Abstract:
:The post-mortem redistribution of a number of psychiatric drugs was investigated. A portion of liver, the gastric contents and blood collected from heart and femoral sites was obtained from 13 cases and analyzed by liquid chromatography-mass spectrometry. Drugs detected included five selective serotonin reuptake inhibitors; venlafaxine, a serotonin/noradrenaline reuptake inhibitor; and risperidone, an atypical antipsychotic. Heart blood concentrations were significantly higher (3.4-fold on average) than those measured in femoral blood when results from all drugs were included together. The range for parent drug concentrations in these two blood specimens was 0.5-6.2. There was no significant correlation of the post-mortem interval, the liver concentration and content of drugs in the gastric contents to the heart:femoral blood concentration ratio. These data serve to demonstrate that variable increases in blood concentration occur post-mortem and limit the interpretative value of such toxicological data.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Rodda KE,Drummer OHdoi
10.1016/j.forsciint.2006.02.013keywords:
subject
Has Abstractpub_date
2006-12-20 00:00:00pages
235-9issue
2-3eissn
0379-0738issn
1872-6283pii
S0379-0738(06)00068-5journal_volume
164pub_type
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journal_title:Forensic science international
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