Intense cold noxious stimulation of the rat hindpaw induces c-fos expression in lumbar spinal cord neurons.

Abstract:

:This study evaluated Fos-like immunoreactivity in lumbar spinal cord neurons following intense cold stimulation and then the modifications induced by opioid administration. Under urethane anaesthesia, the rat's right foot was stimulated by holding it in a regulated temperature bath at 15, 10, 0, -10, -15, -17.5 or -20 degrees C. There was no or little Fos-like immunoreactivity in lumbar spinal cord neurons when the paw was at temperatures between 15 and -10 degrees C (0-5 Fos-like immunoreactive neurons/section). The threshold to induce consistent c-fos expression was -15 degrees C. From -15 to -20 degrees C, the number of Fos-like immunoreactive neurons increased with decreases in temperature. At -20 degrees C, Fos-like immunoreactive neurons were numerous in L3 and L4 segments, in laminae I-II (approximately 60 Fos-like immunoreactive neurons/section) and to a lesser extent in laminae V-VI (approximately 20). Almost no Fos-like immunoreactivity was present in laminae III-IV (< 5). At -20 degrees C, the number of Fos-like immunoreactive neurons increased with the duration of the stimulation. The number of Fos-like immunoreactive neurons induced by the cold stimulation temperatures was significantly decreased by pretreatment with 10 mg/kg s.c. morphine and moderately decreased by 5 mg/kg s.c. This effect was antagonized by the combined administration of morphine (10 mg/kg s.c.) and naloxone (2 mg/kg s.c.). Naloxone (2 mg/kg s.c.) significantly increased the number of Fos-like immunoreactive neurons induced by -20 degrees C as compared to saline-injected rats. This study showed that Fos-like immunoreactivity distribution is in good agreement with the location of neurons receiving noxious inputs and that the threshold to induce c-fos expression with cold was unexpectedly low at -15 degrees C. Taking into account, on the one hand, previous investigations using the same technique using noxious heat stimulation and, on the other hand, electrophysiological and psychophysiological studies using cold stimulation in animals and humans, our results suggest that Fos-like immunoreactivity induced by extremely cold stimulation, which seems to reproduce frostbite, may reflect activation of nociceptors due to vasoconstriction.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Abbadie C,Honoré P,Besson JM

doi

10.1016/0306-4522(94)90609-2

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

457-68

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(94)90609-2

journal_volume

59

pub_type

杂志文章
  • Cerebellin-like peptide: tissue distribution in rat and guinea-pig and its release from rat cerebellum, hypothalamus and cerebellar synaptosomes in vitro.

    abstract::We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(88)90262-x

    authors: Burnet PW,Bretherton-Watt D,Ghatei MA,Bloom SR

    更新日期:1988-05-01 00:00:00

  • Nucleus accumbens muscarinic receptors in the control of behavioral depression: antidepressant-like effects of local M1 antagonist in the Porsolt swim test.

    abstract::Systemically administered cholinomimetics or cholinesterase inhibitors can depress behavior in humans and animals, whereas antimuscarinic agents reverse this effect or even produce euphoria. Although these effects have been well documented, the specific brain regions that mediate them remain largely unknown. In the pr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00133-6

    authors: Chau DT,Rada P,Kosloff RA,Taylor JL,Hoebel BG

    更新日期:2001-01-01 00:00:00

  • Stimulus exposure duration alters implicit processing of neutral and emotional faces.

    abstract::Stimulus exposure duration in emotion perception research is often chosen pragmatically; however, little work exists on the consequences of stimulus duration for the processing of emotional faces. We utilized the spatiotemporal resolution capabilities of magnetoencephalography (MEG) to characterize early implicit proc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.11.030

    authors: Kouptsova JE,Leung RC,Taylor MJ

    更新日期:2017-01-26 00:00:00

  • Development and retraction of a crossed retinal projection to the inferior colliculus in neonatal pigmented rats.

    abstract::A transient aberrant projection from the retina to the contralateral inferior colliculus was demonstrated in pigmented rats in both whole-brains and sections following intra-ocular injection of horseradish peroxidase. The projection was prominent on the day of birth but reached its maximum density and extent after inj...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90087-k

    authors: Cooper AM,Cowey A

    更新日期:1990-01-01 00:00:00

  • Analysis of excitatory synapses in the guinea pig inferior colliculus: a study using electron microscopy and GABA immunocytochemistry.

