当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Induction of homosynaptic long-term depression at spinal synapses of sensory a delta-fibers requires activation of metabotropic glutamate receptors.

Induction of homosynaptic long-term depression at spinal synapses of sensory a delta-fibers requires activation of metabotropic glutamate receptors.

Abstract：

:The synaptic strength between primary afferent Adelta-fibers, many of which convey pain-related information, and second order neurons in the spinal dorsal horn can be depressed for prolonged periods of time in a use- and N-methyl-D-aspartate receptor-dependent fashion. Here, we have used a transverse spinal cord slice-dorsal root preparation of young rat to characterize the nature of this form of long-term depression and the role of metabotropic glutamate receptors. Dorsal roots were bisected and intracellular recordings were made from lamina II neurons with independent excitatory synaptic inputs from both dorsal root halves. Conditioning stimulation of one dorsal root half (1 Hz, 900 pulses) induced long-term depression that was specific for the stimulated pathway, i. e. homosynaptic in nature. The induction of long-term depression was prevented by non-selective group I and group II mGluR antagonist (S)-alpha-methyl-4-carboxyphenylglycine, by selective group I receptor antagonist (S)-4-carboxyphenylglycine and by selective group II mGluR antagonist (RS)-alpha-methylserine-O-phosphate monophenyl ester. Group III mGluR antagonist (RS)-alpha-methylserine-O-phosphate was ineffective. Short-term depression was not affected by any of these antagonists.Thus, a homosynaptic form of long-term depression exists at putative nociceptive synapses in the spinal dorsal horn and its induction requires the activation of both group I and II metabotropic glutamate receptors.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Chen J,Sandkühler J

doi

10.1016/s0306-4522(00)00080-4

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

141-8

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(00)00080-4

journal_volume

98

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Substance P modifies the 6-hydroxydopamine induced alteration of postnatal development of central noradrenaline neurons.

    abstract：:Systemic treatment of new-born rats with the catecholamine neurotoxin 6-hydroxydopamine leads to a permanent and selective alteration of the postnatal development of the central noradrenaline neurons, in particular of the locus coeruleus system. The changes involve a pronounced and permanent degeneration of distant ne...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90113-0

    authors： Jonsson G,Hallman H

    更新日期：1982-01-01 00:00:00

  • Inhibitory Effects of Cyclopiazonic Acid on the Pacemaker Current in Sinoatrial Nodal Cells.

    abstract：OBJECTIVE:The spontaneous action potential of isolated sinoatrial node (SAN) cells is regulated by a coupled-clock system of two clocks: the calcium clock and membrane clock. However, it remains unclear whether calcium clock inhibitors have a direct effect on the membrane clock. The purpose of this study was to investi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.01.018

    authors： Chen Q,Chen JQ,Zhu PL,Wu HL,Xie XT,Dong Y,Xiang GJ,Chen MY,Li Y,Zhang JC

    更新日期：2020-05-01 00:00:00

  • Maintaining stable memory engrams: new roles for Nogo-A in the CNS.

    abstract：:Nogo-A interaction with its different receptors (Nogo receptor 1 (NgR1), S1P receptor 2 (S1PR2), paired immunoglobulin-like receptor B (PirB)) restricts plasticity and growth-dependent processes leading, via the activation of different signaling pathway to the stabilization of the neuronal networks (either development...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.08.030

    authors： Zagrebelsky M,Korte M

    更新日期：2014-12-26 00:00:00

  • Hierarchical Organization Within the Ventral Premotor Cortex of the Macaque Monkey.

    abstract：:Recent studies have revealed that the ventral premotor cortex (PMv) of nonhuman primates plays a pivotal role in various behaviors that require the transformation of sensory cues to appropriate actions. Examples include decision-making based on various sensory cues, preparation for upcoming motor behavior, adaptive se...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2018.04.033

    authors： Kurata K

    更新日期：2018-07-01 00:00:00

  • β functional connectivity modulation during the maintenance of motion information in working memory: importance of the familiarity of the visual context.

    abstract：:The purpose of this study was to examine whether mechanisms, involved during the maintenance of familiar movement information in memory, were influenced by the degree of familiarity of the display in which the movements were embedded. Twelve gymnasts who possessed high visual and motor familiarity with the movements e...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.03.045

    authors： Calmels C,Foutren M,Stam CJ

    更新日期：2012-06-14 00:00:00

  • Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine.

