Density and pharmacology of alpha5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients.

abstract：:Working memory for order information is mediated by different cognitive mechanisms that rely on different neural circuits. Here we discuss evidence that order memory involves mechanisms that range from general supervisory processes to process that maintenance fine-grained temporal position information. We suggest that...

journal_title：Neuroscience

authors： Marshuetz C,Smith EE

更新日期：2006-04-28 00:00:00

abstract：:The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallid...

journal_title：Neuroscience

authors： Turgeon SM,Albin RL

更新日期：1994-09-01 00:00:00

abstract：:Alterations in the phosphorylation state of the microtubule-associated protein tau have been associated with the pathogenesis of neurofibrillary degeneration as well as with a neuroprotective action against apoptotic cell death. Mitogen-activated protein kinases (MAPK) phosphorylate tau protein in vitro but the pathop...

journal_title：Neuroscience

authors： Holzer M,Gärtner U,Klinz FJ,Narz F,Heumann R,Arendt T

更新日期：2001-01-01 00:00:00

abstract：:Recent studies investigating neural correlates of human thirst have identified various subcortical and telencephalic brain areas. The experience of thirst represents a homeostatic emotion and a state that slowly evolves over time. Therefore, the present study aims at systematically examining cerebral perfusion during ...

journal_title：Neuroscience

authors： Meier L,Federspiel A,Jann K,Wiest R,Strik W,Dierks T

更新日期：2018-07-15 00:00:00

abstract：:Lesioning of thalamic target neurons in the adult rat provokes a resorption of terminal axonal branches of afferent neurons from the dorsal column nuclei. There is, however, no massive neuronal loss in the dorsal column nuclei. In the adult, therefore, the thalamic post synaptic target cells influence primarily the ex...

journal_title：Neuroscience

authors： Marty S,Peschanski M

更新日期：1994-10-01 00:00:00

abstract：:A transient aberrant projection from the retina to the contralateral inferior colliculus was demonstrated in pigmented rats in both whole-brains and sections following intra-ocular injection of horseradish peroxidase. The projection was prominent on the day of birth but reached its maximum density and extent after inj...

journal_title：Neuroscience

authors： Cooper AM,Cowey A

更新日期：1990-01-01 00:00:00

abstract：:We sought to determine the impact of 17beta-estradiol throughout the hippocampal trisynaptic pathway and to investigate the afferent fiber systems within CA1 and CA3 in detail. To achieve this objective, we utilized multielectrode arrays to simultaneously record the field excitatory postsynaptic potentials from the CA...

journal_title：Neuroscience

authors： Kim MT,Soussou W,Gholmieh G,Ahuja A,Tanguay A,Berger TW,Brinton RD

更新日期：2006-08-11 00:00:00

abstract：:The effect of transitory blockage of substantia nigra pars compacta glutamatergic inputs by intracranial injections of kynurenic acid were evaluated in two monkey treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The MPTP protocol was designed to mimic the gradual evolution of human Parkinson's disease...

journal_title：Neuroscience

authors： Bezard E,Boraud T,Bioulac B,Gross CE

更新日期：1997-11-01 00:00:00

abstract：:Rats were subjected to 90min of focal ischemia by occluding the left middle cerebral and both common carotid arteries. The dynamic changes in the formation of brain ischemic areas were analyzed by measuring the direct current (DC) potential and reduced nicotinamide adenine dinucleotide (NADH) fluorescence with ultravi...

journal_title：Neuroscience

authors： Naito H,Takeda Y,Danura T,Kass IS,Morita K

更新日期：2013-04-03 00:00:00

abstract：:A satisfactory management to ensure a full restoration of peripheral nerve after trauma is not yet available. Using an experimental protocol, in which crush injury was applied 1 cm above the bifurcation of the rat sciatic nerve for 20 s, we here demonstrate that the levels of neuroactive steroids, such as pregnenolone...

journal_title：Neuroscience

authors： Roglio I,Bianchi R,Gotti S,Scurati S,Giatti S,Pesaresi M,Caruso D,Panzica GC,Melcangi RC

更新日期：2008-08-26 00:00:00

abstract：:Inflammation and hyperalgesia induce a dramatic up-regulation of opioid messenger RNA and peptide levels in nociceptive neurons of the spinal dorsal horn. Descending axons modulate nociceptive transmission at the spinal level during inflammatory pain, and may play a role in the development of persistent pain. The role...

