Statin use is associated with decreased prostate cancer recurrence in men treated with brachytherapy.

Abstract:

PURPOSE/OBJECTIVE(S):Recent in vitro and in vivo evidence has suggested that statin medications may have anticancer activity. We sought to determine whether statin use was associated with improved clinical outcome in men treated with brachytherapy for prostate cancer. MATERIALS/METHODS:A database of men with prostate cancer treated with permanent Iodine-125 brachytherapy between January 1999 and February 2009 was retrospectively analyzed. Standard guidelines (i.e., American Brachytherapy Society selection criteria) were used for selecting patients for brachytherapy. Biochemical failure was defined using the Phoenix definition. RESULTS:From a total of 247 men with prostate adenocarcinoma treated with brachytherapy, 174 patients (70 %) were identified as using statin medications, either during initial visit or during follow-up. Median PSA follow-up was 51 months after date of implant (range 9.4-140.35). Overall biochemical failure rate was 7.3 % (18 patients). On univariate analysis, statin use was associated with significantly improved freedom from biochemical failure [hazard ratio (HR) 0.28; 95 % CI 0.10-0.72; p < 0.01 by log-rank test]. In multivariate Cox analysis performed with the variables statin use, pretreatment PSA, clinical T stage, Gleason score, and D90 or V100, statin use remained significantly associated with improved freedom from biochemical failure (HR 0.288; 95 % CI 0.086-0.886; p = 0.0299). CONCLUSIONS:Statin use was associated with a significant improvement in freedom from biochemical failure in this cohort of men treated with brachytherapy for prostate cancer. Further investigation into the favorable effect of statin use on brachytherapy and radiation therapy in general is warranted, including prospective trials.

journal_name

World J Urol

journal_title

World journal of urology

authors

Oh DS,Koontz B,Freedland SJ,Gerber L,Patel P,Lewis S,Yoo DS,Oleson J,Salama JK

doi

10.1007/s00345-014-1281-x

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

93-7

issue

1

eissn

0724-4983

issn

1433-8726

journal_volume

33

pub_type

杂志文章
  • Results of kidney tumor cryoablation: renal function preservation and oncologic efficacy.

    abstract:INTRODUCTION:Changes in the management of minimally invasive oncologic renal surgery have introduced ablative therapies as the most recent advancement in minimally invasive technology. METHODS:The current evidence-based medicine on the topic of laparoscopic (LCA) and percutaneous (PCA) renal cryoablation was gathered ...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-010-0552-4

    authors: Mues AC,Landman J

    更新日期:2010-10-01 00:00:00

  • Clinical impact of prostate biopsy undergrading in an academic and community setting.

    abstract:PURPOSE:To evaluate whether the rate of Gleason score (GS) upgrade on final pathology, the rate of positive surgical margins (PSM) and the rate of biochemical recurrence (BCR) after radical prostatectomy (RP) were different if prostate biopsy (PB) was graded by community pathologists (CP) as compared to specialized uro...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-016-1788-4

    authors: Mortezavi A,Keller EX,Poyet C,Hermanns T,Saba K,Randazzo M,Fankhauser CD,Wild PJ,Moch H,Sulser T,Eberli D

    更新日期:2016-10-01 00:00:00

  • Contemporary pathologic characteristics and oncologic outcomes of prostate cancers missed by 6- and 12-core biopsy and diagnosed with a 21-core biopsy protocol.

    abstract:PURPOSE:To assess the pathological and the oncologic outcomes of the prostate cancer (PCa) missed by 6- and 12-core biopsy protocols by using a reference 21-core scheme. MATERIALS AND METHODS:Between 2001 and 2009, all patients who had PCa detected in an initial 21-core TRUS biopsy scheme and were treated by a radical...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-011-0800-2

    authors: Ouzaid I,Xylinas E,Campeggi A,Hoznek A,Vordos D,Abbou CC,Vacherot F,Salomon L,de la Taille A,Ploussard G

    更新日期:2013-08-01 00:00:00

  • Complications of primary retroperitoneal lymph-node dissection for low-stage testicular cancer.

