The redistribution of selected psychiatric drugs in post-mortem cases.

Abstract:

:The post-mortem redistribution of a number of psychiatric drugs was investigated. A portion of liver, the gastric contents and blood collected from heart and femoral sites was obtained from 13 cases and analyzed by liquid chromatography-mass spectrometry. Drugs detected included five selective serotonin reuptake inhibitors; venlafaxine, a serotonin/noradrenaline reuptake inhibitor; and risperidone, an atypical antipsychotic. Heart blood concentrations were significantly higher (3.4-fold on average) than those measured in femoral blood when results from all drugs were included together. The range for parent drug concentrations in these two blood specimens was 0.5-6.2. There was no significant correlation of the post-mortem interval, the liver concentration and content of drugs in the gastric contents to the heart:femoral blood concentration ratio. These data serve to demonstrate that variable increases in blood concentration occur post-mortem and limit the interpretative value of such toxicological data.

journal_name

Forensic Sci Int

authors

Rodda KE,Drummer OH

doi

10.1016/j.forsciint.2006.02.013

keywords:

subject

Has Abstract

pub_date

2006-12-20 00:00:00

pages

235-9

issue

2-3

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(06)00068-5

journal_volume

164

pub_type

杂志文章
  • Yield and turnover of illicit indoor cannabis (Cannabis spp.) plantations in Belgium.

    abstract::In prosecution, Belgian judiciary currently uses outdated yield figures (28.1g per plant, sold at € 3/g at grower level) for fining illicit indoor cannabis plantations. Using state-of-the-art cultivation techniques, our growth experiments showed that yield is better expressed in g/m(2) cultivated surface area rather t...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.03.013

    authors: Vanhove W,Surmont T,Van Damme P,De Ruyver B

    更新日期:2012-07-10 00:00:00

  • Application of capillary electrophoresis to examination of color inkjet printing inks for forensic purposes.

    abstract::In the process of questioned document examination, the discrimination of inkjet printing inks is becoming more necessary due to increasingly frequent counterfeiting of documents printed by inkjet printers. Therefore, a method based on micellar electrophoretic capillary chromatography (MECC) has been developed and appl...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2011.05.017

    authors: Szafarska M,Wietecha-Posłuszny R,Woźniakiewicz M,Kościelniak P

    更新日期:2011-10-10 00:00:00

  • Unclear loss of consciousness after clobutinol intake.

    abstract::The case of a 13-month-old boy with a diagnosis of unclear unconsciousness is reported on. As the physical examination did not lead to any explanation of his condition, the administration of drugs in the context of Munchausen syndrome by proxy was suspected. Complex forensic-toxicological analyses using HPLC/UV, LC/MS...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2009.04.021

    authors: Kirschbaum KM,Musshoff F,Madea B

    更新日期:2009-08-10 00:00:00

  • Y-chromosome STR haplotypes in the Canary Islands population (Spain).

    abstract::Haplotype frequencies of eight Y-chromosome STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393 and DYS385) were determined from a sample of 285 unrelated males from Canary Islands. ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2004.05.004

    authors: Zurita AI,Hernandez A,Sanchez JJ,Cuellas JA

    更新日期:2005-03-10 00:00:00

  • The identification of Linda Agostini. The significance of dental evidence in the Albury 'pyjama girl' case. A case report.

    abstract::The discovery in 1934 of the badly burned, pyjama clad body of a young woman protruding from a roadside culvert near Albury, N.S.W., led to one of the largest investigations in the history of Australian crime. Two simple errors, made by a local dentist with no previous experience in forensic odontology called by the p...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(82)90110-4

    authors: Brown KA

    更新日期:1982-07-01 00:00:00

  • Removing and identifying drug contamination in the analysis of human hair.

    abstract::The procedure used in this laboratory for removing and identifying contamination of hair specimens with drugs is demonstrated by its application to hair contaminated by various experimental models. The models include soaking; coating with drug followed by sweat conditions for 6 h; and soaking in a very high concentrat...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2004.04.024

    authors: Cairns T,Hill V,Schaffer M,Thistle W

    更新日期:2004-10-29 00:00:00

  • Raman spectroscopy and microspectrophotometry of reactive dyes on cotton fibres: analysis and detection limits.

