher expression of phosphodiesterase type 5 in the anterior fibromuscular stroma of the human prostate.

    abstract:PURPOSE:To examine phosphodiesterase type 5 (PDE5) expression in the anterior fibromuscular stroma (AFMS) of the prostate. Although PDE5 expression was identified in the human prostate, differences in PDE5 expression in intra-prostatic regions are unknown. The AFMS in the prostate has peculiar innervations that could c...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03095-1

    authors: Iwata T,Fujihara A,Shiraishi T,Yamada Y,Hongo F,Ukimura O

    更新日期:2020-11-01 00:00:00

  • Concomitant carcinoma in situ may not be a prognostic factor for patients with bladder cancer following radical cystectomy: a PRISMA-compliant systematic review and meta-analysis.

    abstract:BACKGROUND:Numerous recent studies have shown that concomitant carcinoma in situ (CIS) can be closely associated with the prognosis of patients with bladder cancer (BCa). However, the prognostic value of CIS in BCa is still not conclusive. Hence, we performed a systematic review and meta-analysis to explore the associa...

    journal_title:World journal of urology

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00345-019-02738-2

    authors: Zhang L,Wu B,Zha Z,Zhao H,Yuan J,Jiang Y

    更新日期:2020-01-01 00:00:00

  • Invasive non-urachal adenocarcinoma of the bladder: analysis of the National Cancer Database.

    abstract:PURPOSE:To review the United States National Cancer Database (NCDB) from 2004 to 2015 and analyze survival outcomes of invasive non-urachal adenocarcinoma based on treatment modality. METHODS:The NCDB 2004-2015 bladder dataset was queried for adenocarcinoma histology, excluding urachal variant, and limited to patients...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2411-7

    authors: Davaro F,Schaefer J,May A,Raza J,Siddiqui S,Hamilton Z

    更新日期:2019-03-01 00:00:00

  • The role of [(18)F] FDG-PET, CT/MRI and tumor marker kinetics in the evaluation of post chemotherapy residual masses in metastatic germ cell tumors--prospects for management.

    abstract::The purpose of this study was to assess the ability of [(18)F]FDG-PET, CT/MRI and serum tumor marker (TM) to predict the viability of residual masses after high-dose chemotherapy (HD-Ctx) in patients with metastatic germ cell tumors (GCT). In a prospective study, 60 residual tumors in 28 GCT patients were classified a...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-003-0392-6

    authors: Pfannenberg AC,Oechsle K,Bokemeyer C,Kollmannsberger C,Dohmen BM,Bares R,Hartmann JT,Vonthein R,Claussen CD

    更新日期:2004-06-01 00:00:00