当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Kainic acid microinjected into the cat raphe dorsal nucleus modulates the somatosensory evoked potentials and their cycles of excitability.

Kainic acid microinjected into the cat raphe dorsal nucleus modulates the somatosensory evoked potentials and their cycles of excitability.

Abstract：

:Studies were made on the effect of the neuroexcitatory agent kainic acid, microinjected into raphe dorsal nucleus by glass micropipette and an air pressure system in doses ranging from 0.2 to 24.0 nmol (in volumes from 0.05 microliter to 0.47 microliter), on the somatosensory evoked potentials and their cycles of recovery (excitability) obtained from cortex (primary somatosensory and parietal associative), thalamus (ventral posterolateral nucleus and centre median nucleus), mesencephalic reticular formation and raphe dorsal nucleus. Kainic acid in doses higher than 3 nmol exerted an activating effect on the evoked potentials and their recovery cycles especially in thalamus and mesencephalic reticular formation. The analysis of these electrophysiological parameters revealed that the non-specific structures were involved to a larger extent in the activating effect of kainic acid than the specific ones. The morphological changes were not severe and were limited to a part of the raphe dorsal nucleus neurons. Our data indicate that kainic acid injected into raphe dorsal nucleus modulates (in direction of facilitation) the somatosensory evoked potentials and their cycles of excitability obtained in some brain structures. The results suggest that this nucleus is involved in the somatosensory information processing in a non-specific manner.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Moyanova S,Dimov S,Ivanova A

doi

10.1016/0306-4522(87)90199-0

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

83-9

issue

1

eissn

0306-4522

issn

1873-7544

pii

0306-4522(87)90199-0

journal_volume

22

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Distribution of serotonin receptor 5-HT6 mRNA in rat neuronal subpopulations: A double in situ hybridization study.

    abstract：:The 5-HT6 receptor (5-HT6R) is almost exclusively expressed in the brain and has emerged as a promising target for cognitive disorders, including Alzheimer's disease. In the present study, we have determined the cell types on which the 5-HT6R is expressed by colocalizing 5-HT6R mRNA with that of a range of neuronal an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.09.064

    authors： Helboe L,Egebjerg J,de Jong IE

    更新日期：2015-12-03 00:00:00

  • Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration.

    abstract：:Dopamine receptors (DARs) in the nucleus accumbens (NAc) are critical for cocaine's actions but the nature of adaptations in DAR function after repeated cocaine exposure remains controversial. This may be due in part to the fact that different methods used in previous studies measured different DAR pools. In the prese...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.04.056

    authors： Conrad KL,Ford K,Marinelli M,Wolf ME

    更新日期：2010-08-11 00:00:00

  • Cav3.2 T-Type Calcium Channels Are Physiologically Mandatory for the Auditory System.

    abstract：:Voltage-gated Ca2+ channels (VGCCs) play key roles in auditory perception and information processing within the inner ear and brainstem. Pharmacological inhibition of low voltage-activated (LVA) T-type Ca2+ channels is related to both age- and noise induced hearing loss in experimental animals and may represent a prom...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.04.024

    authors： Lundt A,Seidel R,Soós J,Henseler C,Müller R,Bakki M,Arshaad MI,Ehninger D,Hescheler J,Sachinidis A,Broich K,Wormuth C,Papazoglou A,Weiergräber M

    更新日期：2019-06-15 00:00:00

  • Sources of endothelin-1 in hippocampus and cortex following traumatic brain injury.

    abstract：:Endothelin 1 (ET-1) exerts normally a powerful vasoconstrictor role in the control of the brain microcirculation. In altered states, such as following traumatic brain injury (TBI), it may contribute to the development of ischemia and/or secondary cell injury. Because little is known of ET-1's cellular compartmentaliza...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00345-7

    authors： Petrov T,Steiner J,Braun B,Rafols JA

    更新日期：2002-01-01 00:00:00

  • Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons.

    abstract：:Cerebellar Purkinje neurons have intracellular regulatory systems including Ca2+-binding proteins, intracellular Ca2+ stores, Ca2+-ATPase and Na+-Ca2+ exchanger (NCX) that keep intracellular Ca2+ concentration ([Ca2+]i) in physiological range. Among these, NCX interacts with AMPA receptors, activation of which induces...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.01.040

    authors： Kim YT,Namkung YL,Kwak J,Suh CK

    更新日期：2007-04-25 00:00:00

  • Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients.

