[Treatment of hepatitis B virus-associated membranous glomerulonephritis with interferon alfa in a 7 year old boy].

Abstract:

BACKGROUND:The association between Hepatitis B virus infection and membranous nephropathy has been confirmed by sources in several countries. Most commonly, the illness is seen as a nephrotic syndrome. Optimal treatment remains undefined. Antiviral therapies observed with recombinant human interferon alpha may be the best treatment option. CASE REPORT:We present a 7-year old boy with membranous glomerulonephritis and nephrotic syndrome. Twelve months after the initial hospitalization therapy was started with recombinant alpha-interferon s.c. three times weekly for six months. After the therapy the patient is stable, without proteinuria, edema or renal failure. He was seronegative for HBsAg, HBV-DNA and antibody to HBeAg. CONCLUSIONS:This case report suggests that alpha interferon is effective in the complete resolution of proteinuria in HBV membranous nephropathy.

journal_name

Klin Padiatr

journal_title

Klinische Padiatrie

authors

Steiss JO,Piske-Keyser K,Gröne HJ,Gortner L

doi

10.1055/s-2000-9689

keywords:

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

283-6

issue

5

eissn

0300-8630

issn

1439-3824

journal_volume

212

pub_type

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