    abstract：:Neuroinflammation is associated with increased vulnerability to diverse psychiatric conditions, including treatment-resistant major depressive disorder (MDD). Here we assessed whether high fat diet (HFD) induced neuroinflammation may be suitable to model a treatment-resistant depressive-like brain state in mice. Male ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.03.003

    authors： Feng M,Crowley NA,Patel A,Guo Y,Bugni SE,Luscher B

    更新日期：2019-05-15 00:00:00

  • Calcium channels controlling acetylcholine release in the guinea-pig isolated anterior pelvic ganglion: an electropharmacological study.

    abstract：:An electropharmacological analysis of the type(s) of calcium channel controlling neurotransmitter release in preganglionic sympathetic nerve terminals in the guinea-pig anterior pelvic ganglion has been carried out. Conventional intracellular recording techniques were used to record excitatory postsynaptic potentials ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00286-9

    authors： Smith AB,Cunnane TC

    更新日期：1999-01-01 00:00:00

  • Phenylethanolamine N-methyltransferase-immunoreactive terminals synapse on adrenal preganglionic neurons in the rat spinal cord.

    abstract：:Adrenergic neurons in the C1 region in the ventrolateral medulla oblongata send descending axons into spinal cord which terminate in thoracic and upper lumbar segments, overlapping the distribution of sympathetic preganglionic neurons. The present study was undertaken to determine whether adrenergic fibers synapse dir...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90099-7

    authors： Bernstein-Goral H,Bohn MC

    更新日期：1989-01-01 00:00:00

  • Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.

    abstract：:Homer is a postsynaptic density (PSD) scaffold protein that is involved in synaptic plasticity, calcium signaling and neurological disorders. Here, we use pre-embedding immunogold electron microscopy to illustrate the differential localization of three Homer gene products (Homer 1, 2, and 3) in different regions of th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.01.066

    authors： Tao-Cheng JH,Thein S,Yang Y,Reese TS,Gallant PE

    更新日期：2014-04-25 00:00:00

  • Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo.

    abstract：:GLE1 mutations cause lethal congenital contracture syndrome 1 (LCCS1), a severe autosomal recessive fetal motor neuron disease, and more recently have been associated with amyotrophic lateral sclerosis (ALS). The gene encodes a highly conserved protein with an essential role in mRNA export. The mechanism linking Gle1 ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.02.039

    authors： Seytanoglu A,Alsomali NI,Valori CF,McGown A,Kim HR,Ning K,Ramesh T,Sharrack B,Wood JD,Azzouz M

    更新日期：2016-05-13 00:00:00

  • Ascorbate modulates pentylenetetrazol-induced convulsions biphasically.

    abstract：:Ascorbate is an antioxidant vitamin that is found in high concentrations in the brain which seems to have neuroprotective properties in some experimental models of excitotoxic neurological disorders, including convulsive behavior and reactive species-related damage. In this study we tested whether ascorbate (30, 100 o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.07.012

    authors： Schneider Oliveira M,Flávia Furian A,Freire Royes LF,Rechia Fighera M,de Carvalho Myskiw J,Gindri Fiorenza N,Mello CF

    更新日期：2004-01-01 00:00:00

  • Immunocytochemical colocalization of GABA-B receptor subunits in gonadotropin-releasing hormone neurons of the sheep.

    abstract：:GABA has been shown to play an important role in the control of gonadotropin-releasing hormone (GnRH) and luteinizing hormone secretion in many mammals. In sheep, seasonal differences in the ability of GABA-B receptor antagonists to alter pulsatile luteinizing hormone secretion have led to the hypothesis that this rec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.03.039

    authors： Sliwowska JH,Billings HJ,Goodman RL,Lehman MN

    更新日期：2006-08-11 00:00:00

  • Redundancy in ascending and descending pathways mediating head turning elicited by entopenducular stimulation in the cat.

    abstract：:Contraversive turning movements of the head were elicited in alert cats by unilateral electrical stimulation of the entopeduncular nucleus. To determine the relative functional importance of ascending and descending pathways activated by the stimulation, the animals were submitted to thalamocortical or midbrain lesion...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90090-8

    authors： Filion M,Hébert R

    更新日期：1983-09-01 00:00:00

  • Effects of early and late neonatal bromocriptine treatment on hypothalamic neuropeptides, dopaminergic reward system and behavior of adult rats.

