Localization of glycine receptor alpha 1 subunit mRNA-containing neurons in the rat brain: an analysis using in situ hybridization histochemistry.

abstract：:It has been suggested that not only mesostriatal but also mesolimbic pathways are involved in the degeneration of dopaminergic neurons in Parkinson's disease. Using quantitative ligand autoradiography we have investigated dopamine transporter sites in basal ganglia of patients affected by Huntington's chorea, Parkinso...

journal_title：Neuroscience

authors： Chinaglia G,Alvarez FJ,Probst A,Palacios JM

更新日期：1992-07-01 00:00:00

abstract：:Recent studies using DNA fragmentation assays suggest a role for apoptosis in cell death in Huntington's disease. In this study, we investigated the relationship between the degree of DNA fragmentation and the number of trinucleotide (CAG) repeats of the Huntington's disease gene in striatal tissue from Huntington's d...

journal_title：Neuroscience

authors： Butterworth NJ,Williams L,Bullock JY,Love DR,Faull RL,Dragunow M

更新日期：1998-11-01 00:00:00

abstract：:After experimentally inducing long term changes in transmitter release, a series of frog neuromuscular junctions were studied with intracellular recording and then semi-serially sectioned and examined in the electron microscope. Transmitter release per unit length of motor nerve terminal was well correlated with sever...

journal_title：Neuroscience

authors： Herrera AA,Grinnell AD,Wolowske B

更新日期：1985-11-01 00:00:00

abstract：:Previous studies from our laboratory and others have shown that there are major age-related differences in brainstem neuronal function. Since GABAA receptors are major targets for GABA-mediated inhibitory modulation and play a key role in regulating cardiorespiratory function, especially during O2 deprivation, we exam...

journal_title：Neuroscience

authors： Xia Y,Haddad GG

更新日期：1992-08-01 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the therapeutic gold standard in Parkinson's disease. However, most patients develop debilitating abnormal involuntary movements termed l-DOPA-induced dyskinesia (LID) as therapy-complicating side effects. The underlying mechanisms of LID pathogenesis are still not fully unders...

journal_title：Neuroscience

authors： Klietz M,Keber U,Carlsson T,Chiu WH,Höglinger GU,Weihe E,Schäfer MK,Depboylu C

更新日期：2016-09-07 00:00:00

abstract：:Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that regulates immune and cell-survival signaling pathways. NF-κB has been reported to be present in neurons wherein it reportedly responds to immune and toxic stimuli, glutamate, and synaptic activity. However, because the brain contains many cell ty...

journal_title：Neuroscience

authors： Listwak SJ,Rathore P,Herkenham M

更新日期：2013-10-10 00:00:00

abstract：:Wobbler mice display forelimb weakness, altered paw positioning, reduced running speed, muscle atrophy and motor neuron loss; co-treatment with glycosaminoglycans and insulin-like growth factor-I counteracts the progression of the disease. Reportedly, treatment with glycosaminoglycans or insulin-like growth factor-I s...

journal_title：Neuroscience

authors： Vergani L,Losa M,Lesma E,Di Giulio AM,Torsello A,Müller EE,Gorio A

更新日期：1999-01-01 00:00:00

abstract：:Neonatal posterior cingulate cortex lesions spare the spatial deficits that characterize adult lesions. The present experiments examined the possibility that the anterior cingulate cortex mediates the spared spatial behavior. Rats were given bilateral lesions of the posterior cingulate cortex or anterior plus posterio...

journal_title：Neuroscience

authors： Gonzalez CL,Whishaw IQ,Kolb B

更新日期：2003-01-01 00:00:00

abstract：:Thrombin and activated protein C (aPC) bound to the endothelial protein C receptor (EPCR) both activate protease-activated receptor 1 (PAR1) generating either harmful or protective signaling respectively. In the present study we examined the localization of PAR-1 and EPCR and thrombin activity in Schwann glial cells o...

journal_title：Neuroscience

authors： Gera O,Shavit-Stein E,Bushi D,Harnof S,Shimon MB,Weiss R,Golderman V,Dori A,Maggio N,Finegold K,Chapman J

