Benzodiazepines block long-term potentiation in slices of hippocampus and piriform cortex.

abstract：:The hippocampus maintains the remarkable ability to generate new neurons throughout the lifespan. Progenitor cells in the subgranular zone give rise mainly to granule cells that migrate to the granule cell layer and become mature, functionally integrated neurons. Numerous factors are capable of regulating the prolifer...

journal_title：Neuroscience

authors： Spanswick SC,Epp JR,Sutherland RJ

更新日期：2011-09-08 00:00:00

abstract：:In the past 15 years the classical view that astrocytes play a relatively passive role in brain function has been overturned and it has become increasingly clear that signaling between neurons and astrocytes may play a crucial role in the information processing that the brain carries out. This new view stems from two ...

journal_title：Neuroscience

authors： Santello M,Volterra A

更新日期：2009-01-12 00:00:00

abstract：:In anaesthetized rats, the intraspinal release of immunoreactive prostaglandin E2 was measured using antibody microprobes. We addressed the question of whether the release of immunoreactive prostaglandin E2 is altered during development of acute inflammation in the knee evoked by intra-articular injections of kaolin a...

journal_title：Neuroscience

authors： Ebersberger A,Grubb BD,Willingale HL,Gardiner NJ,Nebe J,Schaible HG

更新日期：1999-01-01 00:00:00

abstract：:In these experiments a large portion of the pelvic ganglion of adult female rats was transplanted into the wall of the urinary bladder of the same animals. The morphology and fine structure of the transplants were studied in whole-mounts and in sections for light and electron microscopy, from two days up to four month...

journal_title：Neuroscience

authors： Gabella G,Uvelius B

更新日期：1998-03-01 00:00:00

abstract：:Regulation of adult hippocampal neurogenesis in mice responds to behavioral stimuli, including physical activity (RUN) and the exposure to enriched environments (ENR). If studied after days or weeks, these stimuli and the pathological stimulus of kainic acid-induced seizures (KA) show differential effects on different...

journal_title：Neuroscience

authors： Steiner B,Zurborg S,Hörster H,Fabel K,Kempermann G

更新日期：2008-06-23 00:00:00

abstract：:The N-methyl-D-aspartate channel blocker phencyclidine is known to induce psychotic episodes in normal subjects and exacerbate psychosis in schizophrenics; however, its site of action is not clear. The prefrontal cortex, hippocampus, and basal ganglia are brain regions that appear to play a role in the pathophysiology...

journal_title：Neuroscience

authors： O'Donnell P,Grace AA

更新日期：1998-12-01 00:00:00

abstract：:In cultured bovine adrenal medullary cells, neosurugatoxin and histrionicotoxin inhibited carbachol-induced influx of 22Na, 45Ca and secretion of catecholamines with IC50 of 27 nM and 3 microM, respectively. The inhibitory effects of neosurugatoxin were reversed by the increased concentrations of carbachol, whereas th...

journal_title：Neuroscience

authors： Wada A,Uezono Y,Arita M,Tsuji K,Yanagihara N,Kobayashi H,Izumi F

更新日期：1989-01-01 00:00:00

abstract：:Treatment of P19 embryonal carcinoma cells with retinoic acid induces their differentiation into a population of cells consisting of neurons and other cell types normally derived from neuroectoderm. We used immunohistological and histochemical techniques to identify some of the neurotransmitters in the P19-derived neu...

journal_title：Neuroscience

authors： Staines WA,Morassutti DJ,Reuhl KR,Ally AI,McBurney MW

更新日期：1994-02-01 00:00:00

abstract：:Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid precursor mRNAs and opioid peptides deriving therefrom in inflamed tis...

journal_title：Neuroscience

authors： Przewłocki R,Hassan AH,Lason W,Epplen C,Herz A,Stein C

更新日期：1992-01-01 00:00:00

abstract：:A diet consisting of high levels of saturated fat has been linked to a dramatic rise in obesity, type II diabetes, and metabolic syndrome. The effect of these co-morbidities on stroke outcome has not been examined in detail in human or animal studies. In this study we hypothesized that maintaining animals on a high fa...

journal_title：Neuroscience

authors： Langdon KD,Clarke J,Corbett D

更新日期：2011-05-19 00:00:00

abstract：:The distribution in the rat brain of high affinity nicotinic heteromeric acetylcholine receptors and of low affinity nicotinic, alpha7-containing, homomeric receptors was studied using in vitro light microscopic autoradiography. As ligands, we used [3H]epibatidine, or [125I]epibatidine, and [125I]alpha-bungarotoxin, r...

