Abstract:
:Stress has long been associated with the development of neuropsychiatric and neurological disorders. The effects of stress vary depending upon the age during which the stress is incurred, the duration and severity of the stressor, and can further be influenced by levels of circulating gonadal hormones. To date, the majority of research investigating the link between stress and pathology development has focused on stress hormone secretion, receptor activity, and their impact on neuronal development and functioning in developing and adult male and female rodents. In recent years, work has begun to focus on additional neuromodulatory systems that may be significantly impacted by stress that may explain changes in developmental and sex-based susceptibility to stress. New research targets include molecules that play a role in neuronal development and plasticity. Specifically, stress-induced alterations in growth factors such as neurotrophins, in particular brain-derived neurotrophic factor (BDNF), have been identified as a strong candidate modulating stress-associated pathology. Furthermore, changing expression of BDNF and its receptors over development and in response to circulating gonadal hormones extend the attractiveness of this candidate signaling pathway for understanding differences in susceptibility to stress. This review focuses on what is known with regard to the effects of stress on neurotrophin expression in rodents, and the varied effects of stress on BDNF levels as a function of developmental status and sex.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Bath KG,Schilit A,Lee FSdoi
10.1016/j.neuroscience.2013.01.074subject
Has Abstractpub_date
2013-06-03 00:00:00pages
149-56eissn
0306-4522issn
1873-7544pii
S0306-4522(13)00121-8journal_volume
239pub_type
杂志文章,评审相关文献
NEUROSCIENCE文献大全abstract::In situ hybridization histochemistry was used to localize calcitonin gene-related peptide mRNAs in spinal cord, brain stem and dorsal root ganglion neurons of the rat and guinea-pig. A 32P-labeled 23-base-long (23mer) oligodeoxyribonucleotide (oligomer) complementary to calcitonin gene-related peptide mRNA sequences e...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90345-x
更新日期:1989-01-01 00:00:00
abstract::Differences in the uptake of tracers from radioactive 2-deoxyglucose ([1,2-3H] and [2,6-3H]), and glucose ([1-3H], [3-3H]) into hippocampal regions were investigated by freeze-mount microautoradiography after 45 min for 2-deoxyglucose, and after 15 and 45 min for glucose. Silver grains were assessed quantitatively by ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(89)90378-3
更新日期:1989-01-01 00:00:00
abstract::The present experiments examined the effects of direct intracortical microinjections of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovaleric acid directly into the insular cortex of rats, before or immediately after training of conditioned taste aversion and the water maze spatial learning task. In ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00360-1
更新日期:1999-03-01 00:00:00
abstract::This work addresses the presence, pharmacological properties, and anatomical localization of calcitonin gene-related peptide-alpha (CGRPalpha) binding sites and the receptor's accessory proteins in endplate-enriched and non-endplate muscle membrane samples from adult rat gracilis muscles. We examined the binding of (1...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00163-5
更新日期:2003-01-01 00:00:00
abstract::Inflammation is an important event in ischemic injury. These immune responses begin with the expression of pro-inflammatory genes modulating transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducers and activator of transcription-1 (STAT-1). The 70-kDa heat shock prot...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.11.057
更新日期:2015-02-12 00:00:00
abstract::The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI) is a measure of sensorimotor gating which is a basic process whereby...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.06.035
更新日期:2016-09-22 00:00:00
abstract::Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striaton...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(02)00401-3
更新日期:2002-01-01 00:00:00
abstract::The contributions of several Ca(2+)-dependent processes to neurotoxicity were examined in primary cultures of rat cortical neurons. The Ca2+ ionophore ionomycin induced a rapid loss of axonal morphology and concomitant release of inositol phosphates that preceded morphological alterations of neuronal cell bodies, chol...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00070-0
更新日期:1998-10-01 00:00:00
abstract::The aim of the present study was to investigate the existence and distribution of neuropeptide Y receptor subtypes in various regions of the normal human brain using the peptide YY derivative receptor probes, [125I][Leu31,Pro34]polypeptide YY/Y1 and [125I]polypeptide YY(3-36)/Y2, in addition to the non-selective ligan...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(96)00639-2
更新日期:1997-07-01 00:00:00
abstract::Ghrelin is a stomach-derived hormone that regulates rewarding behaviors and reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain structure mainly comprised of dopamine (DA) and gamma-aminobutiric acid (GABA) neurons that are distributed in several VTA sub-nuclei. Here, we investig...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.09.027
更新日期:2018-11-10 00:00:00
abstract::Several types of brain injuries have been associated with alterations in the striatal expression of neurotrophic factors, including glial cell line-derived neurotrophic factor (GDNF). However, contradictory results on the striatal expression of GDNF have been reported in different animal models of Parkinson's disease....
