Abstract：
:This article discusses the immunoassay screening of pain management drugs, and the mass spectrometric confirmation of fentanyl in human hair. Hair specimens were screened for fentanyl, opiates (including oxycodone), tramadol, propoxyphene, carisoprodol, methadone, and benzodiazepines and any positive results were confirmed using gas chromatography or liquid chromatography with mass spectral detection. The specific focus of the work was the determination of fentanyl in hair, since autopsy specimens were also available for comparison with hair concentrations. Using two-dimensional gas chromatography with electron impact mass spectrometric detection, fentanyl was confirmed in four of nine hair specimens collected at autopsy. The accuracy of the assay at 10 pg/mg was 95.17% and the inter-day and intra-day precision was 5.04 and 13.24%, respectively (n=5). The assay was linear over the range 5-200 pg/mg with a correlation of r(2)>0.99. The equation of the calibration curve forced through the origin was y=0.0053x and the limit of quantitation of the assay was 5 pg/mg. The fentanyl concentrations detected were 12, 17, 490, and 1930 pg/mg and the results were compared with toxicology from routine post-mortem analysis. The screening of pain management drugs in hair is useful in cases where other matrices may not be available, and in routine testing of hair for abused drugs.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Moore C,Marinetti L,Coulter C,Crompton Kdoi
10.1016/j.forsciint.2007.06.027subject
Has Abstractpub_date
2008-03-21 00:00:00pages
47-50issue
1eissn
0379-0738issn
1872-6283pii
S0379-0738(07)00756-6journal_volume
176pub_type
杂志文章abstract：:Technology provides new ways to access customers and suppliers while enhancing the security of off-line criminal activity. Since the first cryptomarket, Silk Road, in 2011, cryptomarkets have transformed the traditional drug sale by facilitating the creation of a global network of vendors and buyers. Due to the fragme...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2018.05.002
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Post-mortem Computed Tomography (PMCT) allows non-invasive or minimally invasive detection of findings that may or may not be visible during conventional autopsy, however, it does not allow the investigator to draw any conclusions regarding patency of the vessel's lumen. To address this deficiency, Post-mort...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110171
更新日期：2020-03-01 00:00:00
abstract：:During a stabbing, apparel fabrics are usually damaged and may be penetrated. Despite numerous studies considering forces required to penetrate skin and human stabbing performance, none have systematically evaluated which variables affect severance appearance from a textile science perspective using a human stabbing p...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.01.024
更新日期：2015-04-01 00:00:00
abstract：:With the constantly increasing sensitivity and robustness of liquid chromatography-mass spectrometry-based instruments combined with enhanced reproducibility as well as mass accuracy and resolution, LC-MS(/MS) has become an integral part of sports drug testing programs particularly concerning the detection of peptide ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.06.015
更新日期：2011-12-10 00:00:00
abstract：:3-Methylmethcathinone (3-MMC or metaphedrone) is a synthetic cathinone, recently introduced in the market of the new psychoactive substances (NPS), initially to replace mephedrone (4-methylmethcathinone or 4-MMC), and rapidly widespread among drug users. 3-Methylmethcathinone is legally controlled in many countries, b...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2018.11.024
更新日期：2019-02-01 00:00:00
abstract：:Ten X-chromosomal STRs from two multiplex PCR approaches (DXS9898, DXS6807, HPRTB, DXS101, and androgen receptor (ARA); DXS7133, DXS10011, DXS7424, DXS8377, and DXS8378) have been typed in a Latvian population sample. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.04.006
更新日期：2006-03-10 00:00:00
abstract：:Calculation of a blood alcohol concentration (BAC) at the time of an offence by forward or back-extrapolation, using population average values for ethanol pharmacokinetic parameters or a single estimate of individual specific parameters, ignores the possibility of inter- and intra-subject variability. In order to esti...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.05.011
更新日期：2008-02-25 00:00:00
abstract：:Cannabis cultivation in order to produce drugs is forbidden in Switzerland. Thus, law enforcement authorities regularly ask forensic laboratories to determinate cannabis plant's chemotype from seized material in order to ascertain that the plantation is legal or not. As required by the EU official analysis protocol th...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2010.03.034
更新日期：2010-07-15 00:00:00
abstract：:The experience of the Northern Ireland State Pathology Service is drawn on to illustrate the forensic aspects of death by shooting and bombing caused by terrorists. The investigations into these deaths have to contend with rumours and allegations which can inflame feelings in the community or mislead the investigators...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(88)90215-0
