Survival and morphology of auditory neurons in dissociated cultures of newborn mouse spiral ganglion.

abstract：:Using antisera raised against neurofilaments and the glial fibrillary acidic protein (GFAP) we have examined the appearance and distribution of neurofilament- and GFAP-like immunoreactivity in the enteric nervous system of rat, mouse and guinea-pig. In whole mounts of the external circular and longitudinal muscle laye...

journal_title：Neuroscience

authors： Björklund H,Dahl D,Seiger A

更新日期：1984-05-01 00:00:00

abstract：:In three rhesus monkeys (Macaca mulatta), the inferior motor cortex was explored by electrical stimulation for sites yielding vocal fold adduction. The retrograde tracer wheat germ-agglutinin-conjugated horseradish peroxidase was injected into the effective sites. Within the forebrain, retrogradely labeled cells were ...

journal_title：Neuroscience

authors： Simonyan K,Jürgens U

更新日期：2005-01-01 00:00:00

abstract：:The lurcher mutation induces Purkinje cell degeneration in heterozygous mice, and neonatal death in homozygous animals. Using the D6Mit16 Simple Sequence Length Polymorphic marker in F2 hybrids between AKR +/+ mice and B6+/Lc mice, homozygous lurcher fetuses and newborns as well as heterozygous and normal littermates ...

journal_title：Neuroscience

authors： Resibois A,Cuvelier L,Goffinet AM

更新日期：1997-09-01 00:00:00

abstract：:Motor effects of bilateral lesions of the globus pallidus induced by quinolinic acid (30 and 60 nmol in 0.5 microl) were investigated in rats. Globus pallidus lesions with 60 nmol quinolinic acid produced a significant reduction of spontaneous motor activity measured by a reduced locomotor activity in an open field an...

journal_title：Neuroscience

authors： Hauber W,Lutz S,Münkle M

更新日期：1998-09-01 00:00:00

abstract：:Acidic fibroblast growth factor (aFGF) is a neurotrophic factor which is a powerful neuroprotective and neuroregenerative factor of the nervous system. Prior study had shown that levels of FGFs significantly increase following ischemic injury, reflecting a physiological protection mechanism. However, few reports demon...

journal_title：Neuroscience

authors： Tsai MJ,Tsai SK,Huang MC,Liou DY,Huang SL,Hsieh WH,Huang WC,Huang SS,Cheng H

更新日期：2015-10-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) can provide noninvasive detection of brain metabolite changes in vivo in Alzheimer's disease (AD). AD is a prevalent neurodegenerative disorder characterized by deposition of β-amyloid peptides (Aβ) in multiple brain regions. Brain-derived neurotrophic factor (BDNF) is a...

journal_title：Neuroscience

authors： Zhang W,Wang PJ,Li MH,Gao XL,Gu GJ,Shao ZH

更新日期：2013-08-15 00:00:00

abstract：:Depolarization-induced transmitter release in synaptosomes prepared from the hippocampus of aged rats is decreased compared with release from young animals. Although the underlying cause of this deficit is not known, some evidence suggests that increased membrane rigidity may contribute to these age-related synaptic c...

journal_title：Neuroscience

authors： McGahon BM,Martin DS,Horrobin DF,Lynch MA

更新日期：1999-01-01 00:00:00

abstract：:The tissues of the large intestine which receive an innervation by neurons of the major pelvic ganglia were identified following in vivo and in vitro anterograde labelling with the lipophilic tracer 1,1'didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate in the male rat. The primary target in the gut of major ...

journal_title：Neuroscience

authors： Luckensmeyer GB,Keast JR

更新日期：1998-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor, basic fibroblast growth factor and des(1-3)-insulin-like growth factor-1, a brain specific form of insulin-like growth factor-1, were analysed, in the rat, for their influence on survival, morphological growth, and transmitter-specific differentiation of dopaminergic neurons in vitro...

journal_title：Neuroscience

authors： Beck KD,Knüsel B,Hefti F

更新日期：1993-02-01 00:00:00

abstract：:A synthetic fragment 31-35 of beta-amyloid peptide was used in cultured cortical neurons to examine whether this smaller sequence could trigger apoptotic degeneration in vitro by using morphological, biochemical and flow-cytometric examinations. The results showed that: (i) neurons treated with fragment 31-35 of beta-...

