当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Differential distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat brain.

Differential distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat brain.

Abstract：

:Urocortin, a novel 40 amino acid neuropeptide, is a member of the corticotropin-releasing factor family. With 45% homology to corticotropin-releasing factor, urocortin binds with similar affinity to the corticotropin-releasing factor- and corticotropin-releasing factor-2 receptors and may play a role in modulating many of the same systems as corticotropin-releasing factor. To assess whether urocortin and corticotropin-releasing factor are localized in the same regions of the brain, we compared the distribution of urocortin- and corticotropin-releasing factor-like immunoreactivities in the rat central nervous system. Polyclonal antibodies to rat corticotropin-releasing factor and rat urocortin were generated and utilized to map the distribution of corticotropin-releasing factor- and urocortin-like immunoreactivities throughout the rat forebrain and brainstem. Characterization of the antibodies by radioimmunoassay showed no cross-reactivity with related peptides. Male Sprague-Dawley rats were treated with colchicine for 18-24 h. Following colchicine treatment, the rats were perfused with paraformaldehyde-lysine-periodate fixative and their brains removed. Serial coronal sections were taken throughout the rat brain and processed for either corticotropin-releasing factor- or urocortin-like immunoreactivity. Urocortin-like immunoreactivity shows a discrete localization within several regions including the supraoptic nucleus, the median eminence, Edinger-Westphal nucleus and the sphenoid nucleus. This is in contrast to the more abundant corticotropin-releasing factor-like immunoreactivity. Regions containing high levels of corticotropin-releasing factor immunoreactivity include the lateral septum, paraventricular nucleus of the hypothalamus, median eminence and locus coeruleus. There are a few regions that contain both urocortin-immunoreactive and corticotropin-releasing factor-immunoreactive cells, such as the supraoptic nucleus and the hippocampus. Therefore, urocortin and corticotropin-releasing factor appear to have different distribution patterns which may be indicative of their respective physiological functions.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Morin SM,Ling N,Liu XJ,Kahl SD,Gehlert DR

doi

10.1016/s0306-4522(98)00732-5

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

281-91

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(98)00732-5

journal_volume

92

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.

    abstract：:The striatum, which processes cortical information for behavioral output, is a key target of Huntington's disease (HD), an autosomal dominant condition characterized by cognitive decline and progressive loss of motor control. Increasing evidence implicates deficient glutamate uptake caused by a down-regulation of GLT1...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.02.004

    authors： Miller BR,Dorner JL,Shou M,Sari Y,Barton SJ,Sengelaub DR,Kennedy RT,Rebec GV

    更新日期：2008-04-22 00:00:00

  • Differential neurite growth on astrocyte substrates: interspecies facilitation in green fluorescent protein-transfected rat and human neurons.

    abstract：:In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00430-3

    authors： van den Pol AN,Spencer DD

    更新日期：2000-01-01 00:00:00

  • Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments.

    abstract：:Chitinase activity is increased in Alzheimer's disease (AD). However, the role of chitinase1 in AD is unknown. We investigated the effects of chitinase1 on Alzheimer's pathology and microglia function. Artificial chitinase1 and chitinase inhibitor (chitinase-IN-2) were used to determine the effects of chitinase1 on in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.04.050

    authors： Xiao Q,Yu W,Tian Q,Fu X,Wang X,Gu M,Lü Y

    更新日期：2017-07-04 00:00:00

  • Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration.

    abstract：:The vulnerability of different dopaminergic cell populations to damage caused by the herbicide paraquat was assessed by stereological counts of tyrosine hydroxylase-positive and calbindin-D28k-immunoreactive neurons in A9 (substantia nigra pars compacta) and A10 (ventral tegmental area and other cell groups). In salin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.03.069

    authors： McCormack AL,Atienza JG,Langston JW,Di Monte DA

    更新日期：2006-08-25 00:00:00

  • Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II - induced hypothalamic reactive oxygen species and hypertension.

    abstract：:Activation of angiotensinergic pathways by central aldosterone (Aldo)-mineralocorticoid receptor (MR) pathway plays a critical role in angiotensin II (Ang II)-induced hypertension. The subfornical organ (SFO) contains both MR and angiotensin II type 1 receptors (AT1R) and can relay the signals of circulating Ang II to...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.04.050

    authors： Wang HW,Huang BS,White RA,Chen A,Ahmad M,Leenen FH

    更新日期：2016-08-04 00:00:00

  • Reduced expression and desensitization of adenosine A1 receptor/adenylyl cyclase pathway after chronic (-)N6-phenylisopropyladenosine intake during pregnancy.

