Abstract：
:This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to piperonal by ozonolysis and oxidative cleavage with potassium permanganate and tetrahydrofuran. Vanillin was converted to piperonal by demethylation with pyridine and aluminium chloride followed by methylenation with dichloromethane. The resulting piperonal samples were converted via a commonly encountered route to MDMA. The impurities that indicate a particular route were identified and the feasibility of each method was also assessed.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Gallagher R,Shimmon R,McDonagh AMdoi
10.1016/j.forsciint.2012.10.006subject
Has Abstractpub_date
2012-11-30 00:00:00pages
306-13issue
1-3eissn
0379-0738issn
1872-6283pii
S0379-0738(12)00460-4journal_volume
223pub_type
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