Abstract：
:We investigated the dynamic induction/expression of inducible nitric oxide synthase (iNOS) using human brains made available through death by traumatic brain injury (TBI). Astrocytes, microglia, and neutrophils were identified in tissue using immunohistochemical staining with antibodies against glial fibrillary acidic protein (GFAP), MHC class II antigen, and neutrophil elastase, respectively. The localization of iNOS protein in each of these cell types was evaluated using immunohistochemistry. Within 2 days of injury, iNOS immunoreactivity was not detected. However, after 2 days, immunoreactivity was detected in the traumatized brain. The iNOS immunoreactivity was localized on neutrophils and microglia/macrophages in the areas around the tissue necrosis in the traumatized cortical hemisphere, in the deep part of the cortex and the dentate gyri of the hippocampi adjacent to the hemorrhage, and within the cytoplasm of vascular smooth muscle cell of a small artery or arteriole surrounding the injured region. This reactivity was absent after 8 days post-injury.These observations confirmed the prolonged induction of iNOS within various cells in the injured brain. These responses suggest that iNOS plays a crucial role in cerebrovascular damage and/or secondary brain damage subsequent to traumatic brain injury. Furthermore, the dense nitric oxide (NO) generated by iNOS may play a role in neuronal cell death after injury.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Orihara Y,Ikematsu K,Tsuda R,Nakasono Idoi
10.1016/s0379-0738(01)00537-0keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
142-9issue
2-3eissn
0379-0738issn
1872-6283pii
S0379073801005370journal_volume
123pub_type
杂志文章abstract：:A 56-year-old man is discovered unconscious in a pool of blood in the kitchen of his house. According to findings, the man used a 22 long Rifle to fire 14 shots at his thorax with trajectories going from front to back, from right to left and on a nearly horizontal level. All the projectiles got into the left front sid...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00011-0
更新日期：1999-04-12 00:00:00
abstract：:Research into fingermark enhancement techniques has traditionally used visual comparisons and qualitative methods to assess their effectiveness based on the quality of the developed fingermark. However, with increasing research into the optimisation of these techniques the need for a quantitative evaluative method has...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.02.003
更新日期：2008-06-10 00:00:00
abstract：:Due to the different types and quality of forensic evidence materials, their DNA content can vary substantially, and particularly low quantities can impact the results in an identification analysis. In this study, the quantity of mitochondrial and nuclear DNA was determined in a variety of materials using a previously...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.11.024
更新日期：2006-12-01 00:00:00
abstract：:The importance of temperature data in minimum postmortem interval (minPMI) estimations in criminal investigations is well known. To maximise the accuracy of minPMI estimations, it is imperative to investigate the different components involved in temperature modelling, such as the duration of temperature data logger pl...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.110028
更新日期：2020-01-01 00:00:00
abstract：:The pharmacokinetics of ethanol in the blood, vitreous humour and aqueous humour of the rabbit after intravenous administration of single dose have been compared. Ethanol levels were determined by gas-liquid chromatography. Certain parallelism between ethanol levels in these body fluids were observed after 80 min. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(89)90236-3
更新日期：1989-04-01 00:00:00
abstract：:Weapons related webpages from nine cryptomarkets were manually duplicated in February 2016. Information about the listings (i.e. sales proposals) and vendors' profiles were extracted to draw an overview of the actual online trafficking of weapons. Relationships between vendors were also inferred through the analysis o...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.12.008
更新日期：2018-02-01 00:00:00
abstract：:Chemicals associated with clandestine drug laboratories are often disposed of covertly into soil, sewerage systems, or public waste management facilities. There are two significant issues relating to such dumps of materials; they might contain valuable evidence as to drug manufacture, and they might be a source of pol...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00110-5
更新日期：2003-06-24 00:00:00
abstract：:The objective of the present work was to compare previously published methods and provide validation data to detect simultaneously cocaine (COC), benzoylecgonine (BE) and norcocaine (NCOC) in nail. Finger and toenail samples (5mg) were cut in very small pieces and submitted to an initial procedure for external deconta...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.07.021
更新日期：2006-06-02 00:00:00
abstract：:We examined the immunohistochemical distributions of ubiquitin (Ub) and myoglobin (Mb) in human kidney tissues to assist the pathological assessment of death due to trauma. Medicolegal autopsy cases at our institute (n=138: 0-96 years of age, 105 males and 33 females) were examined. Causes of death were blunt injury (...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.10.016
更新日期：2007-09-13 00:00:00
abstract：:Human teeth are biological structures that resist extreme conditions thus becoming a useful source of DNA for human forensic identification purposes. When it is possible, forensic prefer only non-damaged teeth whereas those with cavities are usually rejected to avoid both external and internal bacterial contamination....