journal_title：Neuroscience

authors： Yan XZ,Qiao JT,Dou Y,Qiao ZD

更新日期：1999-01-01 00:00:00

abstract：:How obesity exacerbates migraine and other pain disorders remains unknown. Trigeminal nociceptive processing, crucial in migraine pathophysiology, is abnormal in mice with diet induced obesity. However, it is not known if this is also true in genetic models of obesity. We hypothesized that obese mice, regardless of th...

journal_title：Neuroscience

authors： Rossi HL,Raj NR,Marquez de Prado B,Kuburas A,Luu AKS,Barr GA,Recober A

更新日期：2019-09-01 00:00:00

abstract：:GABAB receptors affect short-term signalling in various cell types. However, nothing is known about possible long-term effects on transcription. To analyse such effects in the CNS, we studied GABAB receptor-mediated gene regulation in primary cultures of cerebellar granule neurons. Transcription was followed using a c...

journal_title：Neuroscience

authors： Barthel F,Kienlen Campard P,Demeneix BA,Feltz P,Loeffler JP

更新日期：1996-01-01 00:00:00

abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

journal_title：Neuroscience

authors： Barger SW

更新日期：1999-03-01 00:00:00

abstract：:The widespread distribution of neurons containing alpha-atrial natriuretic polypeptide-like immunoreactivity in the rat brain was demonstrated using radioimmunoassay and immunohistochemistry in conjunction with specific antisera. The highest concentrations of alpha-atrial natriuretic polypeptide-like immunoreactivity ...

journal_title：Neuroscience

authors： Kawata M,Nakao K,Morii N,Kiso Y,Yamashita H,Imura H,Sano Y

更新日期：1985-11-01 00:00:00

abstract：:Pituitary adenylate-cyclase activating polypeptide (PACAP) has been implicated in the (patho)physiology of stress-adaptation. PACAP deficient (PACAP(-/-)) mice show altered anxiety levels and depression-like behavior, but little is known about the underlying mechanisms in stress-related brain areas. Therefore, we aime...

journal_title：Neuroscience

authors： Gaszner B,Kormos V,Kozicz T,Hashimoto H,Reglodi D,Helyes Z

更新日期：2012-01-27 00:00:00

abstract：:In reaction time (RT) tasks, presentation of a startling acoustic stimulus (SAS) together with a visual imperative stimulus can dramatically reduce RT while leaving response execution unchanged. It has been suggested that a prepared motor response program is triggered early by the SAS but is not otherwise affected. Mo...

journal_title：Neuroscience

authors： Tresilian JR,Plooy AM

更新日期：2006-10-13 00:00:00

abstract：:Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P. Recently, axonal transport of opiate receptors was found to increase in rat sciatic nerves in the model of Freund's adjuvant-induc...

journal_title：Neuroscience

authors： Jeanjean AP,Moussaoui SM,Maloteaux JM,Laduron PM

更新日期：1995-09-01 00:00:00

abstract：:The distribution and staining pattern of gamma-aminobutyric acid immunoreactivity have been examined by both light and electron microscopy in the dorsal part of the lateral geniculate nucleus of three reptilian species: the turtle Chinemys reevesi, the lizard Ophisaurus apodus and the snake Vipera aspis. After perfusi...

journal_title：Neuroscience

authors： Rio JP,Reperant J,Ward R,Miceli D,Medina M

更新日期：1992-01-01 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the therapeutic gold standard in Parkinson's disease. However, most patients develop debilitating abnormal involuntary movements termed l-DOPA-induced dyskinesia (LID) as therapy-complicating side effects. The underlying mechanisms of LID pathogenesis are still not fully unders...

journal_title：Neuroscience

authors： Klietz M,Keber U,Carlsson T,Chiu WH,Höglinger GU,Weihe E,Schäfer MK,Depboylu C

更新日期：2016-09-07 00:00:00

abstract：:The dopamine D1 and D2 receptors form the D1-D2 receptor heteromer in a subset of neurons and couple to the Gq protein to regulate intracellular calcium signaling. In the present study the effect of D1-D2 heteromer activation and disruption on neuronal activation in the rat brain was mapped. This was accomplished usin...