    abstract：:In humans, bromocriptine (BRO) is used as a treatment for many disorders, such as prolactinomas, even during pregnancy and lactation. Previously we demonstrated that maternal BRO treatment at the end of lactation programs offspring for obesity and several endocrine dysfunctions. Here, we studied the long-term effects ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.03.046

    authors： Carvalho JC,Lisboa PC,de Oliveira E,Peixoto-Silva N,Pinheiro CR,Fraga MC,Claudio-Neto S,Franci CR,Manhães AC,Moura EG

    更新日期：2016-06-14 00:00:00

  • Mechanisms regulating the activity of facial nucleus motoneurones--1. Antidromic activation.

    abstract：:The antidromic activation of facial nucleus montoneurones has been studied in acute experiments on cats by means of extra- and intracellular recording techniques. Time and amplitude characteristics of separate components of the antidromic action potential and the after--potentials accompanying it have been analyzed. A...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90270-1

    authors： Fanardjian VV,Manvelyan LR,Kasabyan SA

    更新日期：1983-08-01 00:00:00

  • Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia.

    abstract：:In the previous study, we observed chronological alterations of glutamic acid decarboxylase (GAD), which is the enzyme converting glutamate into GABA. GAD isoforms (GAD65 and GAD67) differ substantially in their interactions with cofactor pyridoxal 5'-phosphate, which is catalyzed by pyridoxal kinase (PLK). In the pre...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.06.061

    authors： Hwang IK,Yoo KY,Kim DS,Eum WS,Park JK,Park J,Kwon OS,Kang TC,Choi SY,Won MH

    更新日期：2004-01-01 00:00:00

  • Microbial genome dynamics in CNS pathogenesis.

    abstract：:The balancing act between microbes and their host in commensal and disease states needs to be deciphered in order to fully treat and combat infectious diseases. The elucidation of microbial genome dynamics in each instance is therefore required. In this context, the major bacterial meningitis pathogens are Neisseria m...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2007.01.059

    authors： Davidsen T,Koomey M,Tønjum T

    更新日期：2007-04-14 00:00:00

  • Dopamine turnover and metabolism in the striatum of parkinsonian rats grafted with genetically-modified human astrocytes.

    abstract：:The potential of a novel therapeutic approach for treating Parkinson's disease, which involves the transplantation of a transfected human astrocyte cell line SVG-TH, that stably expresses the rate-limiting enzyme for dopamine production, tyrosine hydroxylase, was examined. SVG-TH and untransfected parent cells were gr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00635-0

    authors： Fitoussi N,Sotnik-Barkai I,Tornatore C,Herzberg U,Yadid G

    更新日期：1998-07-01 00:00:00

  • Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation.

    abstract：:A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.09.029

    authors： Pérez M,Ribe E,Rubio A,Lim F,Morán MA,Ramos PG,Ferrer I,Isla MT,Avila J

    更新日期：2005-01-01 00:00:00

  • Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem.

    abstract：:Pontine gray neurons of the brain stem are a major source of mossy fiber (MF) afferents to granule cells of the cerebellum. Achieving this connectivity involves an early regionalization of pontine gray neuron cell bodies within the brainstem pontine nuclei, as well as establishing the proper ratio of crossed versus un...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.082

    authors： Dipietrantonio HJ,Dymecki SM

    更新日期：2009-09-01 00:00:00

  • Differential modulation by tetraethylammonium of the processes underlying network bursting in the neonatal rat spinal cord in vitro.

    abstract：:In the rat spinal cord in vitro, block of synaptic inhibition evokes persistent, regular disinhibited bursting which is a manifestation of the intrinsic network rhythmicity and is readily recorded from ventral roots. This model is advantageous to explore the network mechanisms controlling burst periodicity, and durati...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.03.033

    authors： Taccola G,Nistri A

    更新日期：2007-06-08 00:00:00

  • Dye coupling among immunocytochemically identified neurons in the supraoptic nucleus: increased incidence in lactating rats.

    abstract：:The hypothesis that electrotonic spread among oxytocinergic neurons contributes to synchronized bursting in the lactating rat leads to the prediction that coupling among oxytocinergic neurons would be stronger and more abundant in lactating than in non-lactating animals. We tested this prediction using, as an index of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90047-9

    authors： Hatton GI,Yang QZ,Cobbett P

    更新日期：1987-06-01 00:00:00

  • Membrane resistivity estimated for the Purkinje neuron by means of a passive computer model.