journal_title：Neuroscience

authors： MacArthur L,Ren K,Pfaffenroth E,Franklin E,Ruda MA

更新日期：1999-01-01 00:00:00

abstract：:In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses...

journal_title：Neuroscience

authors： Surmeier DJ,Carrillo-Reid L,Bargas J

更新日期：2011-12-15 00:00:00

abstract：:Rats exposed to repeated unavoidable stress show decreased dopamine output in the nucleus accumbens shell (NAcS) and do not acquire vanilla sugar (VS)-sustained appetitive behavior (VAB). Rats treated with lithium for 3 weeks also show decreased NAcS dopamine output, yet they acquire VAB. Feeding a novel palatable foo...

journal_title：Neuroscience

authors： Gambarana C,Masi F,Leggio B,Grappi S,Nanni G,Scheggi S,De Montis MG,Tagliamonte A

更新日期：2003-01-01 00:00:00

abstract：:Motor effects of bilateral lesions of the globus pallidus induced by quinolinic acid (30 and 60 nmol in 0.5 microl) were investigated in rats. Globus pallidus lesions with 60 nmol quinolinic acid produced a significant reduction of spontaneous motor activity measured by a reduced locomotor activity in an open field an...

journal_title：Neuroscience

authors： Hauber W,Lutz S,Münkle M

更新日期：1998-09-01 00:00:00

abstract：:Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these injuries, clinicians rely solely on surgery and rehabilitation to tr...

journal_title：Neuroscience

authors： Kemp SWP,Szynkaruk M,Stanoulis KN,Wood MD,Liu EH,Willand MP,Morlock L,Naidoo J,Williams NS,Ready JM,Mangano TJ,Beggs S,Salter MW,Gordon T,Pieper AA,Borschel GH

更新日期：2015-01-22 00:00:00

abstract：:The application of subsensory noise stimulation over the lower limbs has been shown to improve proprioception and postural control under certain conditions. Whereas the effect specificity seems to depend on several factors, studies are still needed to determine the appropriate method for training and rehabilitation pu...

journal_title：Neuroscience

authors： Toledo DR,Barela JA,Kohn AF

更新日期：2017-09-01 00:00:00

abstract：:In the adult CNS, GABA is the predominant inhibitory neurotransmitter, mediating the hyperpolarization of membrane potential and regulating the glutamatergic activity. In the immature CNS, on the other hand, GABA mediates depolarization and is involved in controlling morphogenesis. This developmental shift in GABA act...

journal_title：Neuroscience

authors： Takayama C,Inoue Y

更新日期：2006-12-01 00:00:00

abstract：:Opioid binding sites were localized in cryostat sections of guinea-pig brain by in vitro autoradiography using (-)-[3H]bremazocine. Quantification of binding sites in gray matter was accomplished using standard samples of tritium mixed in brain gray matter. The binding sites in fiber tracts were quantified using stand...

journal_title：Neuroscience

authors： Foote RW

更新日期：1987-01-01 00:00:00

abstract：:Intracerebral neural xenografts elicit a host immune response that results in their rapid rejection. This forms a key barrier to the therapeutic use of xenogeneic tissue transplantation for conditions such as Parkinson's disease. The current study sought to provide insight into the cellular components of donor cell su...

journal_title：Neuroscience

authors： Armstrong RJ,Harrower TP,Hurelbrink CB,McLaughin M,Ratcliffe EL,Tyers P,Richards A,Dunnett SB,Rosser AE,Barker RA

更新日期：2001-01-01 00:00:00

abstract：:The glycine transporter GLYT2 is present in axonal boutons throughout the spinal cord, and its laminar distribution matches that of glycine-enriched axons, which are presumed to be glycinergic. In order to determine whether boutons which possess GLYT2 are glycine-enriched, we have carried out pre-embedding immunocytoc...

journal_title：Neuroscience

authors： Spike RC,Watt C,Zafra F,Todd AJ

更新日期：1997-03-01 00:00:00

abstract：:Neuroinflammation contributes to neuronal death in cerebral ischemia. Urolithin A (UA), a gut microbial metabolite of ellagic acid, has emerged as a potential anti-inflammatory agent. However, its roles and precise mechanisms in stroke remain unknown. Here we found that UA treatment ameliorated infarction, neurologica...