    abstract::A collaborative study on Raman spectroscopy and microspectrophotometry (MSP) was carried out by members of the ENFSI (European Network of Forensic Science Institutes) European Fibres Group (EFG) on different dyed cotton fabrics. The detection limits of the two methods were tested on two cotton sets with a dye concentr...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.05.025

    authors: Massonnet G,Buzzini P,Monard F,Jochem G,Fido L,Bell S,Stauber M,Coyle T,Roux C,Hemmings J,Leijenhorst H,Van Zanten Z,Wiggins K,Smith C,Chabli S,Sauneuf T,Rosengarten A,Meile C,Ketterer S,Blumer A

    更新日期:2012-10-10 00:00:00

  • Dental age assessment using Demirjian's method on northern Turkish children.

    abstract::Tooth formation is widely used to assess maturity and to predict age. Within clinical dentistry, such information aids in diagnosis and treatment planning. Numerous methods exist that allow either the prediction of age or an assessment of maturation. One widely used method was first described in 1973 by Demirjian et a...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2007.04.228

    authors: Tunc ES,Koyuturk AE

    更新日期:2008-02-25 00:00:00

  • The effectiveness of strong afterglow phosphor powder in the detection of fingermarks.

    abstract::There are numerous types of fluorescent fingermark powders or reagents used with the visualization of latent fingermarks deposited on multicolored substrate surfaces that can present a contrast problem if developed with regular fingermark powders. The developed fingermarks can show bright fluorescence upon exposure to...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2008.10.008

    authors: Liu L,Zhang Z,Zhang L,Zhai Y

    更新日期:2009-01-10 00:00:00

  • Four novel alkyl 2-cyanoacylate monomers and their use in latent fingermark detection by mid-infrared spectral imaging.

    abstract::Four novel alkyl 2-cyanoacrylate monomers (alkyl=1-cyanoethyl, 2-cyanoethyl, trideuteromethyl and pentadeuteroethyl) have been tested for their ability to develop latent fingermarks that can then be visualized using mid-infrared spectral (chemical) imaging. Each of the four monomers was chosen for its potential to pro...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2010.10.012

    authors: Tahtouh M,Scott SA,Kalman JR,Reedy BJ

    更新日期:2011-04-15 00:00:00

  • Duration of detection of methamphetamine in hair after abstinence.

    abstract::Researchers in the field of hair analysis have known for at least two decades that test results for many chemical compounds remain positive for a considerable period of time after subjects have reported cessation of use. These findings were generally based on small sample populations or individual case studies. Within...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2015.06.030

    authors: Suwannachom N,Thananchai T,Junkuy A,O'Brien TE,Sribanditmongkol P

    更新日期:2015-09-01 00:00:00

  • 16 Y chromosomal STR haplotypes in Japanese.

    abstract::A total of 1079 Japanese males were typed for the following 16 Y chromosomal short tandem repeat (Y-STR) markers: DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385, DYS393, DYS391, DYS439, DYS635, DYS392, Y GATA H4, DYS437, DYS438 and DYS448 using an AmpFlSTR(R) Yfiler PCR Amplification kit (Applied Biosystems)...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2007.01.032

    authors: Mizuno N,Nakahara H,Sekiguchi K,Yoshida K,Nakano M,Kasai K

    更新日期:2008-01-15 00:00:00

  • Formation of phosphatidylethanol from endogenous phosphatidylcholines in animal tissues from pig, calf, and goat.

    abstract::In the presence of alcohol, phosphatidylcholine (PC) is transformed to the direct alcohol biomarker phosphatidylethanol (PEth). This reaction is catalyzed by the enzyme phospholipase D (PLD) and dependent on substrate availability. As recent methods have solely focused on the determination of PEth, information about t...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2017.12.030

    authors: Luginbühl M,Willem S,Schürch S,Weinmann W

    更新日期:2018-02-01 00:00:00

  • STR data for PowerPlex 16 System from Neuquen population, SW Argentina.

