Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid.

abstract：:We have previously shown that the spinal cord is capable of learning a sensorimotor task in the absence of supraspinal input. Given the action of brain-derived neurotrophic factor (BDNF) on hippocampal learning, the current studies examined the role of BDNF in spinal learning. BDNF is a strong synaptic facilitator and...

journal_title：Neuroscience

authors： Gómez-Pinilla F,Huie JR,Ying Z,Ferguson AR,Crown ED,Baumbauer KM,Edgerton VR,Grau JW

更新日期：2007-09-21 00:00:00

abstract：:Among vertebrates hippocampus forms the major component of the brain in consolidating information from short-term memory to long-term memory. Aging is considered as the major risk factor for memory impairment in sporadic Alzheimer's disease (SAD) like pathology. Present study thus aims at investigating whether age-spe...

journal_title：Neuroscience

authors： Moorthi P,Premkumar P,Priyanka R,Jayachandran KS,Anusuyadevi M

更新日期：2015-08-20 00:00:00

abstract：:Alzheimer's disease (AD) is a debilitating disease and the most common cause of dementia. As the world population ages even modest advances in therapies and preventative strategies would be of benefit. The specific physiological function of the amyloid precursor protein (APP) remains unclear despite strong genetic and...

journal_title：Neuroscience

authors： Bamford RA,Widagdo J,Takamura N,Eve M,Anggono V,Oguro-Ando A

更新日期：2020-01-01 00:00:00

abstract：:Mice provide a highly valuable resource for investigating learning and memory processes; however, many of the established tasks for evaluating learning and memory were developed for rats. Behaviors of mice in these tasks appear to be driven by different motivational factors, and as a result, they often do not perform ...

journal_title：Neuroscience

authors： Pistell PJ,Ingram DK

更新日期：2010-03-10 00:00:00

abstract：:The circling rat is an autosomal recessive mutant (homozygous ci2/ci2) that displays lateralized circling behavior, locomotor hyperactivity, hyperexcitability, ataxia, and stereotypic head-movement. These abnormal behaviors are induced or intensified by stress. Heterozygous (ci2/+) littermates display normal spontaneo...

journal_title：Neuroscience

authors： Fedrowitz M,Potschka H,Richter A,Löscher W

更新日期：2000-01-01 00:00:00

abstract：:Biochemical and immunocytochemical analyses were performed to resolve how glutamate and glutamine are handled in rat cerebellar cortex in acute hypoosmotic stress. Rats were subjected to a 15-20% reduction in plasma osmolality by intraperitoneal injection of distilled water and then perfusion fixed after 4 or 8 h surv...

journal_title：Neuroscience

authors： Nagelhus EA,Lehmann A,Ottersen OP

更新日期：1996-06-01 00:00:00

abstract：:Hippocampal cholinergic neurostimulating peptide, an undecapeptide originally isolated from the hippocampus of young rats, enhances acetylcholine synthesis in rat medial septal nucleus in vitro. Hippocampal cholinergic neurostimulating peptide is derived from the N-terminal region of its 21-kmol.wt precursor protein. ...

journal_title：Neuroscience

authors： Iwase T,Ojika K,Matsukawa N,Nishino H,Yamamoto T,Okada H,Fujimori O,Ueda R

更新日期：2001-01-01 00:00:00

abstract：:Cannabinoid ligands have been shown to be anti-nociceptive in animal models of acute and chronic pain by acting at the two known cannabinoid receptors, cannabinoid-1 receptor (CB-1) and cannabinoid-2 receptor (CB-2). A major concern with the use of cannabinoids for pain relief is that they activate receptors at sites ...

journal_title：Neuroscience

authors： Palmer JA,Higuera ES,Chang L,Chaplan SR

更新日期：2008-07-17 00:00:00

abstract：:Neurons containing melanin-concentrating hormone (MCH) in the lateral hypothalamic area (LH) have been shown to promote rapid eye movement sleep (REMs) in mice. However, the downstream neural pathways through which MCH neurons influence REMs remained unclear. Because MCH neurons are considered to be primarily inhibito...

