Reduced expression and desensitization of adenosine A1 receptor/adenylyl cyclase pathway after chronic (-)N6-phenylisopropyladenosine intake during pregnancy.

abstract：:A previously developed model of exercise-induced muscle contracture using iodoacetate to inhibit glyceraldehyde-3-phosphate dehydrogenase in rat hindlimb muscles produced selective type II myofiber damage. Utilizing a modification of the same model system, rats were given intra-aortic ortho-iodosobenzoic acid (700 nmo...

journal_title：Neuroscience

authors： Locklear I,Feeback DL,Brumback RA

更新日期：1990-01-01 00:00:00

abstract：:Excitability and axon/dendrite specification are the most distinctive features in the establishment of neuronal polarization. Conditioned medium from rat sciatic nerve (CM) induced a neuronal-like morphology in PC12 cells. Here we show that CM neuritogenic activity is limited to the induction of dendrites in PC12 cell...

journal_title：Neuroscience

authors： Longart M,García L,Castillo C,Martínez JC,Medina R,Forsyth P,Malavé C

更新日期：2009-03-17 00:00:00

abstract：:Compelling lines of evidence indicate that overexpression of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) in subjects with trisomy 21 (Down syndrome[DS]) contributes to the abnormal structure and function of the DS brain. In the present study, we used a novel, phospho-dependent antibody r...

journal_title：Neuroscience

authors： Kida E,Walus M,Jarząbek K,Palminiello S,Albertini G,Rabe A,Hwang YW,Golabek AA

更新日期：2011-11-10 00:00:00

abstract：:The tachykinin peptide substance P (SP) is expressed by many interneurons and some projection neurons in the superficial dorsal horn of the spinal cord. We have recently shown that SP-expressing excitatory interneurons in lamina II correspond largely to a morphological class known as radial cells. However, little is k...

journal_title：Neuroscience

authors： Polgár E,Bell AM,Gutierrez-Mecinas M,Dickie AC,Akar O,Costreie M,Watanabe M,Todd AJ

更新日期：2020-12-01 00:00:00

abstract：:This study examines the effect of chronic alcohol consumption on the human cerebellum using operational criteria for case selection [Caine D. et al. (1997) J. Neurol. Neurosurg. Psychiat. 62, 51-60] and unbiased stereological techniques. We describe, for the first time, structural changes in different functional zones...

journal_title：Neuroscience

authors： Baker KG,Harding AJ,Halliday GM,Kril JJ,Harper CG

更新日期：1999-01-01 00:00:00

abstract：:Two volatile agents, isoflurane and sevoflurane have similar anesthetic properties but different potencies; this allows the discrimination between anesthetic potency and other properties on the protective mechanisms of volatile anesthesia. Two times the minimal alveolar concentration of an anesthetic is approximately ...

journal_title：Neuroscience

authors： Wang J,Meng F,Cottrell JE,Kass IS

更新日期：2006-07-07 00:00:00

abstract：:The midbrain periaqueductal gray matter has been identified as a reflex centre located uppermost in the central organization of diverse defensive reactions. We recently found that when activated, the caudal third of the lateral periaqueductal gray was also capable of provoking a marked increase in cortical blood flow....

journal_title：Neuroscience

authors： Nakai M,Ogata J,Fukui K,Nakai Y,Maeda M

更新日期：1997-07-01 00:00:00

abstract：:Microinjection of L-glutamate into a subregion of the gigantocellular nucleus of the rat medulla oblongata significantly lowers arterial pressure. This vasodepressor area, the gigantocellular depressor area, is topographically distinct from other vasoactive areas of the medulla. We sought to determine the efferent pro...

journal_title：Neuroscience

authors： Aicher SA,Reis DJ,Ruggiero DA,Milner TA

更新日期：1994-06-01 00:00:00

abstract：:Neuronal differentiation is a critical developmental process that determines accurate synaptic connection and circuit wiring. A wide variety of naturally occurring compounds have been shown as promising drug leads for the generation and differentiation of neurons. Here we report that a diarylheptanoid from the plant A...

journal_title：Neuroscience

authors： Tang G,Dong X,Huang X,Huang XJ,Liu H,Wang Y,Ye WC,Shi L

更新日期：2015-09-10 00:00:00

abstract：:The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI) is a measure of sensorimotor gating which is a basic process whereby...