    abstract::The inferior colliculus (IC) integrates ascending auditory input from the lower brainstem and descending input from the auditory cortex. Understanding how IC cells integrate these inputs requires identification of their synaptic arrangements. We describe excitatory synapses in the dorsal cortex, central nucleus, and l...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.01.061

    authors: Nakamoto KT,Mellott JG,Killius J,Storey-Workley ME,Sowick CS,Schofield BR

    更新日期:2013-05-01 00:00:00

  • Preattentive mechanisms of change detection in early auditory cortex: a 7 Tesla fMRI study.

    abstract::The auditory system continuously monitors the environment for irregularities in an automatic, preattentive fashion. This is presumably accomplished by two mechanisms: a sensory mechanism detects a deviant sound on the basis of differential refractoriness of neural populations sensitive to the standard and deviant soun...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.08.039

    authors: Szycik GR,Stadler J,Brechmann A,Münte TF

    更新日期:2013-12-03 00:00:00

  • Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats.

    abstract::Beta-amyloid (Aβ) deposition and neuroinflammation are involved in Alzheimer's disease (AD)-type neurodegeneration with cognitive deficits. Phosphodiesterase-5 (PDE5) inhibitors have recently been studied as a potential target for cognitive enhancement by reducing inflammatory responses and Aβ levels. The present stud...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.04.022

    authors: Yin C,Deng Y,Gao J,Li X,Liu Y,Gong Q

    更新日期:2016-07-22 00:00:00

  • Peri-infarct flow transients predict outcome in rat focal brain ischemia.

    abstract::Spreading depolarizations are accompanied by transient changes in cerebral blood flow (CBF). In a post hoc analysis of previously studied control rats we analyzed CBF time courses after middle cerebral artery occlusion in the rat in order to test whether intra-ischemic flow, reperfusion, and different parameters of pe...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.08.049

    authors: Lückl J,Dreier JP,Szabados T,Wiesenthal D,Bari F,Greenberg JH

    更新日期:2012-12-13 00:00:00

  • Effects of early and late neonatal bromocriptine treatment on hypothalamic neuropeptides, dopaminergic reward system and behavior of adult rats.

    abstract::In humans, bromocriptine (BRO) is used as a treatment for many disorders, such as prolactinomas, even during pregnancy and lactation. Previously we demonstrated that maternal BRO treatment at the end of lactation programs offspring for obesity and several endocrine dysfunctions. Here, we studied the long-term effects ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.03.046

    authors: Carvalho JC,Lisboa PC,de Oliveira E,Peixoto-Silva N,Pinheiro CR,Fraga MC,Claudio-Neto S,Franci CR,Manhães AC,Moura EG

    更新日期:2016-06-14 00:00:00

  • Endotoxin-induced appearance of immunoreactive interleukin-1 beta in ramified microglia in rat brain: a light and electron microscopic study.

    abstract::Interleukin-1 plays an important role as mediator of endotoxin-induced responses in the brain such as fever, sleep, anorexia, behavioural and neuroendocrine changes. In the present study, interleukin-1 beta immunocytochemistry has been performed at the light and electron microscopic level to study the cellular and sub...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)00549-k

    authors: Van Dam AM,Bauer J,Tilders FJ,Berkenbosch F

    更新日期:1995-04-01 00:00:00

  • Acetylcholinesterase-containing neurons, substance P and enkephalin fibers in the ventral horns of developing human embryos and fetuses.

    abstract::The presence of the acetylcholinesterase neurons and substance P-like and enkephalin-like fibers in the various nuclear columns of the ventral horns of the spinal cords was studied in the developing human by acetylcholinesterase histochemistry and substance P and enkephalin immunohistochemistry. Acetylcholinesterase-p...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90286-b

    authors: Luo CB,Yew DT,Zheng DR,Liu YQ

    更新日期:1992-06-01 00:00:00

  • Short-circuited neuron: a note.