    abstract：:A multicompartment passive electrotonic computer model is constructed for the cerebellar Purkinje cell of the guinea-pig. The model has 1089 coupled compartments to accurately represent the morphology of the Purkinje cell. In order that the calculated behavior of the model fit the published electrophysiological observ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90168-x

    authors： Shelton DP

    更新日期：1985-01-01 00:00:00

  • Carnosine-like immunoreactivity in astrocytes of the glial tubes and in newly-generated cells within the tangential part of the rostral migratory stream of rodents.

    abstract：:In the nervous system, the aminoacylhistidine dipeptide carnosine (beta-alanyl-L-histidine) has been shown to be expressed in the olfactory receptor neurons and in brain astrocytes. Using immunocytochemical techniques, we report here a dense carnosine-like immunoreactivity in the subependymal layer of the rodent foreb...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00596-4

    authors： Peretto P,Bonfanti L,Merighi A,Fasolo A

    更新日期：1998-07-01 00:00:00

  • Control of rat hypothalamic pro-opiomelanocortin neurons by a circadian clock that is entrained by the daily light-off signal.

    abstract：:Previous studies have clearly demonstrated that the immediate-early gene, c-fos can regulate, through its protein product Fos, the expression of the pro-opiomelanocortin gene. In the present study, immunohistochemistry for Fos and beta-endorphin was used to assess the basal activity of hypothalamic pro-opiomelanocorti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00208-0

    authors： Jamali KA,Tramu G

    更新日期：1999-01-01 00:00:00

  • Increased levels and activity of cathepsins B and D in kainate-induced toxicity.

    abstract：:Administration of kainic acid induces acute seizures that result in the loss of neurons, gliosis and reorganization of mossy fiber pathways in the hippocampus resembling those observed in human temporal lobe epilepsy. Although these structural changes have been well characterized, the mechanisms underlying the degener...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.10.003

    authors： Banerjee M,Sasse VA,Wang Y,Maulik M,Kar S

    更新日期：2015-01-22 00:00:00

  • Noradrenergic regulation of period1 expression in spinal astrocytes is involved in protein kinase A, c-Jun N-terminal kinase and extracellular signal-regulated kinase activation mediated by α1- and β2-adrenoceptors.

    abstract：:Our recent data suggest that noradrenaline (NA) regulates expression of Per1 mRNA in rat C6 cells, as a model of brain astrocytes, by two distinct NA-mediating pathways. Although C6 cells possess potential astrocyte-type characteristics, we hypothesize that astrocytes located in a distinct tissue or organ play specifi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.04.024

    authors： Sugimoto T,Morioka N,Sato K,Hisaoka K,Nakata Y

    更新日期：2011-06-30 00:00:00

  • Role of blood-brain barrier in temporal lobe epilepsy and pharmacoresistance.

    abstract：:Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is often initiated by an insult or brain injury which triggers a series of alterations which ultimately lead to seizures (epilepsy). In 50-70% of people with TLE the condition cannot be adequately treated by the present antiepilepti...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.07.030

    authors： van Vliet EA,Aronica E,Gorter JA

    更新日期：2014-09-26 00:00:00

  • A strategy of faster movements used by elderly humans to lift objects of increasing weight in ecological context.

    abstract：:It is not known whether, during the course of aging, changes occur in the motor strategies used by the CNS for lifting objects of different weights. Here, we analyzed the kinematics of object-lifting in two different healthy groups (young and elderly people) plus one well-known deafferented patient (GL). The task was ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.04.010

    authors： Hoellinger T,McIntyre J,Jami L,Hanneton S,Cheron G,Roby-Brami A

    更新日期：2017-08-15 00:00:00

  • Tropism and corticospinal target selection in the rat.

    abstract：:Layer V pyramidal cells in the intermediate part of the cerebral cortex enter the lumbar spinal gray, but not the cervical spinal gray matter, during the first postnatal week. To study if the ingrowth of intermediate corticospinal axons into the lumbar spinal gray is guided by a diffusible tropic factor, we co-culture...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90096-5

    authors： Joosten EA,Gispen WH,Bär PR

    更新日期：1994-03-01 00:00:00