Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats.

abstract：:In the dog cerebral cortex and spinal cord, [3H]bremazocine and [3H]U69593 both bound with high affinity to an apparent single population of binding sites under kappa-selective conditions. In the cortex similar Bmax values for both radioligands in the saturation studies and the high affinity of the kappa-selective age...

journal_title：Neuroscience

authors： Hunter JC,Birchmore B,Woodruff R,Hughes J

更新日期：1989-01-01 00:00:00

abstract：:Astrocyte hypertrophy and swelling occur in a variety of pathophysiological conditions, including diseases associated with hyperammonemia. Ammonia is rapidly incorporated into glutamine by glutamine synthetase localized in astrocytes. We tested the hypotheses that (1) 6 h of hyperammonemia (500-600 microM) is adequate...

journal_title：Neuroscience

authors： Willard-Mack CL,Koehler RC,Hirata T,Cork LC,Takahashi H,Traystman RJ,Brusilow SW

更新日期：1996-03-01 00:00:00

abstract：:Relay cells of dorsal lateral geniculate nucleus (LGN) receive a Class 1 glutamatergic input from the retina and a Class 2 input from cortical layer 6. Among the properties of Class 2 synapses is the ability to activate metabotropic glutamate receptors (mGluRs), and mGluR activation is known to affect thalamocortical ...

journal_title：Neuroscience

authors： Lam YW,Sherman SM

更新日期：2013-07-09 00:00:00

abstract：:In mammals, the extraocular muscle fibers can be categorized in singly-innervated and multiply-innervated muscle fibers. In the monkey oculomotor, trochlear and abducens nucleus the motoneurons of multiply-innervated muscle fibers lie separated from those innervating singly-innervated muscle fibers and show different ...

journal_title：Neuroscience

authors： Eberhorn AC,Büttner-Ennever JA,Horn AK

更新日期：2006-02-01 00:00:00

abstract：:The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI) is a measure of sensorimotor gating which is a basic process whereby...

journal_title：Neuroscience

authors： Marks WN,Greba Q,Cain SM,Snutch TP,Howland JG

更新日期：2016-09-22 00:00:00

abstract：:The hypocretin/orexin system regulates, among other things, sleep and energy homeostasis. The system is likely regulated by both homeostatic and circadian mechanisms. Little is known about local differences in the regulation of hypocretin activity. The aim of this study was to establish an optimized peptide quantifica...

journal_title：Neuroscience

authors： Justinussen JL,Holm A,Kornum BR

更新日期：2015-12-03 00:00:00

abstract：:This study shows that the neurons of the entopeduncular nucleus are derived from a longitudinal slab of isochronically generated neurons on day 11 and 15 h of gestation. Many neurons of this longitudinal slab which we have named the basal forebrain cell column, originate from an ependymal matrix closely associated wit...

journal_title：Neuroscience

authors： Marchand R,Lajoie L,Blanchet C

更新日期：1986-03-01 00:00:00

abstract：:The cerebellum, which controls coordinated and rapid movements, is a potential target for the deleterious effects of drugs of abuse including cannabis (i.e. marijuana, cannabinoids). Prenatal exposure to cannabinoids has been documented to cause abnormalities in motor and cognitive development, but the exact mechanism...

journal_title：Neuroscience

authors： Shabani M,Hosseinmardi N,Haghani M,Shaibani V,Janahmadi M

更新日期：2011-01-13 00:00:00

abstract：:Neurofibrillary tangles in Alzheimer's disease are composed of hyperphosphorylated forms of the microtubule-associated protein tau. Based on biochemical criteria, several enzymes have emerged as potential tau protein kinases, including the extracellularly regulated kinases 1, 2 and 3. In situ hybridization was used to...

journal_title：Neuroscience

authors： Hollister RD,Page KJ,Hyman BT

更新日期：1997-08-01 00:00:00

abstract：:In an attempt to improve the survival of implanted dopamine cells, we have readdressed the optimal embryonic donor age for dopamine grafts. In a rat model of Parkinson's disease, animals with unilateral 6-hydroxydopamine lesions of the median forebrain bundle received dopamine-rich ventral mesencephalic grafts derived...

