Abstract:
:Since it is established that human chorionic gonadotropin (hCG) affects testosterone production and release in the human body, the use of this hormone as a performance enhancing drug has been prohibited by the World Anti-Doping Agency. Nowadays, the only validated biomarker of a hCG doping is its direct quantification in urine. However, this specific parameter is subjected to large inter-individual variability and its determination is directly dependent on the reliability of hCG immunoassays used. In order to counteract these weaknesses, new biomarkers need to be evidenced. To address this issue, a pilot clinical study was performed on 10 volunteers submitted to 3 subsequent hCG injections. Blood and urine samples were collected during two weeks in order to follow the physiological effects on related compounds such as the steroid profile or hormones involved in the hypothalamo-pituitary axis. The hCG pharmacokinetic observed in all subjects was, as expected, prone to important inter-individual variations. Using ROC plots, level of testosterone and testosterone on luteinizing hormone ratio in both blood and urine were found to be the most relevant biomarker of a hCG abuse, regardless of inter-individual variations. In conclusion, this study showed the crucial importance of reliable quantification methods to assess low differences in hormonal patterns. In regard to these results and to anti-doping requirements and constraints, blood together with urine matrix should be included in the anti-doping testing program. Together with a longitudinal follow-up approach it could constitute a new strategy to detect a hCG abuse, applicable to further forms of steroid or other forbidden drug manipulation.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Strahm E,Marques-Vidal P,Pralong F,Dvorak J,Saugy M,Baume Ndoi
10.1016/j.forsciint.2011.07.002subject
Has Abstractpub_date
2011-12-10 00:00:00pages
62-72issue
1-3eissn
0379-0738issn
1872-6283pii
S0379-0738(11)00317-3journal_volume
213pub_type
杂志文章abstract::Changes related to chronological age are seen in both hard and soft tissue. A number of methods for age estimation have been proposed which can be classified in four categories, namely, clinical, radiological, histological and chemical analysis. In forensic odontology, age estimation based on tooth development is univ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2013.09.020
更新日期:2014-01-01 00:00:00
abstract::Forensic pathologists are familiar with alcohol abusers, who are found dead and in whom the cause of death cannot be ascertained. In order to examine the possible role of ketoacidosis for the cause of death in this group of alcohol abusers, the concentrations of ketone bodies (acetone, acetoacetate, D-beta-hydroxybuty...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(95)01783-6
更新日期:1995-10-30 00:00:00
abstract::Making the correct decision based on results from DNA analyses and other information in family reunification cases can be complicated for a number of reasons. These include stratified populations, cultural differences in family constellations, families with different population origin, and complicated family relations...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2006.12.015
更新日期:2007-10-25 00:00:00
abstract::Clothing damage analysis is an integral part of the examinations carried out in sexual assault type cases. This analysis can be used to corroborate different versions of events and is at its most powerful in elucidating false allegation cases and consent cases. The purpose of this study was to determine to what extent...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2006.06.038
更新日期:2007-04-11 00:00:00
abstract::Preliminary results concerning the use of liquid crystals (LC) in fingerprinting are given. These were based on thin layers of liquid crystals, changing colours (observed in linear polarized light) due to dissolved organic matter, transferred from fingers' surfaces. The possibility is shown of using LC to illustrate n...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(91)90137-8
更新日期:1991-07-01 00:00:00
abstract::Numerous studies have mentioned to the high percentage of violent deaths in prison psychiatric hospitals, with suicide being the principal cause. The aim of this study was to analyze the circumstances related with the deaths recorded in a high security institution. Postmortem reports on all the deaths at the Alicante ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(00)00441-2
更新日期:2001-07-15 00:00:00
abstract::To estimate age using DNA based on telomere shortening, we determined the terminal restriction fragment (TRF) length, as telomere length, using Southern blot analysis of peripheral human blood and blood stains. All blood stains had been stored at room temperature for 5 months. The average TRF length clearly showed a t...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(02)00086-5