    abstract::The surgical complications encountered in 478 patients who underwent primary retroperitoneal lymph-node dissection for clinical stage A and B nonseminomatous testicular cancer during the period ranging from 1982 to 1992 were reviewed. There were 54 complications in 51 patients (10.6%), and there was no surgery-related...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/BF00192272

    authors: Baniel J,Foster RS,Rowland RG,Bihrle R,Donohue JP

    更新日期:1994-01-01 00:00:00

  • Following the crowd: patterns of crowdsourcing on Twitter among urologists.

    abstract:PURPOSE:To examine patterns of crowdsourcing on the social media platform Twitter among urologists. METHODS:Urologists' public Twitter accounts were reviewed for original posts seeking clinical advice or feedback, and associated reply posts, before and after the 140-character-limit expansion in 2017. Predictors of res...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2405-5

    authors: Koo K,Shee K,Gormley EA

    更新日期:2019-03-01 00:00:00

  • Long-term oncological outcomes in patients with limited nodal disease undergoing radical prostatectomy and pelvic lymph node dissection without adjuvant treatment.

    abstract:PURPOSE:This study aimed at analysing long-term oncologic outcomes in prostate cancer patients with limited nodal disease (1-2 positive lymph nodes) without adjuvant therapy after radical prostatectomy (RP). METHODS:We retrospectively analysed data of 209 pN1 patients who underwent RP between January 1998 and 2010 wit...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-017-2079-4

    authors: Mandel P,Rosenbaum C,Pompe RS,Steuber T,Salomon G,Chun FK,Graefen M,Huland H,Tilki D

    更新日期:2017-12-01 00:00:00

  • Long-term functional outcomes after robotic vs. retropubic radical prostatectomy in routine care: a 6-year follow-up of a large German health services research study.

    abstract:PURPOSE:To compare long-term functional outcomes after robotic vs. retropubic RP for patients with localized prostate cancer in routine care. METHODS:"HAROW" was a large German noninterventional health services research study that prospectively evaluated the treatment of patients with localized prostate cancer (≤ T2c)...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-019-02956-8

    authors: Baunacke M,Schmidt ML,Thomas C,Groeben C,Borkowetz A,Koch R,Chun FK,Weissbach L,Huber J

    更新日期:2020-07-01 00:00:00

  • Genital skin loss: unified reconstructive approach to a heterogeneous entity.

    abstract::Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect coverage depends more on the remaining genital skin than on the etio...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s003450050115

    authors: Wessells H

    更新日期:1999-04-01 00:00:00

  • Molecular predictors of response to PD-1/PD-L1 inhibition in urothelial cancer.

    abstract:INTRODUCTION:The survival of patients with metastatic urothelial cancer (mUC) is poor. During the last 40 years, chemotherapy was the predominant treatment modality for mUC. The discovery of the immune checkpoint inhibitors (ICI), especially the inhibitors of the programmed cell death 1 and its ligand (PD-1/PD-L1), has...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-018-2538-6

    authors: Stühler V,Maas JM,Bochem J,da Costa IA,Todenhöfer T,Stenzl A,Bedke J

    更新日期:2019-09-01 00:00:00

  • Evaluation of the "Teaching Guide for Basic Laparoscopic Skills" as a stand-alone educational tool for hands-on training sessions: a pilot study.

    abstract:INTRODUCTION AND OBJECTIVES:Standardization of hands-on training (HoT) has profoundly impacted the educational field in the last decade. To provide quality training sessions on a global scale, the European School of Urology Training group developed a teaching guide for tutors in 2015. Our study aims to understand wheth...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03161-8

    authors: Veneziano D,Morgia G,Castelli T,Cimino S,Russo G,Privitera S,Goezen A,Van Cleynenbreugel B,Ahmed K,Somani B,Urzì D,ESU-ESUT training Research group.

