Attenuation of ethanol-induced ataxia by alpha(4)beta(2) nicotinic acetylcholine receptor subtype in mouse cerebellum: a functional interaction.

abstract：:Secretion of neurotrophins is critical for the delivery of neurotrophic support. Brain-derived neurotrophic factor is targeted to a regulated secretory pathway in neurons as well as the neurosecretory AtT-20 cells. Here, we show that pertussis toxin, which inactivates Gi and Go G proteins, inhibits up to 50% of the re...

journal_title：Neuroscience

authors： Gunther EC,von Bartheld CS,Goodman LJ,Johnson JE,Bothwell M

更新日期：2000-01-01 00:00:00

abstract：:We have systematically characterized neuronal survival and growth in cultures derived from newborn/postnatal day 1 mouse cochlea. Dissociated cultures of the cochlear spiral ganglion provide an experimental environment in which to examine molecular mechanisms of survival, development and physiology of auditory neurons...

journal_title：Neuroscience

authors： Whitlon DS,Ketels KV,Coulson MT,Williams T,Grover M,Edpao W,Richter CP

更新日期：2006-01-01 00:00:00

abstract：:Tau hyperphosphorylation leads to formation of paired helical filament/neurofibrillary tangles, the hallmark lesion seen in Alzheimer's disease (AD) brain. An imbalanced regulation in protein kinases and protein phosphatases in the affected neurons is proposed to be a reasonable causative factor to the disease process...

journal_title：Neuroscience

authors： Sun L,Liu SY,Zhou XW,Wang XC,Liu R,Wang Q,Wang JZ

更新日期：2003-01-01 00:00:00

abstract：:Sensorineural hearing loss (SNHL) comprises hearing disorders with diverse pathologies of the inner ear and the auditory nerve. To date, an unambiguous phenotypical characterization of the specific pathologies in an affected individual remains impossible. Here, we evaluated the use of scalp-recorded auditory steady-st...

journal_title：Neuroscience

authors： Pauli-Magnus D,Hoch G,Strenzke N,Anderson S,Jentsch TJ,Moser T

更新日期：2007-11-09 00:00:00

abstract：:Ascending projections from the several nuclei of the medullary reticular formation were examined using the autoradiographic method. The majority of fibers labeled after injections of [3H]leucine into nucleus gigantocellularis ascended within Forel's tractus fasciculorum tegmenti which is located ventrolateral to the m...

journal_title：Neuroscience

authors： Vertes RP,Martin GF,Waltzer R

更新日期：1986-11-01 00:00:00

abstract：:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

journal_title：Neuroscience

authors： Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

更新日期：2013-02-12 00:00:00

abstract：:The guanidine-like compound creatine exerts bioenergetic, antiexcitotoxic, antioxidant and neuroprotective properties; however, the intracellular mechanisms responsible for these effects are still not well established. The purpose of this study was to investigate the protective effect of creatine against 6-hydroxydopa...

journal_title：Neuroscience

authors： Cunha MP,Martín-de-Saavedra MD,Romero A,Parada E,Egea J,Del Barrio L,Rodrigues AL,López MG

更新日期：2013-05-15 00:00:00

abstract：:To examine the effect of glucose on the cerebral metabolism of glutamine, rat brain slices were incubated with 5mM [3-(13)C]glutamine without and with 5mM unlabeled glucose. Tissue plus medium extracts were analyzed by using enzymatic and (13)C NMR techniques and fluxes through the enzymatic steps involved were calcul...

journal_title：Neuroscience

authors： El Hage M,Baverel G,Conjard-Duplany A,Martin G

更新日期：2013-09-17 00:00:00

abstract：:The importance and diversity of calcium signaling in the brain is mirrored by the expression of a multitude of voltage-activated calcium channel (Ca(V)) isoforms. Whereas the overall distributions of alpha(1) subunits are well established, the expression patterns of distinct channel isoforms in specific brain regions ...

journal_title：Neuroscience

authors： Schlick B,Flucher BE,Obermair GJ

更新日期：2010-05-19 00:00:00

abstract：:A diet high in total fat (HF) reduces hippocampal levels of brain-derived neurotrophic factor (BDNF), a crucial modulator of synaptic plasticity, and a predictor of learning efficacy. We have evaluated the capacity of voluntary exercise to interact with the effects of diet at the molecular level. Animal groups were ex...

