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Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities.

Abstract：

:Growth and morphogenesis of the prostate involves mesenchymal-epithelial interactions. Transforming growth factor-beta 1 (TGF-beta1) is one growth factor that may play a role in these paracrine interactions. We have localized TGF-beta1 by molecular and immunohistochemical analysis in the developing mouse prostate. Accumulations of TGF-beta1 protein were localized in the mesenchyme surrounding ductules in fetal and neonatal prostate. Previous studies in the mouse prostate reconstitution (MPR) model system have localized accumulations of TGF-beta1 to regions of oncogene-induced abnormalities. In surgically excised adult human prostate tissues, localized accumulations of TGF-beta1 are associated with prostate cancer and benign prostatic hyperplasia (BPH). Intracellular TGF-beta1 was more often associated with stromal cells in BPH and with neoplastic epithelial cells in prostate cancer. The production and accumulation of TGF-beta1 appears to involve interactions between mesenchymal and epithelial cells. Further experimental studies may clarify the relationships between TGF-beta1 and abnormal prostatic growth.

journal_name

World J Urol

journal_title

World journal of urology

authors

Timme TL,Yang G,Truong LD,Kadmon D,Park SH,Thompson TC

doi

10.1007/BF00191212

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

324-8

issue

6

eissn

0724-4983

issn

1433-8726

journal_volume

13

pub_type

杂志文章

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