    abstract：:Little is known about the G protein-coupled receptor desensitization process during pregnancy. Wistar pregnant rats were treated with (-)N(6)-phenylisopropyladenosine (R-PIA), an adenosine A(1) receptor (A(1)R) agonist, in their drinking water during pregnancy, and the effect on A(1)R/adenylyl cyclase system was studi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.06.050

    authors： León DA,Castillo CA,Albasanz JL,Martín M

    更新日期：2009-10-06 00:00:00

  • Identification of intellectual disability genes showing circadian clock-dependent expression in the mouse hippocampus.

    abstract：:Sleep is strongly implicated in learning, especially in the reprocessing of recently acquired memory. Children with intellectual disability (ID) tend to have sleep-wake disturbances, which may contribute to the pathophysiology of the disease. Given that sleep is partly controlled by the circadian clock, we decided to ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.08.066

    authors： Renaud J,Dumont F,Khelfaoui M,Foisset SR,Letourneur F,Bienvenu T,Khwaja O,Dorseuil O,Billuart P

    更新日期：2015-11-12 00:00:00

  • Working memory and the homeostatic control of brain adenosine by adenosine kinase.

    abstract：:The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effect...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.03.051

    authors： Singer P,McGarrity S,Shen HY,Boison D,Yee BK

    更新日期：2012-06-28 00:00:00

  • The role of ventral tegmental dopamine neurons in locomotor sensitization following quinpirole or (+)-amphetamine: ex vivo voltammetric evidence.

    abstract：:Behavioural sensitization to the locomotor stimulating effects of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Following expression of sensitization, locomotor activity scores on day 9 were: vehicle 87 +/- 9, (+)-amphetamine 1441 +/- 227 and quinpirole 2078 +/- 214. Electrical...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00389-2

    authors： Muscat R,Iravani MM,Kruk ZL

    更新日期：1996-12-01 00:00:00

  • Induction of neurofilament phosphorylation in cultured chromaffin cells.

    abstract：:The distribution, structural organization and state of phosphorylation of neurofilaments have been examined in chromaffin cells from adult bovine adrenal medulla cultured under various conditions using a series of monoclonal antibodies directed against phosphorylated and nonphosphorylated epitopes of the 200,000 mol. ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90301-6

    authors： Grant NJ,Demeneix B,Aunis D,Langley OK

    更新日期：1988-11-01 00:00:00

  • Neuronal uptake and laminar distribution of tritiated aspartate, glutamate, gamma-aminobutyrate and glycine in the prestriate cortex of squirrel monkeys: correlation with levels of cytochrome oxidase activity and their uptake in area 17.

    abstract：:The neuronal uptake and laminar distribution of cortically injected tritium-labeled gamma-aminobutyrate (GABA), aspartic acid, glutamate and glycine was examined in the prestriate cortex of squirrel monkeys. The intent of this investigation was not to examine the role of these amino acids as neurotransmitters, but to ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90343-5

    authors： Carroll EW,Wong-Riley M

    更新日期：1987-08-01 00:00:00

  • A role for the neural cell adhesion molecule in a late, consolidating phase of glycoprotein synthesis six hours following passive avoidance training of the young chick.

    abstract：:We have investigated the effect of intracranial injections of the amnestic anti-metabolite, 2-deoxygalactose, and antibodies to the neural cell adhesion molecule on retention of a one-trial passive avoidance task in chicks. Groups of chicks received bilateral intracranial injections of 10 mumol/hemisphere 2-deoxygalac...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90519-l

    authors： Scholey AB,Rose SP,Zamani MR,Bock E,Schachner M

    更新日期：1993-07-01 00:00:00

  • Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels.

    abstract：:Central neuropathic pain (CNP) in the spinal cord, such as chronic pain after spinal cord injury (SCI), is an incurable ailment. However, little is known about the spinal cord mechanisms underlying CNP. Recently, reactive oxygen species (ROS) have been recognized to play an important role in CNP of the spinal cord. Ho...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.05.023

    authors： Nishio N,Taniguchi W,Sugimura YK,Takiguchi N,Yamanaka M,Kiyoyuki Y,Yamada H,Miyazaki N,Yoshida M,Nakatsuka T