journal_title：Neuroscience

authors： Molteni R,Wu A,Vaynman S,Ying Z,Barnard RJ,Gómez-Pinilla F

更新日期：2004-01-01 00:00:00

abstract：:Mental function has as its cerebral basis a specific dynamic structure. In particular, cortical and limbic areas involved in "higher brain functions" such as learning, memory, perception, self-awareness and consciousness continuously need to be self-adjusted even after development is completed. By this lifelong self-o...

journal_title：Neuroscience

authors： Arendt T

更新日期：2001-01-01 00:00:00

abstract：:The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [3H]noradrenaline were assessed in rat hippocampus. The effect of nicotinic agonists to induce [3H]noradrenaline release was examined in superfused slices. The nicotinic agonists (-)-epibatidine, (+)-anatoxin-a, ...

journal_title：Neuroscience

authors： Sershen H,Balla A,Lajtha A,Vizi ES

更新日期：1997-03-01 00:00:00

abstract：:The participation of excitatory neurotransmitter systems in the basal ganglia in the initiation and propagation of limbic seizures induced by pilocarpine has been investigated in the rat. Limbic seizures (electrographic and motor) occur in rats receiving bilateral microinjections into the entopeduncular nucleus of 12....

journal_title：Neuroscience

authors： Patel S,De Sarro GB,Meldrum BS

更新日期：1988-12-01 00:00:00

abstract：:Ionotropic glutamate receptors in the substantia nigra pars compacta regulate the activity of dopamine neurons. We have used dual-label immunofluoresence and confocal laser microscopy to study the localization of subunits of two types of ionotropic receptors within the substantia nigra pars compacta of the rat. Immuno...

journal_title：Neuroscience

authors： Albers DS,Weiss SW,Iadarola MJ,Standaert DG

更新日期：1999-03-01 00:00:00

abstract：:Brain-derived neurotrophic factor, basic fibroblast growth factor and des(1-3)-insulin-like growth factor-1, a brain specific form of insulin-like growth factor-1, were analysed, in the rat, for their influence on survival, morphological growth, and transmitter-specific differentiation of dopaminergic neurons in vitro...

journal_title：Neuroscience

authors： Beck KD,Knüsel B,Hefti F

更新日期：1993-02-01 00:00:00

abstract：:Early gestation is a neurodevelopmental period that is especially vulnerable to environmental insult and one in which neurogenesis features prominently. Prenatal perturbation during early gestation has been linked to neuropsychiatric illnesses such as autism and schizophrenia, and severe environmental insult during th...

journal_title：Neuroscience

authors： Selemon LD,Begovic A

更新日期：2020-08-21 00:00:00

abstract：:Prenatal exposures to a variety of infections have been associated with an increased incidence of schizophrenia. We have reported that a single injection of the synthetic cytokine releaser PolyI:C to pregnant mice produced offspring that exhibited multiple schizophrenia-related behavioral deficits in adulthood. Here, ...

journal_title：Neuroscience

authors： Nyffeler M,Meyer U,Yee BK,Feldon J,Knuesel I

更新日期：2006-11-17 00:00:00

abstract：:Cortical auditory evoked potential (CAEP) testing, a non-invasive technique, is widely employed to study auditory brain development. The aim of this study was to investigate the development of the auditory electrophysiological signal without addressing specific abilities such as speech or music discrimination. We were...

journal_title：Neuroscience

authors： Lippé S,Martinez-Montes E,Arcand C,Lassonde M

更新日期：2009-12-15 00:00:00

abstract：:Calpain-mediated tau cleavage into the neurotoxic tau45-230 fragment plays an important role in Alzheimer's disease (AD). This tau fragment accumulates mainly in the cytoplasm of degenerating neurons. However, subcellular localization studies indicated that a pool of tau45-230 associates with the cytoskeleton in hippo...

journal_title：Neuroscience

authors： Afreen S,Ferreira A

更新日期：2019-08-01 00:00:00

abstract：:In mice, the compact hippocampal primordium is formed during the prenatal stage by early-generated neurons that migrate from the lateral ventricular zone. However, despite much being understood about the formation of the hippocampus, the molecular mechanisms that maintain the morphology of the hippocampal primordium a...

