Abstract：
:The majority of work examining the nucleus accumbens core (NAc) has focused on functions pertaining to behaviors guided by appetitive outcomes. These studies have pointed to the NAc as being critical for motivating behavior toward desirable outcomes. For example, we have recently shown that lesions of the NAc impaired performance on a reward-guided decision-making task that required rats to choose between differently valued rewards. Unfortunately, much less is known about the role that the NAc plays in motivating behavior when aversive outcomes are predicted. To address this issue we asked if NAc lesions impact performance on a two-way active avoidance task in which rats must learn to shuttle back and forth in a behavioral training box in order to avoid a footshock predicted by an auditory tone. Although bilateral NAc lesions initially impaired reward-guided decision-making, we found that the same lesions improved acquisition and retention of two-way active avoidance.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Lichtenberg NT,Kashtelyan V,Burton AC,Bissonette GB,Roesch MRdoi
10.1016/j.neuroscience.2013.11.028subject
Has Abstractpub_date
2014-01-31 00:00:00pages
340-6eissn
0306-4522issn
1873-7544pii
S0306-4522(13)00975-5journal_volume
258pub_type
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