Abstract：
:In Switzerland, the sale of cannabis with tetrahydrocannabinol (THC) content less than 1% has recently been legalized. As a consequence, cannabis with low THC and high cannabidiol (CBD) values up to approximately 25% is legally available on the market. In this study, we investigated cannabinoid blood and urine concentrations of a naive user and of a modeled chronic user after smoking a single CBD joint. Chronic use was modeled as smoking 2 joints per day for 10 days. Joints contained 200mg of cannabis with THC concentrations of 0.94% and 0.8% and CBD concentrations of 23.5% and 17% in the naive-smoker and chronic-smoker experiment, respectively. After smoking, blood and urine samples were collected for 4 and 20h after smoking start, respectively. THC blood concentrations reached 2.7 and 4.5ng/mL in the naive and chronic user, respectively. In both cases, the blood THC concentration is significantly above the Swiss road traffic threshold of 1.5ng/mL. Consequently, the user was legally unfit to drive directly after smoking. CBD blood concentrations of 45.7 and 82.6ng/mL were reached for the naive and chronic user, respectively. During the 10-day smoking period, blood and urine samples were regularly collected. No accumulation of any cannabinoid was found in the blood during this time. Urinary 11-nor-9-carboxy-THC concentrations seemed to increase during the 10-day period, which is important in abstinence testing.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Meier U,Dussy F,Scheurer E,Mercer-Chalmers-Bender K,Hangartner Sdoi
10.1016/j.forsciint.2018.08.009subject
Has Abstractpub_date
2018-10-01 00:00:00pages
62-67eissn
0379-0738issn
1872-6283pii
S0379-0738(18)30497-3journal_volume
291pub_type
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