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.08.021
更新日期：2015-12-01 00:00:00
abstract：:Urine is often the sample of choice for drug screening in aviation/general forensic toxicology and in workplace drug testing. In some instances, the origin of the submitted samples may be challenged because of the medicolegal and socioeconomic consequences of a positive drug test. Methods for individualization of biol...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00034-1
更新日期：1999-05-31 00:00:00
abstract：:Obtaining palynological and other botanical evidence from murder victims is becoming part of routine mortuary protocol in the United Kingdom. Forensic pathologists are often keen to cooperate in the collection of classes of material that have, in the past, been considered to be of little importance in criminal investi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.06.070
更新日期：2006-11-22 00:00:00
abstract：:The rapid development of many open source and commercial image editing software makes the authenticity of the digital images questionable. Copy-move forgery is one of the most widely used tampering techniques to create desirable objects or conceal undesirable objects in a scene. Existing techniques reported in the lit...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.06.005
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Depression and other psychiatric illnesses are common during pregnancy and are often treated with antidepressants. Physiological changes of pregnancy may alter the pharmacokinetics of medications and ultimately affect the dose required to maintain effective therapy. Human hair offers a safe, non-invasive way...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.12.034
更新日期：2010-03-20 00:00:00
abstract：:Characterization and assessment of inks on sensitive documents for absolute/relative age determination is the challenging forensic problem in spite of practical difficulties. Tagging of ballpoint pen ink with suitable taggant(s) is a unique method to come out with definitive inferences on the detection of forgery in d...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.05.037
更新日期：2006-05-25 00:00:00
abstract：:In the case of disasters or crime scenes, forensic anthropometric methods have been utilized as a reliable way to quickly confirm the identification of victims using only a few parts of the body. A total of 321 measurement data (from 167 males and 154 females) were analyzed to investigate the suitability of detailed h...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.10.014
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the benefits of using serial measurements of plasma cholinesterase (butyrylcholinesterase, BuChE) activity in the management of cholinesterase inhibitor insecticidal poisoning. METHOD:After establishing and validating BuChE activity test, and making it available for clinical service in the toxico...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.06.074
更新日期：2006-10-16 00:00:00
abstract：:A decline in 3,4-methylenedioxy-N-methylamphetamine (MDMA) use in Adelaide, Australia from 2009 to 2010 was confirmed by us previously. Reports suggested that the shortage in MDMA supply was associated with an increased prevalence of other synthetic stimulants, but quantitative measurements were unavailable. To obtain...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.06.007
更新日期：2013-09-10 00:00:00
abstract：:We often refer to road fatalities without knowing exactly what injuries are responsible for them. Based on the Rhône Road Trauma Registry this paper sets out to describe the topography, nature and frequency of the fatal injuries sustained by car drivers. Mean annual mortality at the wheel of a car, computed by dividin...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.11.007
更新日期：2009-01-30 00:00:00
abstract：:The amplification of the STR DYS391, using the primers described in the Genome Data Base (GDB: G00-365-251), shows not only an additional band to the Y-specific one in males with a size range of 26 bp less than those of DYS391 locus alleles, but also a polymorphic pattern in females in the same size range as the addit...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00171-7
更新日期：2000-07-24 00:00:00
abstract：:In this research, the allelic distribution of 15 tetrameric short tandem repeats (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, FGA) were obtained from 167 Mulao and 108 Maonan unrelated individuals. The Genepop v3.4 and the PowerStats v1.2 we...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.06.023
更新日期：2006-10-16 00:00:00
abstract：:DNA typing of 15 short tandem repeat (STR) loci included in the AmpFlSTR Identifiler PCR amplification kit (Applied Biosystems), was carried out in three Egyptian populations of different ethnic groups: the Berbers from the Siwa oasis (in the North-Western Egyptian desert), the Muslims and the Copts from Adaima (Upper...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.03.017
更新日期：2007-07-04 00:00:00
abstract：:Chemical evaluation of gunshot residues (GSR) produced by non-toxic lead-free ammunition (NTA) has been a challenge to forensic analyses. Our group developed some luminescent markers specific to the detection of GSR. Here, we evaluated the performance of selected markers in experiments that mimic forensic context and/...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.09.001
更新日期：2014-11-01 00:00:00
abstract：:The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensa...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.03.034
更新日期：2016-06-01 00:00:00
abstract：:Allele frequencies and haplotype and haplogroup analysis have been performed for 16 Y-chromosome binary markers and 8 Y-chromosome STRs (DYS19, DYS385I and II, DYS389I and II, DYS390, DYS391, DYS392, DYS393). Data was obtained from a general sample of 93 unrelated individuals living in metropolitan areas from El Salva...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.07.005
更新日期：2007-09-13 00:00:00
abstract：:Morphometric cranial variation among Spanish samples was compared to a 19th century Portuguese sample using both traditional and three-dimensional approaches. The Spanish samples included the regional 19th century Oloriz collection and the local 16-17th century Villanubla and Vallolid sample from northwestern Spain. R...
journal_title：Forensic science international
pub_type： 历史文章,杂志文章
doi：10.1016/j.forsciint.2011.01.003
更新日期：2011-03-20 00:00:00
abstract：:This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to pipe...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.10.006
更新日期：2012-11-30 00:00:00
abstract：:A few cases of the sudden unintended acceleration have been reported over the last few years [1-11] and some of them seemed to be somewhat related to an electronic throttle control (ETC) system [11,12]. In this experimental study, efforts were made to reproduce the cases of sudden unintended acceleration possibly rela...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.08.014
更新日期：2016-10-01 00:00:00
abstract：:The population genetic data of 18 X-chromosomal short tandem repeat (STR) markers DXS6807, DXS8378, DXS9895, DXS9902, DXS6810, DXS7132, DXS981, DXS6800, DXS9898, DXS6789, DXS101, DXS6797, GATA172D05, GATA165B12, HPRTB, GATA31E08, DXS8377, and DXS7423 were analyzed in samples of unrelated 220 males and 181 females from...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.04.012
更新日期：2005-01-06 00:00:00
abstract：:The aim of the study was to improve the objectivity of X-ray image comparison for the identification of unknown dead individuals. CT-data were collected for 30 macerated skulls. An already presented computer program which uses CT data to establish virtual X-ray images was used to obtain X-rays with different beam angu...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00452-7
更新日期：2001-03-01 00:00:00
