Abstract：
:Calculation of a blood alcohol concentration (BAC) at the time of an offence by forward or back-extrapolation, using population average values for ethanol pharmacokinetic parameters or a single estimate of individual specific parameters, ignores the possibility of inter- and intra-subject variability. In order to estimate inter- and intra-subject variability in the elimination rate and absorption rate, BAC was measured over time in 12 male volunteers on 4 occasions. Subjects received 0.44 g kg(-1) body weight of ethanol on the first study day, and 0.70 g kg(-1) body weight on subsequent study days 1, 11 and 12 weeks later, to enable comparisons in variability over short and long time periods and when the same or different doses were administered. Evidence of both inter- and intra-subject variability was found, with inter-subject variability substantially smaller than intra-subject variability when the dose varied. Forensically important differences in pharmacokinetic parameters were observed within individuals between occasions. These findings could have an important impact on medico-legal issues related to ethanol pharmacokinetics.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Yelland LN,Burns JP,Sims DN,Salter AB,White JMdoi
10.1016/j.forsciint.2007.05.011subject
Has Abstractpub_date
2008-02-25 00:00:00pages
65-72issue
1eissn
0379-0738issn
1872-6283pii
S0379-0738(07)00519-1journal_volume
175pub_type
杂志文章abstract：:Allele and genotype frequencies for D1S80, 3'ApoB and YNZ22 loci have been determined in a population sample of the North of Portugal using the polymerase chain reaction (PCR) amplification and nonradioactive detection. The distribution of genotypes in the three polymorphisms studied is in agreement with expected valu...
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journal_title：Forensic science international
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journal_title：Forensic science international
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journal_title：Forensic science international
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更新日期：1998-04-05 00:00:00
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journal_title：Forensic science international
pub_type： 信件
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更新日期：2012-05-10 00:00:00
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