当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation.

Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation.

Abstract：

:Electroconvulsive therapy has been commonly applied in the treatment of refractory depression, but its cognitive side effects are noticed and restrict its application. The molecular mechanisms underlying the side effects remain elusive, and there is no efficient prevention. By employing a recognized electroconvulsive shock (ECS) rat model, we found in the present study that ECS induced spatial memory deficits with simultaneous decreases in synaptic proteins of N-methyl-D-aspartate receptor 2A/B (NR2A/B) and postsynaptic density 95 (PSD95), the immediate early gene c-Fos and cAMP response element binding (CREB) proteins, all of which are memory-related proteins. ECS also caused tau hyperphosphorylation at multiple Alzheimer-related phosphorylation sites with activation of glycogen synthase kinase-3beta (GSK-3beta), Akt and phospho-PKR-like endoreticulum (PERK), and inhibition of protein phosphatase-2A (PP)-2A. Intraperitoneal injection of phenylbutyric acid (PBA), an aromatic short chain fatty acid with the functions of molecule chaperon, prevented rats from the ECS-induced memory deficits, alterations of the memory-associated proteins, and tau hyperphosphorylation. Our data suggest that PBA may be potentially used for attenuating the side effects caused by electroconvulsive therapy.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Yao Z,Guo Z,Yang C,Tian Q,Gong CX,Liu G,Wang JZ

doi

10.1016/j.neuroscience.2010.03.060

subject

Has Abstract

pub_date

2010-06-30 00:00:00

pages

405-15

issue

2

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(10)00495-1

journal_volume

168

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra.

    abstract：:GABA release was recorded in vivo by push-pull perfusion from the globus pallidus and substantia nigra of control rats, rats with unilateral ibotenic acid lesions of the neostriatum, and rats with embryonic striatal tissue grafts implanted in the lesioned striatum. The lesions reduced baseline levels of GABA release t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90068-1

    authors： Sirinathsinghji DJ,Dunnett SB,Isacson O,Clarke DJ,Kendrick K,Björklund A

    更新日期：1988-03-01 00:00:00

  • Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors.

    abstract：:This study has investigated the role of hypothalamic and amygdalar type-1 cannabinoid (CB1) receptors in the emotional and neuroendocrine responses to stress. To do so, we used the Cre/loxP system to generate conditional mutant mice lacking the CB1 gene in neurons expressing the transcription factor single-minded 1 (S...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.08.049

    authors： Dubreucq S,Kambire S,Conforzi M,Metna-Laurent M,Cannich A,Soria-Gomez E,Richard E,Marsicano G,Chaouloff F

    更新日期：2012-03-01 00:00:00

  • Characterization of the feeding inhibition and neural activation produced by dorsomedial hypothalamic cholecystokinin administration.

    abstract：:Within the dorsomedial hypothalamus (DMH), cholecystokinin (CCK) has been proposed to modulate neuropeptide Y (NPY) signaling to affect food intake. However, the neural circuitry underlying the actions of this CCK-NPY signaling system in the controls of food intake has yet to be determined. We sought to characterize t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.12.004

    authors： Chen J,Scott KA,Zhao Z,Moran TH,Bi S

    更新日期：2008-03-03 00:00:00

  • Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats.

    abstract：:Exposure to severe stress leads to development of neuropsychiatric disorders, including depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide Y (NPY) is associated with resilience or improved recovery. Therefore exogenous administration to the brain has therapeutic potential althoug...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.01.040

    authors： Serova LI,Tillinger A,Alaluf LG,Laukova M,Keegan K,Sabban EL

    更新日期：2013-04-16 00:00:00

  • Prostaglandin E receptor subtype EP4 agonist protects cochleae against noise-induced trauma.

    abstract：:Prostaglandin E(1) is frequently used for the clinical treatment of acute sensorineural hearing loss. However, the mechanisms underlying the effects of prostaglandin E(1) on the inner ear have not yet been elucidated. The physiological effects of prostaglandin E(1) are mediated by the prostanoid receptors prostaglandi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.03.014

    authors： Hori R,Nakagawa T,Sugimoto Y,Sakamoto T,Yamamoto N,Hamaguchi K,Ito J

    更新日期：2009-06-02 00:00:00

  • Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation.