    abstract：:People with schizophrenia display sensory encoding deficits across a broad range of electrophysiological and behavioral measures, suggesting fundamental impairments in the ability to transduce the external environment into coherent neural representations. This inability to create basic components of complex stimuli in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.04.028

    authors： Maxwell CR,Liang Y,Kelly MP,Kanes SJ,Abel T,Siegel SJ

    更新日期：2006-09-01 00:00:00

  • Insect mouthpart motor patterns: central circuits modified for highly derived appendages?

    abstract：:The interrelationships of motor patterns controlling the mouthparts and the salivary gland of the migratory locust were studied in a deafferented preparation activated by the muscarinic agonist pilocarpine. The aim of the study was to check whether motor output of different neuromeres of the suboesophageal ganglion an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00406-7

    authors： Rast GF,Bräunig P

    更新日期：2001-01-01 00:00:00

  • Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation.

    abstract：:Ethanol modulates the actions of multiple neurotransmitter systems, including GABA. However, its enhancing effects on GABA signaling typically are seen only at high concentrations. In contrast, although GABA is a prominent neurotransmitter in the circadian clock of the suprachiasmatic nucleus (SCN), we see ethanol mod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.08.020

    authors： McElroy B,Zakaria A,Glass JD,Prosser RA

    更新日期：2009-12-01 00:00:00

  • Patch clamp recordings of hair cells isolated from zebrafish auditory and vestibular end organs.

    abstract：:The senses of hearing and balance in vertebrates are transduced by hair cells in the inner ear. Hair cells from a wide variety of organisms have been described electrophysiologically but this is the first report of the application of these techniques to the genetically tractable zebrafish model system. Auditory and ve...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.05.062

    authors： Haden M,Einarsson R,Yazejian B

    更新日期：2013-09-17 00:00:00

  • Expression of NR2B in different brain regions and effect of NR2B antagonism on learning deficits after experimental subarachnoid hemorrhage.

    abstract：:Approximately 50% of patients who survived after aneurysmal subarachnoid hemorrhage (SAH) have cognitive or neurobehavioral dysfunction. The mechanisms are not known. NR2B, one of the subunits of N-methyl-d-aspartate (NMDA) receptors, has been proved to be an important factor for synapse function and behavior cognitio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.11.024

    authors： Chen G,Li Q,Feng D,Hu T,Fang Q,Wang Z

    更新日期：2013-02-12 00:00:00

  • Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles.

    abstract：:This work addresses the presence, pharmacological properties, and anatomical localization of calcitonin gene-related peptide-alpha (CGRPalpha) binding sites and the receptor's accessory proteins in endplate-enriched and non-endplate muscle membrane samples from adult rat gracilis muscles. We examined the binding of (1...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00163-5

    authors： Fernandez HL,Chen M,Nadelhaft I,Durr JA

    更新日期：2003-01-01 00:00:00

  • Depolarization of rat locus coeruleus neurons by adenosine 5'-triphosphate.

    abstract：:Intracellular recordings were performed in a pontine slice preparation of the rat brain containing the locus coeruleus. The enzymatically stable P2-purinoceptor agonist alpha,beta-methylene ATP increased the firing rate without altering the amplitude or shape of action potentials; the afterhyperpolarization following ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90282-7

    authors： Harms L,Finta EP,Tschöpl M,Illes P

    更新日期：1992-06-01 00:00:00

  • Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus.

    abstract：:Pannexins (Panx) constitute a new family of gap junction type proteins. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions but also proved to be active in forming of unopposed hemichannels. In the vertebrate brain pannexins have been found in neurons...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.01.061

    authors： Zoidl G,Petrasch-Parwez E,Ray A,Meier C,Bunse S,Habbes HW,Dahl G,Dermietzel R

    更新日期：2007-04-25 00:00:00

  • Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat.

    abstract：:Gut microbiota colonization is a key event for host physiology that occurs early in life. Disruption of this process leads to altered brain development which ultimately manifests as changes in brain function and behaviour in adulthood. Studies using germ-free (GF) mice highlight the extreme impact on brain health that...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.10.003

    authors： Hoban AE,Moloney RD,Golubeva AV,McVey Neufeld KA,O'Sullivan O,Patterson E,Stanton C,Dinan TG,Clarke G,Cryan JF

    更新日期：2016-12-17 00:00:00

  • Age and sex affect spatial and emotional behaviors in rats: the role of repeated elevated plus maze test.

