Over-expressed EGR1 may exaggerate ischemic injury after experimental stroke by decreasing BDNF expression.

abstract：:The cellular origin and degree of collateralization of the subcortical afferents to the caudate nucleus and the putamen in squirrel monkeys (Saimiri sciureus) were studied using the following combinations of fluorescent retrograde tracers: Evans blue and DAPI-Primuline, Fast blue and Nuclear yellow, True blue and Nucl...

journal_title：Neuroscience

authors： Parent A,Mackey A,De Bellefeuille L

更新日期：1983-12-01 00:00:00

abstract：:The 2-deoxyglucose metabolic mapping technique has been used to investigate the neural mechanisms which underlie the symptoms of Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. In six cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was either (a) ...

journal_title：Neuroscience

authors： Mitchell IJ,Clarke CE,Boyce S,Robertson RG,Peggs D,Sambrook MA,Crossman AR

更新日期：1989-01-01 00:00:00

abstract：:Long-term treatment with diazepam, a full allosteric modulator of the GABA(A) receptor, results in tolerance to its anticonvulsant effects, whereas an equipotent treatment with the partial allosteric modulator imidazenil does not produce tolerance. Use of subunit-specific antibodies linked to gold particles allowed an...

journal_title：Neuroscience

authors： Pesold C,Caruncho HJ,Impagnatiello F,Berg MJ,Fritschy JM,Guidotti A,Costa E

更新日期：1997-07-01 00:00:00

abstract：:Adverse environments during early life may lead to different neurophysiological and behavioral consequences, including depression and learning and memory deficits that persist into adulthood. Previously, we demonstrated that exposure to an enriched environment during adolescence mitigates the cognitive impairment obse...

journal_title：Neuroscience

authors： Cordier JM,Aguggia JP,Danelon V,Mir FR,Rivarola MA,Mascó D

更新日期：2021-01-15 00:00:00

abstract：:Rats were systemically pre-treated with capsaicin either on the first day of life or at an age of 1 month. Both treatments were found to deplete substance P levels in the trigeminal nucleus caudalis (55.6% and 57.9% depletions, respectively). Extracellular single neurone recordings in the trigeminal nucleus caudalis r...

journal_title：Neuroscience

authors： Salt TE,Crozier CS,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR. Its association with mental disorders has been identified, but its function in disease development is largely unknown. Long-term potentiation (LTP) is a functiona...

journal_title：Neuroscience

authors： Qiu B,Xu Y,Wang J,Liu M,Dou L,Deng R,Wang C,Williams KE,Stewart RB,Xie Z,Ren W,Zhao Z,Shou W,Liang T,Yong W

更新日期：2019-03-15 00:00:00

abstract：:The identification of leptin and a range of novel anorectic and orexigenic peptides has focussed attention on the neural circuitry involved in the genesis of food intake and the reflex control of thermogenesis. Here, the neurotropic virus pseudorabies has been utilised in conjunction with the immunocytochemical locali...

journal_title：Neuroscience

authors： Oldfield BJ,Giles ME,Watson A,Anderson C,Colvill LM,McKinley MJ

更新日期：2002-01-01 00:00:00

abstract：:Alterations in the brain that contribute to the development of epilepsy, also called epileptogenesis, are not well understood, which makes it difficult to develop strategies for preventing epilepsy. Here we have studied the role of the CRE binding transcription factors, cyclic-AMP responsive element modulator (CREM) a...

journal_title：Neuroscience

authors： Porter BE,Lund IV,Varodayan FP,Wallace RW,Blendy JA

更新日期：2008-03-27 00:00:00

abstract：:Selective replacement of degenerated neurons in the adult brain with allogeneic fetal neuroblasts is a promising therapeutic modality for human neurodegenerative diseases, but is confounded with practical and potential ethical problems. To evaluate the potential of xenogeneic donors as a cell source for neural transpl...

journal_title：Neuroscience

authors： Pakzaban P,Isacson O

更新日期：1994-10-01 00:00:00

abstract：:The present study was undertaken to quantify selected neuropeptides (thyrotropin releasing hormone, substance P, methionine and leucine enkephalin) in the cervical spinal cord and other regions of the central nervous system of Wobbler mice by radioimmunoassays during several stages of the motoneuron disease compared w...