更新日期：2016-12-17 00:00:00

abstract：:Cognitive aging affects episodic memory and executive functions, and these vulnerable domains are postulated to be modulated by endogenous and exogenous estrogen exposures. In midlife and late-life women without dementia, estrogen effects on cognition can be examined through associations with concentrations of serum e...

journal_title：Neuroscience

authors： Henderson VW,Popat RA

更新日期：2011-09-15 00:00:00

abstract：:Vascular cognitive impairment and dementia (VCID) is the second leading cause of dementia behind Alzheimer's disease (AD) and is a frequent co-morbidity with AD. Despite its prevalence, little is known about the molecular mechanisms underlying the cognitive dysfunction resulting from cerebrovascular disease. Astrocyti...

journal_title：Neuroscience

authors： Sudduth TL,Weekman EM,Price BR,Gooch JL,Woolums A,Norris CM,Wilcock DM

更新日期：2017-01-26 00:00:00

abstract：:The consequences of excessive fructose intake extend beyond those of metabolic disorder to changes in emotional regulation and cognitive function. Long-term consumption of fructose, particularly common when begun in adolescence, is more likely to lead to deleterious consequences than acute consumption. These long-term...

journal_title：Neuroscience

authors： Kloster A,Hyer MM,Dyer S,Salome-Sanchez C,Neigh GN

更新日期：2021-02-01 00:00:00

abstract：:Carbon monoxide (CO), like other gaseous neuromodulators, has a dual nature as both a toxic gas and a physiologically relevant signaling molecule. In the nervous system, high concentrations of CO can lead to neuronal injury while lower concentrations are found to be neuroprotective. The number of cellular targets affe...

journal_title：Neuroscience

authors： Estes S,Zhong LR,Artinian L,Rehder V

更新日期：2015-12-17 00:00:00

abstract：:Experimental animal studies have demonstrated a number of receptor localizations on specific cortical afferents and neurons. The present study of human posterior cingulate cortex evaluates the laminar distributions of particular receptors and their likely association with components of the neuropil. Coverslip autoradi...

journal_title：Neuroscience

authors： Vogt BA,Plager MD,Crino PB,Bird ED

更新日期：1990-01-01 00:00:00

abstract：:Serotonergic systems are thought to play an important role in control of motor activity and emotional states. We used a fear-potentiated startle paradigm to investigate the effects of a motor-eliciting stimulus in the presence or absence of induction of an acute fear state on serotonergic neurons in the dorsal raphe n...

journal_title：Neuroscience

authors： Spannuth BM,Hale MW,Evans AK,Lukkes JL,Campeau S,Lowry CA

更新日期：2011-04-14 00:00:00

abstract：:Hyperacusis, an exaggerated, sometimes painful perception of loudness even for soft sounds, is a poorly understood distressing condition. While the involvement of modified gain of central auditory neurons and the influence of nonauditory brain regions are well-documented, the issue of where in the auditory system thes...

journal_title：Neuroscience

authors： Duron J,Monconduit L,Avan P

更新日期：2020-02-01 00:00:00

abstract：:The effects of X-irradiation on proliferating cells in the dentate subgranular zone were assessed in young adult Fisher 344 rats exposed to a range of X-ray doses and followed for up to 120 days. Apoptosis was quantified using morphology and end-labeling immunohistochemistry, and cell proliferation was detected using ...

journal_title：Neuroscience

authors： Tada E,Parent JM,Lowenstein DH,Fike JR

更新日期：2000-01-01 00:00:00

abstract：:In the present study, we investigated the possible participation of the endocannabinoid system in the basolateral amygdala and N-methyl-d-aspartate (NMDA) or GABA-A receptor neurotransmission in the ventral tegmental area in the memory consolidation impairment induced by morphine administration. To measure memory form...

journal_title：Neuroscience

authors： Sharifi KA,Rezayof A,Torkaman-Boutorabi A,Zarrindast MR

更新日期：2017-06-14 00:00:00

abstract：:The cerebellum receives input from visual cortical areas via a relay in the pontine nuclei. We have compared the location in the pontine nuclei of terminal fields of fibres from visual areas 18 and 20, and the posteromedial lateral suprasylvian visual area. Due to individual variations in the precise location of termi...

