Abstract：
:The purpose of this study was to assess the ability of [(18)F]FDG-PET, CT/MRI and serum tumor marker (TM) to predict the viability of residual masses after high-dose chemotherapy (HD-Ctx) in patients with metastatic germ cell tumors (GCT). In a prospective study, 60 residual tumors in 28 GCT patients were classified as viable/nonviable by FDG-PET, CT/MRI and TM levels. The results were validated either by histological examination of a resected mass and/or biopsy or by clinical/radiological follow-up for at least 6 months. There were no significant differences among the sensitivities observed with PET, CT/MRI and TM, but PET was significantly more specific than CT/MRI in predicting residual mass viability. TM showed the highest specificity. The highest accuracy in classification of residual tumors was achieved by a combination of PET, CT/MRI and TM (area under the ROC curve =0.91). All mature teratomas showed false-negative PET results with SUVs in the same range as necrosis. For classification of residual masses after HD-Ctx of metastatic GCT, [(18)F]FDG-PET is a valuable diagnostic method to complement the established procedures CT and TM. Positive PET results are highly correlated with the presence of viable tumor, but residual masses with negative PET findings still require resection. In cases of tumor progression diagnosed by CT and elevated TM, additional PET examinations are without benefit. PET seems useful in patients with stable disease or partial remission in CT/MRI and normalized TM as well as in marker-negative disease.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Pfannenberg AC,Oechsle K,Bokemeyer C,Kollmannsberger C,Dohmen BM,Bares R,Hartmann JT,Vonthein R,Claussen CDdoi
10.1007/s00345-003-0392-6keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
132-9issue
2eissn
0724-4983issn
1433-8726journal_volume
22pub_type
杂志文章abstract：BACKGROUND:In this study, we investigated the influence of hematuria on the performance of the bladder tumor antigen (BTA) tests in a clinical cohort and in an experimental model. MATERIALS AND METHODS:Urine samples from a cohort of 126 subjects (64 with BCa and 62 controls) were analyzed by ELISA for hemoglobin and B...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0935-9
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:Given that the tumor-promoting inflammation has been previously established in squamous cell carcinoma of the bladder but its contribution to development of urothelial carcinoma (UC) still remains elusive, our aim was to study changes in expression and activity of inflammation-mediating NF-κB and STAT3 transcri...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1237-1
更新日期：2014-12-01 00:00:00
abstract：:Sacral nerve modulation (SNM) is an effective way to treat non-neurogenic dysfunctions of pelvic organs. For over 20 years, this technique has been used for the treatment of overactive bladder, urinary retention, pelvic pain and even more recently, fecal incontinence and constipation. The objective of the study is to ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-007-0204-5
更新日期：2007-12-01 00:00:00
abstract：:The diagnosis of prostate cancer is based on histology. Prostate biopsies are obtained based on the triad of prostate specific antigen (PSA), digital rectal examination (DRE) and transrectal ultrasound. Because prostate biopsies still have a large percentage of negative outcomes, patient selection and biopsy direction...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0189-0
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Previous study compared limited number of parameters post the treatment of cold knife and laser urethrotomy for urethral stricture and controversy about the superiority of those two techniques still remains. This study aims to update the evidence and provide better clinical guidance. METHOD:We systematicall...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-019-02729-3
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:Patients and their families utilize online resources when dealing with a diagnosis of bladder cancer. Many patients have questions regarding clinical management options. Online research forums may help researchers and providers identify research areas of interest. Our objective was to review online forums and i...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2479-0
更新日期：2019-06-01 00:00:00
abstract：:A review of the current literature is conducted to explore the developmental aspects, animal and human experiences and the effects of pharmacological manipulation to explain the role androgens play in sexual function with special emphasis on erectile function and the erectile tissue. This review reveals that androgens...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF01275152
更新日期：1997-01-01 00:00:00
abstract：:The funding number was incorrect in the original published article. The correct funding number should read as follows. ...
journal_title：World journal of urology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00345-018-2289-4
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To review current practices in manual bladder washouts (MBW) for haematuria with clot retention, comparing those conducted by a urology unit to other inpatient services. Secondly, to describe a standardised protocol for MBWs. METHODS:Prospective data were collected for patients treated for clot retention, from...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2346-z
更新日期：2018-12-01 00:00:00
abstract：:Recent investigations have given a clearer insight into the genetic progression of bladder cancer. In this review we identify the clinical courses of bladder cancer, review the basic concepts of carcinogenesis, and focus on the specific cytogenetic and molecular alterations observed in bladder cancer. Progression mode...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/BF00184243
更新日期：1994-01-01 00:00:00
abstract：:We prospectively compared, within the same center and during the same period of time, the perioperative parameters as well as the oncological and functional results of both open retropubic (ORP) and laparoscopic radical prostatectomy (LRP). From September 1999 to September 2001, 162 patients with prostate cancer were ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-002-0306-z
更新日期：2003-05-01 00:00:00
abstract：:There is a definite need for an effective and reversible form of male contraception, both for maintaining a stable population in industrial countries and for diminishing population growth in developing countries. It has been agreed upon that contraception is an essential component of reproductive health for men and wo...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-003-0369-5
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:To highlight a new imaging acquisition protocol during (18)F-fluorocholine PET/CT in patients with biochemical recurrence after RP. METHODS:A total of 146 patients with PSA levels between 0.2 and 1 ng/ml with negative conventional imaging who did not receive salvage treatment were prospectively enrolled. Imagi...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1481-z
更新日期：2015-10-01 00:00:00
abstract：:One of the historic landmarks in urology is the first planned nephrectomy performed in 1869 by Gustav Simon of Heidelberg (1824-1877). In the history of medicine the reflections and considerations of the specialized surgeon reveal distinguished analyses of the "case" and, thus, the beginning of a modern scientific dis...