journal_title：Neuroscience

authors： Tribollet E,Bertrand D,Marguerat A,Raggenbass M

更新日期：2004-01-01 00:00:00

abstract：:In the present study the effect of cocaine on thymidine, uridine and leucine incorporation was assessed in primary cortical glial and C6 glioma cells. Cocaine exposure for 24 h inhibited thymidine and uridine incorporation in cortical glial and C6 glioma cells. However, the effect of cocaine on uridine incorporation w...

journal_title：Neuroscience

authors： Garg UC,Turndorf H,Bansinath M

更新日期：1993-11-01 00:00:00

abstract：:Organotypic cultures of fetal or early postnatal striatum were used to assess striatal patch formation and maintenance in the presence or absence of dopaminergic and glutamatergic influences. Vibratome-cut slices of the striatum prepared from embryonic day 19 to postnatal day 4 rat pups were maintained in static cultu...

journal_title：Neuroscience

authors： Snyder-Keller A,Costantini LC,Graber DJ

更新日期：2001-01-01 00:00:00

abstract：:The human myelin proteolipid protein 1 gene (hPLP1), which encodes the major structural myelin proteins of the central nervous system (CNS), is classically described as expressed in the oligodendrocytes, the CNS myelinating cells. We identified two new exons in the intron 1 of the hPLP1 gene that lead to the expressio...

journal_title：Neuroscience

authors： Sarret C,Combes P,Micheau P,Gelot A,Boespflug-Tanguy O,Vaurs-Barriere C

更新日期：2010-03-17 00:00:00

abstract：:Pituitary adenylate-cyclase activating polypeptide (PACAP) has been implicated in the (patho)physiology of stress-adaptation. PACAP deficient (PACAP(-/-)) mice show altered anxiety levels and depression-like behavior, but little is known about the underlying mechanisms in stress-related brain areas. Therefore, we aime...

journal_title：Neuroscience

authors： Gaszner B,Kormos V,Kozicz T,Hashimoto H,Reglodi D,Helyes Z

更新日期：2012-01-27 00:00:00

abstract：:Characterization of the expression pattern of connexins in neural tissue is a necessary prerequisite for understanding the functional relevance of the corresponding gap junction channels in brain. Here we describe the cell type-specific expression of connexin45 in the CNS and the spatiotemporal expression pattern from...

journal_title：Neuroscience

authors： Maxeiner S,Krüger O,Schilling K,Traub O,Urschel S,Willecke K

更新日期：2003-01-01 00:00:00

abstract：:It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution and influence aspects of speech and language. Recently it was shown that when these substitutions are introduced into the endogenous Foxp2 gene of mice, they increase dendrite l...

journal_title：Neuroscience

authors： Reimers-Kipping S,Hevers W,Pääbo S,Enard W

更新日期：2011-02-23 00:00:00

abstract：:The protective effect of diphenyliodonium, known as an inhibitor of flavin enzymes including nitric oxide synthases, was examined against the neurotoxicity of excitatory amino acids on cultured spinal neurons of the rat. Diphenyliodonium reduced the neuronal damage induced by 15-min exposure to glutamate or N-methyl-D...

journal_title：Neuroscience

authors： Nakamura Y,Tsuji K,Shuto M,Ogita K,Yoneda Y,Shimamoto K,Shibata T,Kataoka K

更新日期：1997-01-01 00:00:00

abstract：:Long-term hyperexcitability was found after unilateral, permanent middle cerebral artery occlusion in exofocal neocortical areas of the adult mouse [Mittmann et al. (1998) Neuroscience 85, 15-27]. The aim of the present study was to test the hypothesis in an identical paradigm of ischemia. whether alterations in the d...

journal_title：Neuroscience

authors： Qü M,Mittmann T,Luhmann HJ,Schleicher A,Zilles K

更新日期：1998-07-01 00:00:00

abstract：:Deficits in forepaw adjusting steps in rats have been proposed as a non-drug-induced model of the akinesia associated with Parkinson's disease. The present study examined the relationship between contralateral forepaw adjusting steps and dopamine depletion after medial forebrain bundle lesions with 6-hydroxydopamine. ...