    更新日期:2020-03-21 00:00:00

  • Prostate cancer rates in patients with initially negative elastography-targeted biopsy vs. systematic biopsy.

    abstract:PURPOSE:To assess whether real-time elastography-targeted biopsy (RTE-bx) is superior to the standard systematic transrectal ultrasound (TRUS)-guided biopsy in predicting subsequent prostate cancer (PCa) rates in patients with initially negative biopsy and to specifically reveal differences in the occurrence of high-gr...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2178-x

    authors: Kratzenberg J,Salomon G,Tennstedt P,Dell'Oglio P,Tilki D,Haferkamp A,Graefen M,Boehm K

    更新日期:2018-04-01 00:00:00

  • Donor kidney volume measured by computed tomography is a strong predictor of recipient eGFR in living donor kidney transplantation.

    abstract:PURPOSE:The effect of living donor kidney allograft size on recipient outcomes is not well understood. In this study, we sought to investigate the relationship between preoperatively measured donor kidney volume and recipient estimated glomerular filtration rate (eGFR) in living donor kidney transplantation (LDKT). ME...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2595-x

    authors: Al-Adra DP,Lambadaris M,Barbas A,Li Y,Selzner M,Singh SK,Famure O,Kim SJ,Ghanekar A

    更新日期:2019-09-01 00:00:00

  • Efficacy of post-nephroureterectomy cisplatin-based adjuvant chemotherapy for locally advanced upper tract urothelial carcinoma: a multi-institutional retrospective study.

    abstract:PURPOSE:To evaluate the efficacy of adjuvant systemic chemotherapy for locally advanced (pT3-4pN0/xM0) upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS:We retrospectively reviewed the medical records of 109 patients with pT3-4pN0/xM0 UTUC who had undergone radical nephroureterectomy between 1996 and 2013...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-017-2032-6

    authors: Nakagawa T,Komemushi Y,Kawai T,Otsuka M,Miyakawa J,Uemura Y,Kanatani A,Taguchi S,Naito A,Suzuki M,Nishimatsu H,Hirano Y,Tanaka Y,Matsumoto A,Miyazaki H,Fujimura T,Fukuhara H,Kume H,Igawa Y,Homma Y

    更新日期:2017-10-01 00:00:00

  • Robotic-assisted laparoscopic radical cystectomy: history, techniques and outcomes.

    abstract:OBJECTIVE:Robotic-assisted radical cystectomy (RARC) is a less invasive means of performing the radical cystectomy operation, which holds promise for improved patient morbidity. We review the history, technique and current literature pertaining to RARC and place the current results in context with the open procedure. ...

    journal_title:World journal of urology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/s00345-013-1053-z

    authors: Liss MA,Kader AK

    更新日期:2013-06-01 00:00:00

  • Long-term metabolic effects in patients with urinary diversion.

    abstract::The use of intestinal segments in genitourinary reconstruction could influence vitamin metabolism and affect the skeletal bone and its mineral content in the long term. In 137 patients, serum levels of the vitamins A, B1, B2, B6, B12, D, and E and of folic acid, bile acid, and ammonia as well as levels of intracorpusc...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s003450050069

    authors: Stein R,Lotz J,Andreas J,Fisch M,Prellwitz W,Hohenfellner R,Thüroff JW

    更新日期:1998-01-01 00:00:00

  • Prospective evaluation of a urinary biomarker panel to detect and predict recurrence of non-muscle-invasive bladder cancer.

    abstract:PURPOSE:To perform a feasibility phase study of a panel of putative protein biomarkers and determine whether it can identify and predict tumor recurrence in patients with non-muscle-invasive bladder cancer (NMIBC) on follow-up. METHODS:We prospectively analyzed the urine of 152 patients previously treated for NMIBC. Q...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-020-03188-x

    authors: Srougi V,Reis ST,Viana N,Gallucci FP,Leite KR,Srougi M,Nahas WC

    更新日期:2020-04-06 00:00:00

  • Involvement of renin-angiotensin-aldosterone system in calcium oxalate crystal induced activation of NADPH oxidase and renal cell injury.