更新日期：1988-01-01 00:00:00
abstract：:The discrimination of sex is central to the process of establishing a personal identification from human skeletal remains. Previous study has demonstrated that osteometric analysis of the sternal extremity of the fourth rib provides a reasonably accurate method for assessing this biological attribute in diverse human ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.09.007
更新日期：2012-11-30 00:00:00
abstract：:A new method was developed for the simultaneous detection and quantitation of 6-acetyl-morphine (MAM), amphetamine, benzoylecgonine (BZE), cocaine, codeine, dihydrocodeine, EDDP (methadone metabolite), methadone and morphine in hair. The hair samples were washed, cut into 2-cm segments, pulverized, incubated with phos...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90273-d
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Depression and other psychiatric illnesses are common during pregnancy and are often treated with antidepressants. Physiological changes of pregnancy may alter the pharmacokinetics of medications and ultimately affect the dose required to maintain effective therapy. Human hair offers a safe, non-invasive way...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.12.034
更新日期：2010-03-20 00:00:00
abstract：:Allele frequency data for eight short tandem repeat (STR) loci, HUMF13A01, HUMFESFPS, HUMF13B, HUMLPL, HUMCSF1PO, HUMTPOX, HUMTHO1 and HUMvWA, were obtained for unrelated individuals in a Saudi Arabian population. All loci, except F13B (P = 0.037) and LPL (P = 0.035), meet Hardy-Weinberg expectations, based on the exa...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00107-3
更新日期：1999-10-11 00:00:00
abstract：:The post-mortem redistribution of a number of psychiatric drugs was investigated. A portion of liver, the gastric contents and blood collected from heart and femoral sites was obtained from 13 cases and analyzed by liquid chromatography-mass spectrometry. Drugs detected included five selective serotonin reuptake inhib...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.02.013
更新日期：2006-12-20 00:00:00
abstract：:The livings have responsibilities for the dead; and in particular, civilized societies recognize the need for identity both during life and at death, particularly in circumstances when an unknown body is summoned for medico-legal autopsy. There are numerous tools for identification of an unknown body which includes vi...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.10.018
更新日期：2009-01-10 00:00:00
abstract：OBJECTIVE:To evaluate the benefits of using serial measurements of plasma cholinesterase (butyrylcholinesterase, BuChE) activity in the management of cholinesterase inhibitor insecticidal poisoning. METHOD:After establishing and validating BuChE activity test, and making it available for clinical service in the toxico...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2006.06.074
更新日期：2006-10-16 00:00:00
abstract：:The present study investigated the interobserver variation between a radiologist and a forensic pathologist in 994 injury diagnoses obtained by postmortem computed tomography (CT) of 67 traffic fatality victims, and the results were compared with diagnoses obtained by autopsy. The injuries were coded according to the ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.03.028
更新日期：2013-02-10 00:00:00
abstract：:Material and failure analysis techniques are key tools for determining causation in case of explosive and bursting accident result from material and process defect of product in the field of forensic science. The boiler rupture generated by defect of the welding division, corrosion, overheating and degradation of the ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.07.036
更新日期：2017-09-01 00:00:00
abstract：:Toolmark analysis involves examining marks created on an object to identify the likely tool responsible for creating those marks (e.g., a knife). Although a potentially powerful forensic tool, knife mark analysis is still in its infancy and the validation of imaging techniques as well as quantitative approaches is ong...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.12.039
更新日期：2018-02-01 00:00:00
abstract：:As part of a transcultural investigation of violent behaviour in Argentina and Denmark an analysis was made of the incidents involving deliberate violence as registered in the emergency wards of Hospital Fernandez and Hospital Pinero in Capital Federal Buenos Aires over a period of 13 and 17 months, respectively. In t...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(89)90208-9
更新日期：1989-07-01 00:00:00
abstract：:A multicentre retrospective analysis of 4450 autopsies carried out due to suspicion of medical malpractice in 17 German institutes of forensic medicine from 1990 to 2000 was performed for the German Federal Ministry of Health. During the time period analysed an increase of cases could be mentioned. The main results of...