journal_title：Neuroscience

authors： Chang JW,Wachtel SR,Young D,Kang UJ

更新日期：1999-01-01 00:00:00

abstract：:It has been hypothesized [Colpaert, F.C., 1994. In: Briley, M., Marien, M. (Eds.), Noradrenergic Mechanisms in Parkinson's Disease. CRC Press, Boca Raton, FL, pp. 225-254] that a deficiency in the noradrenergic system originating from the locus coeruleus is a decisive factor in the progression of central neurodegenera...

journal_title：Neuroscience

authors： Debeir T,Marien M,Chopin P,Martel JC,Colpaert F,Raisman-Vozari R

更新日期：2002-01-01 00:00:00

abstract：:Opioid binding sites were localized in cryostat sections of guinea-pig brain by in vitro autoradiography using (-)-[3H]bremazocine. Quantification of binding sites in gray matter was accomplished using standard samples of tritium mixed in brain gray matter. The binding sites in fiber tracts were quantified using stand...

journal_title：Neuroscience

authors： Foote RW

更新日期：1987-01-01 00:00:00

abstract：:Urocortin, a novel 40 amino acid neuropeptide, is a member of the corticotropin-releasing factor family. With 45% homology to corticotropin-releasing factor, urocortin binds with similar affinity to the corticotropin-releasing factor- and corticotropin-releasing factor-2 receptors and may play a role in modulating man...

journal_title：Neuroscience

authors： Morin SM,Ling N,Liu XJ,Kahl SD,Gehlert DR

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Electrophysiological responses to auditory stimuli have provided a useful means of elucidating mechanisms and evaluating treatments in psychiatric disorders. Deficits in gating during paired-click tasks and lack of mismatch negativity following deviant stimuli have been well characterized in patients with ...

journal_title：Neuroscience

authors： Ehrlichman RS,Gandal MJ,Maxwell CR,Lazarewicz MT,Finkel LH,Contreras D,Turetsky BI,Siegel SJ

更新日期：2009-01-23 00:00:00

abstract：:Professional Pingju actors have been shown to exhibit practice-induced plastic changes in spontaneous regional brain activity; however, whether these changes are present in resting-state regional cerebral blood flow (CBF) remains largely unclear. Here, twenty professional Pingju opera actors and 20 age-, sex-, and han...

journal_title：Neuroscience

authors： Zhao F,Zhang W,Zhu D,Wang X,Qin W,Liu F

更新日期：2020-06-01 00:00:00

abstract：:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. Dietary fatty acids, especially polyunsaturated fatty acids, have been shown to enhance learning and memory and prevent memory deficits in various...

journal_title：Neuroscience

authors： Jia D,Heng LJ,Yang RH,Gao GD

更新日期：2014-01-31 00:00:00

abstract：:The nucleus accumbens septi is the major target of mesolimbic dopamine neurons originating in the ventral tegmental area of the mesencephalon. Studies involving experimental manipulation of dopamine transmission by drugs and by lesions, as well as in vivo monitoring of extracellular dopamine concentrations, have provi...

journal_title：Neuroscience

authors： Bassareo V,Di Chiara G

更新日期：1999-03-01 00:00:00

abstract：:Group I metabotropic glutamate receptors (mGluR1 and mGluR5) are functionally linked to estrogen receptors and play a key role in the plasticity of central neurons. Estrogen status strongly influences sensory input from the temporomandibular joint (TMJ) to neurons at the spinomedullary (Vc/C1-2) region. This study tes...

journal_title：Neuroscience

authors： Tashiro A,Nishida Y,Bereiter DA

更新日期：2015-07-23 00:00:00

abstract：:Stimulation of cervical vagal afferents inhibits central sympathetic outflows in part by inhibiting the ongoing activity of putative baroreceptive neurons in the rostral ventrolateral medulla oblongata. The aim of the present study was to examine the electrophysiological characteristics of vagal responses and their in...

journal_title：Neuroscience

authors： Zagon A,Rocha I,Ishizuka K,Spyer KM

更新日期：1999-01-01 00:00:00

abstract：:Epidemiological studies have demonstrated a relationship between advancing age and susceptibility to risk factors for median neuropathies and musculoskeletal disorders. In this study, we determined if performance of a voluntary reaching task by aged rats induced sensorimotor declines, median nerve dysfunction and incr...

journal_title：Neuroscience

authors： Elliott MB,Barr AE,Clark BD,Wade CK,Barbe MF

更新日期：2010-10-27 00:00:00