    abstract：:Nicotinic stimulation and high K+ depolarization of bovine chromaffin cells cause disassembly of cortical filamentous actin networks. Previous work from our laboratory has demonstrated that disassembly of actin filaments is Ca(2+)-dependent, precedes exocytosis and occurs in cortical areas of low cytoplasmic viscosity...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90330-5

    authors： Vitale ML,Rodríguez Del Castillo A,Trifaró JM

    更新日期：1992-11-01 00:00:00

  • Inflammation-induced increase in evoked calcium transients in subpopulations of rat dorsal root ganglion neurons.

    abstract：:The concentration of intracellular Ca(2+) ([Ca(2+)](i)) influences neuronal properties ranging from excitability to neurotransmitter release. Persistent inflammation is associated with changes in the properties of primary afferent neurons ranging from excitability to transmitter release. The purpose of the present stu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.02.006

    authors： Lu SG,Gold MS

    更新日期：2008-04-22 00:00:00

  • Excitatory actions of GABA in developing brain are mediated by l-type Ca2+ channels and dependent on age, sex, and brain region.

    abstract：:Although GABA is the major inhibitory neurotransmitter in adult brain, it exerts depolarizing actions in developing neurons that include activation of voltage-gated calcium channels. The depolarizing actions of GABA serve an obvious trophic function, but the specific physiological significance of excitatory versus inh...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00794-7

    authors： Perrot-Sinal TS,Auger AP,McCarthy MM

    更新日期：2003-01-01 00:00:00

  • Age-related effects on perceptual and semantic encoding in memory.

    abstract：:This study examined the age-related subsequent memory effect (SME) in perceptual and semantic encoding using event-related potentials (ERPs). Seventeen younger adults and 17 older adults studied a series of Chinese characters either perceptually (by inspecting orthographic components) or semantically (by determining w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.12.036

    authors： Kuo MC,Liu KP,Ting KH,Chan CC

    更新日期：2014-03-07 00:00:00

  • Biochemical analysis of GABA(A) receptor subunits alpha 1, alpha 5, beta 1, beta 2 in the hippocampus of patients with Alzheimer's disease neuropathology.

    abstract：:Alzheimer's disease (AD) is characterized by selective vulnerability of specific neuronal populations within particular brain regions. For example, hippocampal glutamatergic cell populations within the CA1/subicular pyramidal cell fields have been found to be particularly vulnerable early in AD progression. In contras...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00030-7

    authors： Rissman RA,Mishizen-Eberz AJ,Carter TL,Wolfe BB,De Blas AL,Miralles CP,Ikonomovic MD,Armstrong DM

    更新日期：2003-01-01 00:00:00

  • The dorsal midbrain anticonvulsant zone--III. Effects of efferent pathway transections on suppression of electroshock seizures and defence-like reactions produced by local injections of bicuculline.

    abstract：:Having provided an anatomical description of the efferent projections of the dorsal midbrain anticonvulsant zone [Shehab S. et al. (1995) Neuroscience 65, 681-695], our purpose in the present study was to establish which outputs from this region are responsible for mediating the anticonvulsant and behavioural properti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)00517-9

    authors： Shehab S,Simkins M,Dean P,Redgrave P

    更新日期：1995-04-01 00:00:00

  • Reduced Midbrain Dopamine Neuron Number in the Adult Non-human Primate Brain after Fetal Radiation Exposure.

    abstract：:Early gestation is a neurodevelopmental period that is especially vulnerable to environmental insult and one in which neurogenesis features prominently. Prenatal perturbation during early gestation has been linked to neuropsychiatric illnesses such as autism and schizophrenia, and severe environmental insult during th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.07.005

    authors： Selemon LD,Begovic A

    更新日期：2020-08-21 00:00:00

  • Probucol inhibits neural cell apoptosis via inhibition of mTOR signaling pathway after spinal cord injury.

    abstract：:Autophagy plays an essential role in neurodevelopment, axonal guidance, neuropathic pain remission, and neuronal survival. Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway can induce the occurrence of autophagy. In this study, we initially detected the effect of probucol on autophagy after spinal ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.05.019

    authors： Zhou Z,Chen S,Zhao H,Wang C,Gao K,Guo Y,Shen Z,Wang Y,Wang H,Mei X

    更新日期：2016-08-04 00:00:00

  • Unilateral hindpaw inflammation produces a bilateral increase in NADPH-diaphorase histochemical staining in the rat lumbar spinal cord.