journal_title：Forensic science international
pub_type： 杂志文章,多中心研究
doi：10.1016/j.forsciint.2009.05.013
更新日期：2009-09-10 00:00:00
abstract：:A previous study conducted in 1995 showed that psychoactive drug use by workers was higher in safety/security workstations than in the rest of the labour force. In order to verify this finding, we conducted a new study in 2003-2004 in the Nord-Pas-de-Calais region, restricted to truck drivers. The aim of this study wa...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2007.03.004
更新日期：2008-01-30 00:00:00
abstract：BACKGROUND:Studies testing the Willems method of age estimation with gender-specific scores on different population groups have reported consistently more accurate results over other methods. Not enough is known about the validity of Willems non-gender specific scores. AIM:The present study aimed to compare the accura...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.05.012
更新日期：2016-09-01 00:00:00
abstract：:We have performed a population genetic study on a population from South Saxony-Anhalt, Germany. The allele distributions of the systems DYS19, DYS385, DYS389I/II DYS390, DYS391, DYS392 and DYS393 were investigated in a sample of 234 unrelated males. PCR products were detected using capillary electrophoresis on the ABI...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.01.004
更新日期：2005-12-20 00:00:00
abstract：:The aim of this work was to study the efficiency of automatic fibre searching with the Maxcan fibre finder (Cox Analytical Systems, Sweden) in comparison to manual searching. The influence of some parameters (color, thickness, background noise) on the results of a fibre search was considered. Eighteen experimental tap...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.08.015
更新日期：2006-07-13 00:00:00
abstract：:An ingestion of an unknown quantity of U 46 D-Fluid (500 g dichlorophenoxyacetic acid/l) in a suicide is described. Although 2,4-dichlorophenoxyacetic acid (2,4 D) is widely used as a herbicide, intoxications are relatively rare. Quantitation of 2,4-D was performed by diethyl ether extraction from acidified samples (v...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(94)90295-x
更新日期：1994-03-01 00:00:00
abstract：:The mass spectrum of the drug of abuse 2,5-dimethoxyamphetamine (2,5-DMA) is characterized by an imine fragment base peak at m/z 44 and additional fragments at m/z 151/152 for the dimethoxybenzyl cation and radical cation, respectively. Five positional ring isomers of dimethoxyamphetamines (DMA) have an isomeric relat...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.08.010
更新日期：2009-11-20 00:00:00
abstract：:Time-of-flight secondary ion mass spectrometry (TOF-SIMS) was utilized to obtain characteristic mass spectra from three different smokeless powders and six different black powder samples. In these mass spectra, peaks indicative of both the organic and inorganic additive constituents in the gunpowders were observed. TO...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.02.036
更新日期：2006-04-20 00:00:00
abstract：:There are many techniques available for the recovery of fingermarks at scenes of crime including the possibility of taking casts of the marks. Casts can be advantageous in cases where other destructive recovery techniques might not be suitable, such as when recovering finger marks deposited on valued or immobile items...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2008.04.001
更新日期：2008-07-04 00:00:00
abstract：:Diastereomeric dipeptides were derived from the amino acid enantiomers in dentin by O-phthalaldehyde-N-acetyl-L-cysteine. The products were separated using high performance liquid chromatography (HPLC) and detected by fluorescence detector. A short analysis time (total analysis time was 15 min, including retention tim...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(95)01709-7
更新日期：1995-05-09 00:00:00