journal_title：Neuroscience

authors： Kroeger D,Bandaru SS,Madara JC,Vetrivelan R

更新日期：2019-05-15 00:00:00

abstract：:The purpose of the present study was to test the respective roles of the intrinsic neurons and of the catecholaminergic fibers in two behaviors elicited by electrical stimulation of the lateral hypothalamus, intracranial self-stimulation and the increase in locomotor activity produced by noncontingent stimulation. One...

journal_title：Neuroscience

authors： Velley L,Verney C,Kempf E,Berger B

更新日期：1988-05-01 00:00:00

abstract：:The effects of treatment with the antidepressant drug imipramine on neuropeptide Y immunoreactivity were studied immunocytochemically in the rat brain cortex and hypothalamus. It was found that the level of neuropeptide Y immunoreactivity in the cortex was significantly lowered three and 24 h after the last dose of ch...

journal_title：Neuroscience

authors： Smiałowska M,Legutko B

更新日期：1991-01-01 00:00:00

abstract：:The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...

journal_title：Neuroscience

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1989-01-01 00:00:00

abstract：:The mesolimbic dopaminergic system, originating from the ventral tegmental area (VTA) is implicated in the rewarding properties of ethanol. VTA dopaminergic neurons are under the tonic control of GABAergic innervations. Application of GABAergic agents changes ethanol consumption. However, it is unclear how acute ethan...

journal_title：Neuroscience

authors： Xiao C,Ye JH

更新日期：2008-04-22 00:00:00

abstract：:Dopaminergic mechanisms were analyzed in an isolated preparation of the turtle olfactory bulb. Field potentials were evoked by antidromic or orthodromic stimulation, and the effects determined of pharmacological manipulations of the bathing medium. In the presence of dopamine or a dopamine agonist, apomorphine, there ...

journal_title：Neuroscience

authors： Nowycky MC,Halász N,Shepherd GM

更新日期：1983-04-01 00:00:00

abstract：:Three structurally distinct groups of antagonists were used to test the hypothesis that integrin adhesion receptors play an essential role in consolidating (stabilizing) long term potentiation of the Schaffer collaterals in rat hippocampus. Comparisons were made of percent potentiation at antagonist-treated versus con...

journal_title：Neuroscience

authors： Chun D,Gall CM,Bi X,Lynch G

更新日期：2001-01-01 00:00:00

abstract：:Changes in the distribution of 5-hydroxytryptamine-like immunoreactivity have been examined in enteric neurons at various times after microsurgical lesions of the enteric plexuses. In the myenteric plexus, varicose immunoreactive nerve fibres disappeared or were reduced in number in ganglia anal to an interruption of ...

journal_title：Neuroscience

authors： Furness JB,Costa M

更新日期：1982-02-01 00:00:00

abstract：:Studies in multiple species, including in post-mortem human tissue, have shown that normal aging and/or acoustic overexposure can lead to a significant loss of afferent synapses innervating the cochlea. Hypothetically, this cochlear synaptopathy can lead to perceptual deficits in challenging environments and can contr...

journal_title：Neuroscience

authors： Bharadwaj HM,Mai AR,Simpson JM,Choi I,Heinz MG,Shinn-Cunningham BG

更新日期：2019-05-21 00:00:00

abstract：:On mating with a stud male, virgin female mice from an olfactory memory to this male which is essential to their reproductive success. Failure to form this memory results in the stud male being treated as strange, and hence, his pheromones block pregnancy. This study investigates the duration of the olfactory memory, ...

journal_title：Neuroscience

authors： Kaba H,Rosser AE,Keverne EB

更新日期：1988-01-01 00:00:00

abstract：:The effect of lacosamide (LCS), a functionalized molecule with anti-convulsant properties, on ion channels was investigated, with the aid of patch clamp technology and simulation modeling. In NSC-34 neuronal cells, LCS was found to block voltage-gated Na(+) current (INa) in a frequency- and concentration-dependent man...

journal_title：Neuroscience

authors： Huang CW,Hung TY,Wu SN

更新日期：2015-02-26 00:00:00

abstract：:Considerable effort has been directed toward the development of methods to selectively activate specific subtypes of neurons. Focus has been placed on the heterologous expression of proteins that are capable of exciting neurons in which they are expressed. Here we describe the heterologous expression of the invertebra...

