Expression of NR2B in different brain regions and effect of NR2B antagonism on learning deficits after experimental subarachnoid hemorrhage.

abstract：:Expression of calcium channel alpha1 subunits in oocytes or cell lines has proven to be a powerful method in the analysis of structure-function relations, but these experimental systems are of limited value in the examination of neuron-specific functions such as transmitter release. Cell lines derived from neurons are...

journal_title：Neuroscience

authors： Gottschalk W,Kim DS,Chin H,Stanley EF

更新日期：1999-01-01 00:00:00

abstract：:The role of brain corticotropin-releasing hormone receptors in modulating hypothalamic-pituitary-adrenal and sympathoadrenal responses to acute immobilization stress was studied in conscious rats under central corticotropin-releasing hormone receptor blockade by intracerebroventricular injection of a peptide corticotr...

journal_title：Neuroscience

authors： Jezova D,Ochedalski T,Glickman M,Kiss A,Aguilera G

更新日期：1999-01-01 00:00:00

abstract：:The innervation of the suprachiasmatic nucleus by serotoninergic fibers has been studied in rats from the 22nd embryonic until the 21st postnatal day. The serotoninergic fibers were detected with the pre-embedding immunocytochemical technique at the electron-microscopic level using antibodies to serotonin. Serotonin-i...

journal_title：Neuroscience

authors： Ugrumov MV,Popov AP,Vladimirov SV,Kasmambetova S,Novodjilova AP,Tramu G

更新日期：1994-01-01 00:00:00

abstract：:A variety of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists, and the antiepileptic drug lamotrigine, were examined for their ability to restore locomotion and other behaviours when injected stereotaxically via indwelling cannulae into the striatum or substantia n...

journal_title：Neuroscience

authors： Kaur S,Starr MS

更新日期：1997-01-01 00:00:00

abstract：:γ-Hydroxybutyrate (GHB) has a complex array of neural actions that include effects on its own high-affinity GHB receptor, the release of neuroactive steroids, and agonist actions at GABAA and GABAB receptors. We previously reported partial overlap in the c-Fos expression patterns produced by GHB and the GABAB agonist,...

journal_title：Neuroscience

authors： van Nieuwenhuijzen PS,McGregor IS,Chebib M,Hunt GE

更新日期：2014-09-26 00:00:00

abstract：:Repeated exposure to cocaine during adolescence may affect both physical and psychological conditions in the brain, and increase the risk of psychiatric disorders and addiction behaviors in adulthood. Adolescence represents a critical development period for the hippocampus. Moreover, different regions of the hippocamp...

journal_title：Neuroscience

authors： Zhu W,Mao Z,Zhu C,Li M,Cao C,Guan Y,Yuan J,Xie G,Guan X

更新日期：2016-01-28 00:00:00

abstract：:Retrograde transport of horseradish peroxidase has been used to single out a distinct functional cortical cell type for ultrastructural study. Following injection of horseradish peroxidase into the superior colliculus, labelled pyramidal cells were found in layer V of the visual cortex. Examination of the labelled cor...

journal_title：Neuroscience

authors： Kennedy H

更新日期：1982-01-01 00:00:00

abstract：:Stimulation of the mu-opioid receptor (MOR) on nociceptors with fentanyl can produce hyperalgesia (opioid-induced hyperalgesia, OIH) and hyperalgesic priming, a model of transition to chronic pain. We investigated if local and systemic administration of biased MOR agonists (PZM21 and TRV130 [oliceridine]), which prefe...

journal_title：Neuroscience

authors： Araldi D,Ferrari LF,Levine JD

更新日期：2018-12-01 00:00:00

abstract：:To determine the role of the frontal cortex in the generalization of limbic seizures, we first produced unilateral cortical spreading depression to reversibly suppress neuronal activity in the motor cortex and then triggered an amygdala-kindled seizure. Three minutes following induction of unilateral spreading depress...

journal_title：Neuroscience

authors： Kelly ME,Battye RA,McIntyre DC

更新日期：1999-01-01 00:00:00

abstract：:Conventional extracellular recording has revealed cross-modal alterations of auditory cell activities by cutaneous electrical stimulation of the hindpaw in first- and higher-order auditory thalamic nuclei (Donishi et al., 2011). Juxta-cellular recording and labeling techniques were used in the present study to examine...