journal_title：Neuroscience

authors： Bjaalie JG,Brodal P

更新日期：1989-01-01 00:00:00

abstract：:Light and electron microscopic immunocytochemical methods were used to study the distribution and the morphology of substance P-positive fibers and axon terminals in the dorsal column nuclei of rats and cats, and to determine whether they are part of an ascending input to these nuclei. In rats, substance P-positive fi...

journal_title：Neuroscience

authors： Conti F,De Biasi S,Giuffrida R,Rustioni A

更新日期：1990-01-01 00:00:00

abstract：:The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use of pumps may increase the incidence of infection within the cochlea, making this technique unsuitable for neurotrophin administration in a cl...

journal_title：Neuroscience

authors： Pettingill LN,Minter RL,Shepherd RK

更新日期：2008-03-27 00:00:00

abstract：:Cultures of 11 day old chick embryo pectoral muscle were used to study the effects of direct electrical stimulation and neurochemicals such as acetylcholine, acetyl-beta-methylcholine, tetrodotoxin, and d-tubocurarine on the acetylcholinesterase levels of muscle. The results suggest that excitation-contraction is an i...

journal_title：Neuroscience

authors： Walker CR,Wilson BW

更新日期：1976-06-01 00:00:00

abstract：:It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...

journal_title：Neuroscience

authors： Legendre A,Courville J

更新日期：1987-06-01 00:00:00

abstract：:Seipin is a widely expressed protein but with highest levels found in the brain and testes. Seipin function is not yet completely understood, therefore the aim of this study was to evaluate the expression of BSCL2 transcripts in the central nervous system (CNS) of humans and investigate the effect of their overexpress...

journal_title：Neuroscience

authors： Sánchez-Iglesias S,Fernández-Liste A,Guillín-Amarelle C,Rábano A,Rodriguez-Cañete L,González-Méndez B,Fernández-Pombo A,Senra A,Araújo-Vilar D

更新日期：2019-01-01 00:00:00

abstract：:The immediate-early gene encoded transcription factor c-Jun is highly inducible following axotomy and therefore serves as a valuable marker in neuronal de- and regeneration. As the signals that may trigger c-Jun expression are still obscure, molecules derived from lesioned neurons and/or their targets such as growth f...

journal_title：Neuroscience

authors： Blottner D,Herdegen T

更新日期：1998-01-01 00:00:00

abstract：:Membrane potential or ionic conductance of neurones of the mammalian central or peripheral nervous system maintained in vitro can be measured over periods of several hours. Drugs or transmitters which change potential or conductance can be applied repeatedly under equilibrium conditions, and pharmacological null metho...

journal_title：Neuroscience

authors： North RA

更新日期：1986-04-01 00:00:00

abstract：:Granulocyte-colony stimulating factor (G-CSF) is a growth factor that regulates proliferation, differentiation and survival of hematopoietic progenitor cells. There is growing evidence to suggest that G-CSF exerts a powerful neuroprotective effect in different neurological disorders. However, it has remained to be elu...

journal_title：Neuroscience

authors： Liu H,Jia D,Fu J,Zhao S,He G,Ling EA,Gao J,Hao A

更新日期：2009-12-29 00:00:00

abstract：:Caffeine works through a variety of complex mechanisms to exert an often bidirectional set of functional and structural neurological changes in vertebrates. We investigated the effects of chronic caffeine exposure on functional recovery of the dorsal light reflex (DLR) in hemilabyrinthectomized common goldfish, Carass...

journal_title：Neuroscience

authors： Goodson NB,Brockhoff BL,Huston JP,Spieler RE

更新日期：2015-04-30 00:00:00

abstract：:In adult females many of the effects of the neuropeptide oxytocin are steroid, and especially estrogen dependent. Here we demonstrate for the first time that neonatal manipulation of oxytocin can affect the expression of estrogen receptor alpha. On the first day of postnatal life male and female prairie voles (Microtu...

journal_title：Neuroscience

authors： Yamamoto Y,Carter CS,Cushing BS

更新日期：2006-01-01 00:00:00

abstract：:Updating the position of an earth-fixed target during whole-body rotation seems to rely on cognitive processes such as the utilization of external feedback. According to perceptual learning models, improvement in performance can also occur without external feedback. The aim of this study was to assess spatial updating...

journal_title：Neuroscience

authors： Mackrous I,Simoneau M

更新日期：2015-08-06 00:00:00