    更新日期：2013-09-05 00:00:00

  • Genetic deletion of MT₁/MT₂ melatonin receptors enhances murine cognitive and motor performance.

    abstract：:Melatonin, an indoleamine hormone secreted into circulation at night primarily by the brain's pineal gland, has been shown to have a wide variety of actions on the development and physiology of neurons in the CNS. Acting via two G-protein-coupled membrane receptors (MT1 and MT2), melatonin modulates neurogenesis, syna...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.07.018

    authors： O'Neal-Moffitt G,Pilli J,Kumar SS,Olcese J

    更新日期：2014-09-26 00:00:00

  • Involvement of brain protein kinase C in nitrous oxide-induced antinociception in mice.

    abstract：:Exposure of mice to the anesthetic gas nitrous oxide (N(2)O) produces a marked antinociceptive effect. Protein kinase C is a key regulatory enzyme that may be targeted by general anesthetics. However, a relationship between N(2)O-induced antinociception and protein kinase C has yet to be established. The present study...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.001

    authors： Ishikawa M,Matsushita Y,Abe K,Utsunomiya I,Hoshi K,Quock RM,Taguchi K

    更新日期：2006-06-19 00:00:00

  • PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) belongs to a family of ligand-activated transcription factors, and its ligands are known to control many physiological and pathological conditions. The hypothesis of our study was that the PPARγ agonist (rosiglitazone) could mediate tumor necrosis factor alpha (...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.11.003

    authors： Chiang MC,Cheng YC,Lin KH,Yen CH

    更新日期：2013-01-15 00:00:00

  • Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats.

    abstract：:Choline is essential to the development and function of the central nervous system and supplemental choline during development is neuroprotective against a variety of insults, including neurotoxins like dizocilpine (MK-801). MK-801 is an NMDA receptor antagonist that is frequently used in rodent models of psychologica...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.07.071

    authors： Nickerson CA,Brown AL,Yu W,Chun Y,Glenn MJ

    更新日期：2017-10-11 00:00:00

  • Short increase of BDNF messenger RNA triggers kainic acid-induced neuronal hypertrophy in adult mice.

    abstract：:Neurotrophin gene expression in adult brain varies according to physiological activity and following brain injury, suggesting a role in neuronal maintenance and plasticity. However, the exact roles and mechanisms of action of neurotrophins in the adult brain are still poorly understood. We have recently demonstrated t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00005-x

    authors： Guilhem D,Dreyfus PA,Makiura Y,Suzuki F,Onteniente B

    更新日期：1996-06-01 00:00:00

  • Correlations between immediate early gene induction and the persistence of long-term potentiation.

    abstract：:The duration of long-term potentiation in the dentate gyrus of awake rats was examined following systematic manipulation of the number of stimulus trains delivered. This was correlated with the induction of immediate early genes in separate groups of animals given identical stimulus regimes. Following 10 trains of sti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90369-q

    authors： Abraham WC,Mason SE,Demmer J,Williams JM,Richardson CL,Tate WP,Lawlor PA,Dragunow M

    更新日期：1993-10-01 00:00:00

  • Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex.

    abstract：:Neuronal gap junctions in the brain, providing intercellular electrotonic signal transfer, have been implicated in physiological and behavioral correlates of learning and memory. In connexin31.1 (Cx31.1) knockout (KO) mice the coding region of the Cx31.1 gene was replaced by a LacZ reporter gene. We investigated the i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.01.077

    authors： Dere E,Zheng-Fischhöfer Q,Viggiano D,Gironi Carnevale UA,Ruocco LA,Zlomuzica A,Schnichels M,Willecke K,Huston JP,Sadile AG

    更新日期：2008-05-02 00:00:00

  • Early-life Photoperiod Influences Depression-like Behavior, Prepulse Inhibition of the Acoustic Startle Response, and Hippocampal Astrogenesis in Mice.

    abstract：:Environmental factors during early life stages affect behavioral and physiological phenotypes in adulthood. We examined the effect of photoperiods during development on neurogenesis and affective behaviors during adolescence/adulthood using C57BL/6J mice. Mice were born and raised until weaning under long-day conditio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.01.038

    authors： Takai Y,Kawai M,Ogo T,Ichinose T,Furuya S,Takaki N,Tone Y,Udo H,Furuse M,Yasuo S

    更新日期：2018-03-15 00:00:00

  • Characteristics and specific localization of receptors for atrial natriuretic peptides at non-neuronal cells in cultured mouse spinal cord cells.