journal_title：Neuroscience

authors： Yung KK,Tang F,Fielding R,Du YH,Vacca-Galloway LL

更新日期：1992-09-01 00:00:00

abstract：:The recognition molecule myelin-associated glycoprotein is expressed by oligodendrocytes, the myelinating cells of the central nervous system. The myelin-associated glycoprotein gene gives rise to two alternatively spliced transcript variants ("early" and "late" message) which are developmentally regulated. In this st...

journal_title：Neuroscience

authors： Kirchhoff F,Ohlemeyer C,Kettenmann H

更新日期：1997-05-01 00:00:00

abstract：:We have examined the relationship between brain-derived neurotrophic factor gene expression in the hippocampus and memory retention as well as long-term potentiation of rats. One-way inhibitory avoidance learning was adopted as the behavioural paradigm. Results revealed that brain-derived neurotrophic factor messenger...

journal_title：Neuroscience

authors： Ma YL,Wang HL,Wu HC,Wei CL,Lee EH

更新日期：1998-02-01 00:00:00

abstract：:Sodium-dependent high-affinity amino-acid transporters play crucial roles in terminating synaptic transmission in the central nervous system (CNS). However, there is lack of information about the mechanisms underlying the regulation of amino-acid transport by fast-acting neuromodulators, like ATP. Here, we investigate...

journal_title：Neuroscience

authors： Barros-Barbosa AR,Lobo MG,Ferreirinha F,Correia-de-Sá P,Cordeiro JM

更新日期：2015-10-15 00:00:00

abstract：:Retinitis pigmentosa (RP) is a heterogeneous group of retinal degenerative diseases in which the final pathological feature is photoreceptor cell apoptosis. Currently, the pathogenesis of RP remains poorly understood and therapeutics are ineffective. 17β-Oestradiol (βE2) is universally acknowledged as a neuroprotectiv...

journal_title：Neuroscience

authors： Xiong YC,Chen T,Yang XB,Deng CL,Ning QL,Quan R,Yu XR

更新日期：2021-01-01 00:00:00

abstract：:Since functional imaging of whole body movements is not feasible with functional magnetic resonance imaging (fMRI), the present study presents in vivo functional near-infrared spectroscopy (fNIRS) as a suitable technique to measure body movement effects on fronto-temporo-parietal cortical activation in single- and dua...

journal_title：Neuroscience

authors： Metzger FG,Ehlis AC,Haeussinger FB,Schneeweiss P,Hudak J,Fallgatter AJ,Schneider S

更新日期：2017-02-20 00:00:00

abstract：:Theta frequency oscillation of the septo-hippocampal system has been considered as a prominent activity associated with cognitive function and affective processes. It is well documented that anxiolytic drugs diminish septo-hippocampal oscillatory Theta activity contributing to their either therapeutic or unwanted side...

journal_title：Neuroscience

authors： Hajós M,Hoffmann WE,Orbán G,Kiss T,Erdi P

更新日期：2004-01-01 00:00:00

abstract：:Ablation of capsaicin-sensitive afferent neurons enhances experimentally induced ulceration in the rat gastric mucosa, which suggests that these neurons are involved in gastric mucosal protection. To provide direct evidence for such a function it was investigated whether stimulation of afferent nerve endings by the in...

journal_title：Neuroscience

authors： Holzer P,Lippe IT

更新日期：1988-12-01 00:00:00

abstract：:The antidromic activation of facial nucleus montoneurones has been studied in acute experiments on cats by means of extra- and intracellular recording techniques. Time and amplitude characteristics of separate components of the antidromic action potential and the after--potentials accompanying it have been analyzed. A...

journal_title：Neuroscience

authors： Fanardjian VV,Manvelyan LR,Kasabyan SA

更新日期：1983-08-01 00:00:00

abstract：:Hippocampal neurogenesis and associated cognitive behaviors are regulated by a number of factors including stress, inflammation, and exercise. However, the interplay between these factors remains relatively unexplored, especially across the lifespan. In the current study, the effect of social isolation stress during t...

journal_title：Neuroscience

authors： Hueston CM,Cryan JF,Nolan YM

更新日期：2017-12-04 00:00:00

abstract：:The localization of glycine receptors in the rat brain was examined by means of in situ hybridization histochemistry using an oligonucleotide probe to the sequence of the alpha 1 subunit. Strongly- or moderately-labeled neurons were found in the cranial nuclei, sensory nuclei such as the spinal trigeminal nucleus, pri...

journal_title：Neuroscience

authors： Sato K,Zhang JH,Saika T,Sato M,Tada K,Tohyama M

更新日期：1991-01-01 00:00:00

abstract：:Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons and control the synthesis, release and uptake of dopamine. These Gi/o-coupled inhibitory receptors play a major part in shaping dopamine transmission. Found at both somatodendritic and axonal sites, autoreceptors regulate the firi...