更新日期:2002-05-23 00:00:00
abstract::Forensic assessment of skeletal material includes age estimation of unknown individuals. When dealing with extremely fragmented human remains that lack macro-features used in age estimation, histological assessment of the skeletal elements can be employed. Historically, microscopic methods for age assessment used by f...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2020.110335
更新日期:2020-08-01 00:00:00
abstract::The allelic distribution of 15 short tandem repeat (STR) loci included in the AmpFl STR Identifiler kit was examined in 100 Changdu Tibetan and 118 Naqu Tibetan unrelated individuals living in the Tibet Province, PR China. The distribution of these observed genotypes was not significantly different from the expected d...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2006.03.012
更新日期:2007-07-04 00:00:00
abstract:UNLABELLED:It is frequently difficult to prove the vitality in cases of fatal hanging. Using impulse cytophotometry, Müller et al. (Krim. Forens. Wiss. 44, 1981) reported on possibly vital alterations of the DNA content in five strangulation marks (hypodiploidy). The objective of the present study was to perform a re-e...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(97)00069-8
更新日期:1997-09-19 00:00:00
abstract::Chemical evaluation of gunshot residues (GSR) produced by non-toxic lead-free ammunition (NTA) has been a challenge to forensic analyses. Our group developed some luminescent markers specific to the detection of GSR. Here, we evaluated the performance of selected markers in experiments that mimic forensic context and/...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2014.09.001
更新日期:2014-11-01 00:00:00
abstract::The presence of Ethyl glucuronide (EtG) in hair provides a strong indication of ethanol consumption and its investigation is of interest in both clinical and forensic contexts because of the wide window of detection. However, due to the possibility of false negative results in cases of small ethanol intake or excessiv...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2019.110071
更新日期:2020-01-01 00:00:00
abstract::In Japan, recent trends have seen wild silk preferred over cultivated silk because of its texture. Some cases of fraud have occurred where cultivated silk garments are sold as wild silk. Samples from these cases, morphological observation using light microscope and polarized microscope have been conducted in forensic ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2013.05.004
更新日期:2013-09-10 00:00:00
abstract::In developed countries, sudden infant death syndrome (SIDS) represents the most prevalent cause of death in children between 1 month and 1 year of age. SIDS is a diagnosis of exclusion, a negative autopsy which requires the absence of structural organ disease. Although investigators have confirmed that a significant p...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2012.01.018
更新日期:2012-06-10 00:00:00
abstract::Continuing instances of ethical misconduct and recent advances in the practice of forensic science, the latter reflected by increased growth and professionalism, along with heightening public scrutiny, require that the profession be clear, current, and forthright about its core values. A way of expressing these values...
journal_title:Forensic science international
pub_type: 杂志文章,评审
doi:10.1016/s0379-0738(01)00645-4
更新日期:2002-02-18 00:00:00
abstract::In this paper, a high performance liquid chromatographic method with fluorescence detection (HPLC-FL) for the determination of fenfluramine (Fen) and norfenfluramine (Norf) in human hair as biomarker metabolites of N-nitrosofenfluramine (N-Fen) is described. Washed and cut hair segments were extracted by ultrasonicati...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2004.03.018
更新日期:2004-11-10 00:00:00
abstract::False positives due to the presence of antimony in vehicle seat fabrics are a problem in gunshot residue (GSR) analysis, in particular, when graphite furnace atomic absorption spectrometry (GFAAS) is employed. In this study, we sought to determine the reason for the prevalence of false positive results and to propose ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2015.03.006
更新日期:2015-05-01 00:00:00
abstract::In a differential study to distinguish bruises from putrefactive discoloration, glycophorin A, a component of the erythrocyte membrane, was extracted from discolored skins and detected by immunological methods utilizing an anti-glycophorin A serum. Skin samples of 18 bruises, 8 postmortem hypostasises and 7 putrefacti...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(93)90219-z
更新日期:1993-10-01 00:00:00
