Intergeneric communication in dental plaque biofilms.

Abstract:

:Dental plaque is a complex biofilm that accretes in a series of discrete steps proceeding from a gram-positive streptococcus-rich biofilm to a structure rich in gram-negative anaerobes. This study investigated information flow between two unrelated plaque bacteria, Streptococcus cristatus and Porphyromonas gingivalis. A surface protein of S. cristatus caused repression of the P. gingivalis fimbrial gene (fimA), as determined by a chromosomal fimA promoter-lacZ reporter construct and by reverse transcription-PCR. Signaling activity was associated with a 59-kDa surface protein of S. cristatus and showed specificity for the fimA gene. Furthermore, P. gingivalis was unable to form biofilm microcolonies with S. cristatus. Thus, S. cristatus is capable of modulating virulence gene expression in P. gingivalis, consequently influencing the development of pathogenic plaque.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Xie H,Cook GS,Costerton JW,Bruce G,Rose TM,Lamont RJ

doi

10.1128/jb.182.24.7067-7069.2000

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

7067-9

issue

24

eissn

0021-9193

issn

1098-5530

journal_volume

182

pub_type

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