journal_title：Neuroscience

authors： Perreault ML,Shen MY,Fan T,George SR

更新日期：2015-01-29 00:00:00

abstract：:Estrogen exerts many of its receptor-mediated neuroprotective functions through the activation of various intracellular signal transduction pathways including the mitogen activating protein kinase (MAPK), phospho inositol-3 kinase and protein kinase C pathways. Here we have used a hippocampal slice culture model of ka...

journal_title：Neuroscience

authors： Goodenough S,Schleusner D,Pietrzik C,Skutella T,Behl C

更新日期：2005-01-01 00:00:00

abstract：:During a critical period in its postnatal development the mammalian visual cortex displays susceptibility to experience-dependent alterations of neuronal response properties. Plasticity represents an integrated set of developmental processes controlled by a transcriptional hierarchy that coordinates the action of many...

journal_title：Neuroscience

authors： Prasad SS,Kojic LZ,Li P,Mitchell DE,Hachisuka A,Sawada J,Gu Q,Cynader MS

更新日期：2002-01-01 00:00:00

abstract：:We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...

journal_title：Neuroscience

authors： Zurgil N,Yarom M,Zisapel N

更新日期：1986-12-01 00:00:00

abstract：:The majority of work examining the nucleus accumbens core (NAc) has focused on functions pertaining to behaviors guided by appetitive outcomes. These studies have pointed to the NAc as being critical for motivating behavior toward desirable outcomes. For example, we have recently shown that lesions of the NAc impaired...

journal_title：Neuroscience

authors： Lichtenberg NT,Kashtelyan V,Burton AC,Bissonette GB,Roesch MR

更新日期：2014-01-31 00:00:00

abstract：:Flies acquire information about self-rotation via Coriolis forces detected by their moving halteres. Information processing in the haltere system was analysed by exploiting the method of simulating rotational stimuli by vibrating the fly's body and simultaneously observing compensatory head and wing reactions. Althoug...

journal_title：Neuroscience

authors： Nalbach G

更新日期：1994-07-01 00:00:00

abstract：:Glutathione S-transferase (GST)-pi is a cytosolic isoenzyme used as a marker for mature oligodendrocytes in the mammalian brain. However, the cellular properties of GST-pi-immunoreactive [GST-pi (+)] cells in adult brain are not completely understood. We immunohistochemically demonstrated the existence of two subtypes...

journal_title：Neuroscience

authors： Tamura Y,Kataoka Y,Cui Y,Takamori Y,Watanabe Y,Yamada H

更新日期：2007-08-24 00:00:00

abstract：:The incidence of anxiety, mood, substance abuse disorders and schizophrenia increases during adolescence. Epidemiological evidence confirms that exposure to stress during sensitive periods of development can create vulnerabilities that put genetically predisposed individuals at increased risk for psychiatric disorders...

journal_title：Neuroscience

authors： Taylor SB,Taylor AR,Koenig JI

更新日期：2013-09-26 00:00:00

abstract：:Acetylcholine release in the frontal cortex of awake rats after acute or chronic lesions of the nucleus basalis magnocellularis and grafting of cholinergic-rich basal forebrain tissue was studied by in vivo microdialysis. Three to four weeks and five months after a unilateral quisqualic acid lesion of the nucleus basa...

journal_title：Neuroscience

authors： Rosenblad C,Nilsson OG

更新日期：1993-07-01 00:00:00

abstract：:To investigate whether the ageing process might affect neuron-target interactions which influence the phenotype of septal cholinergic neurons, we compared the response of these neurons to partial loss of target tissue in young adult and aged animals. Groups of young adult (four to six months) or aged (24-33 months) ma...

journal_title：Neuroscience

authors： Cooper JD,Sofroniew MV

更新日期：1996-11-01 00:00:00

abstract：:Although there is little overlap in core diagnostic criteria for ADHD and Autism Spectrum Disorder (ASD), ASD symptoms are estimated to co-occur in children with ADHD in 20-50% of cases. As motor control deficits are common to both disorders, we investigated the impact of ASD symptoms on ocular motor control in childr...

journal_title：Neuroscience

authors： Connolly AJ,Rinehart NJ,Johnson B,Papadopoulos N,Fielding J

更新日期：2016-10-15 00:00:00