    abstract::Here, we demonstrate in a direct electrophysiological experiment that a neuron can form electrical connections to itself. An isolated identified neuron with a long axon was plated in culture and the axon was looped so that its distal end contacted the cell body. After two days in culture, the cell body and the axon we...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00589-8

    authors: Panchin YV,Kelmanson IV

    更新日期:2000-01-01 00:00:00

  • Astrocytes in Memory Function: Pioneering Findings and Future Directions.

    abstract::Astrocytes have been generally believed to perform mainly homeostatic and supportive functions for neurons in the central nervous system. Recently, a growing body of evidence suggests previously unrecognized and surprising functions for astrocytes, including regulation of synaptic formation, transmission and plasticit...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2017.05.033

    authors: Adamsky A,Goshen I

    更新日期:2018-02-01 00:00:00

  • β functional connectivity modulation during the maintenance of motion information in working memory: importance of the familiarity of the visual context.

    abstract::The purpose of this study was to examine whether mechanisms, involved during the maintenance of familiar movement information in memory, were influenced by the degree of familiarity of the display in which the movements were embedded. Twelve gymnasts who possessed high visual and motor familiarity with the movements e...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.03.045

    authors: Calmels C,Foutren M,Stam CJ

    更新日期:2012-06-14 00:00:00

  • Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus.

    abstract::Studies with animal seizure models have indicated that changes in temporal and spatial expression of voltage-gated sodium channels may be important in the pathology of epilepsy. Here, by using in situ hybridisation with previously characterised subtype-selective oligonucleotide probes [Whitaker et al. (2000) J. Comp. ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00212-3

    authors: Whitaker WR,Faull RL,Dragunow M,Mee EW,Emson PC,Clare JJ

    更新日期:2001-01-01 00:00:00

  • Effects of ethanol and Ro 15-4513 in an electrophysiological model of anxiolytic action.

    abstract::Previous research has implicated hippocampal rhythmical slow activity in the mechanisms of action of the anxiolytic drugs. In this study ethanol and a putative ethanol antagonist, Ro 15-4513, were investigated with reticular elicitation of rhythmical slow activity. Doses of ethanol between 0.6 and 3.1 g/kg were used. ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90337-4

    authors: Coop CF,McNaughton N,Warnock K,Laverty R

    更新日期:1990-01-01 00:00:00

  • The effects of aging on N-methyl-D-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory.

    abstract::There are declines in the protein expression of the NR2B (mouse epsilon2) and NR1 (mouse zeta1) subunits of the N-methyl-D-aspartate (NMDA) receptor in the cerebral cortex and hippocampus during aging in C57BL/6 mice. This study was designed to determine if there is a greater effect of aging on subunit expression and ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.05.018

    authors: Zhao X,Rosenke R,Kronemann D,Brim B,Das SR,Dunah AW,Magnusson KR

    更新日期:2009-09-15 00:00:00

  • Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene.

    abstract::The human myelin proteolipid protein 1 gene (hPLP1), which encodes the major structural myelin proteins of the central nervous system (CNS), is classically described as expressed in the oligodendrocytes, the CNS myelinating cells. We identified two new exons in the intron 1 of the hPLP1 gene that lead to the expressio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.12.047

    authors: Sarret C,Combes P,Micheau P,Gelot A,Boespflug-Tanguy O,Vaurs-Barriere C

    更新日期:2010-03-17 00:00:00

  • Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus.

    abstract::Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that re...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.07.059

    authors: Zhu YY,Jing L,Duan TT,Yuan Q,Cao J,Zhou QX,Xu L

    更新日期:2013-10-10 00:00:00

  • Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling.

    abstract::A systematic line-sampling method is described for counting and mapping myelinated axons in transverse sections of the spinal cord. Its advantages over random sampling of small areas are considered. The technique was applied to quantifying experimental weight-drop contusion injuries of cat spinal cord, from several mo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(83)90150-1

    authors: Blight AR

    更新日期:1983-10-01 00:00:00

  • Muscarinic, adenosine A(2) and histamine H(3) receptor modulation of haloperidol-induced c-fos expression in the striatum and nucleus accumbens.

    abstract::It is generally believed that haloperidol exerts its motor side effects and therapeutic effects mainly by antagonizing dopamine D(2) receptors in the striatum and the nucleus accumbens, respectively. Several neurotransmitters/modulators, including glutamate, acetylcholine, adenosine and histamine, affect dopaminergic ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00069-6

    authors: Hussain N,Flumerfelt BA,Rajakumar N

    更新日期:2002-01-01 00:00:00

  • A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis.