    abstract：:The main objective of the study was to investigate the effects of age and sex differences on locomotor activity, learning and memory in rats. Another objective was to investigate whether repeated elevated plus maze tests induce anxiety in rats. Eighty Wistar rats were divided into eight groups according to their sex, ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.09.036

    authors： Belviranli M,Atalik KE,Okudan N,Gökbel H

    更新日期：2012-12-27 00:00:00

  • Maternal creatine supplementation affects the morpho-functional development of hippocampal neurons in rat offspring.

    abstract：:Creatine supplementation has been shown to protect neurons from oxidative damage due to its antioxidant and ergogenic functions. These features have led to the hypothesis of creatine supplementation use during pregnancy as prophylactic treatment to prevent CNS damage, such as hypoxic-ischemic encephalopathy. Unfortuna...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.11.017

    authors： Sartini S,Lattanzi D,Ambrogini P,Di Palma M,Galati C,Savelli D,Polidori E,Calcabrini C,Rocchi MB,Sestili P,Cuppini R

    更新日期：2016-01-15 00:00:00

  • Postnatal alterations in dopaminergic markers in the human prefrontal cortex.

    abstract：:Dopamine in the prefrontal cortex plays a critical role in normal cognition throughout the lifespan and has been implicated in the pathophysiology of neuropsychiatric disorders such as schizophrenia and attention deficit disorder. Little is known, however, about the postnatal development of the dopaminergic system in ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.10.009

    authors： Weickert CS,Webster MJ,Gondipalli P,Rothmond D,Fatula RJ,Herman MM,Kleinman JE,Akil M

    更新日期：2007-02-09 00:00:00

  • Strain differences in the effects of adrenalectomy on the midbrain dopamine system: implication for behavioral sensitization to cocaine.

    abstract：:Adrenalectomy (ADX) abolishes behavioral sensitization to cocaine in DBA/2, but not C57BL/6 inbred mice. The present study tests the hypothesis that this ADX effect on behavioral sensitization in the DBA/2 strain involves changes in midbrain dopamine systems that do not occur in the C57BL/6 strain. For that purpose, w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.03.004

    authors： de Jong IE,Steenbergen PJ,de Kloet ER

    更新日期：2008-05-15 00:00:00

  • Redundancy in ascending and descending pathways mediating head turning elicited by entopenducular stimulation in the cat.

    abstract：:Contraversive turning movements of the head were elicited in alert cats by unilateral electrical stimulation of the entopeduncular nucleus. To determine the relative functional importance of ascending and descending pathways activated by the stimulation, the animals were submitted to thalamocortical or midbrain lesion...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90090-8

    authors： Filion M,Hébert R

    更新日期：1983-09-01 00:00:00

  • The Secretome of Microglia Regulate Neural Stem Cell Function.

    abstract：:Brain injury is associated with neuroinflammation, and microglia are key players in this process. Microglia can acquire pro-inflammatory or anti-inflammatory properties, but how this affects neural stem cells (NSCs) remains controversial. Here, NSCs were grown in conditioned media collected from either non-stimulated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.10.034

    authors： Osman AM,Rodhe J,Shen X,Dominguez CA,Joseph B,Blomgren K

    更新日期：2019-05-01 00:00:00

  • Effects of letrozole on hippocampal and cortical catecholaminergic neurotransmitter levels, neural cell adhesion molecule expression and spatial learning and memory in female rats.

    abstract：:We have investigated effects of letrozole, an aromatase inhibitor, on spatial learning and memory, expression of neural cell adhesion molecules (NCAM) and catecholaminergic neurotransmitters in the hippocampus and cortex of female rats. In the intact model, adult Sprague-Dawley rats were divided into four groups (n=8)...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.09.005

    authors： Aydin M,Yilmaz B,Alcin E,Nedzvetsky VS,Sahin Z,Tuzcu M

    更新日期：2008-01-02 00:00:00

  • GABA(B) receptors at glutamatergic synapses in the rat striatum.

    abstract：:Although multiple effects of GABA(B) receptor activation on synaptic transmission in the striatum have been described, the precise locations of the receptors mediating these effects have not been determined. To address this issue, we carried out pre-embedding immunogold electron microscopy in the rat using antibodies ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.07.013

    authors： Lacey CJ,Boyes J,Gerlach O,Chen L,Magill PJ,Bolam JP

    更新日期：2005-01-01 00:00:00

  • Up-regulation of Eph tyrosine kinase receptors after excitotoxic injury in adult hippocampus.