journal_title：Neuroscience

authors： Ford CP

更新日期：2014-12-12 00:00:00

abstract：:The mechanical response of human m. flexor pollicis longus to slow (3.2 degrees/s) linear stretch by 5.5 degrees was measured during sustained (45-60 s, 9-13.5 p.p.s.) unfused tetanus evoked by electrical stimulation. The stiffness increased during unfused tetanus. At the late phase of unfused tetanus it was 1.8 +/- 0...

journal_title：Neuroscience

authors： Gurfinkel VS,Ivanenko YP,Levik YS

更新日期：1997-09-01 00:00:00

abstract：:Quantitative autoradiography of [3H]SCH 23390 and [3H](-)-sulpiride binding was performed in the brain of rats of various ages (3, 11 and 24 months) in order to study the changes in D1 and D2 receptor density with age. Binding of [3H]SCH 23390 in the caudate-putamen decreased progressively and markedly at rostral leve...

journal_title：Neuroscience

authors： Morelli M,Mennini T,Cagnotto A,Toffano G,Di Chiara G

更新日期：1990-01-01 00:00:00

abstract：:The effects of two benzodiazepines, diazepam and triazolam, on long-term potentiation were tested in slices of hippocampus and piriform cortex. The drugs had little influence on baseline synaptic responses but both were very effective in blocking LTP elicited by theta pattern stimulation. The effects were fully revers...

journal_title：Neuroscience

authors： del Cerro S,Jung M,Lynch G

更新日期：1992-07-01 00:00:00

abstract：:Acetylcholine (ACh) plays important roles in the modulation of activity and plasticity of primary sensory cortices, thus influencing sensory detection and integration. We examined this in urethane-anesthetized rats, comparing cholinergic modulation of short latency, large amplitude field postsynaptic potentials (fPSPs...

journal_title：Neuroscience

authors： Kuo MC,Rasmusson DD,Dringenberg HC

更新日期：2009-09-29 00:00:00

abstract：:Astrocytic endothelin receptors are involved in the appearance of activated astrocytes upon injury of the brain [Ishikawa N. et al. (1997) Eur. J. Neurosci. 9, 895-901; Koyama Y. et al. (1999) Glia 26, 268-271]. To clarify signal transduction triggered by endothelin receptors, we examined the effects of endothelins on...

journal_title：Neuroscience

authors： Koyama Y,Yoshioka Y,Hashimoto H,Matsuda T,Baba A

更新日期：2000-01-01 00:00:00

abstract：:We tested the hypothesis that efferents from the nucleus basalis magnocellularis (NBM) play a direct role in the regulation of neuropeptide synthesis and expression by neurons of the rat suprachiasmatic nucleus (SCN). Adult male rats in which the NBM was destroyed with quinolinic acid, either unilaterally or bilateral...

journal_title：Neuroscience

authors： Madeira MD,Pereira PA,Silva SM,Cadete-Leite A,Paula-Barbosa MM

更新日期：2004-01-01 00:00:00

abstract：:The neuropeptide substance P is an excitatory neurotransmitter produced by various cells including neurons and microglia that is involved in regulating inflammation and cerebral blood flow--functions that affect sleep and slow-wave activity (SWA). Substance P is the major ligand for the neurokinin-1 receptor (NK-1R), ...

journal_title：Neuroscience

authors： Zielinski MR,Karpova SA,Yang X,Gerashchenko D

更新日期：2015-01-22 00:00:00

abstract：:Autotomy in experimental animals following peripheral nerve section has been interpreted as a sign of pain corresponding to the chronic pain observed in patients with extensive nerve lesions. Such pain may be alleviated by spinal cord stimulation. In the present study, the effect of such stimulation, via chronically i...

journal_title：Neuroscience

authors： Gao XX,Ren B,Linderoth B,Meyerson BA

更新日期：1996-11-01 00:00:00

abstract：:GABAergic neurons occur in the myenteric plexus and submucosa and their innervations of the gut, where GABA stimulates motor neurons, and non-neural cells via "central type" GABA(A) receptors. These receptors occur on half of the neurons in the rat intestine. The GABA(A) receptor is a ligand-gated chloride channel con...

journal_title：Neuroscience

authors： Poulter MO,Singhal R,Brown LA,Krantis A

更新日期：1999-01-01 00:00:00