    abstract::Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striaton...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00401-3

    authors: Ghorayeb I,Fernagut PO,Hervier L,Labattu B,Bioulac B,Tison F

    更新日期:2002-01-01 00:00:00

  • Towards Cell and Subtype Resolved Functional Organization: Mouse as a Model for the Cortical Control of Movement.

    abstract::Despite a long history of interrogation, the functional organization of motor cortex remains obscure. A major barrier has been the inability to measure and perturb activity with sufficient resolution to reveal clear functional elements within motor cortex and its associated circuits. Increasingly, the mouse has been e...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2020.07.054

    authors: Warriner CL,Fageiry SK,Carmona LM,Miri A

    更新日期:2020-12-01 00:00:00

  • Nasal Respiration is Necessary for the Generation of γ Oscillation in the Olfactory Bulb.

    abstract::γ oscillations (30-120 Hz) are generated intrinsically within local networks in the mammalian olfactory bulb (OB). The OB directly receives peripheral input from olfactory sensory neurons (OSNs) that can respond to nasal airflow, and centrifugal input from neuromodulatory systems whose activities are affected by the b...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2018.12.011

    authors: Zhuang L,Zhang B,Qin Z,Wang P

    更新日期:2019-02-01 00:00:00

  • Dynorphin in pro-opiomelanocortin neurons of the hypothalamic arcuate nucleus.

    abstract::Considerable evidence suggests that dynorphin participates in the regulation of energy balance. In this study, we have used immunohistochemistry to investigate in detail the cellular localization of pro-dynorphin (DYN) immunoreactive cell bodies in the mediobasal hypothalamus with special reference to neurons producin...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.04.011

    authors: Maolood N,Meister B

    更新日期:2008-06-26 00:00:00

  • SNHG12 Promotes Angiogenesis Following Ischemic Stroke via Regulating miR-150/VEGF Pathway.

    abstract::The promotion of angiogenesis is a promising therapeutic strategy for ischemic stroke. Many long noncoding RNAs (lncRNAs) are related to angiogenesis following ischemic stroke. LncRNA small nucleolar RNA host gene 12 (SNHG12) was upregulated in oxygen-glucose deprivation (OGD)-exposed primary brain microvascular endot...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2018.08.029

    authors: Zhao M,Wang J,Xi X,Tan N,Zhang L

    更新日期:2018-10-15 00:00:00

  • Stress-related changes in the activity of cocaine- and amphetamine-regulated transcript and nesfatin neurons in the midbrain non-preganglionic Edinger-Westphal nucleus in the rat.

    abstract::Cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/nucleobindin 2 (NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are highly expressed in the midbrain non-preganglionic Edinger-Westphal nucleus (npEW), a center implicated in the regulation of stress adaptation and...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.07.001

    authors: Xu L,Bloem B,Gaszner B,Roubos EW,Kozicz T

    更新日期:2010-10-13 00:00:00

  • Using rats for vision research.

    abstract::A wide variety of species are used for the study of visual neuroscience. This is beneficial because fundamental mechanisms and theoretical principles of vision are likely to be highly conserved, while different species exhibit different visual capacities and present different technical advantages for experiments. Eigh...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2014.12.025

    authors: Reinagel P

    更新日期:2015-06-18 00:00:00

  • Plasticity in the in vitro neurohypophysis: effects of osmotic changes on pituicytes.

    abstract::The ultrastructure of rat neurohypophyses incubated in vitro was studied to investigate secretion-related changes that may be intrinsic to the isolated neurohypophysis and to establish the morphological integrity of this preparation. Neurohypophyses were incubated for 2 h in an in vitro chamber in medium of low (290 m...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(84)90069-1

    authors: Perlmutter LS,Hatton GI,Tweedle CD

    更新日期:1984-06-01 00:00:00

  • Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.

    abstract::Brain iron accumulation and oxidative stress are common features of many neurodegenerative diseases, and could be due in part to increased iron influx across the blood-brain interface. The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.04.008

    authors: Loke SY,Siddiqi NJ,Alhomida AS,Kim HC,Ong WY

    更新日期:2013-08-15 00:00:00