    abstract：:The molecular mechanisms underlying the response to injury in the central nervous system are incompletely understood. Many cell activation systems may be involved. Tyrosine kinase receptors and their ligands play key roles in cell activation throughout life. The Eph family of tyrosine kinase receptors/ ligands are dev...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00568-5

    authors： Moreno-Flores MT,Wandosell F

    更新日期：1999-01-01 00:00:00

  • Alpha-2 adrenergic regulation of pedunculopontine nucleus neurons during development.

    abstract：:Rapid eye movement sleep decreases between 10 and 30 days postnatally in the rat. The pedunculopontine nucleus is known to modulate waking and rapid eye movement sleep, and pedunculopontine nucleus neurons are thought to be hyperpolarized by noradrenergic input from the locus coeruleus. The goal of the study was to in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.04.045

    authors： Bay KD,Mamiya K,Good CH,Skinner RD,Garcia-Rill E

    更新日期：2006-08-25 00:00:00

  • Effects of the alpha 2-adrenoreceptor antagonist dexefaroxan on neurogenesis in the olfactory bulb of the adult rat in vivo: selective protection against neuronal death.

    abstract：:A dysfunction of noradrenergic mechanisms originating in the locus coeruleus has been hypothesised to be the critical factor underlying the evolution of central neurodegenerative diseases [Colpaert FC (1994) Noradrenergic mechanism Parkinson's disease: a theory. In: Noradrenergic mechanisms in Parkinson's disease (Bri...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00757-1

    authors： Bauer S,Moyse E,Jourdan F,Colpaert F,Martel JC,Marien M

    更新日期：2003-01-01 00:00:00

  • Roles of the Cerebellum in Motor Preparation and Prediction of Timing.

    abstract：:The cerebellum is thought to have a variety of functions because it developed with the evolution of the cerebrum and connects with different areas in the frontoparietal cortices. Like neurons in the cerebral cortex, those in the cerebellum also exhibit strong activity during planning in addition to the execution of mo...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2020.04.039

    authors： Tanaka M,Kunimatsu J,Suzuki TW,Kameda M,Ohmae S,Uematsu A,Takeya R

    更新日期：2020-04-30 00:00:00

  • D1-like dopamine receptor density in nuclei involved in social behavior correlates with song in a context-dependent fashion in male European starlings.

    abstract：:Research in songbirds shows that singing behavior is regulated by both brain areas involved in vocal behavior as well as those involved in social behavior. Interestingly, the precise role of these regions in song can vary as a function of the social, environmental and breeding context. To date, little is known about t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.01.042

    authors： Heimovics SA,Cornil CA,Ball GF,Riters LV

    更新日期：2009-03-31 00:00:00

  • Unusual interactions of excitatory amino acid receptor agonists: alpha- and beta-kainate antagonize motor responses to N-methyl-D-aspartate in rodents.

    abstract：:The alpha- and beta-stereoisomers of kainate correspond sterically to the L- and D-isomers of glutamate. Alpha-Kainate is a potent excitant at a specific membrane receptor site (kainate receptor). Beta-Kainate has been proposed as a functional N-methyl-D-aspartate antagonist in vivo. Because of the structural similari...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90020-0

    authors： Turski L,Klockgether T,Schwarz M,Sontag KH,Meldrum BS

    更新日期：1987-01-01 00:00:00

  • Distribution of metabotropic glutamate receptors in the parabrachial and Kölliker-Fuse nuclei of the rat.

    abstract：:In the present study, we analysed the distribution and cellular localization of metabotropic glutamate receptors (1alpha, 2/3, 5) in parabrachial and Kölliker-Fuse nuclei using subtype-specific antisera. Immunolabelling revealed that different nuclei express different sets of metabotropic glutamate receptors. Metabotr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00387-x

    authors： Guthmann A,Herbert H

    更新日期：1999-03-01 00:00:00

  • Electrophysiological characterization of activation state-dependent Ca(v)2 channel antagonist TROX-1 in spinal nerve injured rats.

    abstract：:Prialt, a synthetic version of Ca(v)2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain. However, due to the narrow therapeutic window and considerable side effects associated with systemic dosing, Prialt is only ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.03.057

    authors： Patel R,Rutten K,Valdor M,Schiene K,Wigge S,Schunk S,Damann N,Christoph T,Dickenson AH

    更新日期：2015-06-25 00:00:00