journal_title：Neuroscience

authors： Marks WN,Greba Q,Cain SM,Snutch TP,Howland JG

更新日期：2016-09-22 00:00:00

abstract：:Accumulating evidence indicates that activation of spinal cord astrocytes contributes importantly to nerve injury and inflammation-induced persistent pain and chronic opioid-induced antinociceptive tolerance. Phosphorylation of extracellular signal-regulated kinase (pERK) and induction of interleukin-1 beta (IL-1β) in...

journal_title：Neuroscience

authors： Berta T,Liu YC,Xu ZZ,Ji RR

更新日期：2013-09-05 00:00:00

abstract：:NADPH-diaphorase histochemical staining demonstrated a distinct neural group that might synthesize nitric oxide in the lower brainstem of rats. The NADPH-diaphorase stain revealed a Golgi-like network in the dorsomedial spinal trigeminal nucleus oralis and rostrolateral solitary tract nucleus, whereas this network was...

journal_title：Neuroscience

authors： Takemura M,Wakisaka S,Yoshida A,Nagase Y,Bae YC,Shigenaga Y

更新日期：1994-08-01 00:00:00

abstract：:Cytoplasmic pH (pH1) of crayfish lateral giant axons was monitored using antimony microelectrodes placed near septate junctions and variations of internal pH was induced by short applications of ammonium sulfate in the perfusing bath of the preparation. This treatment produced a rapid cell alkalinization followed, aft...

journal_title：Neuroscience

authors： Giaume C,Korn H

更新日期：1982-07-01 00:00:00

abstract：:Whereas activation of α1-adrenoceptors (α1-ARs) modulates glutamatergic transmission, the roles of α1-ARs in GABAergic transmission in the medial prefrontal cortex (mPFC) are elusive. Here, we examined the effects of the α1-AR agonist phenylephrine (Phe) on GABAergic transmission onto pyramidal neurons in the deep lay...

journal_title：Neuroscience

authors： Luo F,Tang H,Cheng ZY

更新日期：2015-08-06 00:00:00

abstract：:Modeling Parkinson's disease remains a major challenge for preclinical researchers, as existing models fail to reliably recapitulate all of the classic features of the disease, namely, the progressive emergence of a bradykinetic motor syndrome with underlying nigrostriatal α-synuclein protein accumulation and nigrostr...

journal_title：Neuroscience

authors： Mulcahy P,O'Doherty A,Paucard A,O'Brien T,Kirik D,Dowd E

更新日期：2012-02-17 00:00:00

abstract：:The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...

journal_title：Neuroscience

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1989-01-01 00:00:00

abstract：:This study examined the age-related subsequent memory effect (SME) in perceptual and semantic encoding using event-related potentials (ERPs). Seventeen younger adults and 17 older adults studied a series of Chinese characters either perceptually (by inspecting orthographic components) or semantically (by determining w...

journal_title：Neuroscience

authors： Kuo MC,Liu KP,Ting KH,Chan CC

更新日期：2014-03-07 00:00:00

abstract：:The globus pallidus, one of the basal ganglia nuclei, plays a major role in both basal ganglia physiology and pathophysiology. The globus pallidus is innervated mainly by striatal spiny neurons and globus pallidus collaterals. These GABAergic synapses constitute 90% of the input to globus pallidus cells. Despite the d...

journal_title：Neuroscience

authors： Rav-Acha M,Sagiv N,Segev I,Bergman H,Yarom Y

更新日期：2005-01-01 00:00:00

abstract：:Purkinje cell maturation during thyroxine-induced metamorphosis in premetamorphic bullfrog tadpoles was studied using electron microscopy and Golgi (silver-impregnated) preparations. Cerebella from tadpoles were examined following 1, 2, or 3 weeks of thyroxine treatment. Particular attention was paid to possible diffe...

journal_title：Neuroscience

authors： Hauser KF,Gona AG

更新日期：1984-01-01 00:00:00

abstract：:After transection of the sciatic nerve there is a dramatic increase in both galanin/galanin message-associated peptide-like immunoreactivities and preprogalanin messenger RNA levels in rat and mouse lumbar 4 and 5 dorsal root ganglion neurons. There is strong evidence that after nerve injury leukemia inhibitor factor ...