    abstract：:Tissue injury results in several changes in spinal cord neurons that contribute to hyperalgesia arising from the injured tissue. In models of unilateral hindpaw inflammation, changes in the neurochemistry and electrophysiology of dorsal horn neurons ipsilateral, and to a much lesser extent contralateral, to the inflam...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90290-i

    authors： Solodkin A,Traub RJ,Gebhart GF

    更新日期：1992-12-01 00:00:00

  • Exercise preconditioning and brain ischemic tolerance.

    abstract：:It is well established that physical exercise can exert neuroprotection both in clinical settings and animal experiments. A series of studies have demonstrated that physical exercise may be a promising preconditioning method to induce brain ischemic tolerance through the promotion of angiogenesis, mediation of the inf...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2011.01.018

    authors： Zhang F,Wu Y,Jia J

    更新日期：2011-03-17 00:00:00

  • Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

    abstract：:The 2-deoxyglucose metabolic mapping technique has been used to investigate the neural mechanisms which underlie the symptoms of Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. In six cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was either (a) ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90120-6

    authors： Mitchell IJ,Clarke CE,Boyce S,Robertson RG,Peggs D,Sambrook MA,Crossman AR

    更新日期：1989-01-01 00:00:00

  • Developmental patterns of somatostatin-receptors and somatostatin-immunoreactivity during early neurogenesis in the rat.

    abstract：:The temporal pattern of distribution of somatostatin receptor was investigated using the somatostatin analogue [125I]Tyr0-DTrp8-somatostatin14 as a ligand and compared with that of somatostatin immunoreactivity during early developmental stages in the spinal cord and the sensory derivatives in rat fetuses. Qualitative...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90335-2

    authors： Maubert E,Slama A,Ciofi P,Viollet C,Tramu G,Dupouy JP,Epelbaum J

    更新日期：1994-09-01 00:00:00

  • Local NMDA receptor hypofunction evokes generalized effects on gamma and high-frequency oscillations and behavior.

    abstract：:The NMDA receptor (NMDAr) hypofunction theory of schizophrenia suggests that aberrant signaling through NMDAr underlies the pathophysiology of this disease. This is commonly modeled in rodents via treatment with NMDAr antagonists, which causes a range of behavioral effects that represent endophenotypes related to schi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.06.039

    authors： Lee J,Hudson MR,O'Brien TJ,Nithianantharajah J,Jones NC

    更新日期：2017-09-01 00:00:00

  • Investigating univariate temporal patterns for intrinsic connectivity networks based on complexity and low-frequency oscillation: a test-retest reliability study.

    abstract：:Intrinsic connectivity networks (ICNs) are composed of spatial components and time courses. The spatial components of ICNs were discovered with moderate-to-high reliability. So far as we know, few studies focused on the reliability of the temporal patterns for ICNs based their individual time courses. The goals of thi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.09.009

    authors： Wang X,Jiao Y,Tang T,Wang H,Lu Z

    更新日期：2013-12-19 00:00:00

  • Capsaicin-induced stimulation of polymodal nociceptors is antagonized by ruthenium red independently of extracellular calcium.

    abstract：:The dual effect of capsaicin on primary afferent neurons, excitation and stimulation of transmitter release, its dependence on extracellular calcium and its modulation by Ruthenium Red have been investigated in the rabbit ear. Injection of capsaicin into the central artery of the isolated perfused ear with intact neur...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90124-3

    authors： Amann R,Donnerer J,Lembeck F

    更新日期：1989-01-01 00:00:00

  • Distinct intrinsic membrane properties determine differential information processing between main and accessory olfactory bulb mitral cells.

    abstract：:Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.05.039

    authors： Zibman S,Shpak G,Wagner S

    更新日期：2011-08-25 00:00:00

  • Upregulation of pronociceptive mediators and downregulation of opioid peptide by adrenomedullin following chronic exposure to morphine in rats.

    abstract：:Adrenomedullin (AM) belongs to a calcitonin gene-related peptide (CGRP) family and has been demonstrated to recruit CGRP following chronic use of morphine and neuronal nitric oxide synthase (nNOS) in inflammation. The present study investigated the possibility that AM initiates the changes of other molecules contribut...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.08.048

    authors： Wang D,Li J,Chen P,Hong Y

    更新日期：2014-11-07 00:00:00

  • Membrane specializations and extracellular material associated with host astrocytes in peripheral neural transplants.

