Abstract:
:To investigate the pathological changes in the heart induced by pulmonary embolism, 20 autopsy cases of pulmonary embolism and 10 control cases of acute death from traumatic injury were examined. Adding to the routine hematoxylin-eosin (HE) staining, immunostaining with CD68 pan-macrophage marker was performed on the specimens obtained from both right and left ventricular walls. The number of macrophages was counted semi-quantitatively in 100 random high-power fields (HPF). Although typical pathological findings of myocardial infarction was not observed in any of the cases, 16 of the 20 pulmonary embolism cases showed an increase in the number of macrophages, mainly in the right ventricular wall. Four cases showed massive macrophage infiltration in the entire right ventricular wall. It is speculated that ischemia due to pulmonary embolism may be connected to its pathogenesis.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Iwadate K,Doi M,Tanno K,Katsumura S,Ito H,Sato K,Yonemura I,Ito Ydoi
10.1016/s0379-0738(03)00138-5keywords:
subject
Has Abstractpub_date
2003-07-08 00:00:00pages
147-53issue
2-3eissn
0379-0738issn
1872-6283pii
S0379073803001385journal_volume
134pub_type
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journal_title:Forensic science international
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