journal_title：Neuroscience

authors： Torres EM,Monville C,Gates MA,Bagga V,Dunnett SB

更新日期：2007-06-08 00:00:00

abstract：:Immunosuppression remains a key issue in neural transplantation. Systemic administration of cyclosporin-A is currently widely used but has many severe adverse side effects. Newer immunosuppressive agents, such as tacrolimus (TAC) and rapamycin (RAPA), have been investigated for their neuroprotective properties on dopa...

journal_title：Neuroscience

authors： Alemdar AY,Sadi D,McAlister V,Mendez I

更新日期：2007-04-25 00:00:00

abstract：:Examination of spontaneous miniature endplate potentials (MEPPs) in murine skeletal muscle has revealed that in conditions such as botulinum poisoning, during nerve terminal regeneration or in the presence of the drug 4-aminoquinoline, two types of acetylcholine release are responsible for the MEPPs. In addition to th...

journal_title：Neuroscience

authors： Thesleff S,Molgó J

更新日期：1983-05-01 00:00:00

abstract：:Activation of poly (ADP-ribose) polymerases (PARP) contributes to ischemic damage by causing neuronal nicotinamide adenine dinucleotide (NAD(+)) depletion, release of apoptosis-inducing factor and consequent caspase-independent cell death. PARP-mediated cell death is sexually dimorphic, participating in ischemic damag...

journal_title：Neuroscience

authors： Vagnerova K,Liu K,Ardeshiri A,Cheng J,Murphy SJ,Hurn PD,Herson PS

更新日期：2010-03-17 00:00:00

abstract：:Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striaton...

journal_title：Neuroscience

authors： Ghorayeb I,Fernagut PO,Hervier L,Labattu B,Bioulac B,Tison F

更新日期：2002-01-01 00:00:00

abstract：:The immediate-early gene encoded transcription factor c-Jun is highly inducible following axotomy and therefore serves as a valuable marker in neuronal de- and regeneration. As the signals that may trigger c-Jun expression are still obscure, molecules derived from lesioned neurons and/or their targets such as growth f...

journal_title：Neuroscience

authors： Blottner D,Herdegen T

更新日期：1998-01-01 00:00:00

abstract：:Capsaicin, a neurotoxin which depletes substance P from primary afferent nerve fibres, was injected systematically into adult guinea pigs. The effects of capsaicin were studied by immunohistochemistry, electron microscopy and radioimmunoassay at times from 5 min to 1 year. Within 5 min after a single injection of caps...

journal_title：Neuroscience

authors： Papka RE,Furness JB,Della NG,Murphy R,Costa M

更新日期：1984-08-01 00:00:00

abstract：:Endothelins play a role in the regulation of astrocytic functions in brain pathologies such as hyperplasia and neurotrophic factor production. The present study examined the effects of endothelins on production of neurotrophin-3, a member of the neurotrophin family of neurotrophic factors, in cultured astrocytes and r...

journal_title：Neuroscience

authors： Koyama Y,Baba A,Matsuda T

更新日期：2005-01-01 00:00:00

abstract：:Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote vascular remodeling. Whether HMGB1 supports angiogenesis after ICH is unclear, as are the receptors and downstream signaling pathway(s) involved. We used the rat model of collagenase-induced ICH to determine whether HMGB1 a...

journal_title：Neuroscience

authors： Lei C,Zhang S,Cao T,Tao W,Liu M,Wu B

更新日期：2015-06-04 00:00:00

abstract：:Fetal striatal transplantation has emerged as a new therapeutic strategy in Huntington's disease (HD). Hypoxia is one of the microenvironmental stress conditions to which fetal tissue is exposed as soon as it is isolated and transplanted into the diseased host brain. Mechanisms that support neuroblast survival and rep...

journal_title：Neuroscience

authors： Ambrosini S,Sarchielli E,Comeglio P,Porfirio B,Gallina P,Morelli A,Vannelli GB

更新日期：2015-03-19 00:00:00

abstract：:Thrombin plays important roles in the pathology of intracerebral hemorrhage (ICH). The recruitment of activated microglia, accompanied by thrombin-induced phosphorylation of the mitogen-activated protein kinase (MAPK) family, contributes to ICH-associated neuron loss. Here we investigated the possibility that sesamin,...