journal_title：World journal of urology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s003450050125
更新日期：1999-06-01 00:00:00
abstract：PURPOSE:To compare the perioperative relative renal function and determine predictors of deterioration and recovery of separate renal function in patients with renal stones >10 mm and who underwent mini-percutaneous nephrolithotomy or retrograde intra-renal surgery. PATIENTS AND METHODS:A main stone >10 mm or stones g...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1653-x
更新日期：2016-05-01 00:00:00
abstract：:It is well established that transmitters of the nonadrenergic-noncholinergic (NANC) system are involved in the control of sexual arousal and penile erection in healthy males. The proerectile activity of dopamine D1/D2 receptor agonist apomorphine-HCl (IXENSE, UPRIMA) involves oxytocinergic pathways descending from the...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-002-0300-5
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Different methods for induction and monitoring of urethral sphincter deficiency were explored in a large animal model. METHODS:Sphincter deficiency was established in female pigs by dilatation and cauterization, and amount and frequencies of voiding were monitored and explored by pad test. Sphincteric closu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2088-3
更新日期：2017-12-01 00:00:00
abstract：INTRODUCTION:Urinary incontinence in men after radical prostatectomy affects strongly quality of life. If conservative treatment fails, surgical treatment consists of implantable devices. If the requirement of manual dexterity in the artificial sphincter is to be avoided, the ProACT system offers a readjustable system,...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2483-4
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:To compare the efficacy, safety, Patient Global Impression of Improvement (PGI-I), and complications rates after 180-W GreenLight laser (180-W GL laser) standard and anatomical photoselective vaporization (sPVP and aPVP). METHODS:Within a multi-institutional database, we identified patients who underwent sPVP ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-017-2106-5
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:To evaluate histological changes in stenotic urethral tissue post-radiation therapy. Treatment of prostate cancer by radiation therapy carries a risk of off-target injury to the membranous urethra causing urethral stenosis. Limited characterization of post-radiation urethral stenosis exists in the literature. W...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03031-y
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To assess the effects of warm ischaemia time (WIT) on renal function after laparoscopic partial nephrectomy (LPN) for renal masses in patients with a normal contralateral kidney. METHODS:From October 2006 to December 2008, 53 patients treated with LPN were enrolled in this prospective study. Effective renal pl...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-011-0729-5
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:To propose a new coating to silicone implants using Manganese dioxide. We present bacterial adhesion and proliferation when implants are challenged with Escherichia coli. METHODS:Coated and control silicon implants were placed in two independent subcutaneous pouches in the dorsum of Wistar rats. After skin clo...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02856-x
更新日期：2020-03-01 00:00:00
abstract：:The field of tissue engineering has developed in phases: initially researchers searched for "inert" biomaterials to act solely as replacement structures in the body. Then, they explored biodegradable scaffolds--both naturally derived and synthetic--for the temporary support of growing tissues. Now, a third phase of ti...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-008-0273-0
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To assess the efficacy of an accelerated proficiency-based training protocol in robotic simulation practice in delivering durable proficiency compared to conventional training methods. METHODS:Novice medical students (n = 16) were randomized into either the accelerated skills acquisition protocol (ASAP) or con...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02858-9
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:Nephron-sparing surgery (NSS) is the gold standard treatment for resectable renal tumors. In the last decade, laparoscopic partial nephrectomy (LPN) has evolved in technical, surgical and oncological aspects and is an accepted treatment option for local-stage renal tumors. Improvements in not only surgical tech...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-014-1404-4
更新日期：2015-10-01 00:00:00
abstract：:Vesicoureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. The current indications for the surgical correction of VUR depend on the presence or absence of renal scars. If no scars are present, primary ureteral reimplantation is only indicated in high-grade bil...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0408-x
更新日期：2004-06-01 00:00:00
abstract：PURPOSE:To review the recent advances in terms of surgical technique and new robotic platforms applied to radical perineal prostatectomy (RPP). METHODS:A literature review was performed focusing on original articles on perineal prostatectomy searching via Medline/Pubmed and Embase. The entire spectrum was covered such...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-03004-1
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:To present current evidence supporting the vessel sparing technique to reconstruct bulbar urethral strictures via primary anastomosis. METHODS:English literature review of presented series of transecting and non-transecting bulbar urethroplasty from 2000 to 2018. RESULTS:Since its introduction in 2007, vessel...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02867-8
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:To assess the feasibility, safety, and outcomes of an expedited One-Stop prostate cancer (PCa) diagnostic pathway. PATIENTS AND METHODS:We identified 370 consecutive patients who underwent multiparametric magnetic resonance imaging (mpMRI) and transrectal ultrasound fusion prostate biopsy (MRI/TRUS-PBx) from o...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02835-2
更新日期：2020-04-01 00:00:00
abstract：:The orthotopic neobladder has become the preferred method of handling the urinary tract after removal of the bladder in men and women. However, an improved quality of life compared to urinary diversion fails to be realized when voiding dysfunction arises. These difficulties with urination range from retention to incon...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450000146
更新日期：2000-10-01 00:00:00