journal_title：Neuroscience

authors： Kimura A,Imbe H

更新日期：2018-02-21 00:00:00

abstract：:The results of a previous experiment suggest that the cell bodies of many jaw closing muscle spindle afferents in the trigeminal mesencephalic nucleus of the rabbit are phasically inhibited during fictive mastication. The aim of this study was to investigate one possible neurotransmitter system that could be involved ...

journal_title：Neuroscience

authors： Kolta A,Dubuc R,Lund JP

更新日期：1993-04-01 00:00:00

abstract：:Neonatal handling, an experimental model of early life experiences, is known to affect the hypothalamic-pituitary-adrenal axis function thus increasing adaptability, coping with stress, cognitive abilities and in general brain plasticity-related processes. A molecule that plays a most critical role in such processes i...

journal_title：Neuroscience

authors： Stamatakis A,Toutountzi E,Fragioudaki K,Kouvelas ED,Stylianopoulou F,Mitsacos A

更新日期：2009-12-29 00:00:00

abstract：:The main objective of the study was to investigate the effects of age and sex differences on locomotor activity, learning and memory in rats. Another objective was to investigate whether repeated elevated plus maze tests induce anxiety in rats. Eighty Wistar rats were divided into eight groups according to their sex, ...

journal_title：Neuroscience

authors： Belviranli M,Atalik KE,Okudan N,Gökbel H

更新日期：2012-12-27 00:00:00

abstract：:Nicotinic stimulation and high K+ depolarization of bovine chromaffin cells cause disassembly of cortical filamentous actin networks. Previous work from our laboratory has demonstrated that disassembly of actin filaments is Ca(2+)-dependent, precedes exocytosis and occurs in cortical areas of low cytoplasmic viscosity...

journal_title：Neuroscience

authors： Vitale ML,Rodríguez Del Castillo A,Trifaró JM

更新日期：1992-11-01 00:00:00

abstract：:Our human visual system exploits spatiotemporal regularity to interpret incoming visual signals. With a dynamic stimulus sequence of four collinear bars (predictors) appearing consecutively toward the fovea, followed by a target bar with varying contrasts, we have previously found that this predictable spatiotemporal ...

journal_title：Neuroscience

authors： Roebuck H,Bourke P,Guo K

更新日期：2014-03-28 00:00:00

abstract：:Many epidemiological studies support the notion that people who drink alcohol also smoke cigarettes and vice versa thereby suggesting a possible functional interaction between these two most widely used psychoactive substances. We have earlier demonstrated that direct intracerebellar (ICB) microinfusion of nicotine do...

journal_title：Neuroscience

authors： Taslim N,Al-Rejaie S,Saeed Dar M

更新日期：2008-11-11 00:00:00

abstract：:Glutamate excitotoxicity has been suggested to play a role in amyotrophic lateral sclerosis, since overstimulation of post-synaptic glutamate receptors by accumulated extracellular glutamate leads to motoneuron cell death. It is however unclear as to why some groups of motoneurons degenerate in this disease while othe...

journal_title：Neuroscience

authors： Ma L,Ostrovsky H,Miles G,Lipski J,Funk GD,Nicholson LF

更新日期：2006-11-17 00:00:00

abstract：:Receptor-associated protein appears to play an important role in low-density lipoprotein receptor-related protein trafficking. Since ligands for the low-density lipoprotein receptor-related protein have been implicated in Alzheimer's disease and normal functioning of this protein is indispensable for central nervous s...

journal_title：Neuroscience

authors： Van Uden E,Veinbergs I,Mallory M,Orlando R,Masliah E

更新日期：1999-01-01 00:00:00

abstract：:Attentional automatic processes and cerebral activity may differ between individuals with different weight statuses in the presence of food stimuli (e.g. odors, pictures). In the present study, we used an implicit olfactory priming paradigm to test the influence of non-attentively perceived food odors on the cerebral ...

journal_title：Neuroscience

authors： Zsoldos I,Sinding C,Godet A,Chambaron S

更新日期：2021-01-19 00:00:00

abstract：:Development of functional synapses is crucial for the transmission and storage of information in the brain. Post establishment of the initial synaptic contact, synapses are stabilized through neuronal activity-induced signals. Emerging studies have implicated ubiquitination; a reversible posttranslational modification...