journal_title：Neuroscience

authors： Ohnishi M,Monda A,Takemoto R,Matsuoka Y,Kitamura C,Ohashi K,Shibuya H,Inoue A

更新日期：2013-03-01 00:00:00

abstract：:Hippocampal oscillations, particularly theta (6-12 Hz) and gamma (30-90 Hz) frequency bands, play an important role in several cognitive functions. Theta and gamma oscillations show cross-frequency coupling (CFC), wherein the phase of theta rhythm modulates the amplitude of the gamma oscillation, and this CFC is belie...

journal_title：Neuroscience

authors： Nakazono T,Takahashi S,Sakurai Y

更新日期：2019-08-01 00:00:00

abstract：:Synapse specific differences in NR2 subunit expression exist in several systems within the mammalian CNS. Here we have studied such differences on motoneurons in the neonatal rat cord using ifenprodil known to inhibit voltage-, use- and glycine-independent responses mediated by NR2B-containing N-methyl-d-aspartate rec...

journal_title：Neuroscience

authors： Shanthanelson M,Mendell LM

更新日期：2010-03-17 00:00:00

abstract：PURPOSE:This study aimed to clarify whether ischemia-induced early growth response 1 (EGR1) influenced the outcomes of experimental stroke by regulating brain-derived neurotrophic factor (BDNF) expression. METHODS AND RESULTS:To mimic ischemia, mice were subjected to middle cerebral artery occlusion, and neurons chall...

journal_title：Neuroscience

authors： Yang L,Jiang Y,Wen Z,Xu X,Xu X,Zhu J,Xie X,Xu L,Xie Y,Liu X,Xu G

更新日期：2015-04-02 00:00:00

abstract：:Neuronal loss is the most common and critical feature of a spectrum of brain traumas and neurodegenerative disorders such as Alzheimer's disease (AD). The capacity to generate new neurons in the central nervous system diminishes early during brain development and is restricted mainly to two brain areas in the mature b...

journal_title：Neuroscience

authors： Yeung ST,Myczek K,Kang AP,Chabrier MA,Baglietto-Vargas D,Laferla FM

更新日期：2014-02-14 00:00:00

abstract：:The coordinate representation of the sense of limb orientation was investigated psychophysically by asking subjects to match the orientation of the arm or of the forearm in several different coordinate representations. Movement of all degrees of freedom of one arm was permitted while movement of the other limb was res...

journal_title：Neuroscience

authors： Soechting JF,Ross B

更新日期：1984-10-01 00:00:00

abstract：:Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...

journal_title：Neuroscience

authors： Zibman S,Shpak G,Wagner S

更新日期：2011-08-25 00:00:00

abstract：:In a complex linguistic environment, while speech sounds can greatly vary, some shared features are often invariant. These invariant features constitute so-called abstract auditory rules. Our previous study has shown that with auditory sensory intelligence, the human brain can automatically extract the abstract audito...

journal_title：Neuroscience

authors： Guo XT,Wang XD,Liang XY,Wang M,Chen L

更新日期：2018-02-21 00:00:00

abstract：:In the present study the time-course of DNA fragmentation following insulin-induced hypoglycemia was examined. In situ localization of DNA breaks were studied by the terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labelling method, and the temporal profile of DNA-fragmentation ...

journal_title：Neuroscience

authors： Ferrand-Drake M,Friberg H,Wieloch T

更新日期：1999-01-01 00:00:00

abstract：:The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie vol...

journal_title：Neuroscience

authors： Fukushiro DF,Olivera A,Liu Y,Wang Z

更新日期：2015-10-29 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and affects the CNS. Dystrophin is absent in muscle and CNS of both DMD patients and mdx mouse, a model of DMD. While the involvement of vascular compartment in DMD was poorly investigated, some studies suggested a role for mast cells (MC). Tryp...

journal_title：Neuroscience

authors： Nico B,Marzullo A,Corsi P,Vacca A,Roncali L,Ribatti D

更新日期：2004-01-01 00:00:00