    abstract：:The work of Aguayo and colleagues [Aguayo, David and Bray (1981) J. Exp. Biol. 95, 231-240] demonstrates that grafts of peripheral neural tissue are able to induce regenerative elongation of cut axons in the adult central nervous system. Elucidation of the mechanism of this response requires an understanding of the ce...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90261-2

    authors： Lawrence JM,Raisman G

    更新日期：1987-03-01 00:00:00

  • Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid.

    abstract：:Neurodegeneration in Alzheimer's disease is characterized by a selective loss of particular cell populations. Several recent lines of evidence suggest that beta-amyloid protein directly contributes to the disease's progression and is likely responsible for the observed pattern of neuronal death. We have previously dem...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90331-9

    authors： Pike CJ,Cotman CW

    更新日期：1993-09-01 00:00:00

  • Suprachiasmatic nucleus projection to the medial prefrontal cortex: a viral transneuronal tracing study.

    abstract：:The viral transneuronal labeling method was used to examine whether the suprachiasmatic nucleus (SCN) is linked by multisynaptic connections to the medial prefrontal cortex of the rat. In separate experiments, pseudorabies virus (PRV) was injected into one of the three different cytoarchitectonic regions that comprise...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00361-5

    authors： Sylvester CM,Krout KE,Loewy AD

    更新日期：2002-01-01 00:00:00

  • Response to Hypoxic Preconditioning of Glial Cells from the Roof of the Fourth Ventricle.

    abstract：:The cerebellum harbors a specialized area on the roof of the fourth ventricle that is composed of glial cells and neurons that interface with the cerebrospinal fluid. This region includes the so-called ventromedial cord (VMC), which is composed of cells that are glial fibrillary acidic protein (GFAP)-positive and nest...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.09.015

    authors： Becerra-González M,Varman Durairaj R,Ostos Valverde A,Gualda EJ,Loza-Alvarez P,Portillo Martínez W,Gómez-González GB,Buffo A,Martínez-Torres A

    更新日期：2020-07-15 00:00:00

  • Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits.

    abstract：:The tachykinin peptide substance P (SP) is expressed by many interneurons and some projection neurons in the superficial dorsal horn of the spinal cord. We have recently shown that SP-expressing excitatory interneurons in lamina II correspond largely to a morphological class known as radial cells. However, little is k...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.06.038

    authors： Polgár E,Bell AM,Gutierrez-Mecinas M,Dickie AC,Akar O,Costreie M,Watanabe M,Todd AJ

    更新日期：2020-12-01 00:00:00

  • Electrophysiological characteristics of cells in the anterior caudal lobe of the mormyrid cerebellum.

    abstract：:We have examined the basic electrophysiology and pharmacology of cells in the anterior caudal lobe (CLa) of the mormyrid cerebellum. Intracellular recordings were performed in an in vitro slice preparation using the whole-cell patch recording method. The responses of cells to parallel fiber (PF) and climbing fiber (CF...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.08.033

    authors： Zhang Y,Magnus G,Han VZ

    更新日期：2010-11-24 00:00:00

  • Anatomical characterization of a novel reticulospinal vasodepressor area in the rat medulla oblongata.

    abstract：:Microinjection of L-glutamate into a subregion of the gigantocellular nucleus of the rat medulla oblongata significantly lowers arterial pressure. This vasodepressor area, the gigantocellular depressor area, is topographically distinct from other vasoactive areas of the medulla. We sought to determine the efferent pro...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90503-7

    authors： Aicher SA,Reis DJ,Ruggiero DA,Milner TA

    更新日期：1994-06-01 00:00:00

  • Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine.

    abstract：:The heme oxygenase (HO) enzyme system has been shown to participate in nociceptive signaling in a number of different models of pain. In these experiments we investigated the role of the HO type 2 (HO-2) isozyme in tolerance to the analgesic effects of morphine, and the hyperalgesia and allodynia which are measurable ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00483-4

    authors： Liang D,Li X,Lighthall G,Clark JD

    更新日期：2003-01-01 00:00:00