abstract::Sixty nine participants in the United Kingdom national external quality assessment scheme for drugs of abuse in urine reported details of their sample extraction technique by questionnaire. Laboratories were categorised by differences in technique and their analytical test results compared for samples containing D-amf...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(00)00383-2
更新日期:2001-06-01 00:00:00
abstract::The effect of population subdivision on the determination of kinship of any two persons is investigated in this paper. Expressions of the joint genotype probabilities and likelihood ratios on kinship testing are reported. Two real cases are analysed using the Hong Kong Chinese population data and the Spanish data. Var...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(03)00168-3
更新日期:2003-08-12 00:00:00
abstract::This method for the determination of haloperidol (HAL) in plasma is based on high-performance liquid chromatography (HPLC) with a reversed-phase column, ODS-C18. HAL is rapidly extracted from human plasma by using Bond Elut C18 cartridge and its recovery is over 90%. The mobile phase is a mixture of 1% acetate/acetoni...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(87)90025-9
更新日期:1987-09-01 00:00:00
abstract::A revised technique is described in which the sino-atrial node, the atrio-ventricular node and the distal part of the His bundle and the bundle brances of the cardiac conduction system are demonstrated in longitudinal sections through cutting of 4-5 blocks. The longitudinal sectioning allows observation of continuity ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(97)00047-9
更新日期:1997-04-18 00:00:00
abstract::This study explores the applicability of micro-Raman spectroscopy as a non-destructive technique for the analysis of color toner printed counterfeits. The main aim of the research paper was to find out whether Raman spectroscopy is a suitable method for establishing the connection between different specimens of counte...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2012.10.007
更新日期:2012-11-30 00:00:00
abstract::The purpose of this study was to evaluate the influence of the secular trend on development of third molars in 30 years period in Littoral region of Croatia. A total of 1103 panoramic radiographs of subjects aged from 6 to 18 years were analysed. First group comprised 531 panoramic radiographs (258 girls) taken from y...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2015.02.002
更新日期:2015-04-01 00:00:00
abstract::This study investigated the effect of seasonal variables on decomposition in the early post-mortem period using 26 donated human cadavers at the University of Tennessee's Anthropology Research Facility (ARF), USA. The rate and pattern of decomposition in human cadavers (as measured by TBS and the revised TBSsurf metho...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2020.110419
更新日期:2020-10-01 00:00:00
abstract::Allele frequencies for the 15 autosomic STR loci included in the PowerPlex 16 System kit (Promega) were estimated from a sample of 111 unrelated individuals living in Neuquen province, southwest of Argentina. Population showed to be in HWE. ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(03)00126-9
更新日期:2003-07-08 00:00:00
abstract::The discovery in 1934 of the badly burned, pyjama clad body of a young woman protruding from a roadside culvert near Albury, N.S.W., led to one of the largest investigations in the history of Australian crime. Two simple errors, made by a local dentist with no previous experience in forensic odontology called by the p...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/0379-0738(82)90110-4
更新日期:1982-07-01 00:00:00
abstract::Gunshot wounds in suicide cases are self-inflicted wounds. Self-inflicted wounds in suicide cases are usually caused by contact firing and are of great forensic significance. Evaluation of contact wound may be associated with difficulties if the bore gets obstruction prior to firing. This paper investigates the phenom...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/s0379-0738(03)00005-7
更新日期:2003-05-05 00:00:00
abstract::A cadaver and dead plant organic matter, or litter, are rich energy sources that undergo a complex decomposition process, which impact the surrounding environmental microbiota. Advances in molecular microbiology techniques, with study of the 16S RNA genes, in particular, have highlighted the application of forensic ec...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2017.04.024
更新日期:2017-07-01 00:00:00
abstract::Following the introduction of limit values for blood alcohol and breath alcohol concentrations of 0.5 g/kg and 0.25 mg/L, respectively, as provided under s. 24 a of the German Road Traffic Act the question is whether also breath alcohol concentrations can be back calculated to the time of the traffic offence in cases ...
journal_title:Forensic science international
pub_type: 杂志文章
doi:10.1016/j.forsciint.2004.03.023
更新日期:2004-07-16 00:00:00