    abstract::Allele frequencies for the 15 autosomic STR loci included in the PowerPlex 16 System kit (Promega) were estimated from a sample of 111 unrelated individuals living in Neuquen province, southwest of Argentina. Population showed to be in HWE. ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(03)00126-9

    authors: Toscanini U,Berardi G,Raimondi E

    更新日期:2003-07-08 00:00:00

  • The effect of mark enhancement techniques on the subsequent detection of semen/spermatozoa.

    abstract::Fingermarks, footwear marks, blood and semen are amongst the most commonly encountered types of evidence at crime scenes. Previous work has extensively investigated fingermark and blood enhancement techniques and a sequence developed to maximise evidence recovery; however, there is limited research as to the effect of...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2014.08.027

    authors: Simmons R,Deacon P,Phillips DJ,Farrugia K

    更新日期:2014-11-01 00:00:00

  • A review of Anglo-American forensic professional codes of ethics with considerations for code design.

    abstract::Continuing instances of ethical misconduct and recent advances in the practice of forensic science, the latter reflected by increased growth and professionalism, along with heightening public scrutiny, require that the profession be clear, current, and forthright about its core values. A way of expressing these values...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审

    doi:10.1016/s0379-0738(01)00645-4

    authors: Mario JR

    更新日期:2002-02-18 00:00:00

  • Differentiation of red lipsticks using the attenuated total reflection technique supported by two chemometric methods.

    abstract::The main challenge for the identification and differentiation of lipsticks for forensic purposes is the fact that they have a similar chemical composition - in particular, samples of the same hue. The objective of the presented research was to solve this problem using a nondestructive analytical technique - attenuated...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2017.09.019

    authors: Gładysz M,Król M,Kościelniak P

    更新日期:2017-11-01 00:00:00

  • Different likelihood ratio approaches to evaluate the strength of evidence of MDMA tablet comparisons.

    abstract::Two likelihood ratio (LR) approaches are presented to evaluate the strength of evidence of MDMA tablet comparisons. The first one is based on a more 'traditional' comparison of MDMA tablets by using distance measures (e.g., Pearson correlation distance or a Euclidean distance). In this approach, LRs are calculated usi...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2009.06.006

    authors: Bolck A,Weyermann C,Dujourdy L,Esseiva P,van den Berg J

    更新日期:2009-10-30 00:00:00

  • Suicide identification during on-site inspection. Proposal and application of an interpretative method for death scene investigation.

    abstract::Death scene investigation (DSI) is critically important for the identification of the manner of death. The present study aims to present a scoring system for the correct framing of a case as a suicide starting from the DSI and its preliminary application. The method is based on five items: (1) statistical frequency of...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2019.01.029

    authors: Visentin S,Massaro L,Viel G,Cecchetto G,Montisci M

    更新日期:2019-04-01 00:00:00

  • Postmortem changes in blood tranylcypromine concentration: competing redistribution and degradation effects.

    abstract::Site and temporal changes in tranylcypromine (TCP) and lithium concentrations in blood were studied in a human poisoning case. Blood samples from peripheral vessels and six central vessels were obtained at 0, 6, 24, 48 and 72 h after starting the autopsy. Nine tissue samples were obtained on completion. TCP showed pre...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(93)90157-6

    authors: Yonemitsu K,Pounder DJ

    更新日期:1993-05-01 00:00:00

  • The study on facial soft tissue thickness using Han population in Xinjiang.

    abstract::Facial profile is an important aspect in physical anthropology, forensic science, and cosmetic research. Thus, facial soft tissue measurement technology plays a significant role in facial restoration. A considerable amount of work has investigated facial soft tissue thickness, which significantly varies according to g...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.04.032

    authors: Wang J,Zhao X,Mi C,Raza I

    更新日期:2016-09-01 00:00:00

  • Air bag injuries--a literature review in consideration of demands in forensic autopsies.

    abstract::Air bags have been implicated in saving lives and reducing morbidity associated with motor vehicle crashes since their introduction in the mid-1970s. However, there is increasing evidence showing that air bags can be a source of injury and even death in certain circumstances. As the number of air bag-equipped vehicles...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审

    doi:10.1016/s0379-0738(02)00197-4

    authors: Sato Y,Ohshima T,Kondo T

    更新日期:2002-08-28 00:00:00

  • Determination of pesticides in postmortem blood and bone marrow of pesticide treated rabbits.

