Abstract：
:Site and temporal changes in tranylcypromine (TCP) and lithium concentrations in blood were studied in a human poisoning case. Blood samples from peripheral vessels and six central vessels were obtained at 0, 6, 24, 48 and 72 h after starting the autopsy. Nine tissue samples were obtained on completion. TCP showed preferential concentration in liver (2.21 micrograms/g) and brainstem (2.46 micrograms/g). There was a moderate post mortem redistribution phenomenon with TCP concentrations lowest in peripheral blood (0.17 micrograms/ml) at 0 h and highest in central vessels at 24 h (0.52 micrograms/ml). At 72 h blood TCP concentrations fell below those at 0 time but the samples showed marked putrefactive changes. Control blood samples spiked with TCP and incubated for 48 h at 37 degrees C showed a 58% fall in drug concentration. By contrast with TCP, lithium, which has a small Vd (0.8 l/kg) and is chemically stable, did not show this pattern of change in blood concentration. The site and temporal differences in TCP concentration in blood can be explained by the competing effects of post mortem redistribution and drug degradation. Redistribution is an early post mortem phenomenon characterised by diffusion, along a concentration gradient, from drug reservoirs in solid organs into adjacent blood vessels. Drug degradation is a later phenomenon associated with putrefactive change.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Yonemitsu K,Pounder DJdoi
10.1016/0379-0738(93)90157-6subject
Has Abstractpub_date
1993-05-01 00:00:00pages
177-84issue
2eissn
0379-0738issn
1872-6283pii
0379-0738(93)90157-6journal_volume
59pub_type
杂志文章abstract：:Since it is established that human chorionic gonadotropin (hCG) affects testosterone production and release in the human body, the use of this hormone as a performance enhancing drug has been prohibited by the World Anti-Doping Agency. Nowadays, the only validated biomarker of a hCG doping is its direct quantification...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.07.002
更新日期：2011-12-10 00:00:00
abstract：:Laser-induced breakdown spectroscopy (LIBS), X-ray fluorescence spectroscopy (XRF) and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) are compared in terms of their discrimination power when applied to Australian soil specimens. SEM/EDX and XRF are frequently used in forensic laboratories ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.10.018
更新日期：2014-12-01 00:00:00
abstract：:Our study provides population genetic data on two population samples collected in a Hungarian speaking region of Transylvania, Romania. Allele frequency and profile databases were generated on 17 autosomal STR loci (D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, VWA, FGA, TH01, T...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.10.020
更新日期：2006-12-20 00:00:00
abstract：:The extent of aspartic acid racemization in human dentin can be used to assess chronological age of the individual. This novel chemical method of aging human remains has potential applications in forensic sciences. Six autopsy cases have been analyzed for D/L aspartic acid contents, and their ages at death calculated....
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(86)90080-0
更新日期：1986-11-01 00:00:00
abstract：:Single metal deposition (SMD II) is a fingermark detection technique based on the use of colloidal gold. The technique has been simplified and optimised over the years to become more reliable, sensitive and user-friendly. Physical developer (PD) is a well-established detection method based on silver deposition from a ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2018.10.032
更新日期：2019-01-01 00:00:00
abstract：:5F-MDMB-PICA has been detected in products sold on the internet as well as in biological samples since 2016. It is associated with serious adverse health and behavioral effects and even death. Herein we report on twelve cases with proven 5F-MDMB-PICA consumption, including three fatalities, four cases of driving under...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110410
更新日期：2020-09-01 00:00:00
abstract：:Numerous studies have mentioned to the high percentage of violent deaths in prison psychiatric hospitals, with suicide being the principal cause. The aim of this study was to analyze the circumstances related with the deaths recorded in a high security institution. Postmortem reports on all the deaths at the Alicante ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00441-2
更新日期：2001-07-15 00:00:00
abstract：:The forensic toxicology community has recognized flunitrazepam and its metabolite (7-aminoflunitrazepam) as compounds of concern for several years. In this procedure, the analytes were extracted from whole blood and urine onto single mode solid phase cartridges (butyl) using nitrazepam as an internal standard. The col...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.03.019
更新日期：2006-03-10 00:00:00
abstract：:The present report describes the unexpected death of a 6-month-old female infant who had been clinically diagnosed with Joubert syndrome. This is a relatively rare congenital neurological disorder characterized by hypoplasia/aplasia of cerebellar vermis, which transmits information from the body to the cerebellum, and...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2008.06.003
更新日期：2008-08-06 00:00:00
abstract：:Hair analysis has been presented by some authors as a possible tool of investigation for estimating patients' compliance to long-term therapies. This paper summarises the different publications that have been devoted to this topic and highlights the available statistically data presented to support this proposition. Q...