    abstract：:Characteristics of atrial natriuretic peptide receptors were determined in cultured mouse spinal cord cells. Saturation and competition experiments demonstrated the presence of a single class of atrial natriuretic peptide binding sites with high affinity (KD = 0.054 nM) and a density of 1.92 fmoles/10(6) cells. A simi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90342-4

    authors： Simonnet G,Allard M,Legendre P,Gabrion J,Vincent JD

    更新日期：1989-01-01 00:00:00

  • Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons.

    abstract：:Whole-cell recordings were made from neurons of the rat locus coeruleus in a tissue slice removed from rat brain. Substance P caused an inward current in cells voltage-clamped at -60 mV. The effect of substance P was concentration-dependent (30 nM-3 microM) and was mimicked by similar concentrations of substance K and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90428-5

    authors： Shen KZ,North RA

    更新日期：1992-09-01 00:00:00

  • Reconstruction of shifting elbow joint compliant characteristics during fast and slow movements.

    abstract：:The purpose of this study was to experimentally investigate the applicability of the equilibrium-point hypothesis to the dynamics of single-joint movements. Subjects were trained to perform relatively slow (movement time 600-1000 ms) or fast (movement time 200-300 ms) single-joint elbow flexion movements against a con...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90328-l

    authors： Latash ML,Gottlieb GL

    更新日期：1991-01-01 00:00:00

  • Functional Compensation and Mechanism of Choline Acetyltransferase in the Treatment of Cognitive Deficits in Aged Dementia Mice.

    abstract：:Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine (Ach). Exogenous supplementation with ChAT can functionally compensate for decreased Ach levels and ameliorate memory and cognitive deficits. In this paper, the treatment efficacy of recombinant ChAT (peptide transduction domain (PTD)-ChAT...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.05.016

    authors： Zhu Z,Zhang L,Cui Y,Li M,Ren R,Li G,Sun X,Li Q

    更新日期：2020-08-21 00:00:00

  • Distribution of the omega-conotoxin receptor in rat brain. An autoradiographic mapping.

    abstract：:The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90089-4

    authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

    更新日期：1989-01-01 00:00:00

  • Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia.

    abstract：:Dopamine and endocannabinoids are neurotransmitters known to play a role in the activity of the basal ganglia motor circuit. While a number of studies have demonstrated functional interactions between type 1 cannabinoid (CB1) receptors and dopaminergic systems, we still lack detailed neuroanatomical evidence to explai...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00070-8

    authors： Julian MD,Martin AB,Cuellar B,Rodriguez De Fonseca F,Navarro M,Moratalla R,Garcia-Segura LM

    更新日期：2003-01-01 00:00:00

  • Selective irreversible blockade of 5-hydroxytryptamine1A and 5-hydroxytryptamine1C receptor binding sites in the rat brain by 8-MeO-2'-chloro-PAT: a quantitative autoradiographic study.

    abstract：:The possible irreversible blockade of 5-hydroxytryptamine1 receptor subtypes 5-hydroxytryptamine1A, 5-hydroxytryptamine1B/5-hydroxytryptamine1D and 5-hydroxytryptamine1C by the chloramine 8-methoxy-2-(N-2'-chloropropyl,N-propyl)aminotetralin (8-MeO-2'-chloro-PAT) was investigated in rat brain sections by quantitative ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90436-3

    authors： Radja F,Daval G,Emerit MB,Gallissot MC,Hamon M,Vergé D

    更新日期：1989-01-01 00:00:00

  • Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.

    abstract：:Adenosine tonically inhibits synaptic transmission through actions at A(1) receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A(2A) receptor activation or from indirect control of inhibitory GABAergic transmission. The A(2A) receptor agoni...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00080-5

    authors： Lopes LV,Cunha RA,Kull B,Fredholm BB,Ribeiro JA

    更新日期：2002-01-01 00:00:00

  • Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro.

    abstract：:During spinal cord maturation neuronal excitability gradually differentiates to meet different functional demands. Spontaneous activity, appearing early during spinal development, is regulated by the expression pattern of ion channels in individual neurons. While emerging excitability of embryonic motoneurons has been...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.06.040

    authors： Furlan F,Guasti L,Avossa D,Becchetti A,Cilia E,Ballerini L,Arcangeli A

    更新日期：2005-01-01 00:00:00