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Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury.

Abstract：

:Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these injuries, clinicians rely solely on surgery and rehabilitation to treat patients. Unfortunately, patient outcomes remain poor despite application of the most advanced microsurgical and rehabilitative techniques. We hypothesized that the detrimental effects of traumatic neonatal nerve injury could be mitigated with pharmacologic neuroprotection, and tested whether the novel neuroprotective agent P7C3 would block peripheral neuron cell death and enhance functional recovery in a rat neonatal nerve injury model. Administration of P7C3 after sciatic nerve crush injury doubled motor and sensory neuron survival, and also promoted axon regeneration in a dose-dependent manner. Treatment with P7C3 also enhanced behavioral and muscle functional recovery, and reversed pathological mobilization of spinal microglia after injury. Our findings suggest that the P7C3 family of neuroprotective compounds may provide a basis for the development of a new neuroprotective drug to enhance recovery following peripheral nerve injury.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Kemp SWP,Szynkaruk M,Stanoulis KN,Wood MD,Liu EH,Willand MP,Morlock L,Naidoo J,Williams NS,Ready JM,Mangano TJ,Beggs S,Salter MW,Gordon T,Pieper AA,Borschel GH

doi

10.1016/j.neuroscience.2014.10.005

subject

Has Abstract

pub_date

2015-01-22 00:00:00

pages

202-216

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(14)00859-8

journal_volume

284

pub_type

杂志文章

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