    abstract:INTRODUCTION AND OBJECTIVES:Reactive oxygen species (ROS) are produced during the interaction between oxalate/calcium oxalate monohydrate (COM) crystals and renal epithelial cells and are responsible for the various cellular responses through the activation of NADPH oxidase (Nox). Ox and COM also activate the renin-ang...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-015-1563-y

    authors: Tsuji H,Wang W,Sunil J,Shimizu N,Yoshimura K,Uemura H,Peck AB,Khan SR

    更新日期:2016-01-01 00:00:00

  • Correction to: Tissue engineering of the urethra: where are we in 2019?

    abstract::It has been brought to our attention that the first sentence of the Conclusion in the original publication [1] is incorrect. We have removed this sentence and the correct version can be found in this Erratum. ...

    journal_title:World journal of urology

    pub_type: 已发布勘误

    doi:10.1007/s00345-019-02929-x

    authors: Chapple C

    更新日期:2020-09-01 00:00:00

  • The present and future burden of urinary bladder cancer in the world.

    abstract::Urinary bladder cancer (UBC) is a common disease worldwide. At any point in time 2.7 million people have a history of UBC. The incidence of UBC varies over the world with highest rates in developed communities. But the burden of UBC will increase in less developed areas of the world. These changes can be attributed to...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-009-0383-3

    authors: Ploeg M,Aben KK,Kiemeney LA

    更新日期:2009-06-01 00:00:00

  • Epidemiology of stone disease across the world.

    abstract::Nephrolithiasis is a highly prevalent disease worldwide with rates ranging from 7 to 13% in North America, 5-9% in Europe, and 1-5% in Asia. Due to high rates of new and recurrent stones, management of stones is expensive and the disease has a high level of acute and chronic morbidity. The goal of this study is to rev...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-017-2008-6

    authors: Sorokin I,Mamoulakis C,Miyazawa K,Rodgers A,Talati J,Lotan Y

    更新日期:2017-09-01 00:00:00

  • Multiparametric ultrasound-targeted biopsy compares favorably to multiparametric MRI-transrectal ultrasound fusion-targeted biopsy on initial biopsy of men at risk for prostate cancer.

    abstract:PURPOSE:The purpose this study is to evaluate the efficacy of multiparametric ultrasound-targeted biopsies in patients undergoing initial biopsy of the prostate for the suspicion of prostate cancer. MATERIALS AND METHODS:A total of 167 patients who are biopsy naïve underwent multiparametric ultrasound-targeted biopsy ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2187-9

    authors: Fulgham PF

    更新日期:2018-05-01 00:00:00

  • Prostate-specific antigen kinetics after I125-brachytherapy for prostate adenocarcinoma.

    abstract:PURPOSE:To investigate a potential correlation between the achievement of a cut-off of nadir PSA (nPSA) after brachytherapy (BRT) with biochemical Disease-Free Survival (bDFS) and to define the rate of post-BRT PSA bounces. METHODS:Retrospective analysis was carried out in 105 consecutive patients affected with early-...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-012-0932-z

    authors: Guarneri A,Botticella A,Ragona R,Filippi AR,Munoz F,Casetta G,Gontero P,Tizzani A,Ricardi U

    更新日期:2013-04-01 00:00:00

  • Evolution and controversies in the management of low-stage nonseminomatous germ-cell tumors of the testis.

    abstract::The results of changing treatment modalities in 690 consecutive patients with low stages nonseminomatous germ-cell tumors (NSGCT) of the testis were analyzed. Overall, 120 patients (17.4%) suffered relapses, and 25 (3.6%) died of cancer after a follow-up period ranging from 2 to 20 years. The indications for primary (...

    journal_title:World journal of urology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00192265

    authors: Pizzocaro G,Nicolai N,Salvioni R

    更新日期:1994-01-01 00:00:00

  • Multivariate risk prediction tools including MRI for individualized biopsy decision in prostate cancer diagnosis: current status and future directions.