journal_title：Forensic science international
pub_type： 杂志文章,meta分析
doi：10.1016/0379-0738(94)01626-g
更新日期：1995-01-05 00:00:00
abstract：:Allele and haplotype frequencies of 16 chromosome STR loci, 15 of them included in the Kit PowerPlex16 System from Promega were determined in a sample of unrelated males from the Açores Archipelago. All subjects were subjected to an interview in order to make sure that their ancestors belonged to the same island at le...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(02)00203-7
更新日期：2002-09-10 00:00:00
abstract：:Facial profile is an important aspect in physical anthropology, forensic science, and cosmetic research. Thus, facial soft tissue measurement technology plays a significant role in facial restoration. A considerable amount of work has investigated facial soft tissue thickness, which significantly varies according to g...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2016.04.032
更新日期：2016-09-01 00:00:00
abstract：:The systematic exhumation of mass graves is becoming a frequent occurrence globally. Historically, it has been mostly anthropologists with their particular expertise in osteology that have been engaged by non-governmental organizations (NGO) to monitor mass grave exhumations and postmortem examinations, conducted by a...
journal_title：Forensic science international
pub_type： 指南,杂志文章
doi：10.1016/s0379-0738(03)00124-5
更新日期：2003-07-08 00:00:00
abstract：:Reported are various techniques to determine the early postmortem period by examining the eye. These include corneal opacity, retinal vessel segmentation, pupil reaction, retinal changes and intraocular pressure. All are subjective, requiring experience to implement the techniques. ...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/0379-0738(94)90230-5
更新日期：1994-02-01 00:00:00
abstract：:The alarming increase of drug mortality rates in Germany was followed by research projects to enlighten the causes of this increase. The results of the Bremen, Hamburg and Berlin studies 1991-92, led to the conclusion that specific risk constellations have to be considered in the process of improving the drug counsell...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90053-d
更新日期：1993-11-01 00:00:00
abstract：:The spectrophotometric method for the determination of carboxyhemoglobin (HbCO) in blood reported by Fretwurst and Meinecke was modified so as to give the same values of percentage HbCO (HbCO%) as those determined by the oxygen electrode method. Values of HbCO% of nine practical samples determined by both the oxygen e...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(81)90157-2
更新日期：1981-09-01 00:00:00
abstract：:Conservation of the three-dimensional aspect of bitemarks optimizes their analysis. Although bitemarks could be recorded with a surface scanner, in clinical dentistry, intraoral scanners are used as an alternative to conventional dental impressions. Here we assess the reproducibility and the reliability of a three-dim...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110198
更新日期：2020-04-01 00:00:00
abstract：:The detection and identification of volatile compounds is essential to the successful undertaking of numerous forensic analyses. Biological olfactory systems possess the extraordinary ability to not only detect many thousands of distinct volatile compounds (odors) but also to discriminate between them. Whole-organism ...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2013.07.004
更新日期：2013-10-10 00:00:00
abstract：:Almost 6 million people died in Poland during the Nazi occupation and about 570 thousand during the Soviet occupation. But the end of the war was not the end of the trauma. Historians estimate that at least 30 thousand people were killed during the Stalinist regime in Poland. In 2012 the Institute of National Remembra...