journal_title：Neuroscience

authors： Lin XH,Ye XJ,Li QF,Gong Z,Cao X,Li JH,Zhao ST,Sun XD,He XS,Xuan AG

更新日期：2020-11-10 00:00:00

abstract：:Calmodulin (CaM) and neurogranin (Ng) are two abundant neuronal proteins in the forebrain whose interactions are implicated in the enhancement of synaptic plasticity. To gain further insight into the actions of these two proteins we investigated whether they co-localize in principle neurons and whether they respond to...

journal_title：Neuroscience

authors： Huang KP,Huang FL,Shetty PK

更新日期：2011-03-31 00:00:00

abstract：:During rapid cell growth the availability of phospholipid precursors like cytidine triphosphate and diacylglycerol can become limiting in the formation of key membrane constituents like phosphatidylcholine. Uridine, a normal plasma constituent, can be converted to cytidine triphosphate in PC12 [corrected] cells and in...

journal_title：Neuroscience

authors： Pooler AM,Guez DH,Benedictus R,Wurtman RJ

更新日期：2005-01-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is a neurotrophin (NT) known to participate in chronic somatic pain. A recent study has indicated that BDNF may participate in chronic cystitis at the peripheral level. However, the principal site of action for this NT is the central nervous system, most notably the spinal cord...

journal_title：Neuroscience

authors： Frias B,Allen S,Dawbarn D,Charrua A,Cruz F,Cruz CD

更新日期：2013-03-27 00:00:00

abstract：:The effects of the dopamine D(3) receptor, a putative autoreceptor, have been investigated by comparing behavioral and neurochemical properties of wild-type mice and mice with a genetic deletion of the D(3) receptor. The D(3) knock-out mice were modestly hyper-responsive to a novel environment relative to wild-type mi...

journal_title：Neuroscience

authors： Joseph JD,Wang YM,Miles PR,Budygin EA,Picetti R,Gainetdinov RR,Caron MG,Wightman RM

更新日期：2002-01-01 00:00:00

abstract：:Investigation of the integrity of the ryanodine receptor in Alzheimer's disease is important because it plays a critical role in the regulation of calcium release from the endoplasmic reticulum in brain, impairment of which is believed to contribute to the pathogenesis of Alzheimer's disease. The present study compare...

journal_title：Neuroscience

authors： Kelliher M,Fastbom J,Cowburn RF,Bonkale W,Ohm TG,Ravid R,Sorrentino V,O'Neill C

更新日期：1999-01-01 00:00:00

abstract：:Inward rectifier potassium currents and calcium-dependent potassium currents have been studied in cultured embryonic mouse motoneurons. Sustained unitary inward rectifier potassium currents were recorded from cell-attached patches and the channel conductance was dependent on external K+ concentration with a value of 2...

journal_title：Neuroscience

authors： McLarnon JG,Kim SU,Michikawa M,Xu R

更新日期：1995-01-01 00:00:00

abstract：:On mating with a stud male, virgin female mice from an olfactory memory to this male which is essential to their reproductive success. Failure to form this memory results in the stud male being treated as strange, and hence, his pheromones block pregnancy. This study investigates the duration of the olfactory memory, ...

journal_title：Neuroscience

authors： Kaba H,Rosser AE,Keverne EB

更新日期：1988-01-01 00:00:00

abstract：:We explored the contribution of inhibitory peanut-binding extracellular matrix glycoproteins to the regeneration of characteristic outgrowth patterns by different types of identified neurons. Adult leech neurons were isolated one by one and plated in culture on a substrate that consisted of the capsules that encase th...

journal_title：Neuroscience

authors： Flores-Abreu N,Vargas J,De-Miguel FF

更新日期：2006-01-01 00:00:00

abstract：:It has previously been found that, in the presence of naloxone, the ganglionic blocking drug hexamethonium fails to completely block peristaltic motility in the isolated ileum of the guinea-pig. This hexamethonium-resistant peristaltic activity is coordinated by enteric nerves since it is abolished by tetrodotoxin. In...

journal_title：Neuroscience

authors： Barthó L,Holzer P,Leander S,Lembeck F

更新日期：1989-01-01 00:00:00