    abstract:BACKGROUND AND PURPOSE:Individualized risk-adapted algorithms in prostate cancer (PCa) diagnosis using predictive prebiopsy variables in addition to prostate-specific antigen value may result in a considerable reduction of unnecessary systematic biopsies. Multi-parametric magnetic resonance imaging (mpMRI) has emerged ...

    journal_title:World journal of urology

    pub_type: 杂志文章,评审

    doi:10.1007/s00345-019-02707-9

    authors: Schoots IG,Roobol MJ

    更新日期:2020-03-01 00:00:00

  • The cardiovascular risk factors in men with lower urinary tract symptoms.

    abstract:OBJECTIVE:It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS:It is a cross-sectional study on pat...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-018-2432-2

    authors: Yee CH,Yip JSY,Cheng NMY,Kwan CH,Li KM,Teoh JYC,Chiu PKF,Wong JH,Chan ESY,Chan CK,Hou SSM,Ng CF

    更新日期:2019-04-01 00:00:00

  • Dhat syndrome, an emergent condition within urology in Spain.

    abstract:BACKGROUND:Dhat syndrome (DS) consists of vague somatic symptoms and at times sexual dysfunction which the patient falsely attributes to involuntary emissions of semen outside of sexual relations. OBJECTIVE:Describe and analyse the occurrences of DS in patients attending the clinic and clarify the existence of this co...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-012-0911-4

    authors: Menéndez V,Fernández-Suárez A,Placer J,García-Linares M,Tarragon S,Liso E

    更新日期:2013-08-01 00:00:00

  • Matched pair analysis of laparoscopic versus open radical nephrectomy for the treatment of T3 renal cell carcinoma.

    abstract:PURPOSE:The perioperative and oncological outcomes of laparoscopic radical nephrectomy (LRN) for T1-T2 renal cell carcinoma (RCC) are well established. We aim to determine whether LRN is a comparable alternative to open radical nephrectomy (ORN) in the treatment of T3 RCC using a matched pair analysis study design. ME...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-014-1280-y

    authors: Laird A,Choy KC,Delaney H,Cutress ML,O'Connor KM,Tolley DA,McNeill SA,Stewart GD,Riddick AC

    更新日期:2015-01-01 00:00:00

  • The ileal neobladder in female patients with bladder cancer: long-term clinical, functional, and oncological outcome.

    abstract:PURPOSE:To assess long-term clinical and oncological outcome in women undergoing radical cystectomy and ileal neobladder reconstruction for invasive bladder cancer. METHODS:From 1995 to 2010, a total of 121 women with clinically organ-confined urothelial carcinoma underwent radical cystectomy with an orthotopic ileal ...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-012-0837-x

    authors: Jentzmik F,Schrader AJ,de Petriconi R,Hefty R,Mueller J,Doetterl J,Eickhoff A,Schrader M

    更新日期:2012-12-01 00:00:00

  • Long-term outcome of kidneys with initially poor drainage or no drainage following pyeloplasty.

    abstract::Pyeloplasty for congenital ureteropelvic junction (UPJ) obstruction enjoys a 90-95% success rate. Although treatment of the failed pyeloplasty has been addressed in the literature, management of the poorly draining or nondraining renal unit in the immediate postoperative period has not received any attention. For this...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/BF00183119

    authors: Miyamoto KK,Mesrobian HG

    更新日期:1996-01-01 00:00:00

  • Prediction of perioperative outcomes following minimally invasive partial nephrectomy: role of the R.E.N.A.L nephrometry score.

    abstract:OBJECTIVES:Objective characterization of renal mass anatomy facilitates treatment selection and prediction of surgical outcomes. We investigated R.E.N.A.L nephrometry score (NS) efficacy in predicting outcomes after minimally invasive nephron-sparing surgery (MINSS). METHODS:A total of 250 patients with 252 renal mass...

    journal_title:World journal of urology

    pub_type: 杂志文章

    doi:10.1007/s00345-012-0876-3

    authors: Liu ZW,Olweny EO,Yin G,Faddegon S,Tan YK,Han WK,Cadeddu JA

    更新日期:2013-10-01 00:00:00