journal_title：Neuroscience

authors： Schanuel SM,Bell KA,Henderson SC,McQuiston AR

更新日期：2008-08-13 00:00:00

abstract：:Antisera raised against protein-glutaraldehyde-amino acid conjugates were used to study the light and electron microscopic distribution of GABA, glutamate, glutamine and taurine in organotypic slice cultures of rat hippocampi. In the stratum oriens and radiatum, glutamate-like immunoreactivity was particularly concent...

journal_title：Neuroscience

authors： Torp R,Haug FM,Tønder N,Zimmer J,Ottersen OP

更新日期：1992-01-01 00:00:00

abstract：:Patients with dysphagia can have higher risks of aspiration after repetitive swallowing activity due to the "fatigue effect". However, it is still unknown how consecutive swallows affect brain activity. Therefore, we sought to investigate differences in swallowing brain networks formed during consecutive swallows usin...

journal_title：Neuroscience

authors： Jestrović I,Coyle JL,Sejdić E

更新日期：2017-03-06 00:00:00

abstract：:In IMR32 neuroblastoma cells, the two adenosine receptor agonists N6-R-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine dose-dependently stimulated membrane adenylate cyclase activity with potencies consistent with the presence of adenosine receptors of the A2-subtype. The S enantiomer of N6-R-phenylisoprop...

journal_title：Neuroscience

authors： Abbracchio MP,Cattabeni F,Clementi F,Sher E

更新日期：1989-01-01 00:00:00

abstract：:The present studies aimed to determine whether cocaine- and amphetamine-regulated transcript (CART) peptide in the nucleus of accumbens shell (AcbSh) is implicated in the regulation of food intake. Bilateral intranuclear injections of CART peptide (55-102, 1 microg/microl/side) into the AcbSh decreased food intake wit...

journal_title：Neuroscience

authors： Yang SC,Shieh KR,Li HY

更新日期：2005-01-01 00:00:00

abstract：:Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays a role in the physiological and emotional changes coincident with adolescence. An emerging line of research has indicated that stressors experienced during this crucial developmental stage may affe...

journal_title：Neuroscience

authors： Eiland L,Romeo RD

更新日期：2013-09-26 00:00:00

abstract：:A number of viral vectors are currently being evaluated as potential gene therapy vectors for gene delivery to the brain. As well as evaluating their ability to express a transgene for extended periods of time it is also essential to examine any cytotoxic immune response to such vectors as this may not only limit tran...

journal_title：Neuroscience

authors： McMenamin MM,Byrnes AP,Charlton HM,Coffin RS,Latchman DS,Wood MJ

更新日期：1998-04-01 00:00:00

abstract：:Studies were made on the effect of the neuroexcitatory agent kainic acid, microinjected into raphe dorsal nucleus by glass micropipette and an air pressure system in doses ranging from 0.2 to 24.0 nmol (in volumes from 0.05 microliter to 0.47 microliter), on the somatosensory evoked potentials and their cycles of reco...

journal_title：Neuroscience

authors： Moyanova S,Dimov S,Ivanova A

更新日期：1987-07-01 00:00:00

abstract：:Recent in vivo electrophysiological studies suggest that chronic dopamine depletion alters profoundly the firing pattern of basal ganglia neurons. These changes may disrupt the processing of cortical information flow from the striatum to the output nuclei, and presumably underlie the clinical manifestations of Parkins...

journal_title：Neuroscience

authors： Tseng KY,Riquelme LA,Murer MG

更新日期：2004-01-01 00:00:00

abstract：:Tianeptine (Tian) has been widely used in treating mood and anxiety disorders, and recently as a nootropic to improve cognitive performance. However, its mechanisms of action are insufficiently clear. We used a comparative proteomic approach to identify sub-proteome changes in hippocampal cytosol and non-synaptic mito...

journal_title：Neuroscience

authors： Perić I,Costina V,Findeisen P,Gass P,Filipović D

更新日期：2020-12-15 00:00:00

abstract：:Both [3H]clonidine and [3H]idazoxan bind to alpha 2 adrenoceptors. The former also labels imidazoline receptors, and the latter non-adrenergic idazoxan binding sites. In order to investigate whether the imidazoline receptors and non-adrenergic idazoxan binding sites are identical, we compared the binding characteristi...

journal_title：Neuroscience

authors： De Vos H,Bricca G,De Keyser J,De Backer JP,Bousquet P,Vauquelin G

更新日期：1994-04-01 00:00:00