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Dye coupling among immunocytochemically identified neurons in the supraoptic nucleus: increased incidence in lactating rats.

Abstract：

:The hypothesis that electrotonic spread among oxytocinergic neurons contributes to synchronized bursting in the lactating rat leads to the prediction that coupling among oxytocinergic neurons would be stronger and more abundant in lactating than in non-lactating animals. We tested this prediction using, as an index of electrical coupling, transfer among neurons of the fluorescent dye Lucifer Yellow CH, which crosses gap junctions. Intracellular injections (total of 159) of the dye were made in supraoptic nucleus neurons in hypothalamic slices from virgin female and lactating rats. In virgins, 86 injections resulted in 76 single, 8 coupled pairs and 2 triplets of dye-filled neurons. In contrast, 73 injections in lactators yielded 51 single, 16 coupled pairs and 6 triplets, (greater than 100% increase) a difference significant at P less than 0.001. Immunocytochemical identification of the dye-filled cells revealed that there was an increase over virgins in coupling among both oxytocinergic and vasopressinergic neurons. These results are consistent with the hypothesis that electrical coupling is involved in synchronizing oxytocin cell bursting in lactators. They are also consistent with published data indicating that vasopressin neurons are metabolically activated (show increased glucose uptake) during suckling and may show correlated activity.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Hatton GI,Yang QZ,Cobbett P

doi

10.1016/0306-4522(87)90047-9

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

923-30

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(87)90047-9

journal_volume

21

pub_type

杂志文章

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