    abstract::Forensic toxicological analyses have traditionally focused on the use of blood, body fluids, and certain organs in examinations of deaths due to intoxication. However, in some situations, putrefaction and contamination make proper sampling from tissues impossible, such as in exhumation cases. In these cases, bone marr...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2009.04.017

    authors: Akcan R,Hilal A,Daglioglu N,Cekin N,Gulmen MK

    更新日期:2009-08-10 00:00:00

  • Testing for kinship in a subdivided population.

    abstract::The effect of population subdivision on the determination of kinship of any two persons is investigated in this paper. Expressions of the joint genotype probabilities and likelihood ratios on kinship testing are reported. Two real cases are analysed using the Hong Kong Chinese population data and the Spanish data. Var...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(03)00168-3

    authors: Fung WK,Carracedo A,Hu YQ

    更新日期:2003-08-12 00:00:00

  • Death attributed to the toxic interaction of triazolam, amitriptyline and other psychotropic drugs.

    abstract::A 71-year-old man was found dead in a car into which exhaust fumes had been introduced. His wife who was in the same car recovered consciousness following hospitalization. She claimed that they had both attempted suicide by taking a large number of sleeping pills. Autopsy revealed no significant external injuries or m...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(97)02110-5

    authors: Kudo K,Imamura T,Jitsufuchi N,Zhang XX,Tokunaga H,Nagata T

    更新日期:1997-04-18 00:00:00

  • Suicide through doxylamine poisoning.

    abstract::Doxylamine is an antihistamine of the ethanolamine class. It is used primarily as a sleep-inducing agent. Only a few reports can be found in the literature about lethal intoxications with doxylamine, but many with combined intoxications. Doxylamine is, aside from diphenhydramine, the only chemically defined active ing...

    journal_title:Forensic science international

    pub_type: 杂志文章,评审

    doi:10.1016/s0379-0738(00)00393-5

    authors: Bockholdt B,Klug E,Schneider V

    更新日期:2001-06-01 00:00:00

  • Complex investigation of body and clothing injuries during the identification of the assault instrument.

    abstract::The value of complex analyses of body injuries and clothing has been proven by practice. The purpose of presented study is to discuss what additional information can be obtained during investigations of clothes in the area of injury. A case study, in which results of visual and stereomicroscopic morphological analysis...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2004.09.023

    authors: Sitiene R,Varnaite J,Zakaras A

    更新日期:2004-12-02 00:00:00

  • Genital and anal injuries: A cross-sectional Australian study of 1266 women alleging recent sexual assault.

    abstract:OBJECTIVES:To describe the frequency of genital and anal injury and associated demographic and assault characteristics in women alleging sexual assault. DESIGN:Cross-sectional study. SETTING:Sexual Assault Resource Centre (SARC), Western Australia. PARTICIPANTS:Total of 1266 women attending SARC from Jan-2009 to Mar...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2017.03.013

    authors: Zilkens RR,Smith DA,Phillips MA,Mukhtar SA,Semmens JB,Kelly MC

    更新日期:2017-06-01 00:00:00

  • A robust and non-invertible fingerprint template for fingerprint matching system.

    abstract::Fingerprint Recognition System is widely deployed in variety of application domain, ranging from forensic to mobile phones. Its widespread deployment in various applications were person authentication are required, has caused concern that a leaked fingerprint template may be used to reconstruct the original fingerprin...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2018.04.045

    authors: Trivedi AK,Thounaojam DM,Pal S

    更新日期:2018-07-01 00:00:00

  • Experimental studies on postmortem diffusion of ethanol-d6 using rats.

    abstract::In an investigation of postmortem ethanol diffusion deuterium-labeled ethanol-d6 was instilled by peroral gavage immediately after death by CO into the stomach of rat carcasses which were subsequently kept for 12-72 h at 5 or 30 degrees C. The heart blood, abdominal fluid and several tissues were collected and analyze...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(95)01820-4

    authors: Takayasu T,Ohshima T,Tanaka N,Maeda H,Kondo T,Nishigami J,Ohtsuji M,Nagano T

    更新日期:1995-12-29 00:00:00