journal_title：Neuroscience

authors： Wang HT,Zeng L,Chen Q,Zhang X,Liu JW,Lu TJ,Xiong ZQ,Zheng J,Hu ZL

更新日期：2015-01-22 00:00:00

abstract：:In the present normal anatomical light and electron microscopic study in the rat, histochemical (Nissl, Timm, Golgi) or immunocytochemical (microtubule-associated protein type 2, glutamate decarboxylase, glutamate receptor subunit 1, synaptophysin) stains were used to analyse neurons embedded within the stria terminal...

journal_title：Neuroscience

authors： Alheid GF,Beltramino CA,De Olmos JS,Forbes MS,Swanson DJ,Heimer L

更新日期：1998-06-01 00:00:00

abstract：:The aim of the present work was to determine whether paraventricular neurons possess functional acetylcholine nicotinic receptors. Using infrared videomicroscopy and differential interference contrast optics, we performed whole-cell recordings in hypothalamic slices containing the paraventricular nucleus. Acetylcholin...

journal_title：Neuroscience

authors： Zaninetti M,Tribollet E,Bertrand D,Raggenbass M

更新日期：2002-01-01 00:00:00

abstract：:Recent studies have shown a decrease in glial number and glial fibrillary acidic protein (GFAP) levels in the frontal and cingulate cortices of individuals with mood disorders and schizophrenia. In an attempt to verify and expand these findings we examined GFAP messenger ribonucleic acid (mRNA) levels in postmortem se...

journal_title：Neuroscience

authors： Webster MJ,O'Grady J,Kleinman JE,Weickert CS

更新日期：2005-01-01 00:00:00

abstract：:The electrical activity of 132 neurons located in the inhibitory area of the medullary reticular formation, namely, in the medial aspects of the nucleus reticularis gigantocellularis, magnocellularis and ventralis has been recorded in precollicular decerebrate cats during sinusoidal displacement of the neck. This was ...

journal_title：Neuroscience

authors： Srivastava UC,Manzoni D,Pompeiano O,Stampacchia G

更新日期：1984-02-01 00:00:00

abstract：:Cholinergic interneurons, which provide the main source of acetylcholine (ACh) in the striatum, control the striatal local circuits and deeply involve in the pathogenesis of neurodegenerative diseases. Glycogen synthase kinase-3 (GSK-3) is a crucial kinase with diverse fundamental functions and accepted that deregulat...

journal_title：Neuroscience

authors： Zhao L,Chu CB,Li JF,Yang YT,Niu SQ,Qin W,Hao YG,Dong Q,Guan R,Hu WL,Wang Y

更新日期：2013-01-01 00:00:00

abstract：:We have used the evoked expression of the immediate early gene-encoded proteins (c-Fos, Fos B, Jun B, Jun D, c-Jun and Krox-24) to monitor sensory processing in the hindbrain structures of rats undergoing somatic inflammation. Experiments were performed on freely moving animals that did not experience constraints othe...

journal_title：Neuroscience

authors： Lantéri-Minet M,Weil-Fugazza J,de Pommery J,Menétrey D

更新日期：1994-01-01 00:00:00

abstract：:In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...

journal_title：Neuroscience

authors： van den Pol AN,Spencer DD

更新日期：2000-01-01 00:00:00

abstract：:Persistence of horizontal cell (HC) light responses in extracellular solutions containing low Ca2+ plus divalent cations to block Ca2+ currents (ICa) has been attributed to Ca2+-independent neurotransmission. Using a retinal slice preparation to record both ICa and light responses, we demonstrate that persistence of H...

journal_title：Neuroscience

authors： Cadetti L,Thoreson WB,Piccolino M

更新日期：2004-01-01 00:00:00

abstract：:Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but may involve both neuroinflammation and a dysregulated neuroendocrine stress axis. Thus, the aim ...

journal_title：Neuroscience

authors： Winther G,Elfving B,Müller HK,Lund S,Wegener G

更新日期：2018-09-15 00:00:00

abstract：:The aged dog brain accumulates beta-amyloid in the form of diffuse senile plaques, which provides a potentially useful in vivo model system for studying the events surrounding the deposition of beta-amyloid. We used postembedding immunocytochemistry at the electron microscopic level to determine the subcellular distri...

journal_title：Neuroscience

authors： Torp R,Head E,Milgram NW,Hahn F,Ottersen OP,Cotman CW

更新日期：2000-01-01 00:00:00