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.04.036
更新日期:2009-08-04 00:00:00
abstract::Previous studies suggested that Group I metabotropic glutamate (mGlu) receptors play a role in mechanotransduction processes of slowly adapting type I mechanoreceptors. Using an isolated rat sinus hair follicle preparation we tested a range of compounds. Surprisingly, only non-competitive mGlu1 receptor antagonists pr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.07.015
更新日期:2009-10-20 00:00:00
abstract::Huntington's disease is a progressive, inherited neurodegenerative disorder characterized by the loss of subsets of neurons primarily in the striatum. In this study, we assessed the neuroprotective effect of lithium against striatal lesion formation in a rat model of Huntington's disease in which quinolinic acid was u...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00311-6
更新日期:2001-01-01 00:00:00
abstract::In vitro receptor autoradiography was used to localize, quantify and characterize [125I-Tyr8]bradykinin binding sites in all major spinal cord segments of normal rats and animals subjected to various chemical treatments and surgical lesions. [125I-Tyr8]bradykinin specific binding sites were predominantly located to su...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00161-b
更新日期:1995-10-01 00:00:00
abstract::Immunohistochemical methods were used to characterize the distribution of staining for leucine enkephalin-like and methionine enkephalin-like immunoreactivities in the telencephalon of Caiman crocodilus. Very similar distributions of both leucine enkephalin-like and methionine enkephalin-like immunoreactivity were obs...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90028-9
更新日期:1984-02-01 00:00:00
abstract::Attentional deficits including difficulty in switching attention between tasks or rules, sustaining attention, and selectively attending to specific stimuli are commonly seen in patients with Parkinson's disease (PD). While these deficits are frequently reported, it is unclear how traditional dopamine replacement ther...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.09.022
更新日期:2016-11-19 00:00:00
abstract::It is not known whether, during the course of aging, changes occur in the motor strategies used by the CNS for lifting objects of different weights. Here, we analyzed the kinematics of object-lifting in two different healthy groups (young and elderly people) plus one well-known deafferented patient (GL). The task was ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.04.010
更新日期:2017-08-15 00:00:00
abstract::Corticothalamic axons from layer 5 of primary and secondary auditory and visual areas have large terminals that make multiple synaptic contacts on proximal dendrites of relay cells in higher order thalamic nuclei and have been termed "driver" inputs. The corticothalamic cells express mRNA for the presynaptic growth-as...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.08.033
更新日期:2005-01-01 00:00:00
abstract::The aim of this study was to assess the effect of blocking the axonal transport of sensory neuropeptides, by local injection of colchicine at pelvic ganglia level, on the sensory and efferent functions mediated by capsaicin-sensitive primary afferent neurons innervating the rat urinary bladder. Bilateral injection of ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00422-x
更新日期:1996-03-01 00:00:00
abstract::Adolescence is a period of progressive changes in brain that likely contribute to the maturation of behavior. Human adolescents consume large amounts of ethanol. To investigate the effects of ethanol on adolescent neural progenitor cells, male rats (35-40 days old) were treated with an acute dose of ethanol (1.0, 2.5 ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.08.090
更新日期:2006-01-01 00:00:00
abstract::Amyloid beta peptide (Abeta) plays a major role in the pathogenesis of Alzheimer's disease (AD). Abeta is toxic to neurons, possibly through causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca(2+). Calpain (Ca(2+)-dependent protease) and caspase have been implicated ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.07.072
更新日期:2008-10-28 00:00:00
abstract::It is now well established that vestibular information plays an important role in spatial memory processes. Although vestibular lesions induce anxiety in humans, this finding remains controversial in rodents. However, it is possible that anxiety-related behavior is associated with spatial memory impairments after vest...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.05.029
更新日期:2012-08-30 00:00:00
abstract::Forebrain neuronal circuits containing hypocretin-1 (hcrt-1) and norepinephrine (NE) are important components of central arousal-related processes. Recently, these two systems have been shown to have an overlapping distribution within the bed nucleus of the stria terminalis (BST), a limbic structure activated by stres...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.09.032
更新日期:2013-01-01 00:00:00
abstract::The study explored unintentional force changes elicited by removing visual feedback during cyclical, two-finger isometric force production tasks. Subjects performed two types of tasks at 1Hz, paced by an auditory metronome. One - Force task - required cyclical changes in total force while maintaining the sharing, defi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.03.022
更新日期:2017-05-14 00:00:00
abstract::Apart from therapeutic discovery, the study of mild traumatic brain injury (mTBI) has been focused on two challenges: why do a majority of individuals recover with little concern, while a considerable proportion suffer with persistent and often debilitating symptomology; and, how do mild injuries significantly increas...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.12.034
更新日期:2015-03-12 00:00:00
abstract::Erythropoietin (EPO) and its receptor (EPO-R), mediate neuroprotection from axonopathy and apoptosis in the peripheral nervous system (PNS). We examined the impact and potential mechanisms of local EPO signaling on regenerating PNS axons in vivo and in vitro. As a consequence of injury, peripheral nerve axons and DRG ...
journal_title:Neuroscience
pub_type: 杂志文章,收录出版
doi:10.1016/j.neuroscience.2008.03.052
更新日期:2008-06-23 00:00:00
abstract::Arising from studies on the amnesia that follows site-specific physical or chemical lesions, the acquisition and consolidation of certain behavioral tasks has been demonstrated to be associated with different hippocampal subregions. Although not absolute, spatial learning is reliant on the dorsal region of the hippoca...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.01.020
更新日期:2012-05-03 00:00:00
abstract::The aim of the present study was to identify potential biomarkers for depression in the search for novel disease targets and treatment regimens. Furthermore, the study includes a search for biomarkers involved in treatment resistance and stress resilience in order to investigate mechanisms underlying antidepressant dr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.08.024
更新日期:2011-11-24 00:00:00
abstract::Endocannabinoids modulate a diverse array of functions including progenitor cell proliferation in the central nervous system, and odorant detection and food intake in the mammalian central olfactory system and larval Xenopus laevis peripheral olfactory system. However, the presence and role of endocannabinoids in the ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.05.056
更新日期:2015-08-06 00:00:00
abstract::Enkephalins are peptides which have pharmacological properties similar to those of morphine. Guinea pigs were immunized with a leucine-enkephalin/thyroglobulin conjugate. Immunofluorescence histochemistry with antiserum revealed a widely distributed system of axons and their terminals in the nervous system of the rat....
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(76)90063-4
更新日期:1976-08-01 00:00:00