Abstract:
:Duchenne muscular dystrophy (DMD) is characterized by muscle degeneration and affects the CNS. Dystrophin is absent in muscle and CNS of both DMD patients and mdx mouse, a model of DMD. While the involvement of vascular compartment in DMD was poorly investigated, some studies suggested a role for mast cells (MC). Tryptase, contained in the MC granules, stimulates angiogenesis in vitro and in vivo. We demonstrated for the first time a correlation between the extent of angiogenesis and the number of tryptase-positive neurons and microvessels and suggest that the tryptase contained in the neurons and in the endothelial cells of the mdx mouse brain may be involved in the regulation of angiogenesis taking place in mdx mouse.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Nico B,Marzullo A,Corsi P,Vacca A,Roncali L,Ribatti Ddoi
10.1016/j.neuroscience.2003.11.006keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
585-8issue
3eissn
0306-4522issn
1873-7544pii
S0306452203008558journal_volume
123pub_type
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