journal_title：Neuroscience

authors： Kumari P,Srinivasan B,Banerjee S

更新日期：2017-11-19 00:00:00

abstract：:Substance P is an important neuropeptide neurotransmitter in the central, autonomic and enteric nervous systems. In sympathetic ganglia, substance P is thought to play a role in modulating synaptic transmission. Release of substance P by neuronal stimulation or direct application of substance P to ganglionic neurons i...

journal_title：Neuroscience

authors： Simmons MA,Brodbeck RM,Karpitskiy VV,Schneider CR,Neff DP,Krause JE

更新日期：1997-08-01 00:00:00

abstract：:Treatment of Parkinson's disease (PD) with dopamine replacement relieves symptoms of poverty of movement, but often causes drug-induced dyskinesias. Accumulating clinical and pre-clinical evidence suggests that the primary motor cortex (M1) is involved in the pathophysiology of PD and that modulating cortical activity...

journal_title：Neuroscience

authors： Lindenbach D,Conti MM,Ostock CY,Dupre KB,Bishop C

更新日期：2015-12-03 00:00:00

abstract：:In rodents, reproductively relevant pheromonal cues are detected by receptors in the vomeronasal organ, which in turn transmit this information centrally via the accessory olfactory bulb, the medial nucleus of the amygdala, the posterior medial bed nucleus of the stria terminalis and the medial preoptic area. In the r...

journal_title：Neuroscience

authors： Bressler SC,Baum MJ

更新日期：1996-04-01 00:00:00

abstract：:The gp130 cytokines leukemia inhibitory factor and interleukin-6 are neuroactive cytokines associated with peripheral nerve injury. Here we show that exogenous administration of these factors selectively regulates neuropeptide phenotype in intact sensory neurons in a manner consistent with their role as injury-induced...

journal_title：Neuroscience

authors： Thompson SW,Priestley JV,Southall A

更新日期：1998-06-01 00:00:00

abstract：:After experimentally inducing long term changes in transmitter release, a series of frog neuromuscular junctions were studied with intracellular recording and then semi-serially sectioned and examined in the electron microscope. Transmitter release per unit length of motor nerve terminal was well correlated with sever...

journal_title：Neuroscience

authors： Herrera AA,Grinnell AD,Wolowske B

更新日期：1985-11-01 00:00:00

abstract：:Acetylcholinesterase is released from both axon terminals and dendrites of nigrostriatal neurons. The relationship of this phenomenon to: (1) activation of receptors, and (2) firing rate, has been examined. In the first series of experiments, apomorphine or acetylcholine were infused into substantiae nigrae of urethan...

journal_title：Neuroscience

authors： Weston J,Greenfield SA

更新日期：1986-04-01 00:00:00

abstract：:Phospholipids and cholesterol were found to be the main lipids in mature and immature neuroblastoma cells. The ratios for the total cholesterol/phospholipids in these undifferentiated and differentiated cells were 0.33 and 0.52, respectively. The ratios of 0.45 and 0.62 were obtained with corresponding plasma membrane...

journal_title：Neuroscience

authors： Gulaya NM,Volkov GL,Klimashevsky VM,Govseeva NN,Melnik AA

更新日期：1989-01-01 00:00:00

abstract：:Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote vascular remodeling. Whether HMGB1 supports angiogenesis after ICH is unclear, as are the receptors and downstream signaling pathway(s) involved. We used the rat model of collagenase-induced ICH to determine whether HMGB1 a...

journal_title：Neuroscience

authors： Lei C,Zhang S,Cao T,Tao W,Liu M,Wu B

更新日期：2015-06-04 00:00:00

abstract：:Using indirect immunofluorescence technique combined with retrograde tracing as well as surgical lesions, a system of spinothalamic neurons containing both galanin- and cholecystokinin-like immunoreactivity has been defined. The cell bodies are located in the lumbar segments L1-L5 with a preferential localization dors...

journal_title：Neuroscience

authors： Ju G,Melander T,Ceccatelli S,Hökfelt T,Frey P

更新日期：1987-02-01 00:00:00

abstract：:Lesioning of the mammalian striatum with the excitotoxin quinolinic acid results in a pattern of neuropathology that resembles that of post mortem Huntington's disease brain. Certain neurotrophic factors can rescue degenerating cells in a variety of lesion types, including those produced by neurotoxins. Several neurot...

journal_title：Neuroscience

authors： Alexi T,Venero JL,Hefti F

更新日期：1997-05-01 00:00:00