journal_title：Neuroscience

authors： Kerekes N,Landry M,Hökfelt T

更新日期：1999-01-01 00:00:00

abstract：:Sensory neurons mediate diabetic peripheral neuropathy. Using a mouse model of diabetic peripheral neuropathy (BKS.Cg-m+/+Lepr(db)/J (db/db) mice) and cultured dorsal root ganglion (DRG) neurons, the present study showed that hyperglycemia downregulated miR-146a expression and elevated interleukin-1 receptor-activated...

journal_title：Neuroscience

authors： Wang L,Chopp M,Szalad A,Zhang Y,Wang X,Zhang RL,Liu XS,Jia L,Zhang ZG

更新日期：2014-02-14 00:00:00

abstract：:Neurones within the rostral ventromedial medulla project to the intermediolateral cell column of the spinal cord where they may influence sympathetic preganglionic neuronal activity controlling cutaneous vascular beds. Here we assess whether such neurones contribute to cutaneous sympathetic vasoconstrictor activity in...

journal_title：Neuroscience

authors： Korsak A,Gilbey MP

更新日期：2004-01-01 00:00:00

abstract：:Oxytocin (OT) levels in plasma increase during sexual response and are significantly lower in patients with depression. A drug for the treatment of sexual dysfunction, sildenafil, enhances the electrically evoked release of OT from the posterior pituitary. In this study, we showed that sildenafil had an antidepressant...

journal_title：Neuroscience

authors： Matsushita H,Matsuzaki M,Han XJ,Nishiki TI,Ohmori I,Michiue H,Matsui H,Tomizawa K

更新日期：2012-01-03 00:00:00

abstract：:To determine the role of the frontal cortex in the generalization of limbic seizures, we first produced unilateral cortical spreading depression to reversibly suppress neuronal activity in the motor cortex and then triggered an amygdala-kindled seizure. Three minutes following induction of unilateral spreading depress...

journal_title：Neuroscience

authors： Kelly ME,Battye RA,McIntyre DC

更新日期：1999-01-01 00:00:00

abstract：:Intrathecally-administered endomorphin-1 and endomorphin-2 produce antinociceptive effects which are different from each other. In order to elucidate a cellular basis for this result, we examined the effects of endomorphin-1 and endomorphin-2 on holding currents and spontaneous glutamatergic excitatory transmission in...

journal_title：Neuroscience

authors： Fujita T,Kumamoto E

更新日期：2006-01-01 00:00:00

abstract：:Ivane Beritashvili ("Beritoff" in Russian, and often in Western languages) was a major figure in 20th-century neuroscience. Mastering the string galvanometer, he founded the electrophysiology of spinal cord reflexes, showing that inhibition is a distinctly different process from excitation, contrary to the concepts of...

journal_title：Neuroscience

authors： Tsagareli MG,Doty RW

更新日期：2009-10-20 00:00:00

abstract：:Neurosteroids are synthesized de novo in the brain and the cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated that the rat Purkinje cell actively produces progesterone de novo from cholesterol only during neonatal life and progesterone promotes dendritic growth, spinogenesis and ...

journal_title：Neuroscience

authors： Sakamoto H,Ukena K,Takemori H,Okamoto M,Kawata M,Tsutsui K

更新日期：2004-01-01 00:00:00

abstract：:An antisense oligodeoxynucleotide selective for the rat neuropeptide Y1 receptor gene was given into the left lateral ventricle in the experimental group of rats, whereas a missense oligodeoxynucleotide or saline was given in the control groups. Some rats were decapitated at 1-2h after the last injection of the oligod...

journal_title：Neuroscience

authors： Cheung RT,Cechetto DF

更新日期：2000-01-01 00:00:00

abstract：:In the latero-anterior hypothalamus (LAH) increased glutamate and vasopressin (AVP) activity facilitate anabolic androgenic steroid (AAS)-induced offensive aggression. In addition, adolescent AAS treatment increases the strength of glutamate-mediated connections between the LAH and the brain nucleus of stria terminali...

journal_title：Neuroscience

authors： Carrillo M,Ricci LA,Melloni RH

更新日期：2011-06-30 00:00:00

abstract：:After a unilateral resection of the frontal cortex in fetal cats the volume of the caudate nucleus increases while the packing density of neuronal and glial cells does not change. In the present report we address the questions of whether a similar lesion sustained neonatally or a more extensive neodecortication sustai...

journal_title：Neuroscience

authors： Loopuijt LD,Villablanca JR,Hovda DA,Huang E,Mancuso S

更新日期：1997-03-01 00:00:00