journal_title：Forensic science international
pub_type： 历史文章,杂志文章
doi：10.1016/j.forsciint.2017.06.038
更新日期：2017-09-01 00:00:00
abstract：:This study was undertaken for the purpose of analysing under the aspect of legal medicine, fatal accidents due to train surfing in the local transport system of Berlin (S-Bahn and underground). The period of investigation was from 1989 through 1995, with 41 train surfing accidents, among them 18 with fatal outcome. Ev...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(98)00064-4
更新日期：1998-06-08 00:00:00
abstract：:Recovery, identification, and burial of casualties from World War I and II is still a topic of interest in many countries. In Slovakia, recent discoveries of such remains are usually accidental. Unfortunately, in many cases the remains are disrupted and without any material culture present, rendering the identificatio...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110673
更新日期：2021-02-01 00:00:00
abstract：:When someone breaks glass a number of tiny fragments may be transferred to that person. If the glass is broken in the commission of a crime then these fragments may be used as evidence. A Bayesian interpretation of this evidence relies on, among other things, the forensic scientist's ability to assess the likelihood t...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(97)00194-1
更新日期：1998-02-16 00:00:00
abstract：AIMS:The aim of this work is to test the stability of mephedrone added to whole blood collected from alive and dead mephedrone free-users and stored at three different temperatures (-20, +4 and +20°C) with and without preservatives up to 6 months, trying to establish the best storage condition in order to reduce possib...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.07.021
更新日期：2015-11-01 00:00:00
abstract：:A urine screening in fatalities with an unnatural or unknown cause of death (13-40 years of age) was carried out to evaluate the proportion of undetected drug-related cases. Ten out of 160 fatalities without a hint of drug consumption were classified as drug-related according to the definition of the Bundeskriminalamt...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90062-f
更新日期：1993-11-01 00:00:00
abstract：:This chapter employs the fracture assessment triad, a systematic analytical approach, as a vehicle to explore the components used to interpret gunshot trauma to the cranium. First, a list of pertinent observations associated with gunshot trauma to the cranium is presented with a brief description of each. These featur...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.05.019
更新日期：2019-08-01 00:00:00
abstract：:The mass spectrum of the drug of abuse 2,5-dimethoxyamphetamine (2,5-DMA) is characterized by an imine fragment base peak at m/z 44 and additional fragments at m/z 151/152 for the dimethoxybenzyl cation and radical cation, respectively. Five positional ring isomers of dimethoxyamphetamines (DMA) have an isomeric relat...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2009.08.010
更新日期：2009-11-20 00:00:00
abstract：:Tooth wear is frequently used as a method of ageing skeletal remains. Fundamental to this method is the ability to measure the amount of tooth wear. The Brothwell chart based on the Miles method of ageing, uses simple ordinal scoring and is frequently used by archeologists. The purpose of the present investigation was...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90110-k
更新日期：1990-12-01 00:00:00
abstract：:Fibronectin, collagen type III, laminin, and cytokeratin 5 were visualized in normal skin and in skin showing early or advanced signs of autolytic decomposition to prove whether the immunohistochemical analysis of these antigens can provide useful information for an age-estimation of skin wounds obtained from putrifie...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(93)90247-8
更新日期：1993-09-01 00:00:00
abstract：:Two amphetamine-like piperazine-containing compounds, 1-(3,4-methylenedioxyphenyl)-2-piperazinopropane (3,4-MDPPP), its positional isomer 1-(2,3-methylenedioxyphenyl)-2-piperazinopropane (2,3-MDPPP) and three methcathinone-like piperazine-containing regioisomeric ring substituted 1-(methoxyphenyl)-2-piperazinopropanon...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.11.015
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Post-mortem Computed Tomography (PMCT) allows non-invasive or minimally invasive detection of findings that may or may not be visible during conventional autopsy, however, it does not allow the investigator to draw any conclusions regarding patency of the vessel's lumen. To address this deficiency, Post-mort...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110171
更新日期：2020-03-01 00:00:00
